Tag Archives: Oslo University Hospital

Postdoc

Department of Cancer Genetics

Department of Cancer Genetics, Åslaug Helland group, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital 


Job description

A 3-year full-time position as a post.doctoral researcher is available in the project group Therapy prediction in lung cancer, Translational studies on solid tumours, Dept of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital (The Norwegian Radium Hospital). 

The post.doc. will be part of a multidisciplinary team of researchers running clinical trials and performing translational analyses to decipher the mechanisms behind treatment response and resistance for patients treated with immunotherapy and radiotherapy for thoracic malignancies. The team consists of medical doctors, biologists, engineers and study nurses.

Our group is ambitious and active in clinical and translational research at an international level. Hospitals in several countries include patients in our trials, and we have translational collaboration with international research groups.

We are currently collecting biological material from patients treated with immunotherapy and radiotherapy. The post.doc. will be responsible for analysing immune responses, using samples from the current clinical trial (COM-IT-2) and data from previous trials.

Head of the translational research group is Åslaug Helland and supervisor for the post.doc. position is Vilde Drageset Haakensen   

https://www.ous-research.no/helland/

Oslo University Hospital is a workplace with great diversity. We believe this is essential to perform the tasks required of us. Therefore, we pursue diversity among our job applicants and encourage everyone to apply regardless of who you are and what background you have.

Application deadline: 28.02.2023

Employer: Oslo universitetssykehus HF

Town/city: Oslo

Title: Postdoc

Positions: 1

Full-time/part-time: Full-time

Percentage of full-time: 100

Webcruiter ID: 4599286751

Start date: 01.07.2023

End date: 30.06.2026

Duties of the position

To a certain degree, the tasks can be adapted to the competence and interests of the applicant, but central tasks will include:

  • Lab analyses (Cytof, digital spatial profiling, DNA-/RNA-extraction and next-generation sequencing of DNA and RNA
  • Bioinformatic analyses and interpretation of sequencing data
  • Multi-level analyses of immune response to cancer treatment (based on lab results from circulating cytokines and immune cells, primary tumour profiling and clinical response)
  • Statistical analyses
  • Co-supervision of PhD students
  • Publication of results
  • Responsibility for organisation and progress of the group’s research projects

Project information

The post.doc. position is part of the COM-IT-2 trial, funded by the Norwegian Cancer Society. The aim is to identify biomarkers and optimize the combination of radiotherapy and immunotherapy using material from the COM-IT-2 trial and previous trials. The COM-IT-2 trial is a randomised phase 2 study comparing the efficacy and safety of combining (chemo)immunotherapy with extensive radiotherapy for patients with advanced non-small cell lung cancer (NSCLC). A total of 30 patients will be included. Patients will be randomized to standard systemic treatment or addition of extensive radiotherapy, including as large parts of the tumour volume as possible. The clinical trial assesses toxicity and efficacy of the combined treatment. Laboratory and clinical data from other clinical trials (COM-IT-1, DART and NIPU) will be included in comprehensive analyses to identify biomarkers for immunotherapy and to optimise the combined treatment with radiotherapy.

Qualification requirements
  • You must have completed a Norwegian doctoral degree or corresponding foreign doctoral degree recognized as equivalent to a Norwegian PhD. If you can document that the PhD thesis has been submitted, your application can be assessed even if you have not yet defended your thesis. Documentation of the obtained doctoral degree must be presented before you can take up the position.
  • Documented experience with the relevant laboratory and bioinformatic/statistical tasks listed above
  • High work capacity and productivity are essential
  • Ability to work independently, take individual initiatives, work structured in a team and take responsibility for work processes
  • Proficiency in the English language is a prerequisite.
Preferred experience and personal skills
  • Good communication skills and ability to work well in a team
  • Critical thinking and a curious mindset with a wish to obtain new knowledge
  • Experience with research on tumour biology including immunology
  • Experience with next-generation sequencing
  • Experience with statistical analyses in R
  • Experience with planning and conducting research projects
  • Experience with research grant applications
  • Ambitions for future research
We offer
  • A strong academic, challenging and friendly working environment
  • Cutting-edge technology
  • Salary according to valid wage agreement
  • Translational research in close colloboration with clinical cancer treatment
  • Favourable pension agreement

How to apply

Only applications registered in WebCruiter will be considered.

The application must include:

  • Cover letter including motivation for the position
  • CV (summarizing education, positions and academic work)
  • Letters of recommendation
  • List of publications and academic work that the applicant wishes to be considered
  • A copy of the doctoral thesis
  • Contact information for two references
  • The application with attachments must be delivered in our electronic recruiting system. Foreign applicants are advised to attach an explanation of their university’s grading system. Please note that all documents should be in English or in a Scandinavian language.
  • In assessing the applications, special emphasis will be placed on the documented experience as well as the candidate’s motivation and personal and interpersonal suitability. Interviews with the best qualified candidates will be arranged. 

Ullernchausseen 70, bygg Oslo, Norway

Vilde Drageset Haakensen

Consultant, PhD

+4798669297

Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel. 

Read the job description at the university homepage

Apply for position

Post expires on Tuesday February 28th, 2023

Postdoctoral research fellow – Department of Radiation Biology


Application deadline:

12.02.2023

Employer: Oslo universitetssykehus HF

Title: Postdoctoral fellow

Positions: 1

Full-time/part-time: Full-time

Percentage of full-time: 100

Webcruiter ID: 4607445822

Start date: 15.03.2023

End date: 14.03.2026

Project description

We are seeking a dedicated, creative and enthusiastic postdoctoral research fellow at our Department of Radiation Biology. The position is funded by the South-Eastern Norway Regional Health Authority (HSØ) and is available for three years with the opportunity for an extension .
The position will be associated with Anette Weyergang’s project group which has developed a new drug (recombinant targeting toxin). The project group has generated supportive in vitro and in vivo data on the treatment of head and neck cancer (HNSCC) and a full preclinical evaluation is now needed to develop this drug towards clinical investigation. The project includes collaboration with the clinical HNSCC team at OUS and harbors evaluation of the drug in clinical relevant settings including adjuvant settings with immunotherapy. The project is related to the Rab5 innovation project https://rab5project.com/ admitted to the SPARK program. Anette Weyergang will supervise the project.

Tasks

The project will involve preclinical testing of the drug in several cancer models both in vivo (mice) and in vitro.  The experiments will evaluate the drug as monotherapy, but also involve strategies for combination therapy including both immunotherapy and photochemical internalization. Methods will include evaluation of anticancer efficacy by tumour growth delay, IHC, IVIS, MRI, in vitro viability assays, evaluation of protein signal transduction (Western blotting, fluorescence microscopy, flow cytometry).  The pharmacokinetic aspects of the drug will also be evaluated. 

Qualifications
  • PhD in pharmacy, medicine, biomedical sciences or equivalent
  • Proven record of research, evidenced by successful publishing in scientific journals
  • Fluent in oral and written English (Norwegian is an advantage)
  • Approved course of laboratory Animal Sciences for scientist FELASA Cat. C
  • Strong research background with animal models including methods relevant for cancer research 
Personal characteristics
  • Ability to work independently and take initiatives
  • Strong teamwork skills
  • Analytical and Critical Thinking
  • Solution oriented
  • Entrepreneurial mindset
We offer
  • A postdoctoral project with high focus on innovation and clinical implementation
  • Excellent facilities for experimental cancer research
  • An interesting and inspiring environment
  • Competitive salary within the framework of postdoctoral fellows

Oslo University Hospital is a workplace with great diversity. We believe this is absolutely crucial to solving the tasks required of us. We therefore want this diversity to be reflected among the applicants for our positions and encourage everyone to apply regardless of who you are and what background you have.

Oslo universitetssykehus Radiumhospitalet, Ullernchausseen 70, Norway

Anette Weyergang

Project group leader

anette.weyergang@rr-research.no

Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel. 

Read the job description at the hospital´s homepage

Apply for position

Post expires on Sunday February 12th, 2023