Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology. CMB is located in Biomedicum, a new interdisciplinary research center designed to concentrate much of the experimental research conducted at Karolinska Institutet Campus Solna under one roof to promote collaboration. Biomedicum houses approximately 1,200 researchers and other personnel and allows expensive equipment to be shared and utilised more effectively.

The main interests of the Spalding research group are to investigate properties of human adipose tissue, with particular attention to human adipocyte biology. We investigate basic cellular functions, such as senescence, adipocyte lipid and cell turnover, adipocyte response to obesity and hyperinsulinemia and cellular heterogeneity in human adipose tissue depots. Understanding the cell biology and heterogeneity of adipocytes in human adipose tissue, with the ultimate aim of understanding their contributions to health and pathology, is a major focus of the group.

The Spalding group has established strong clinical collaborations within Sweden and abroad, ensuring high quality access to human adipose tissue. All necessary platforms, such as FACS, single cellsequencing and microscopy etc. are available.

The doctoral student project and the duties of the doctoral student

Many metabolic diseases, including type 2 diabetes, strongly associate with obesity, making obesity one of the major health challenges facing the world today. Understanding how adipocytes respond to obesity and contribute to pathological processes is more relevant than ever, especially with juvenile and adult levels of obesity reaching epidemic proportions world-wide.

The Spalding lab recently identified senescent fat cells in human adipose tissue, which increases in association with pathology (obesity and hyperinsulinemia), releasing factors that promote inflammation and dysfunction. The proposed project will investigate the prevalence of senescent adipocytes in different fat depots in humans, identify factors secreted by senescent fat cells and identify mechanisms promoting fat cell senescence.

The student will work with human adipose tissue samples to perform adipocyte cell culture,  immunocytochemistry, flow cytometry, confocal and reflected microscopy as well as molecular biology techniques (including western blot, qPCR and RNAseq, comet DNA damage assays).

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

We are seeking a student with a background in molecular biology, biomedicine or the equivalent. The candidate should have a good team spirit, be self-motivated and have a keen interest in human adipose biology. Experience in working with molecular biology techniques, confocal and reflected microscopy, FACS and the isolation and culture of primary human fat cells are a strong plus. A background in DNA damage and repair is also an advantage. The student is required to have good communication skills in English (written and verbal).

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Video about Karolinska Institutet, how we all work towards “a better health for all”

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-12 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Thursday October 12th, 2023

Do you want to contribute to top quality medical research?

We are seeking a postdoctoral research fellow in the field of wearable biosensors to join an international project in translational medical research. This is an exciting opportunity to involve breakthrough research on developing epidermal sensors for medical diagnostics as part of the recently awarded EU project (NEUROSENSE), using a combination of biochemistry, bioelectronics, and material science. We offer a multi-national and collaborative research environment with partners in academia and the biomedical industry.

Applications are invited for a post-doctoral position in Parlak Lab at the Division of Dermatology and Venereology, Department of Medicine, Solna. The lab’s research focus is to develop epidermal sensors for medical diagnostics for the prevention and prediction of neurological and dermatological diseases. The group is building new interdisciplinary research as there is an immense potential for new fundamental insights to be discovered.

Your mission

An experienced postdoctoral research fellow in biosensors and bioelectronics is needed to work at Parlak Lab at Karolinska Institute for our recently funded NEUROSENSE project. You will be part of a research team developing high-quality wearable neuroendocrine sensors. Specifically, you will work on the fabrication of a microelectrode array, synthetic and semi-synthetic biorecognition design for hormone and metabolite detection. You will be integral members of a team which works to generate high throughput wearable biosensor devices. The duties of the position also include reporting and data dissemination. Thus, your work will contribute to the broader goal of NEUROSENSE; to make prevention and prediction of neurological disorders using epidermal biosensors.

Your profile

We are looking for a curiosity-driven, inquisitive and enthusiastic person interested in our area of research and ready to explore new avenues in science. The candidates should have a collaborative approach to research, work productively in a team, and contribute to a good social environment in the laboratory.

The applicant shall hold a Ph.D. degree in natural or engineering sciences. The candidates with previous experience in biosensor design and microfabrication will be prioritized. The candidate should have documented experience with electrochemical biosensors. Experience in synthetic and semi-synthetic biorecognition design and polymer chemistry is significant merit. Experience with clean room facility and electron microscopy are not required but is considered merit.

The applicant needs to have a high degree of independence and motivation but should have no problems working in a team, given the collaborative nature of the project. Fluency in English is a requirement.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location

The position is located within the Department of Medicine, Solna. The department consists of eleven divisions and each division consists of several research groups. The position is located within the research group of Onur Parlak. The Department of Medicine, Solna is one of the largest departments at Karolinska Institute. The core activities of the Department of Medicine are clinical and undergraduate education for medical as well as biomedical students, post-graduate education, including at present 200 registered PhD students, and research in different areas of biomedicine. The department conducts research in a large number of areas. The proximity to patients is one of the department’s strengths. Conducting research in a clinical environment gives excellent opportunities to integrate basic research and patient-centered research.

Parlak Lab is a newly established laboratory in the Division that aims to use innovative science at the interface between biotechnology, materials science, and electronics to tackle the key area of critical importance to society: healthcare and biomaterials. Parlak Lab investigates the application of bioelectronics in medicine to meet the need for complex, dynamic environments and to develop novel devices. The overall aim of the lab is to develop new technologies to combat healthcare challenges and design novel tools for early diagnostics and solutions for digital medicine and remote monitoring.

— [Video about a Karolinska Institutet, how we work towards “a better health for all”] —

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-27 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Friday October 27th, 2023

Do you want to contribute to improving human health?

The position is situated in the Franzén research group at the division of physiotherapy, NVS, KI. The focus of the research groups is on translational research from exploring neural mechanisms to clinical interventions/implementation in the field of neurological and geriatric rehabilitation. Our areas of special interest are balance control, exercise, physical activity and falls in elderly and individuals with neurological diseases (Parkinson’s disease, Multiple sclerosis, stroke and spinal cord injury).

The postdoc will be working in Franzen’s group, consisting of research assistants, doctoral students, postdocs as well as junior and senior researchers. The multidisciplinary project group consists of researchers with extensive expertise in different fields and from several research groups (neuroimaging, neurology, psychology etc). The doctoral student will have their workspace both at the uMOVE core facility in Solna and also at the division of physiotherapy, NVS in Flemingsberg.

Your mission

We are now searching for a postdoctoral fellow who will in several stages develop and test feasibility of a new exercise treatment for people with Parkinson’s disease that is more adapted to different subtypes and each individual’s abilities. The postdoc will also initiate a randomized controlled study of the exercise intervention when it is ready for a full-scale study. The position is full-time, 2 years with the possibility of extension and the position starts on June 1, 2023.

Your work will consist of usual duties at postdoctoral level such as project design, data collection, processing, data analysis and statistical analysis. Both qualitative and quantitative research designs will be used. Writing scientific articles, grant applications and being able to present the research are important tasks. There is also the opportunity to design your own studies in the area. This project is a large collaborative project, which means that an important ability is to be able to collaborate and interact with different parties as well as to also lead and coordinate parts of the project. Teaching and supervision of students and doctoral students may occur.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Applicants should, in addition to the above qualifications, have good experience of patient contact with people with neurodegenerative diseases. Furthermore, applicants should have a basic education in physiotherapy and experience in movement analysis. There is of great importance if you have experience and knowledge of training interventions, feasibility studies and iterative development processes. It is advantageous if you have experience in both qualitative and quantitative research designs.

You should be initiative-taking, independent and structured. We attach great importance to cooperation, flexibility and personal suitability. You should be very good at communicating orally and in writing in English.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 17th of october 2023.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-17 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Tuesday October 17th, 2023

Do you want to contribute to top quality medical research?

1-2 positions are now open in Professor Karin Loré’s group to study mechanisms of action of vaccines. The overall focus of the research group is to investigate immune functions by which different vaccine formulations regulate immunity. The successful candidate will join an enthusiastic team at the Department of Medicine, Solna at Karolinska Institutet and study timely questions in close collaboration with the vaccine industry.

Duties

The studies focus on the generation of high quality and durable B cell and T cell responses by
vaccination. This includes assessments of the early innate immune profile locally and systemically after vaccination as well as the development of antigen-specific responses. This involves high resolution analyses of both early cell activation and gene modulation as well as of the B cell and antibody response such as single cell isolation, sequencing and mapping of antibody specificities. The projects will have a special focus on mRNA vaccines and nanoparticle vaccines with different adjuvants. The studies will employ clinical samples, non-human primate models and several standard immunological and molecular techniques. The research program will partly be shaped to take into account the interests and experience of the candidate.

The position will be based at Karolinska Institutet, Stockholm, Sweden. We work in collaboration with academic partners, vaccine companies as well as funding agencies such as the Bill and Melinda Gates foundation. Thus, the candidate will have the opportunity to interact with and learn various scientific and technical expertise from leading researchers in the vaccine field.

The candidate is expected to learn and take part in experimental design, experimentation, presentation, and publication of results. In addition, he or she is expected to join research-related activities such as group meetings, departmental seminars, national/international meetings, as well as take part in routine work within our research team and help supervise students within the group

Entry requirements

We are seeking highly motivated postdoctoral researcher(s) with a strong desire to study principles of immune system functions. The candidates applying must have or about to get a PhD degree in
biomedicine, immunology, cell biology or a related discipline. Knowledge of immunology and
experience with some of the relevant experimental approaches (e.g. sample processing, flow cytometry, ELISA, molecular biology techniques, bioinformatical analyses) are preferred. Emphasis will be placed on personal suitability and compatibility with lab members. Applicants must have good communication skills in English and ability to collaborate and work productively in a team.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships from KI.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location

The position is located within the Department of Medicine, Solna. The department consists of eleven divisions and each division consists of several research groups. The position is located within the research group of Karin Loré at the Division of Immunology and Allergy. A range of preclinical as well as clinical studies in allergy, infections and immune modulation are being conducted within the division. The successful candidate will join an international team. Stockholm is a vibrant international megapolis with high quality of living standard. English is the working language of the group. The Karolinska Institutet is one of the centers of excellence for biomedical research in the world (ranked as 8th in the world in Life Sciences and Medicine by QS World University Ranking). It possesses cutting edge
infrastructure

https://ki.se/en/meds/research-group-karin-lore.

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-11 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Wednesday October 11th, 2023

Do you want to contribute to top quality medical research?

Overview of the Position

The Strategic Research Programme in Diabetes (SRP Diabetes) at Karolinska Institutet is funding a prestigious fellowship programme for postdoctoral research fellows. The Programme is focused on research in diabetes and its comorbidities. With this postdoctoral programme SRP Diabetes aims to support the next generation of exceptional young scientists within the diabetes area, including both experimental and clinical research. As part of this programme, we are now looking to recruit 4 outstanding postdoctoral research fellows. Full details on each project and contact information to the PIs can be found at: http://ki.se/en/srp-diabetes/postdoctoral-fellowships

Based at Karolinska Institutet, fellows will undertake a cutting-edge research project in a competitive lab and be part of the SRP Diabetes dynamic research environment where several events will be held throughout the year such as high-profile lectures, symposia, internal retreat, etc. which the fellows will attend.

The fellowships are fully funded, and salary is provided for a 2-year period. It is our intention that the positions will start in the autumn of 2023, though some flexibility with the start date might be possible.

Research Project

Development of DNA nanotechnology-based methods to map and target membrane protein nanodomains in vitro and in vivo

At the Teixeira lab (https://ki.se/en/mbb/ana-teixeira-group), we have developed DNA nanotechnology-based  approaches to map and target membrane protein nanodomains (e.g. Spratt, Dias et al., Nature Nanotechnology, 2023; Ambrosetti et al, Nature Nanotechnology, 2021; Fang et al, ACS Nano, 2021; Verheyen, Fang et al, Nucleic Acids Research, 2020; Shaw, Lundin, et al, Nat Methods 2014). In this project, the postdoctoral research fellow will investigate the nanoscale spatial organization of insulin receptors in different tissues. This information will be used to develop multivalent insulin variants using DNA- and protein-based self-assembly. The biodistribution and tissue specific effects of different multivalent insulin variants will be mapped in wild type and diabetes models in zebrafish and mice. This work aims to form the basis for the future development of insulin variants with tailored tissue targeting patterns.

Key responsibilities of the selected applicant:

• Plan, manage and conduct an agreed academic research project and associated activities.
• Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate.
• Develop research questions, analyse detailed and complex qualitative and/or quantitative data from a variety of sources, and contribute original ideas for new research projects.
• Coordinate multiple aspects of work to deliver novel research data in accordance with established timelines set between you and the Principal Investigator.
• Adapt existing and develop new scientific techniques and experimental protocols to support research.
• Regularly write research articles at an international level for peer-reviewed journals, book chapters, and reviews.
• Formally present your research and represent the research group at internal, national and international conferences and meetings, either with other members of the team or alone.
• Informally present your research to the group at established meetings.
• Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques.

Selection Criteria

Essential

• PhD (to be completed in 2023).
• The ability to manage your own academic research and associated activities.
• A strong CV, having published in high impact journals and presented at international meetings.
• Ability to contribute ideas for new research projects and research income generation.
• Ability to work with meticulous attention to detail.
• An enthusiastic interest in diabetes research.
• Evidence of excellent interpersonal skills and leadership, with the ability to communicate research ideas and results in a clear and logical way and the ability to confidently and effectively interact with colleagues and the broader research community.
• Strong verbal and written communication skills in English.
• A conscientious and enthusiastic working approach.
• Excellent planning, organizational and problem-solving skills

In addition, experience in one or several of the following is valued:

• DNA nanotechnology, DNA origami
• Surface Plasmon Resonance
• Atomic Force Microscopy
• Super-resolution microscopy
• Single cell biology

Each Fellowship is for two years. We will prioritize applicants who have the opportunity to complete the project and be employed for two years. Preference should be given to those who were awarded a PhD or attained equivalent research competence no more than three years prior to the expiry of the application period for the position as postdoc.

Location: Solna

How to apply

If you consider that you meet the selection criteria, click on the Login and apply button on this page and follow the on-screen instructions to register as a user. You will then be required to provide information in a number of screens with your application details, relating to your skills and experience. When prompted, please provide details of three references. You will also be required to upload a CV and Personal Letter which explains how you meet the selection criteria for the position. The Personal Letter (maximum two pages) should explain your relevant experience which may have been gained in employment, education, or you may have taken time away from these activities as illness, military service, work for labour unions or student organisations, parental leave or similar circumstances. Your application will be judged in part on the basis of how you demonstrate that you meet the selection criteria outlined above and we are happy to consider evidence of transferable skills or experience which you may have gained outside the context of paid employment or education.

Please save all uploaded documents to show your name and the document type.

The application is to be submitted through the Varbi recruitment system.

The closing date for applications is midnight CEST on Sunday 22nd October, 2023.

Working at Karolinska Institutet

For further information about working at Karolinska Institutet, rules for visa/residence permit, insurance and accommodation please see: https://staff.ki.se/international-staff

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-22 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Sunday October 22nd, 2023

Do you want to contribute to top quality medical research?

The Department of Clinical Sciences at Danderyd Hospital conducts extensive clinical research in several areas. The department is growing and consists of research nurses, biomedical analysts, senior researchers, post docs, and Ph.D students as well as administrative personnel. Each year, about 400 first level students conduct their medical education at the department.

We are searching for an ambitious postdoctoral fellow for an initial appointment of 1 year, with a possible extension for up to 1 additional year, to join the team behind the COMMUNITY (Covid-19 Immunity) study. The COMMUNITY study was initiated 2020 with the aim to investigate immune responses to SARS-CoV-2 infection and vaccination. More than 2000 employees at Danderyd Hospital are followed every few months since enrolment, and the large and extensive database has generated over 40 scientific publications to date. In close collaboration with Uppsala University, Sanquin Research, Amsterdam, Leiden University Medical Center, and National University of Singapore, we will now use machine learning to map and correlate a panel of novel and established biomarkers including antibody subclass distributions, effector functions, antibody glycoanalytics and affinity-based proteomics to continue to explore vaccine responses and correlates of protection against a broad panel of respiratory viruses.

Your mission

The postdoctoral candidate will work with the existing data set as well as ongoing data processing, with a focus on applying AI and machine learning techniques. The position will include close collaborative work within the international network, driving his/her own projects forward. The candidate will also have the opportunity to participate in CAIR-Lab projects, contributing to the development of clinical AI innovations.

Your profile

Applicants should hold a Ph.D. or equivalent expertise in bioinformatics. Coding skills in R or Python are important and will be assessed through a brief coding evaluation, along with your application of basic statistical tools, during the interview. Please submit your GitHub profile (if you have one with a track record of > 1 year) for additional assessment. Previous experience in plasma proteomics, metabolomics, and mass spectrometry is a plus. Interest in immunology is a prerequisite, and knowledge of this research field is an advantage.

Requirements

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Applicants should have significant experience to be able to lead their own project and also coach/supervise other students (master, Ph.D., or assist other colleagues in the group if required); and have first-author publications in recognized peer-reviewed journals. We highly regard careful record keeping, strong collaborative skills, and creative thinking. In addition, good oral and written communication skills in English are required. We put great emphasis on the ability of the person to collaborate with the rest of the team, prioritize tasks, and help the group reach its goals.

For more information, please contact principal investigator Charlotte Thålin, M.D. and associate professor at the Department of Clinical Sciences at Danderyd Hospital: charlotte.thalin@ki.se or Max Gordon, M.D. and associate professor at the Department of Clinical Sciences at Danderyd Hospital (CAIR-Lab): max.gordon@ki.se

What do we offer?

The position will be in the Thålin group at the Department of Clinical Sciences Danderyd Hospital. The project is cutting-edge within a rapidly moving research field and conducted in close collaboration with world-leading international scientific groups and CAIR-Lab. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research.

Location: Danderyd

Department of Clinical Sciences, Danderyd Hospital

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)
• Your GitHub profile or equivalent platform for the assessment of your coding skills (optional but highly recommended)

Interviews will start when applications are received until the position is filled.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-22 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Sunday October 22nd, 2023

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

We are seeking a highly motivated and ambitious person for exploring the molecular and cellular mechanisms regulating the tumour microenvironment in childhood brain tumours. The position is placed in Margareta Wilhelm’s research group at The Department of Microbiology, Tumour and Cell Biology (MTC), Biomedicum at Karolinska Institutet, in a strong medical research environment with extensive possibilities for interaction and support. MTC conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC have about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations.

The doctoral student project and the duties of the doctoral student

Specifically, the student will work on a project aimed at understanding the development of medulloblastoma, with a focus on how the premalignant niche transforms into a promalignant niche and how crosstalk occurs between cells that initiate the cerebellar tumour and neighbouring cells using single cell resolution methods. The project involves advanced stem cell culturing techniques, cerebellar organoid and in vivo modelling, and statistical and bioinformatics analyses of sequencing and patient data. The candidate is expected to work within the general framework of the research project but is encouraged to contribute with ideas and suggestions for experiments.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

We are looking for a highly motivated and enthusiastic individual with a strong interest in tumour biology and neuro-oncology.

Requirements for the position:

• The candidate should be self-motivated and able to work productively both individually and in a group setting and contribute to a good social environment in the laboratory.
• The candidate will be expected to actively participate in both the practical and theoretical parts of the project and have excellent communication and organizational skills.
• Applicants must have a Master’s degree (or equivalent) in biomedicine, molecular medicine or other relevant life science.  
• Excellent laboratory skills in molecular biology and cell culture are required.

Meritorius for the position:

• Previous research experience, knowledge of human stem cell culture techniques, animal models, and bioinformatics will be considered an asset.

Special attention will be given to personal suitability.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

https://ki.se/mtc

https://ki.se/en/mtc/wilhelm-lab

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-19 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Thursday October 19th, 2023

Do you want to contribute to top quality medical research?

Division

Marco Gerlings research group at the department of Biosciences and Nutrition is looking for a Postdoctoral fellow for the period of one year. The position will be financed by a Postdoc scholarhsip paid out by KI. See below the criterias for being granted a Postdoc scholarship at KI.

Duties

You will work in the Cancer Cell Invasion lab, which performs translational research on gastrointestinal cancers. Your task will be to disentangle tumor-normal cell crosstalks at the leading edge of pancreatic cancers and liver metastases of diverse primary tumors. You will use heterotypic organoid models and other in vitro tools to study the interactions of cancer cells with their directly adjacent normal cells, delineating the mechanisms of competition by which tumor cells replace healthy parenchymal cells. These in vitro studies will be the focus of your work. You will use samples from human tumors to validate your findings in ex vivo cultures and patient material.

You will also work with mouse models of these cancer types to study and perturb tumor invasion. Your studies aim to identify targetable pathways that mediate the replacement of normal cells by invading tumor cells.

Qualifications

For the position, a solid background in cell culture is imperative. This includes experience in the isolation of tumors from primary tumor tissues and familiarity with induced pluripotent stem cells (iPSCs), which will serve to create different host tissues in co-culture with tumor cells. A hands-on understanding of 3D cell culture setups is crucial. The candidate must also be proficient in various molecular and cellular techniques, especially histology, immunohistochemistry, and protein expression analysis. Furthermore, the expertise in working with heterotypic organoid models and familiarity with drug testing on patient-derived samples will be advantageous. Experience with mouse models, as gained from prior research engagements, will be a particular merit. Given the translational nature of the research, skills in confocal microscopy and flow cytometry are required. The ideal candidate would have demonstrated experience in these areas, as well as a proven track record of successful collaboration and team-oriented endeavors.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: in the Neo building on the south Campus of KI in Flemingsberg.

Links for further reading: Department of Biosciences and Nutrition
                                            Marco Gerlings research group

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-09 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Monday October 9th, 2023

Do you want to contribute to top quality medical research?

The Chemical Proteomics Core Facility of Karolinska Institutet (ChemProt), Department of Medical Biochemistry and Biophysics, announces a PostDoc position for 2 years.  ChemProt operates at Biomedicum and is the specialized Unit of Chemical Proteomics for two national infrastructures, Science for Life Laboratories (SciLifeLab) and the Swedish National Infrastructure for Biological Mass Spectrometry (BioMS). Dr. Massimiliano Gaetani is heading this Unit within the Division of Chemistry I, led by prof. Roman Zubarev, also scientific director of the Unit

ChemProt is focused on providing liquid chromatography coupled to mass spectrometry (LC-MS)-based proteomics to decipher how active molecules work in cells, majorly by means of proteome profiling for target deconvolution, discovery of additional targets, off-targets and elucidation of the relative mechanism of action. Support to research projects is provided with coordinated and comprehensive service at the ChemProt`s premises, including experimental design and consulting for cost-efficiency, tasks regarding cell culturing, cell treatment, proteomics sample preparation including possible ad-hoc optimization, LC-MS analysis and bioinformatics data processing

Hydrogen-deuterium exchange mass spectrometry (HDX-MS) for elucidation of protein binding interface is also a provided as service at the national level with specialization on using potentially therapeutic small-molecules and antibodies (epitope mapping) as ligands.

The candidate will be involved in a top-rank LC-MS/MS laboratory with multidisciplinary expertise, from cell cultures, sample biochemical and biophysical processing on cells and tissues, LC-MS/MS analysis, proteomics data processing and method development in chemical proteomics. The candidate will gain the unique expertise present at ChemProt as well as gaining advanced technical experience in a comprehensive and well-equipped laboratory including modern equipment of biological safety cabinets class II, CO2 incubators, ultracentrifuge, UPLC for off-line fractionation, and nine high resolution LC-MS Orbitrap systems, including the multiple and recently acquired systems of Fusion Lumos and Exploris480. Performing and maintaining LC-MS/MS operation, proteomics data processing, data analysis, development of new tools for analysis and visualization using multidimensional and orthogonal MS-based proteomics will be of critical relevance for the candidate. ChemProt is also a Unit of SciLifeLab, where its current platform is a growing hub of cooperative projects, integrative data analysis and interactions with the other SciLifeLab platform units.

Your mission

The work requires interaction with the staff and research personnel of both ChemProt and the rest of the Chemistry I Division. The duties include:

• To be a technology- and service-oriented person, with good personal qualities, scientific research mindset, capable of working in teams and take on responsibilities of a users` projects and data analysis, understanding the technical details of the performed experiment and the technical nature of the type of raw data
• To provide qualified competence as well as technological and/or methodological service and development.
• To contribute to everyday operation and troubleshooting of the LC-MS and proteomics laboratory
• To be able to the whole pipeline of work, from cells to data analysis, with focus on LC-MS/MS, data analysis, data acquisition, bioinformatics analysis and developments of pipelines and tools for data analysis and visualization
• To participate in method development and ChemProt`s meetings as requested
• To assist in instrumentation and lab maintenance relatively to the performed activities
• To assist with keeping track and ordering the reagents and consumables relatively to the assigned laboratory activities
• To present analysis reports to the Head of ChemProt, relatively to the activities
• To proficiently communicate and provide reports and presentations in English. 

Your profile

Formal education degree, such as bachelor, is a must. To start, the candidate must have a demonstrated research expertise in the field of proteomics and mass spectrometry and have been awarded, by the time of the start of the contract, a doctorate or a qualification from a foreign higher education institution deemed equivalent to a Swedish Degree of Doctor in related fields. The Ph.D. or its equivalent is not needed by the time of application. The ideal candidate has a demonstrated technological and methodological expertise in proteomics and bioinformatics data analysis, with extensive experience in proteomics software such as Proteome Discoverer, MaxQuant and Peaks. It is a relevant merit of the candidate to hold knowledge of programming languages R, Python and others.

It is well recognized additional experience on cell culturing and use of common laboratory equipment, BSL2 laboratory practices and sterile techniques, while prior experience in quantitative proteomics, knowledge of LC-MS and familiarity with proteomics tasks is a must. In particular, the candidate must be able to carry out, with precision and in a systematic way, the requested chemical proteomics methods with complete and organized reporting.

A service-oriented personality, good inter-personal skills, and the ability to efficiently work in an international research environment are absolutely required. English is the working language; good command of it in oral and written communications is a must.

What do we offer?

The workplace will be at Biomedicum, hosting top-ranked research groups and infrastructure facilities in the KI Solna Campus, near to the SciLifeLab national infrastructure, also hosting research groups and facilities. The work environment is a creative, international, and inspiring environment with wide-ranging expertise and interest.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna Biomedicum

Chemical Proteomics at KI; Chemical Proteomics Unit at SciLifeLab and BioMS

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 2023-10-01

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-01 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Sunday October 1st, 2023

Do you want to contribute to improving human health?

The Department of Medical Epidemiology and Biostatistics conducts research in epidemiology and biostatistics across a broad range of areas within biomedical science. The department is among the largest of its type in Europe and has especially strong research profiles in psychiatric, cancer, reproductive, pediatric, pharmaco, genetic, and geriatric epidemiology, eating disorders, precision medicine, and biostatistics.

Part of the success of our department is due to our collaborative spirit where one factor is that researchers at the Department share and co-finance common resources (e.g., IT and an applied biostatistics group). The department is situated at campus Solna. Further information can be found at http://ki.se/en/meb

Your mission

We are looking for an outstanding and motivated postdoctoral researcher to join our research team. The successful applicant will work on projects related to pharmacological treatment in forensic psychiatry. The project will leverage advanced epidemiologic designs and high-quality Swedish registry data. The results are expected to provide critical information for health care providers about the risks and benefits associated with different pharmacological treatment, in order to improve treatment outcomes of patients in forensic psychiatric care.

The postdoctoral researcher will work with an interdisciplinary research team. The main tasks include literature review, data analysis, and results dissemination.

This is a temporary position for 2 years.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

The successful applicant is expected to have:

• Experience in conducting epidemiology studies in forensic psychiatry.
• Knowledge of the Swedish National Forensic Psychiatric Register (RättspsyK).
• Ability in formulating research questions based on existing evidence in the field.
• Experience and interest in working in an international research group. Excellence in written and verbal communication (in English)
• Ability to collaborate with researchers within and beyond the group.
• Medical degree and clinical experience in forensic psychiatry are merits.

We attach great importance to personal qualities in this recruitment.

What do we offer?

International staff
KI Postdoc Association
Choose to work at KI – Ten reasons why

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-03 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Tuesday October 3rd, 2023

Do you want to contribute to top quality medical research?

We are looking for a postdoctoral researcher for the Aging Epidemiology group at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet in Stockholm. The research in the group concerns several different areas, such as markers for biological aging and pharmacoepidemiological studies. Our main research interest is biological aging; how to measure it in population-based cohorts and how to understand causal relationships between aging and age-related diseases (geroscience).

Your mission

The candidate will investigate the interplay between genes and environment in older individuals. Specifically, analyzes of longitudinal data will be performed to verify the drug’s impact on aging by measuring cognitive function, frailty, functional aging, clinical biomarkers, anthropometry, telomere length, epigenetic data and genotypes.

This is a full-time temporary position for 2 years.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

The applicant is expected to have:

• A doctoral degree related to epidemiology, pharmaco-epidemiology, or aging.
• A formal education in epidemiology, pharmaco-epidemiology, public health or a closely related field.
• A strong research background in aging, pharmaco-epidemiology, epidemiology or related.
• Experience with methods in biostatistics and epidemiological research.
• Experience with registry-based data and/or genetic data.
• Excellent data management skills in R, SAS and/or Stata.
• Excellent communication and writing skills in English.

We stress research expertise when assessing applicants. In addition, great emphasis will be placed on collaborative ability, ability to work independently, and personal suitability. We attach great importance to personal qualities in this recruitment.

What do we offer?

International staff 
KI Postdoc Association  
Choose to work at KI – Ten reasons why

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-04 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Wednesday October 4th, 2023

Do you want to contribute to top quality medical research?

We are recruiting a highly motivated and skilled postdoctoral researcher who has a specific interest in the role of cytotoxic lymphocytes, in particular NK cells, in the human lung during homeostasis and in respiratory diseases such as respiratory viral infections and lung cancer. Our Team has a long-standing interest in NK cells in the lung, and we are offering an international research environment, cutting-edge technologies, and unique collaborative projects with other researchers and clinicians.

Your mission

Together with us, you will be pioneering in the emerging field of human tissue-resident NK cells. Within our ongoing projects, you will be responsible for mapping distinct NK cell subsets in the healthy human lung as well as identify key factors affecting lung and blood NK cell phenotype and function in influenza, COVID-19, and lung cancer. A particular long-term interest of the group is to understand how cytotoxic lymphocytes behave in tissues and how they can be harnessed for cellular immunotherapy in pathological conditions. The work includes several close collaborations with other research groups, but you will also work on individual projects that you will be responsible for to push forward.

The position is in the Team of Dr Nicole Marquardt (Senior Research Specialist) at the Center for Hematology and Regenerative Medicine (HERM) at the Department of Medicine, Huddinge. HERM is highly interactive and international and consists of approximately 90 research fellows and is a nationally leading and internationally competitive environment for studies of the human immune system in the context of malignancy and infectious diseases. HERM offers state-of-the art cell culture, flow cytometry, molecular biology, and imaging facilities.

Your profile

You have a PhD in the field of immunology and have a great interest in immunology in tissues, and you are dedicated and independent, with strong communication skills. The applicant must be familiar with relevant laboratory techniques, in particular high-parameter flow cytometry, cell sorting, tissue dissection and cell isolation, cell culture, and NK cell-relevant in vitro assays. An interest in molecular biology techniques such as RNA isolation and RNA-sequencing as well as gene expression data analysis is of advantage. The applicant must be willing to work in a BSL3 environment, previous related work experience is a merit. Fluency in English (written and verbal) is required.

Sound scientific and technical proficiency are highly important. Additionally, the applicant should have strong presentation skills and be able to summarize and present own scientific projects to national and international audiences, e.g. at seminars or conferences. Previous first-authorships on scientific publications in the field of NK cells and/or tissue immunology is a merit, and experience in working with human immune cells from peripheral blood and/or human tissues is highly valued.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Flemingsberg

The Team of Nicole Marquardt

The Department of Medicine Huddinge 

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 2023-10-10.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-10 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Tuesday October 10th, 2023

Do you want to contribute to better health for all?

We are looking for 2 Postdoctoral Researchers to support research in the domains of Nutrition, Behavioral science, and Epidemiology within the IMPACT research group (Innovative use of Mobile Phones to promote physical activity and nutrition across the life span). The group has wide research interests, spanning from clinical trials to healthy population studies in children and adults, to cohorts and registry studies, to real world data collection and analytics. In all cases we focus on the use of modern analysis techniques and technologies to monitor behavior and support behavioral change. The successful applicants will be working under the supervision of Professor Marie Löf and Researcher Ioannis Ioakeimidis, within the scope of various, recently funded, National Swedish and EU research projects. These positions will combine tasks within eHealth clinical and real-world studies, for lifestyle related analytics and interventions, as well as large cohort and registry dataset management and analysis.

Your mission

As one of the two Postdoctoral Researchers you will be leading and conducting eHealth and mHealth studies where hardware and software is implemented in clinics, in family environments, as well as schools and community events. Alternatively, you will primarily be responsible for analyzing large cohort and registry datasets with lifestyle behaviors and writing manuscripts for a new research program. In all cases the candidates will work in a multidisciplinary team. Administration, management, ethical application writing and technical reporting for research projects (Swedish National and EU) are also part of the responsibilities, in all cases. Furthermore, you will be responsible for supervising doctoral and master students’ projects and may also have pedagogical responsibilities in the form of leading and teaching on Bachelor, Master’s, and Doctoral level in KI.  

Eligibility requirements

We are searching for two candidates who fulfill as many of the requirements below. We will examine all the relevant applications irrespective of some missing qualifications.

The list of skills that we are interested in are: 

• A solid background in nutrition, epidemiology, biostatistics, or relevant health science domains.
• Experience with eHealth and mHealth research, including validation studies, randomized controlled trials and intervention studies (for one of the positions).
• Experience working with quantitative and qualitative data collection and analysis, including data processing and visualizations.
• Experience with registry and cohort study analytics.
• Excellent writing and communication skills (English).

Bases of Assesment

Your scientific expertise in the areas of nutrition, epidemiology, biostatistics, or relevant health science domains will be the most important when assessing candidates. The successful candidates should have documented – and by referees supported – experiences in: i) handling and analyzing large datasets (cohorts and national registries), preferably with exposures related to lifestyle behaviors, and/or ii) use of eHealth and mHealth methodologies for behavioral monitoring, modelling, and modification. Technical capabilities, as well as prior Project management experience are merits, but not solid requirements. Experience with collaborative EU projects will be a strong merit for one of the positions. Excellent writing and communication skills in English are required, and similar skills in Swedish are welcome, but not required. Extra weight will be placed on your data management and analysis skills, especially for large datasets.  Finally, documented experience in acquiring own external grants will be considered as a strong merit.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: in the Neo building on the south Campus of KI in Flemingsberg.

Links:
Department of Biosciences and Nutrition
The IMPACT research group

— [Video about a Karolinska Institutet, how we work towards “a better health for all”] —

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 6 October 2023.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-06 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Friday October 6th, 2023

[Select a photo.]

[Select one of the subheadings below:]

Do you want to contribute to improving human health?

Do you want to contribute to top quality medical research?

Do you want to contribute to better health for all?

Join us in developing education of the highest quality

[Form a selling preamble here. Keep in mind that it should not be more than 3-4 sentences. What is unique about your workplace? Explain why they should work at your department. Describe what the candidate will gain from working with you.?]

Your mission

[Description of duties and areas of responsibility]

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: [Solna, SÖS, Danderyd or Flemingsberg]

[Put links here – max 2, for example the department, research group or Choose to work at KI – Ten reasons why

— [Video about a Karolinska Institutet, how we work towards “a better health for all”] —

— [Video about a Karolinska Institutet, Doctor, Dentist and Optician] —

— [Video about a workingday in Flemingsberg, delete if the location is in Solna] —

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest xxx

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-11 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Wednesday October 11th, 2023

Do you want to contribute to top quality medical research?

The Department of Laboratory Medicine consists of seven divisions and is active in many areas of Laboratory Medicine. The department is involved in advanced basic scientific, clinical and epidemiological research. The department is one of the largest departments of education at Karolinska Institutet.

Division

Our research efforts in the EL Andaloussi´s lab focus on one of the greatest challenges facing modern therapeutics; the delivery of macromolecules to target cells in vivo. Despite the unprecedented knowledge of diseases and their mechanisms due to advances in biomedical sciences; many promising therapeutic approaches are still clinically unavailable. This is simply because there is no efficient means of delivering these therapeutics to the right organ with the right dose. Our research performance involves developing novel and innovative drug delivery technologies that can carry proteins, RNAs, or gene therapies to the target tissues safely and efficiently. Thus, we engineer exosomes with enhanced delivery and targeting capacities and screen our wide array of exosome designs in disease-relevant cellular and animal models.

Another growing area of research in the Andaloussi lab pertains to the delivery of antisense oligonucleotides (ASOs) that are used to either silence genes or induce splice switching. To enhance delivery of these to specific tissues, different bioconjugation strategies to lipids, peptides or monoclonal antibodies are employed. A major focus is on enhancing delivery of therapeutic ASOs to heart and CNS to treat genetic diseases. In addition to enhancing functional delivery to these tissues, the lab also exploits single cell RNA sequencing to accurately determine tissues distribution within organs on single cell level. This project, which is funded by a recently awarded Novo Nordisk Distinguished Innovator grant, seek to unlock functional cardiac delivery of therapeutic ASOs.

Duties

Within your postdoctoral studies you will study a range of novel ASO-conjugates for their ability to silence genes in cell culture and in mice models, with focus on heart delivery. Firstly, fluorescent ASOs conjugated to a range of ligands will be studied for cellular uptake in different cell lines, including cardiomyocytes, using flow cytometry and confocal microscopy. Subsequently, dose-and time response studies will be performed using qPCR to determine the magnitude of gene silencing with the different conjugates across different cell types. Next, in vivo biodistribution studies will be performed using IVIS imaging, following intravenous or subcutaneous administration.

Plasma will additionally be collected for PK analysis and to study protein adsorption. Lead conjugates will then be tested for functional silencing of target genes in different organs in mice following systemic administration of ASOs. To determine the magnitude of silencing in individual cells, different methods will be employed. In screening experiments, the non-coding RNA Malat-1 and the membrane protein CD47 will be used as targets. These are chosen as they are both ubiquitously expressed body-wide but reside in different cellular compartments. CD47 silencing will be assessed by flow cytometry and immunohistochemistry analysis together with antibodies for staining of specific cell types. Malat-1 silencing will be analyzed using single cell RNA sequencing of cells that have taken up Cy3-labelled ASO conjugates in vivo. Using this methodology, it is possible not only to determine the knockdown levels but also call the identity of the cell types within an organ that have internalized the conjugates. In this way, it is possible to distinguish productive uptake from mere cellular internalization into individual cells in vivo.

Finally, after identifying the best conjugates for cardiac delivery, the ASO sequence will be adapted to target disease relevant genes in models of heart disease. The prospective postdoctoral candidate will work closely with a bioconjugate chemist who will synthesize and provide the different ASO conjugates used within the project.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

To be a suitable candidate for the scholarship you should have a solid background in cell biology and extensive experience from cell culture work. Practical lab experience in the following additional areas are required; RNA and protein analysis with qPCR and flow cytometry, experience from laboratory animal work, organ harvesting and single cell isolation from mice as well as immunohistochemistry analysis of tissues. In addition, excellent proficiency in both spoken and written English is important. Strong collaborative skills is a requirement. Experience from RNA sequencing- and bioinformatics analysis is highly meritorious.

As a person We want you to be energetic and passionate and fit in, and actively contribute to our team.

Location: Flemingsberg, Huddinge

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-09 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Monday October 9th, 2023

The research team

A postdoctoral scholarship is available in the lab of Jean Hausser at the Department of Cell and Molecular Biology, Karolinska Institutet and SciLifeLab in Stockholm, Sweden.

(https://www.hausserlab.org).

In cancer, targeting the immune system is a promising therapeutic approach. But immunotherapy only benefits a fraction of cancer patients because tumor immunology is largely patient-specific. Designing immunotherapy effective in a given patient is challenging because anti-cancer immunity is determined by the interaction of many molecules and cells according to laws that are only partially and imperfectly understood.

To reveal these laws, our lab takes advantage of technological advances that quantify thousands of molecules in thousands of tumor cells through cancer progression and therapy. Using this data, we develop physics-inspired AI approaches to model how molecules and cells determine the success or failure of anti-cancer immune response. The vision is for these models to guide immunotherapeutic intervention in the clinic.

Research projects in the Hausser lab are supported by several funding bodies such as SciLifeLab, the Swedish Research Council and the Swedish Cancer Society.

Your mission

Our team features a spectrum of expertise from experimental to data science and bioinformatics to mathematical theory. You will bring in expertise in mathematical theory and data science.

Your responsibilities will include:

• Developing model-based approaches to maximize the potential of large-scale molecular and cellular data for personalized cancer immunotherapy.
• Applying these approaches to large-scale data from human tumors in the context of (a) our internal data and (b) data from a collaboration with Mayo Clinic (Rochester, USA).
• Authoring manuscripts and presenting findings at conferences.
• Co-mentoring junior scientists.
• Punctually helping with lab organization.

We offer

• Exciting science in a lab that combines a rare combination of experimental, computational, and theoretical skills in cancer immunotherapy, an area of direct medical relevance.
• An opportunity to transition from physics to biology. You will acquire the required background in biology, understand how technology is transforming biology into a quantitative science, how to work with large datasets produced by these technologies, and how to effectively collaborate together with experimentalists, medical doctors, and data scientists. This postdoc could serve as a jumping board to an academic career or to leveraging your newly won mix of mathematical modeling and biology expertise in industry (medtech, biotech, pharma).
• A stimulating scientific environment and top research infrastructure. We collaborate with leading cancer, immunology, and technology labs within and outside Sweden, in particular with Mayo Clinic in the context of this project. Karolinska Institutet is among the world’s foremost medical universities and The Nobel Assembly at Karolinska Institutet appoints the laureates for the Nobel Prize in physiology and medicine. SciLifeLab is the Swedish national center for large-scale molecular bioscience, with stimulating researchers and top facilities in-house.
• High life quality: Stockholm consistently tops the rankings of cities with highest quality of life worldwide. 

Entry requirements

• You have a solid background and experience with physics-style mathematical modeling: formalizing complex natural phenomena into equations, performing appropriate analytical approximations and numerical simulations, probabilistic modeling, dynamical systems, and more.
• Experience with large-scale data – thousands to millions of data points with hundreds or thousands of dimensions – ideally in the connection of mathematical model building
• No background in biology or medicine is required for this position; training and experience in these fields will be appreciated.
• The candidate’s interpersonal skills will be highly valued.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Stockholm

The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer, and infection biology. CMB is located in Biomedicum, a new interdisciplinary research center designed to concentrate much of the experimental research conducted at Karolinska Institutet Campus Solna under one roof to promote collaboration. Biomedicum houses approximately 1,200 researchers and other personnel and allows expensive equipment to be shared and utilized more effectively.

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted in the Varbi recruitment system.

Deadline: 2023-10-08 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Sunday October 8th, 2023

Do you want to contribute to top quality medical research?

The Department of Laboratory Medicine consists of seven divisions and is active in many areas of Laboratory Medicine. The department is involved in advanced basic scientific, clinical and epidemiological research. The department is one of the largest departments of education at Karolinska Institutet.

Division

Our research efforts in the EL Andaloussi´s lab focus on one of the greatest challenges facing modern therapeutics; the delivery of macromolecules to target cells in vivo. Despite the unprecedented knowledge of diseases and their mechanisms due to advances in biomedical sciences; many promising therapeutic approaches are still clinically unavailable. This is simply because there is no efficient means of delivering these therapeutics to the right organ with the right dose. Our research performance involves developing novel and innovative drug delivery technologies that can carry proteins, RNAs, or gene therapies to the target tissues safely and efficiently. Thus, we engineer exosomes with enhanced delivery and targeting capacities and screen our wide array of exosome designs in disease-relevant cellular and animal models.

Another growing area of research in the Andaloussi lab pertains to the delivery of antisense oligonucleotides (ASOs) that are used to either silence genes or induce splice switching. To enhance delivery of these to specific tissues, different bioconjugation strategies to lipids, peptides or monoclonal antibodies are employed. A major focus is on enhancing delivery of therapeutic ASOs to heart and CNS to treat genetic diseases. In addition to enhancing functional delivery to these tissues, the lab also exploits single cell RNA sequencing to accurately determine tissues distribution within organs on single cell level. This project, which is funded by a recently awarded Novo Nordisk Distinguished Innovator grant, seek to unlock functional cardiac delivery of therapeutic ASOs.

The objective of this project is to develop new targeting vectors that combine properties of lipids, small molecules, and cell-penetrating/endosomolytic peptides for conjugation to ASOs, as well as to develop methods for linking technology of ligands to ASOs/siRNAs.

Duties

As a Postdoctoral Research fellow, you will be included in the work on the design and synthesis of synthetic ligands and improved strategies for bioconjugation of ligands to ASOs and siRNAs.

Most of the research will exploit methods used in general organic chemistry laboratories including: synthesis, analysis and purification strategies (Flash column chromatography, MS/NMR spectroscopies, HPLC purifications). The duties will additionally involve synthesis of peptides and ASOs using solid phase approaches, their modifications and bioconjugations to various entities. The methods used for bioconjugation include amide bond formation, a number of click chemistry approaches, solid support functionalization and more.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

To be a suitable candidate for this scholarship you must have a solid background in organic chemistry and bioconjugation. Practical lab experience in the following areas are required; organic synthesis, analysis and purification strategies of organic compounds from small molecules to bioconjugates. Secondly, experience from peptide- and oligonucleotide synthesis using automated solid phase approaches are desired. The ideal candidate would furthermore have experience within the click chemistry bioconjugation strategies.

Excellent proficiency in both spoken and written English is a prerequisite. As a person we want you to be energetic and passionate and fit in, and actively contribute to our team.

Location: Flemingsberg, Huddinge.

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-06 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Friday October 6th, 2023

Do you want to contribute to top quality medical research?

At the Clinical Epidemiology Division, one of our six research groups work with clinical epidemiological research on rheumatoid arthritis (RA) and other chronic inflammatory diseases, in close collaboration with translational and clinical researchers. Our work focuses on models for personalized treatment of RA. We use a combination of register-, clinical, genetic, serological and lifestyle data in advanced computational models. We are now recruiting a postdoc to our team to work with patient stratification and prediction models of clinical outcomes in RA.

Your mission

The candidate will work within our international collaborations with a focus on developing models for precision medicine in RA. The candidate will use our existing data collections and apply machine learning (ML) and other modelling techniques in a multimodal approach with the aim to improve disease outcomes in RA.

Your profile

The successful candidate has a background in, and previous experience with, computationally intense methods/ML/prediction modeling, through applications during a PhD or MSc. Previous work experience with medical or biological data is a requirement, so is experience of real-world data, data management, and epidemiological studies. You have formal training in, and experience of, statistical analyses.

The candidate is proficient in programming languages such as R, SAS and Python, and has experience of parallelization of code.
The successful candidate enjoys working in an interdisciplinary team, is thorough and organized, and structures and documents well. Within the department and KI, you will be interacting also with clinical and translational RA researchers. As the candidate will be working as part of a team with several international connections, emphasis is put on communication skills and personal suitability. Fluency in English (oral and written) is a requirement.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location

The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within the research group Chronic inflammatory Diseases at the Clinical Epidemiology Division. Our research group contains well over 30 people (PhD students, postdocs, senior researchers, clinician researchers, and statisticians) with various backgrounds, with a common research interest, namely to study inflammatory diseases through register and clinical data. You find more information on our website: https://ki.se/en/meds/research-group-johan-askling.

— [Video about a Karolinska Institutet, how we work towards “a better health for all”] —

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-07 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Saturday October 7th, 2023

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC have about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations. We are now searching for a postdoc to join the research group of Claudia Kutter.

Division

The research group of Dr Claudia Kutter seeks a Postdoc (either computational or computational/
experimental) in the field of functional genomics and RNA biology. The Kutter lab has a track record in deciphering molecular mechanism by which RNAs (i.e. long noncoding, transfer and small RNA) regulate genes and genome structure in mammalian somatic tissue and in the germline (Geng et al. Genome Research 2022, Søndergaard et al. Gut, 2022, Gao et al. Genome Research 2022, Atanasoai etal. bioRxiv 2021). As a Postdoc in the Kutter lab you will be part of a multidisciplinary and collaborative research team active within the fields of RNA and chromatin biology, functional genomics and regulative transcriptomics.

The Kutter lab interrogates genome- and transcriptome-wide regulation and functionality by employing a combination of next generation sequencing technologies (both bulk and single-cell) and high-throughput genetic screening approaches, develops computational methods, along with applying experimental techniques. The group uses an integrative and collaborative approach, works closely with computational and experimental groups at KI, Science for Life Laboratory (SciLifeLab), and other local and international research groups. Frequent courses are provided on campus. Additional professional training is available through summer schools and recurrent workshops.

The laboratory is located at SciLifeLab on the Karolinska Institute campus in Stockholm. SciLifeLab
offers an attractive research environment, provides state-of-the-art instrumentation and core facilities, and is home to the second largest sequencing cluster in Europe. SciLifeLab is a joint effort between Karolinska Institute, the Swedish Royal Institute of Technology, and Stockholm University. It hosts research groups with diverse backgrounds and expertise, creating a unique interface between basic biology, genomics, bioengineering, drug discovery, and translational medicine.

Duties

As a member of the Kutter lab, you will apply and optimize novel transcriptomic approaches (based on bulk and single cell RNA profiling) to study gene regulation and RNA processing using mammalian systems (primary tissues and cell lines), carry out validation experiments involving biochemical and molecular biological tools, and participate in the general duties of the team. As a Postdoc you will take a strong lead in the project design and management as well as data generation, analyses and interpretation, and collaborate with other team members. You are expected to report the scientific results by writing scientific papers, attending scientific meetings, and effectively communicate with peers. The ability to work in a highly interdisciplinary and international environment, and to engage in continuous professional development is a must.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Links:

https://ki.se/en/mtc/kutter-group-regulatory-transcriptiomics

https://www.scilifelab.se/researchers/claudia-kutter/

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-01 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Sunday October 1st, 2023

Do you want to contribute to top quality medical research?

We are an international, multidisciplinary research team dedicated to developing new strategies for cell and immunotherapy. As part of an EU-funded project, you will have the opportunity to collaborate with experts from different disciplines. The Department of Medicine in Huddinge and SciLifeLab are known for maintaining high international research standards, offering an ideal setting for your growth as a researcher. Your journey with us will involve a balanced blend of learning and development, as we collectively work towards advancing the field of cell and immunotherapy and its implications for healthcare.

Your mission

We are currently seeking a postdoctoral researcher to join our team as part of an EU-funded project. Our project’s primary objective is to delve into innovative approaches that enhance check-point inhibition by bolstering the reactivity of cytotoxic immune cells. In this role, your responsibilities will encompass the planning, execution, and analysis of immunological and cell biological experiments. In particular, the group focuses on using microchip-based live cell imaging techniques to assess immune cell cytotoxicity.

Active participation in local group discussions and journal clubs will be expected, fostering a collaborative environment. Moreover, you will have the opportunity to showcase your findings during meetings with the EU-consortium. As an integral part of our team, contributing to paper writing will play a significant role in the project’s progression.

Additionally, you might find yourself engaged in mentoring project students and participating in grant-writing. Your involvement will be essential in advancing our exploration of improved immune response strategies.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are seeking a candidate with a background in immunology, cell biology, biotechnology, biophysics, or a related field. Prior experience of optical imaging and image analysis is of particular significance, and familiarity with techniques such as flow cytometry, molecular biology, and biochemistry would be advantageous. However, the key attribute we value most is a genuine eagerness to acquire new knowledge and a strong interest in collaboration in a team environment.

Effective communication in English, both spoken and written, is a prerequisite for this role. Your willingness to learn, adapt, and engage in cross-disciplinary research will be pivotal in driving our research initiatives forward.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: The work will be performed in both Scilifelab, Solna and Karolinska Institute campus in Flemingsberg

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 2023-10-06

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-10-06 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Post expires on Friday October 6th, 2023