Department of Cancer Genetics
Department of Cancer Genetics, Åslaug Helland group, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital
A 3-year full-time position as a post.doctoral researcher is available in the project group Therapy prediction in lung cancer, Translational studies on solid tumours, Dept of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital (The Norwegian Radium Hospital).
The post.doc. will be part of a multidisciplinary team of researchers running clinical trials and performing translational analyses to decipher the mechanisms behind treatment response and resistance for patients treated with immunotherapy and radiotherapy for thoracic malignancies. The team consists of medical doctors, biologists, engineers and study nurses.
Our group is ambitious and active in clinical and translational research at an international level. Hospitals in several countries include patients in our trials, and we have translational collaboration with international research groups.
We are currently collecting biological material from patients treated with immunotherapy and radiotherapy. The post.doc. will be responsible for analysing immune responses, using samples from the current clinical trial (COM-IT-2) and data from previous trials.
Head of the translational research group is Åslaug Helland and supervisor for the post.doc. position is Vilde Drageset Haakensen
Oslo University Hospital is a workplace with great diversity. We believe this is essential to perform the tasks required of us. Therefore, we pursue diversity among our job applicants and encourage everyone to apply regardless of who you are and what background you have.
Application deadline: 28.02.2023
Employer: Oslo universitetssykehus HF
Percentage of full-time: 100
Webcruiter ID: 4599286751
Start date: 01.07.2023
End date: 30.06.2026
Duties of the position
To a certain degree, the tasks can be adapted to the competence and interests of the applicant, but central tasks will include:
- Lab analyses (Cytof, digital spatial profiling, DNA-/RNA-extraction and next-generation sequencing of DNA and RNA
- Bioinformatic analyses and interpretation of sequencing data
- Multi-level analyses of immune response to cancer treatment (based on lab results from circulating cytokines and immune cells, primary tumour profiling and clinical response)
- Statistical analyses
- Co-supervision of PhD students
- Publication of results
- Responsibility for organisation and progress of the group’s research projects
The post.doc. position is part of the COM-IT-2 trial, funded by the Norwegian Cancer Society. The aim is to identify biomarkers and optimize the combination of radiotherapy and immunotherapy using material from the COM-IT-2 trial and previous trials. The COM-IT-2 trial is a randomised phase 2 study comparing the efficacy and safety of combining (chemo)immunotherapy with extensive radiotherapy for patients with advanced non-small cell lung cancer (NSCLC). A total of 30 patients will be included. Patients will be randomized to standard systemic treatment or addition of extensive radiotherapy, including as large parts of the tumour volume as possible. The clinical trial assesses toxicity and efficacy of the combined treatment. Laboratory and clinical data from other clinical trials (COM-IT-1, DART and NIPU) will be included in comprehensive analyses to identify biomarkers for immunotherapy and to optimise the combined treatment with radiotherapy.
- You must have completed a Norwegian doctoral degree or corresponding foreign doctoral degree recognized as equivalent to a Norwegian PhD. If you can document that the PhD thesis has been submitted, your application can be assessed even if you have not yet defended your thesis. Documentation of the obtained doctoral degree must be presented before you can take up the position.
- Documented experience with the relevant laboratory and bioinformatic/statistical tasks listed above
- High work capacity and productivity are essential
- Ability to work independently, take individual initiatives, work structured in a team and take responsibility for work processes
- Proficiency in the English language is a prerequisite.
Preferred experience and personal skills
- Good communication skills and ability to work well in a team
- Critical thinking and a curious mindset with a wish to obtain new knowledge
- Experience with research on tumour biology including immunology
- Experience with next-generation sequencing
- Experience with statistical analyses in R
- Experience with planning and conducting research projects
- Experience with research grant applications
- Ambitions for future research
- A strong academic, challenging and friendly working environment
- Cutting-edge technology
- Salary according to valid wage agreement
- Translational research in close colloboration with clinical cancer treatment
- Favourable pension agreement
How to apply
Only applications registered in WebCruiter will be considered.
The application must include:
- Cover letter including motivation for the position
- CV (summarizing education, positions and academic work)
- Letters of recommendation
- List of publications and academic work that the applicant wishes to be considered
- A copy of the doctoral thesis
- Contact information for two references
- The application with attachments must be delivered in our electronic recruiting system. Foreign applicants are advised to attach an explanation of their university’s grading system. Please note that all documents should be in English or in a Scandinavian language.
- In assessing the applications, special emphasis will be placed on the documented experience as well as the candidate’s motivation and personal and interpersonal suitability. Interviews with the best qualified candidates will be arranged.
Ullernchausseen 70, bygg Oslo, Norway
Vilde Drageset Haakensen
Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel.
Post expires on Tuesday February 28th, 2023