Do you want to contribute to better health for all?

We are looking for a motivated postdoc to be part of our collaborative research group with a focus on particle toxicology at the Unit of Biochemical Toxicology, Institute of Environmental Medicine (IMM). The research at the unit aims at understanding the connection between exposure to chemicals and complex negative health effects, such as cancer and effects caused by endocrine disruption. You will participate in various exciting projects with a focus on understanding more about the toxic effects of air pollution particles and microplastics.

Your mission

The research group focuses, among other things, on nanoparticles from the transport sector and the postdoctoral fellow will be active in the EU project nPETs (https://www.npets-project.eu/) and perform some modeling of particle deposition in the lung (the MPPD model) as well as collaborate with researchers from other universities. The research group also focuses on particles from “3D printing” and microplastics, and the postdoctoral fellow will also participate in these projects. The main tasks of the postdoc will be to culture different types of cells, expose them to various particles and perform toxicity testing using a range of in vitro methods including viability assays, comet assay, micronucleus assay and multiplexing of cytokines as well as RNA-sequencing. More advanced exposure techniques may become relevant, such as long-term studies (several weeks) and exposure in “air liquid interface” as well using co-cultures of different cells. Other tasks include performing statistics, writing manuscripts, and participating in meetings and discussions with partners as well as teaching in the master’s program in toxicology. The position is temporary for 12 months. 

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are looking for a highly motivated postdoctoral fellow with a documented background in toxicology with practical experience in cell culture and toxicity assessment. Previous work with particles or microplastics is meritorious. The candidate must be able to work well in a team with researchers from different disciplines, have good collaboration and communication skills and must be able to communicate well in English, both orally and in writing. 

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

https://staff.ki.se/people/hanna-l-karlsson

https://ki.se/en/imm/unit-of-biochemical-toxicology

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-03-27 at 23:59
Unit: The Institute of Environmental Medicine

Read the job description at the university homepage or apply.

Post expires on Monday March 27th, 2023

Do you want to contribute to top quality medical research?

This is an exciting opportunity to participate in a new multidisciplinary neuroscience project investigating variability in brain signal variability and rapid plasticity in both humans and zebrafish using different data and methods (e.g. magnetic resonance imaging of humans, and calcium imaging and electrophysiology of zebrafish). The project is part of a recently awarded Karolinska Institutet Research Incubator (KIRI) project and applications are now invited for a co-supervised postdoctoral position in the Månsson Lab (Department of Clinical Neuroscience) and Ampatzis Lab (Department of Neuroscience).

The Månsson Lab, led by Dr Kristoffer Månsson, investigates psychiatric and non-clinical populations with the goal of elucidating the role of moment-to-moment variability in neural response, as a prognostic factor for psychiatric treatment outcomes. The Ampatzis Lab, led by Dr Konstantinos Ampatzis, focuses on adaptive mechanisms that occur in the central nervous system in response to physiological and pathophysiological stimuli.

Your mission

We are looking for a highly motivated, knowledgeable and experienced postdoctoral researcher to combine science in both basic animal research and human clinical neuroscience. You will be responsible for analyzing brain data acquired with methods such as magnetic resonance imaging (MRI), magnetoencephalography (MEG), epigenome-wide DNA methylation, calcium imaging and immunofluorescence imaging.

The work will mainly focus on computational and statistical analyses. Månsson and Ampatzis Lab use different methods and tools and it is therefore possible to adapt the candidates responsibilities according to their background and expertise. As a postdoc, we want you to thrive, have fun at work, and be able to continue developing a successful track-record for a future in academia. Your main position will be in the Månsson Lab but you will be a key member of both teams.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are looking for a highly motivated, driven, and enthusiastic person sharing our interest in inter-disciplinary research and is ready to explore new avenues in science. The candidates should have a collaborative approach to science, a high degree of independence, but also being able to effectively work in an inter-disciplinary team. We value a postdoc that contributes to a good social environment in our respective laboratories.

The applicant shall hold a PhD degree and have a strong expertise in computations and data analytics (e.g., statistics, math, artificial intelligence, machine learning). Candidates with previous experience with computational imaging analysis, and/or bioinformatics will be prioritized. The candidate should have documented experience with coding/programming languages (e.g., MATLAB, python, bash scripting, R). Experience with multivariate statistical methods and machine learning are significant merits. Experience with human neuroimaging and calcium imaging is not required but is considered merit. Fluency in English is a requirement.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Read more about Karolinska Institutet Research Incubator (KIRI)

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 30th of March 2023.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all!

Deadline: 2023-03-30 at 23:59
Unit: Department of Clinical Neuroscience

Read the job description at the university homepage or apply.

Post expires on Thursday March 30th, 2023

Do you want to contribute to the understanding of non-standard employment and health?

Our research group is a great place to work and were awarded the “KI Work Environment and Health Award 2021”. We offer a dynamic, supportive and open research climate, where you are encouraged to think freely and explore your own ideas. This is the right place for you who want to grow from postdoc to PI.

Your mission

Constant changes in the global economy and new technology combined with a general weakening of trade unions and labour law have created the conditions for a variety of non-standard employment arrangements such as gig, platform, freelancing etc. There are significant research challenges to evaluating the consequences of these employment arrangements that our research program aims to address.

You will work in an international consortium of top researchers from Sweden, Belgium, USA, Canada, Spain and Chile. We have collected quantitative and qualitative data in all countries during the pandemic and we need your help to publish the results. 

You will have the opportunity to develop your skills, take courses, supervise students, develop your own line of research and apply for your own funding. The position temporary for two years.

Your profile

We think that you have a PhD in Public health, political economy, political studies, labor market studies, labor relations, labor law, but we are open to PhD in other subjects.

Requirements:
•    Very good communication skills in English 
•    Strong track-record of publishing as a first author while collaborating with other researchers
•    Project management skills

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

https://ki.se/en/imm/the-new-world-of-work

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-03-24 at 23:59
Unit: The Institute of Environmental Medicine

Read the job description at the university homepage or apply.

Post expires on Friday March 24th, 2023

Do you want to contribute to better health for all?

The Department of Laboratory Medicine consists of 7 divisions and is active in many areas of Laboratory Medicine to promote human health in short and long term. The department has close collaboration with Karolinska Hospital and is involved in advanced basic scientific, clinical, and epidemiological research. The department is one of the largest departments of education at Karolinska Institutet.

The research group of Dr. Ping Chen at the Division of Clinical Chemistry is looking for a postdoctoral fellow interested in artificial intelligence and advanced omics data analysis. We focus on data-driven research to understand the disease pathogenesis and devise better diagnostic and therapeutic strategies for human metabolic disease. In close collaboration with multidisciplinary researchers, we integrate biobanks, longitudinal clinical data, omics technologies as well as novel computational and experimental approaches in our research. A two-year postdoc position is immediately available from the Chen lab.

Division

The Division of Clinical Chemistry is carrying out research to elucidate the molecular basis of cardiometabolic disease integrating basic science, clinical medicine, and translational approaches.

Duties

During the development of obesity and insulin resistance, ectopic lipid accumulation occurs in various organs. In the liver, such condition is called non-alcoholic fatty liver disease (NAFLD), which can progress to more severe stages, such as non-alcoholic steatohepatitis (NASH), cirrhosis, and/or hepatocellular carcinoma. Liver fibrosis is the most important predictor of prognosis in NAFLD patients. In this project, we will focus on NAFLD and develop an innovative non-invasive machine learning model to monitor the real-time disease progression and future risks of NAFLD patients. The tools developed here will allow patient subgroup stratification at a high resolution and further investigate how the immune system is functional in high-risk NAFLD patients during their longitudinal disease progression.

Entry requirements

To quality, the applicants are required to have a PhD in the field of computational biology and have extensive knowledge of biomedical sciences. Specifically, experience with machine learning and analysis of human omics data are of advantage. The person should exhibit a high degree of independence but on the other hand also value a collaborative approach to science and enjoy working in a team. Motivation, the ability to work with people of different disciplines, executive capacity and good communication skills in English are important. A strong publication track record and good manuscript writing skills are desirable. Experience with biopsy specimen collection, flow cytometry, cell culture, and library construction for single-cell sequencing are a benefit but not essential.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: The position is located within the Department of Laboratory Medicine, KI Campus Flemingsberg within the research group of Dr. Ping Chen at the Division of Clinical Chemistry.

Type of scholarship

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent. 

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-03-31 at 23:59
Unit: Department of Laboratory Medicine

Read the job description at the university homepage or apply.

Post expires on Friday March 31st, 2023

Do you want to contribute to better health for all?

At the Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, we conduct research about different aspects of sickness absence, morbidity, work, and life situation. You will have the opportunity to work near top researchers within the sickness absence field and contribute to high quality research at international level. The complex research questions demand an interdisciplinary approach, and people with many different backgrounds work in the project. We also have comprehensive collaborations within Sweden as well as internationally.

Your mission

We are looking for a postdoc who will work in different projects about sickness absence, both among women and men in specific occupations, primarily health and social care and the trade and retail industry, and among people in paid work after age 65, where gender differences are an important aspect of our research. To what extent are they sickness absent, in what diagnoses, etc? How are sociodemographic and work-related factors associated with their sickness absence? What are the associations between their morbidity and their sickness absence? How has this changed over time?

The position involves participating in, planning, and conducting studies based on register data. Your duties will primarily involve analysing data, some data management, and writing manuscripts and grant applications.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Documented experience of epidemiological studies is required for the position. Experience of working with large databases of register and/or survey data as well as analyses in, e.g., SAS, STATA, SPSS, or R, are meriting for the position. Experience of working with nationwide Swedish registers and research within the insurance medicine area are particularly meriting. Good knowledge of spoken and written English is essential, and knowledge of Swedish is meriting. The applicant should show a high degree of conscientiousness, initiative, and independence. The work will be conducted in collaboration with the PI and other project members, and places high demands on flexibility and good collaborative abilities.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Read more about the Department of Clinical Neuroscience here 
Read more about the research group you will be part of here

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest March 22nd 2023.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all!

Deadline: 2023-03-22 at 23:59
Unit: Department of Clinical Neuroscience

Read the job description at the university homepage or apply.

Post expires on Wednesday March 22nd, 2023

Do you want to contribute to better health for all?

The selected candidate will be working and trained in Hong Qian’ group at the Center for hematology and Regenerative Medicine (HERM), the Department of Medicine Huddinge, Flemingsberg Campus.HERMis an interdisciplinary translational research environment and educational platform dedicated to hematology, immunology and regenerative medicine.

The vision of Hong Qian group is to unravel the role of hematopoietic niche including mesenchymal stem cells in myeloid leukemia using patient samples and mouse models, ultimately, to identify new niche- based therapeutic targets for better treatment outcome of diseases. Meanwhile, the group aims to create a nurturing environment for group members to grow together.

The candidate will be working a collaborative environment at HERM and will be given the opportunity to participate in national and international scientific meetings, to apply grants and supervise junior researchers.

Your mission

The successful candidate will conduct the research with a special focus on deciphering molecular pathways mediating leukemic stem cell interaction with their niche under the supervision of the group leader (Dr. Hong Qian). In addition, the candidate is expected to participate in several collaborated project throughout her/his postdoc training. Further, the candidate is expected to participate in supervision of junior students in the group.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are looking for a highly self-motivated person with a strong background in cellular and molecular biology with a keen interest in leukemia microenvironment. Experience in working with tumor microenvironment, molecular and cellular biology techniques, multi-color flow cytometry, confocal imaging and mouse modeling is highly desired; and good ability to communicate in English (written and verbal) is required.

It is considered as a merit if the applicant has experience in flow cytometry, imaging, laboratory animal work (as documented by FELASA C or equivalent) with at least three years hands on experience working with mice or bioinformatics analysis tools.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Flemingsberg

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 2023-04-22

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-04-22 at 23:59
Unit: Department of Medicine, Huddinge

Read the job description at the university homepage or apply.

Post expires on Saturday April 22nd, 2023

Departments of Oncology-Pathology and Molecular Medicine and Surgery

Do you want to contribute to top quality medical research?

Karolinska Institute aims to be a pioneering university. As part of this ambition, in 2022 it created the KI Research Incubator (KIRI), a dynamic environment for top junior researchers, with the aim to strengthen innovative and interdisciplinary collaborations and promote ground-breaking research through its KIRI postdoctoral programme. This postdoctoral position is funded through one of the first selected KIRI interdisciplinary projects “Connecting biological scales – atomic-level interpretation genetic variants in rare diseases”, a collaboration between KIRI fellows Prof. Laura Orellana, who leads the “Protein Dynamics and Mutation” molecular modelling group, and Prof. Giedre Grigelioniene, PI of skeletal dysplasia research team in Clinical Genetics group focused on the identification of new genetic variants associated with rare skeletal malformation syndromes.

Your mission

Your main role will be to develop a computational pipeline to perform a broad range of multiscale computational analyses of potential disease-causing variants, focusing on a clinically curated benchmark of approximately 100 genes related to skeletal dysplasia. The main goal will be to develop new pathogenicity scores for variant classification including dynamical information from coarse-grained and atomistic simulations and potentially also protein-protein and protein-nucleic acid interactions. As a more senior member in a crossroad between two growing research groups, you will have the chance to play a bigger leadership role and mentor MSc and doctoral students, while also benefiting from direct supervision and collaboration from two PI, one who is experienced in structural computational biology and another who has a long clinical and research experience in rare genetic disorders and new gene discoveries. You will have the opportunity to work with significant freedom and independence within an extremely interdisciplinary as well as an international setting. This position is for two years.

Your profile

We are looking for a highly motivated postdoctoral researcher with broad experience in structural bioinformatics and biomolecular modelling.  The candidate is expected to participate in collaborative efforts to develop a workflow for multiscale screening of human mutations, integrating different coarse-grained and atomistic simulation methods. The candidate will hold a shared position between Prof. Orellana “Protein Dynamics and Mutation” lab, focused on the development of biophysical modelling methods with a focus on disease mutations, and Prof. Grigelioniene translational research team, focused on the identification and validation of new genetic variants associated to rare skeletal diseases. He/She will work developing a general computational pipeline for variant clinical scoring, also contributing to modelling and interpretation of selected new variants discovered by Prof. Grigelioniene’s team, which can be potentially validated experimentally.  Ideally, the pipeline will be the basis for a database/server to facilitate the interpretation of new variants by clinicians.

Advanced knowledge in structural bioinformatics and broad proven experience with molecular simulation packages (GROMACS, AMBER, etc) and knowledge of common analysis techniques (Network Analysis, PCA, etc) are prerequisites; ideally, the applicant will also have at least familiarity with some coarse-grained method (MARTINI simulations, NMA, etc). The applicant must have strong skills in programming languages used in the biomolecular simulation field. Previous experience with the evaluation and/or structural interpretation of mutations and developing web applications will be highly valued; additional knowledge of other molecular modelling methods such as molecular docking, virtual screening, homology modelling, etc or machine learning applications will be also appreciated.
Fluency in English, a high level of organizational and communication skills, as well as an ability to work independently, is mandatory. The candidate is also expected to take a strong lead in managing project(s), contribute to writing manuscripts and grants, and train and mentor junior members of the team.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

• An exceptionally interdisciplinary position, between a clinical genetics team and a computational-structural group, that develops advanced biophysical modelling methods and integrates them with cryo-EM and experiments in-house and through a wide national and international collaborative network
• Karolinska Institute is one of the world’s leading medical universities, and responsible to award the Nobel Prize in Medicine. A creative and inspiring environment full of expertise and curiosity, with top-level infrastructure for life sciences
• Karolinska Institute is a public university, which entitles employees to several social benefits, access to sports facilities for free and reimbursements for medical care. 

See Prof. Orellana’s lab page for more information and selected publications:
Laura Orellanas group

Prof Grigelionienes page for more information and selected publications:
Giedre Grigelioniene

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

•  A cover letter, explaining your background, research interests and motivation to join 
• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest March 15th, 2023 

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-04-15 at 23:59
Unit: Department of Molecular Medicine and Surgery

Read the job description at the university homepage or apply.

Post expires on Saturday April 15th, 2023

Do you want to contribute to top quality medical research?

Our research group (PI: Maria Ankarcrona) investigates molecular and cellular mechanisms underlying mitochondrial dysfunction and neuronal cell death in Alzheimer’s disease and other neurodegenerative disorders. The group works in an inspiring and interactive research environment in Bioclinicum, KI-Campus Solna and has on-going collaborative projects with national and international research groups

Your mission

The postdoctoral position will include involvement in projects regarding mitochondrial functions and endoplasmic reticulum-mitochondria interplay in neurodegenerative disorders. The postdoc will be involved in all parts of the projects ranging from planning and performing experimental work to project and data management, and dissemination of results.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Applicants must have a doctoral degree in Medical Sciences or Health Sciences. The candidate is expected to have a background in neurobiology and neurodegeneration with good knowledge of the nervous system at the cellular and molecular level. The candidate should have experience with biochemical and cell biological methods detecting for example mitochondrial functions and inflammation as well as primary cell cultures and animal work. That includes previous knowledge on microscopy, protein and gene expression analysis. Proven interest on exploring targets for therapeutic intervention will be highly recommended. Applicants must be able to work independently, take own initiatives, have good collaborative skills, be socially competent and be fluent in written and spoken English.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

The emplyoment is a fixed-term two year contract 

Location: Solna

 Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 22th of March 2023 

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-03-22 at 23:59
Unit: Division of Neurogeriatric

Read the job description at the university homepage or apply.

Post expires on Wednesday March 22nd, 2023

Do you want to contribute to top quality medical research?

The Department of Oncology-Pathology is searching for a post-doctoral fellow to work with Dr Ola Larsson and co-workers to study the role of mRNA translation in cancer. Dysregulated mRNA translation is emerging as a central facet in cancer progression that is incompletely understood. The Larsson group is seeking the upstream signals as well as the downstream effectors underlying transcript-selective alterations of translation in cancer. The overall goal is to understand how mRNA translation can be targeted in future anti-cancer therapy.

Division

The Larsson lab focuses on understanding the role of mRNA translation in several cancer types; and in both cancer and stromal cells. The focus is on achieving transcriptome-wide and detailed molecular understanding of how mRNA translation is dysregulated in cancer. The lab has expertise in development of state-of-the-art methods for wet-lab based studies of mRNA translation as well as development of computational tools to analyse the generated data. The focus for the project will be to use biostatistics and bioinformatics to understand how mRNA translation is organized and orchestrated in health and disease.

Duties

This project is focused on understanding how mRNA translation is altered in cancer. Initially, multimodal data sets from large-scale studies will be used to delineate how mRNA translation is organized and how it interacts with other steps in the gene-expression pathway to control proteome composition. In the second step, the focus will be to identify mechanisms underlying this organization of mRNA translation and how these are altered in cancer. To this end, data sets from both in-vitro models and patient samples will be used.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Other requirements
The ideal candidate is highly motivated, with an outstanding completed PhD thesis (or equivalent) and a strong drive for a future career in research. The candidate should be capable of generating novel ideas, acquire knowledge independently and possess sufficient computational skills to evaluate and develop new methods for analysis of large scale data sets acquired using next-generation sequencing approaches.

Fluency in spoken and written English is required. At least one paper in a high quality international peer-reviewed journal is necessary to be considered and additional academic merits are also considered. Because of the scope of the project, knowledge and experience in bioinformatics and biostatistics including programming in languages such as R is required. Previous experience with analysis of data from next-generation sequencing at a nucleotide level is strongly preferred.

Experience in analysis of large scale gene expression data sets is an advantage and knowledge in post-transcriptional mechanisms for regulation of gene expression is also a strong merit. In addition, personal suitability will be a factor in the selection process.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system March 31st at the latest.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2023-03-31 at 23:59
Unit: Department of Oncology-Pathology

Read the job description at the university homepage or apply.

Post expires on Friday March 31st, 2023

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Department of Medical Epidemiology and Biostatistics (MEB) at Karolinska Institutet consists of researchers, doctoral students, biostatisticians, programmers, data collectors, database administrators and administrative staff, in total some 280 personnel. The department is also responsible for the Karolinska Institutet Biobank and the Swedish Twin Register. The organization has the necessary resources and infrastructure (servers/IT-systems, database administrators and statisticians) to conduct important and innovative large-scale register studies.

The breast cancer research group currently consists of three senior and three junior researchers and six doctoral students. The research is performed in an interdisciplinary setting with close collaboration with clinical departments and national and international research groups. The aim of our research is to acquire a comprehensive picture of breast cancer risk and prognosis and we are conducting a vast number of auxiliary research projects. Within the framework of KARMA, https://karmastudy.org/, one of the world’s best-characterized cohorts for early detection and prevention of breast cancer, our research group has access to comprehensive data, such as biological samples, survey results and complete clinical data and progression of disease.

For further information about Kamila Czene’s research and research group including relevant publications, please go to https://staff.ki.se/people/kamcze He et al., 2020, Journal of Clinical Oncology; Grassman et al., 2019, Nature Communications; Holm et.al., 2015, Journal of Clinical Oncology.

Supervisors for the doctoral student will be Kamila Czene, Wei He and Keith Humhreys.

The doctoral student project and the duties of the doctoral student

The doctoral project is based on the KARMA cohort and large-scale Swedish register data, aiming to investigate attendance and outcomes of mammography screening for breast cancer. Mammography screening lowers the risk of breast cancer mortality by over 20%. However, 30% of women choose not to participate in the screening. Furthermore, among women who attend screening, over half of them experience—at some time during their lifetime—the very frightening but yet unnecessary false-positive results. Finally, 20% of all breast cancers occur symptomatically between screening rounds. In this project we will continue our previous work on breast cancer screening by exploring non-attendance, false positive and false negative outcome.

Applicant is expected to be able to use advanced epidemiological methods to analyze clinical and molecular data. Main tasks also include handling of data, interpretation of research results and writing scientific manuscripts. Attendance in courses, seminars and conferences and presenting scientific results, both orally and in writing, is included in the education. As a doctoral student at MEB you will work in an internationally established, strong research environment. In your role, you will have the benefit of working both in an interdisciplinary and in an international research environment. MEB is an inclusive workplace, incouraging collaboration within the department and across research areas, which is also reflected in our infrastructure.

For more information about the role, please contact Kamila Czene, details below.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

The applicant should have strong organizational skills and be able to take own initiative and work independently, while also having the ability to work in a group. The applicant should be a highly motivated and enthusiastic person. To succeed in this role, the candidate needs to be structured and flexible to handle and meet deadlines in the project. Special emphasis will be put on previous experience of working with large-scale health data such as national register data and interest and experience of epidemiological, cancer- and/or medical science. Ideally the candidate shall have some prior experience and knowledge of analyses in programs such as R, SAS or STATA.

Excellent communication skills and fluency in both written and spoken English is a requirement.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-06-12 at 23:59

Read the job description at the university homepage or apply.

Post expires on Sunday June 12th, 2022