About the position
A 3-year position as Research Scientist/Postdoc Fellow in cancer immunology is available at the Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital. The position will be part of the Lymphoma Biology Group, headed by Associate Prof. June H. Myklebust. The position is available from June 1th, 2023.
The Myklebust group is one of seven groups in the new Centre of Excellence, Precision Immunotherapy Alliance (PRIMA). We offer a dynamic and stimulating international scientific environment and a young, enthusiastic and motivated team with multidisciplinary expertise. Projects in the group span from basic, translational and preclinical cancer research. We study genomics and cellular composition in the tumor microenvironment to identify prognostic and predictive biomarkers. In addition, we aim to identify and target immunosuppressive cells that limit clinical responses to immunotherapy (https://ous-research.no/lymphomabiology/ ). The Institute for Cancer Research offers outstanding research facilities for translational cancer research, including modern laboratory space and hosts state-of-the-art core facilities for next-generation sequencing, flow/mass cytometry and imaging.
The objective of the current project is to gain new insight into the diversity of immunosuppressive regulatory T cells (Tregs) in the tumor microenvironment by utilizing cancer patient material for single-cell RNA sequencing (scRNA-seq), spatial transcriptomics and proteomics technologies. Another objective is to identify vulnerable genes in Tregs by various strategies including CRISPR/Cas9 perturbation screens. The candidate will also perform ex vivo experiments (organoids) and in vivo experiments (patient-derived xenograft models) to test Treg modulation strategies together with other forms of immunotherapy. The candidate will work in team with other lab members and collaborators including bioinformaticians, experts in cell biology and immunology, clinicians and statisticians.
Oslo University Hospital is a workplace with great diversity. We believe this is essential to perform the tasks required of us. Therefore, we pursue diversity among our job applicants and encourage everyone to apply regardless of who you are and what background you have.
Application deadline: 13.06.2023
Employer: Oslo universitetssykehus HF
Percentage of full-time: 100
Eligibility and Qualifications
- Highly motivated candidates with a PhD in molecular biology, cancer immunology, immunology, cell biology or related field.
- Hold a FELASA C certificate in laboratory animal science or equivalent.
- Prior experiences with molecular biology including CRISPR/Cas9 editing, immunology, and human and mouse work are preferred.
- Expertise with multi-dimensional flow cytometry and cell sorting, immunological assays including cell culture of immune cells and virus transduction are preferred
- Ability to design, plan and interpret original experiments in an independent and innovative manner
- Experience from bioinformatics programming languages, such as Python and R will be beneficial.
- Excellent organizational and communication skills, must be proficient in written and verbal English.
- High working capacity
- Curiosity-driven with a strong motivation
- Excellent teamwork skills and interest to work closely with a multidisciplinary team
- Excellent working conditions
- An exciting and stimulating academic environment
- Focus on career development, with courses at the University of Oslo
- Highly attractive welfare benefits, and Oslo offers a family friendly environment and rich opportunity for culture and outdoor activities
How to Apply
The application with attachments must be submitted in our electronic recruiting system. Please note that all documents should be in English (or a Scandinavian language)
The application must include:
A one-page statement of motivation, summarizing scientific work and research interest
CV (summarizing education, positions, pedagogical experience, administrative experience and other qualifying activity)
A complete list of publications
Transcripts of University Diplomas
Names and contact details for minimum 3 references (name, relation to the candidate, email and phone number)
In assessing the applications, special emphasis will be placed on the documented, academic qualifications, as well as the candidates’ motivation and personal suitability. Interviews with the best qualified candidates will be arranged.
Address: Ullernchausseen 70, 0310 Oslo, Norway
June Helen Myklebust
About the employer
Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel.
Post expires on Tuesday June 13th, 2023
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