The Institute of Clinical Sciences, Department of surgery, is now searching for a postdoctoral fellow to work with preclinical research, mainly concerning extracellular vesicles and cancer. The newly established research group of Rossella Crescitelli conducts translational research in extracellular vesicle field (https://www.gu.se/om-universitetet/hitta-person/rossellacrescitelli). The research group is based at the Institute of Clinical Sciences, but also belongs to the Wallenberg Center for Molecular and Translational Medicine (WCMTM) and Sahlgrenska Center for Cancer Research (SCCR), which provides good opportunities for career development and network building. WCMTM and SCCR consist of a large network of research group leaders and their team members within the University of Gothenburg and also well-functioning national collaborations. Moreover, the research group has access to Krefting Research Center, an exceptionally well-equipped center for research in the field of extracellular vesicles. More information about ongoing research activities and key research groups within Wallenberg Center for Molecular and Translational Medicine, Sahlgrenska Center for Cancer Research and Krefting Research Centre can be found at www.wcmtm.gu.se, https://www.gu.se/en/cancercenter; https://www.gu.se/en/krefting-research.

Subject area 

Extracellular vesicles and Cancer Research 

Subject area description 

The project will elucidate how extracellular vesicles (EVs) mediate communication between cells in the tumor microenvironment. The overall aim of this project is to reveal novel extracellular vesicle-mediated mechanisms of cancer growth and progression. We have recently developed a state-of-the-art method to isolate highly purified EVs directly from tissue (Crescitelli R, Nature Protocols, 2021 https://www.nature.com/articles/s41596-020-00466-1). The postdoctoral fellow will utilize this novel technology to explore and describe EV-mediated communication between cells in the tumor microenvironment. By being placed under the umbrella of Roger Olofsson Bagge´s and Jan Lötvall´s group we have access to both fresh and froze tumor samples as well as to the state-of-the-art equipment for EV research. By isolating EVs derived from tumor tissues, we aim at identifying the pathways by which cells in the tumor microenvironment communicate and how this contributes to tumor progression. The knowledge generated from this project will improve our basic understanding of cancer and will provide a platform for developing future therapies and diagnostics. 

Duties 

The work includes designing, planning, and performing research work aimed at studying the microenvironments in tumors using cellular and molecular methods, including different types of DNA, RNA and protein analyses, as well as work with flow cytometry, electron microscopy and advanced methods for the isolation and characterization of extracellular vesicles. A close collaboration will take place with our clinical laboratory to collect patient samples. The work will mainly be carried out at the Sahlgrenska Center for Cancer Research and Krefting Research Centre.

Eligibility 

To be eligible for appointment as a postdoc, the applicant is required to have a doctoral degree, a doctoral degree in art or a foreign degree that is deemed to be equivalent to a doctoral degree. This eligibility requirement must be met before the employment decision is made. 

In the first instance, those who have completed their degree no more than three years prior to the end of the application period shall be considered. Those who have completed their degree more than three years prior to the end of the application period may also be considered in the first instance if special grounds exist. Special grounds relate to leave of absence due to illness, parental leave, commissions of trust within union organisations, service within the defence services or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area.   

Assessment criteria 

To qualify as a postdoctoral researcher a PhD in biology, biochemistry, biotechnology, molecular biology or equivalent is required. A broad base of expertise, including cell biology (cell culturing), biochemistry (Western blotting) and molecular biology (qRT-PCR) is required. Experience in single-cell transcriptomic analysis, mass spectrometry and flow cytometry analysis will be strongly advantageous. Familiarity with extracellular vesicles and mouse models is an added advantage. Experience in advanced microscopy (i.e. confocal and transmission electron microscopy) is considered a plus. The work takes high demands on self-motivation, independence, and accuracy. Great weight will be given to performance during the interview and personal qualities such as commitment, initiative, and cooperation skills. Ability to communicate in written and spoken English is a must. 

Employment 

The employment is limited (temporary) for two years with the possibility of one year’s extension, 100 % of full-time and is placed at the Institute of Clinical Sciences, Surgery. Starting date; As agreed 

Contact information 

If you have any questions about the position, please contact researcher Rossella Crescitelli on e-mail: rossella.crescitelli@gu.se 

Unions 

Union representatives at the University of Gothenburg can be found here: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande 

 

Application 

Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. The application should be written in English. The application shall include;

• A short cover letter with description of your experience and what makes you qualified for this particular job
• A detailed curriculum vitae (CV)
• A publication list
• Name and contact information of two references

It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.  

 

Applications must be received by: 2014-02-25 

  

Information for International Applicants 

Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit: 

https://www.gu.se/en/about-the-university/welcome-services 
https://www.movetogothenburg.com/ 

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.