Tag Archives: Oslo University Hospital

Research Scientist/Postdoc Fellow in Molecular Immunology/ Cancer Immunology

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About the position

A 3-year position as Research Scientist/Postdoc Fellow in cancer immunology is available at the Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital. The position will be part of the Lymphoma Biology Group, headed by Associate Prof. June H. Myklebust. The position is available from June 1th, 2023.

The Myklebust group is one of seven groups in the new Centre of Excellence, Precision Immunotherapy Alliance (PRIMA). We offer a dynamic and stimulating international scientific environment and a young, enthusiastic and motivated team with multidisciplinary expertise. Projects in the group span from basic, translational and preclinical cancer research. We study genomics and cellular composition in the tumor microenvironment to identify prognostic and predictive biomarkers. In addition, we aim to identify and target immunosuppressive cells that limit clinical responses to immunotherapy (https://ous-research.no/lymphomabiology/ ). The Institute for Cancer Research offers outstanding research facilities for translational cancer research, including modern laboratory space and hosts state-of-the-art core facilities for next-generation sequencing, flow/mass cytometry and imaging.  

The objective of the current project is to gain new insight into the diversity of immunosuppressive regulatory T cells (Tregs) in the tumor microenvironment by utilizing cancer patient material for single-cell RNA sequencing (scRNA-seq), spatial transcriptomics and proteomics technologies. Another objective is to identify vulnerable genes in Tregs by various strategies including CRISPR/Cas9 perturbation screens. The candidate will also perform ex vivo experiments (organoids) and in vivo experiments (patient-derived xenograft models) to test Treg modulation strategies together with other forms of immunotherapy. The candidate will work in team with other lab members and collaborators including bioinformaticians, experts in cell biology and immunology, clinicians and statisticians.


Oslo University Hospital is a workplace with great diversity. We believe this is essential to perform the tasks required of us. Therefore, we pursue diversity among our job applicants and encourage everyone to apply regardless of who you are and what background you have.

Key information

Application deadline: 13.06.2023

Employer: Oslo universitetssykehus HF

Town/city: Oslo

Title: Postdoctor/Researcher

Positions: 1

Full-time/part-time:

Full-time

Employment type:

Contract

Percentage of full-time: 100

Eligibility and Qualifications

  • Highly motivated candidates with a PhD in molecular biology, cancer immunology, immunology, cell biology or related field.
  • Hold a FELASA C certificate in laboratory animal science or equivalent.
  • Prior experiences with molecular biology including CRISPR/Cas9 editing, immunology, and human and mouse work are preferred.
  • Expertise with multi-dimensional flow cytometry and cell sorting, immunological assays including cell culture of immune cells and virus transduction are preferred
  • Ability to design, plan and interpret original experiments in an independent and innovative manner
  • Experience from bioinformatics programming languages, such as Python and R will be beneficial.
  • Excellent organizational and communication skills, must be proficient in written and verbal English.

Personal skills

  • High working capacity
  • Curiosity-driven with a strong motivation
  • Excellent teamwork skills and interest to work closely with a multidisciplinary team

We offer 

  • Excellent working conditions
  • An exciting and stimulating academic environment
  • Focus on career development, with courses at the University of Oslo
  • Highly attractive welfare benefits, and Oslo offers a family friendly environment and rich opportunity for culture and outdoor activities

How to Apply

The application with attachments must be submitted in our electronic recruiting system. Please note that all documents should be in English (or a Scandinavian language)
The application must include:
A one-page statement of motivation, summarizing scientific work and research interest
CV (summarizing education, positions, pedagogical experience, administrative experience and other qualifying activity)
A complete list of publications
Transcripts of University Diplomas
Names and contact details for minimum 3 references (name, relation to the candidate, email and phone number)

In assessing the applications, special emphasis will be placed on the documented, academic qualifications, as well as the candidates’ motivation and personal suitability. Interviews with the best qualified candidates will be arranged.


Address: Ullernchausseen 70, 0310 Oslo, Norway

Contacts

June Helen Myklebust

Associate Professor

Phone: 99109677

Email: j.h.myklebust@medisin.uio.no

About the employer

Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel. 

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Post expires on Tuesday June 13th, 2023

Research Scientist/Postdoc Fellow in Bioinformatics/ Computational Biology

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About the position

A 3-year position as Research Scientist/Postdoc Fellow in computational biology/bioinformatics/machine learning is available at the Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital. The position will be part of the Lymphoma Biology Group, headed by Associate Prof. June H. Myklebust. The position is available from June 1th, 2023.

The Myklebust group is one of seven groups in the new Centre of Excellence, Precision Immunotherapy Alliance (PRIMA). We offer a dynamic and stimulating international scientific environment and a young, enthusiastic and motivated team with multidisciplinary expertise. Projects in the group span from basic, translational and preclinical cancer research. We study genomics and cellular composition in the tumor microenvironment to identify prognostic and predictive biomarkers. In addition, we aim to identify and target immunosuppressive cells that limit clinical responses to immunotherapy (https://ous-research.no/lymphomabiology/ ). The Institute for Cancer Research offers outstanding research facilities for translational cancer research, including modern laboratory space and hosts state-of-the-art core facilities for next-generation sequencing, flow/mass cytometry and imaging.  

The objective of the current project is to gain new insight into the diversity of immunosuppressive regulatory T cells (Tregs) in the tumor microenvironment by utilizing cancer patient material for single-cell RNA sequencing (scRNA-seq), spatial transcriptomics and proteomics technologies. The project involves multimodal computational and machine learning methods on available large datasets, both single-cell and bulk RNA-seq data, to identify cellular states associated with clinical outcome. Another objective is to identify vulnerable genes in Tregs by perturbation screens, with CITE-seq as readout. The candidate will work in team with other lab members and collaborators, including experts in cell biology and immunology, bioinformaticians, clinicians and statisticians. The candidate will be encouraged to supervise bioinformatics students and to build independent research activity.  

Oslo University Hospital is a workplace with great diversity. We believe this is essential to perform the tasks required of us. Therefore, we pursue diversity among our job applicants and encourage everyone to apply regardless of who you are and what background you have.

Key information

Application deadline: 13.06.2023

Employer: Oslo universitetssykehus HF

Title: Research Scientist/Postdoc Fellow in Bioinformatics/ Computational Biology

Positions: 1

Full-time/part-time: Full-time

Employment type:

Contract

Percentage of full-time: 100

Webcruiter ID: 4643607451

Eligibility and Qualifications

  • Highly motivated candidates with a PhD in bioinformatics, computational biology, computer science or related field.
  • Strong experience in machine learning, single-cell and spatial omics, and/or image processing is required.
  • Must be proficient with Linux and programming languages, such as Python and R.
  • Experience in working in machine learning and high performance computing environment is an advantage.
  • Expertise in the analysis and integration of next-generation sequencing data and other multi-omics data including single-cell analysis of patient samples will be preferred.
  • Have a strong interest and experience from translational cancer research and/or immunology.
  • Excellent communication skills, must be proficient in written and verbal English.

Personal skills

  • High working capacity
  • Curiosity-driven with a strong motivation
  • Excellent teamwork skills and interest to work in a multidisciplinary team

We offer

  • Excellent working conditions
  • An exciting and stimulating academic environment
  • Focus on career development, with courses at the University of Oslo
  • Highly attractive welfare benefits, and Oslo offers a family friendly environment and rich opportunity for culture and outdoor activities

How to apply

The application with attachments must be submitted in our electronic recruiting system. Please note that all documents should be in English (or a Scandinavian language)
The application must include:
A one-page statement of motivation, summarizing scientific work and research interest
CV (summarizing education, positions, pedagogical experience, administrative experience and other qualifying activity)
A complete list of publications
Transcripts of University Diplomas
Names and contact details for minimum 3 references (name, relation to the candidate, email and phone number)
 
In assessing the applications, special emphasis will be placed on the documented, academic qualifications, as well as the candidates’ motivation and personal suitability. Interviews with the best qualified candidates will be arranged. 

Address: Ullernchausseen 70, 0310 Oslo, Norway

Contacts

June Helen Myklebust

Associate Professor

Phone: 99109677

Email: j.h.myklebust@medisin.uio.no

About the employer

Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel. 

OUS-symbol-bunn

Post expires on Tuesday June 13th, 2023

PhD fellow Oslo University Hospital, Division of Surgery, Inflammatory Diseases and Transplantation, Research Institute of Internal Medicine 

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About the position

A PhD position dedicated to investigate non-coding RNA in preeclampsia and future cardiovascular disease is available from September 2023 at the Research Institute of Internal Medicine (RIIM), Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet, Norway. 

Oslo University Hospital (OUS) is the largest hospital in Norway with 24 000 employees. With its broad range of medical disciplines and internationally recognized scientists, OUS is an important contributor to research and education in Norway.

The Research Institute of Internal Medicine (RIIM) consists of six main research groups with focus on various fields of inflammation in cardiovascular disease, liver disease, infectious disease and hematological disorders. The research profile of the Institute is to combine clinical medicine and molecular biology to establish a bridge between bench and bedside. This is of utmost importance in order to exploit in clinical medicine the recent development in immunology, biochemistry and molecular biology with the ambitious aim to develop novel treatment modalities and new diagnostic tools. Our profile includes all phases of this research, ranging from characterization of inflammatory profiles in various patient populations and in vitro experiments in various cells and cell lines to experimental studies in animal models, including gene modified mice, and interventional proof of concept studies in various patient populations. Metabolic complications and cardiovascular disease have been a focus in many of the groups at the Institute. See http:// www.ous-research.no/riim/ for more information about RIIM.

Applicants are invited for a 3-year PhD position examining non-coding RNA in relation to cardiovascular disease to be based at the Research Institute of Internal Medicine (RIIM), Oslo University Hospital, Rikshospitalet. The project will be conducted in the group of Professor Thor Ueland and lead by Tove Lekva as main supervisor. The position is financed by Helse Sør-Øst RHA.
Oslo University Hospital is a workplace with great diversity. We believe this is essential to perform the tasks required of us. Therefore, we pursue diversity among our job applicants and encourage everyone to apply regardless of who you are and what background you have.

Key information

Application deadline: 01.06.2023

Employer: Oslo universitetssykehus HF

Town/city: Oslo

Title: PhD fellow

Positions: 1

Full-time/part-time: Full-time

Employment type: Contract

Percentage of full-time: 100

Webcruiter ID: 4639032559

Start date: 01.09.2023

End date: 30.08.2026

Duties and responsibilities 

The candidate will work on the funded project that aims to explore the use of non-coding RNA to identify biomarkers and treatment targets in preeclampsia and future cardiovascular risk. We are particularly interested in an individual with strong expertise in molecular biology/biochemistry and interest in bioinformatics analyses. He/she will participate in obtaining, preparation and processing of clinical materials including the placenta, circulating immune cells, extracellular vesicles and plasma for transcriptomic- and proteomic analysis. In vitro cell culture studies using RNA interference and method development will also be included in the work.   

Qualifications

  • We are looking for a talented and highly motivated candidate of all nationalities who have a keen interest in inflammation and cardiovascular research
  • Fulfill the requirements to be taken up by the UiO doctoral program (evaluation score A or B)
  • Master`s degree (MSc) or medical doctor (MD)

Personal qualities 

  • Highly motivated, goal oriented, and genuine interest in research
  • Dedicated and responsible
  • Ability to work independently and in an interdisciplinary environment
  • Is easy to get along with, flexible and structured
  • Has good English written and oral communication skills

We can offer 

  • A stimulating, challenging, and friendly international working environment with broad expertise
  • Experienced, creative, and friendly research colleagues

The application must include:

Cover letter (statement of motivation, summarizing scientific work and research interest)
CV
Copies of educational certificates
A complete list of publications
List of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number)

In assessing the applications, special emphasis will be placed on the documented, academic qualifications in regards to the project description, and the candidate’s motivation and personal suitability. Interviews with the best qualified candidates will be arranged.

Address: Sognsvannsveien 20, 0372 Oslo, Norway

Contacts

Espen Melum

Professor, Overlege

Phone: +47 91780732

Email: espen.melum@medisin.uio.no

Tove Lekva

Forsker

Phone: +47 97067131

Email: tove.lekva@ous-research.no

About the employer

Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of national and multi-regional assignments, and has several national centers of competence. Oslo University Hospital is responsible for approximately 50 percent of all medical and health care research conducted at Norwegian hospitals, and is a significant role player within the education of a large variety of health care personnel. 

OUS-symbol-bunn

Post expires on Thursday June 1st, 2023