Tag-arkiv: University of Helsinki

Postdoc­toral Re­searcher in Pro­tein Bio­chem­istry and Struc­tural Biology

POST DOCTORAL RESEARCHER IN PROTEIN BIOCHEMISTRY AND STRUCTURAL BIOLOGY

The laboratory of Dr. Tommi Kajander at the Institute of Biotechnology, HiLIFE, University of Helsinki, Finland, is inviting applications for post-doctoral researcher in the area of protein biochemistry and structural biology in a joint project with Prof. Mart Saarma’s laboratory. We are seeking for dedicated and enthusiastic scientist to work on the structure and function of novel endoplasmic reticulum effector protein-receptor interactions in ER stress response regulation. Main targets are CDNF and MANF proteins and their interaction complexes in the ER.

The Institute of Biotechnology is a research institute at University of Helsinki, located in the Viikki science park. The institute harbors ~35 research groups and 250 researchers, and it operates at the highest international level. For more information on the Institute, please visit https://www.helsinki.fi/en/hilife-institute-of-biotechnology.
The institute has excellent infrastructure for structural biology (X-ray, CryoEM, NMR) including the crystallography core facility run by the PI.

The post-doctoral applicants should hold PhD in biochemistry or a related field. Strong experience in protein biochemistry including cloning and mutagenesis and protein expression and purification, from various hosts and good communication skills in English are required. Knowledge and experience in structural biology and molecular biophysics techiques and cell culture is beneficial. This is an opportunity to work on high impact targets and obtain in depth technical skills in the research area. The position will provide excellent opportunities for collaborations, as this is a joint project in close collaboration with Prof. Mart Saarma’s group, with also potential international and national collaborations and visits to e.g. synchrotron sources in Europe (ESRF, DLS, MAXIV). An attitude to carry out ambitious research projects, good problem solving skills, goal-oriented mind-set and willingness to learn and apply new methodologies is highly appreciated. The working language of the laboratory is English; knowledge of Finnish is not a requirement.

The postdoctoral position is initially limited to 1 year, with a possibility of extension to three years. The salaries will be based on the University salary scheme (level 5) for teaching and research personnel composed of both task specific and personal performance component The position is available immediately or as agreed.

Application should include the following documents as a single pdf file (max 5 pages): CV (max 2 pages), list of publications, motivation letter (max 1 page) including a description of your research interests, and the names and contact details of at least two referees. Please submit your application, together with the required pdf attachment, through the University of Helsinki electronic recruitment system by clicking on the ‘Apply for job’ button. Internal applicants (i.e., current employees of the University of Helsinki) should submit their applications through the SAP HR portal. For technical support regarding the recruitment system, please contact ‘rekrytointi@helsinki.fi’.

The deadline for the applications is 31st of August, 2021, or until suitable candidate have been found.

For informal inquiries, contact ‘tommi.kajander(at)helsinki.fi’
See also:
https://www2.helsinki.fi/en/researchgroups/structural-biology-of-protein…
https://www2.helsinki.fi/en/researchgroups/neurotrophic-factors-and-rege…

For technical support regarding the recruitment system, please contact rekrytointi@helsinki.fi.

Selected recent references related to project and the laboratory:
Kovaleva V, Yu LY, Ivanova L, Nam J, Eesmaa A, Kumpula EP, Huiskonen J, Lindholm P, Voutilainen M, Karelson M, Saarma M. MANF regulates unfolded protein response and neuronal survival through its ER-located receptor IRE1α bioRxiv 2020.09.22.307744

Eesmaa A, Yu LY, Göös H, Nõges K, Kovaleva V, Hellman M, Zimmermann R, Jung M, Permi P, Varjosalo M, Lindholm P, Saarma M. The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor. J Biol Chem. 2021 Jan 15;296:100295.

Lindahl M, Saarma M, Lindholm P. Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential. Neurobiol Dis. 2017 Jan;97(Pt B):90-102.

Lindholm, P., Voutilainen, M .H., Laurén, J., et al. and Saarma, M. (2007) Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature, 448, 73-77.

Karki S, Shkumatov AV, Bae S, Kim H, Ko J, Kajander T. Structural basis of SALM3 dimerization and synaptic adhesion complex formation with PTPσ. Sci Rep. 2020 Jul 14;10(1):11557.

Paatero A, Rosti K, Shkumatov AV, Sele C, Brunello C, Kysenius K, Singha P, Jokinen V, Huttunen H, Kajander T. Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding. Biochemistry. 2016 Feb 16;55(6):914-26

Finland is a member of the EU, has high quality free schooling (also in English), generous family benefits and healthcare, and was recently ranked as the best country in the world for expat families and in the world’s top ten most livable cities. Finland and the Helsinki region possess top expertise in sciences in terms of a vibrant talent pool, leading research, strong support services and functioning collaboration networks. For more information about working at the University of Helsinki and living in Finland, please see helsinki.fi/en/university/working-at-the-university.

Helsinki Institute of Life Science (HiLIFE) is a new institute established in 2017 that supports high quality life science research across the University campuses and faculties. HiLIFE builds on existing strengths and new recruits and partnerships to create an attractive international environment for researchers to solve grand challenges in health, food, and environment. HiLIFE coordinates research infrastructures in life sciences and provides research-based interdisciplinary training.

The University of Helsinki, founded in 1640, is one of the world’s leading universities for multidisciplinary research. The university has an international academic community of 40,000 students and staff members. The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and professional development opportunities. The International Staff Services office assists employees from abroad with their transition to work and life in Finland.

Due date

31.08.2021 23:59 EEST

Read the job description at the university homepage

Apply for the position

Post expires on Tuesday August 31st, 2021

POSTDOC­TORAL RE­SEARCH­ERS IN MATHEMATICAL PHYS­ICS

The University of Helsinki (https://www.helsinki.fi/en), founded in 1640, is one of the world’s leading universities for multidisciplinary research. The university has an international academic community of 40,000 students and staff members.

The Department of Mathematics and Statistics (https://www.helsinki.fi/en/faculty-of-science/faculty/mathematics-and-st…) at the Faculty of Science, is the largest department of mathematical sciences in Finland. The Department is responsible for high-end research into mathematics and statistics on an international level, and academic education in mathematics based on that research. The focus areas of the research are mathematical physics, analysis, logic, mathematical biology, inverse problems, and biostatistics.

The Department of Mathematics and Statistics invites applications for

POSTDOCTORAL RESEARCHERS IN MATHEMATICAL PHYSICS

The employment can commence, upon mutual agreement, flexibly between September 2021 and January 2022. The positions are fixed-term with appointments up to max. 3 years.

Position description and requirements

The work will be conducted in the Mathematical physics research group (https://www.helsinki.fi/en/researchgroups/mathematical-physics) together either with professor Antti Kupiainen (https://researchportal.helsinki.fi/en/persons/antti-kupiainen) professor Jani Lukkarinen (https://researchportal.helsinki.fi/en/persons/jani-lukkarinen). The Mathematical Physics Research Group comprises of five faculty members and fifteen post-doctoral researchers and PhD students.

We are looking for researchers with background in at least one of the following mathematical fields related to the projects involved in this call

• Stochastic PDEs, Rigorous statistical mechanics and quantum field theory (Kupiainen)
• Analysis of evolution equations involving nonlinearities, perturbation theory or related graph methods, mathematical kinetic theory, Bose–Einstein or other condensates (Lukkarinen)

The work includes participation in one of the following five research projects:

1. Liouville Conformal Field Theory and related topics (Kupiainen)
2. Renormalization Group in Stochastic PDEs and Quantum Field Theory
(Kupiainen)
3. Coagulation–fragmentation phenomena (Lukkarinen)
4. Kinetic theory of nonlinear wave or Schrödinger evolution (Lukkarinen)
5. Non-equilibrium systems with condensates (Lukkarinen)

The postdoctoral researchers´ work encompasses conducting research in collaboration with members of the research group and a small amount of teaching (approximately 28 hours of lecturing a year).

Salary

The salary of successful candidate will be based on level 5 of the demands level chart for teaching and research personnel in the salary system for Finnish universities. In addition, the appointee will be paid a salary component based on personal performance. The starting salary will be approximately 3400 – 3800 €/month.

The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development. The University provides support for internationally recruited employees and their family members with their transition to work and life in Finland. For more on the University of Helsinki as an employer, please see https://www.helsinki.fi/en/about-us/careers.

How to apply

Please submit your application using through the University of Helsinki Recruitment System via the link “Apply for the position”.

Please attach the following documents as a single pdf file:

• Motivation letter (max 1 page, including your preferred choice among the above listed five projects)
• CV (max 2 pages)
• List of publications
• Two reference letters including contact details of the referees who agreed to provide the letters

Women and other underrepresented groups are particularly encouraged to apply.

The deadline for submitting applications is September 30, 2021 (time zone EEST). Review of applications begins immediately and one position may be filled already during the application period.

Additional information

For more information, please contact Professor Jani Lukkarinen or Professor Antti Kupiainen by email: Jani.Lukkarinen@helsinki.fi and/or Antti.Kupiainen@helsinki.fi.

Due date

30.09.2021 23:59 EEST

Read the job description at the university homepage

Apply for the position

Post expires on Thursday September 30th, 2021

Postdoc­toral re­searcher, De­part­ment of Phys­ics, X-ray Laboratory

The University of Helsinki is the top academic institution in Finland and one of the top 100 academic institutions in the world: http://www.shanghairanking.com/rankings/arwu/2020. The international scientific community consists of 40,000 students and researchers. The Faculty of Science, located at the Kumpula campus, focuses on research in physics, atmospheric sciences, geosciences, geography, chemistry, mathematics, statistics and computer science.

The Department of Physics in the Faculty of Science at the University of Helsinki is now seeking to recruit a

POSTDOCTORAL RESEARCHER

to the X-ray Laboratory (https://www2.helsinki.fi/en/researchgroups/x-ray-laboratory) starting from late autumn 2021 for a fixed-term employment until July, 2023. The postdoctoral researcher will work in a multidisciplinary research project entitled ‘Breaking a barrier in ocular research: understanding the role of the tear film lipid layer in health and disease’.

The postdoctoral researcher will employ X-ray scattering methods (small- and wide-angle x-ray scattering, grazing incidence diffraction and small angle scattering, SAXS, WAXS, GID, GISAS) using in-house X-ray set-ups and international synchrotron light sources to study the structure and function of tear film lipids. The postdoctoral researcher will work in the soft condensed matter research group, Department of Physics and participate in the active collaboration with the Biomolecular chemistry group, Department of Chemistry and the Helsinki Eye Lab, Faculty of Medicine. In addition to a top-level interdisciplinary research community, the project will offer possibilities for international research visits to world leading international synchrotron light facilities, most importantly, the European Synchrotron Radiation Facility (ESRF, France) and the MAX-IV Laboratory (Sweden). The postdoctoral researcher is also expected to participate in teaching and supervision duties at the Department of Physics, with a possibility to enroll in official pedagogical training programs.
We offer a competitive salary, local infrastructure and a top-level interdisciplinary and international collaboration network. Our research has a high profile and we publish in top ranking international journals and participate in international conferences of the field.

The appointee must hold an applicable Ph.D. degree in physics or chemistry or a closely related scientific field and possess good English communication skills. Previous experience in experimental material physics, especially using surface X-ray scattering techniques, is considered a merit. In addition to prior knowledge of experimental work, complementing computational skills are mandatory, e.g. using Matlab/Python for data handling and analysis.

The applicants are requested to enclose with their application a motivation letter and CV with experience and academic merits. Please submit your application documents as a one single pdf file via the University of Helsinki electronic recruitment system by using the University of Helsinki Recruitment System by clicking the Apply for the position button below. Applicants who are employees of the University of Helsinki must submit their applications via the SAP HR portal. Deadline for applications is 10th August 2021.

For any further questions, please contact university lecturer Kirsi Svedström, kirsi.svedstrom(at)helsinki.fi.

Due date

10.08.2021 23:59 EEST

Read the job description at the university homepage

Apply for the position

Post expires on Tuesday August 10th, 2021

Postdoc­toral re­searcher, re­mote sens­ing of Arc­tic eco­sys­tems

The University of Helsinki is a multidisciplinary research university that ranks among the best in the world and the top ten among European universities. The university has some 36,000 degree students.

The Department of Geosciences and Geography (https://www2.helsinki.fi/en/faculty-of-science/faculty/geosciences-and-g…) at the Faculty of Science is the leading research and education unit in its field in Finland. In addition to research in geology, geophysics and geography, research into seismology and official duties in the field of seismology is carried out at the department. The staff at the department numbers some 100.

Faculty of Science invites applications for

POSTDOCTORAL RESEARCHER

in remote sensing of Arctic ecosystems starting from 1.9.2021 or as agreed for a four years fixed-term employment contract. A six-month trial period will be applied.
The postdoctoral researcher will work on the project “Resilience of Arctic terrestrial ecosystems under bioclimatic change” funded by the Academy of Finland. The project focuses on the impacts of climate change on the Arctic ecosystems at high spatiotemporal resolution but across large extents. The project will provide new knowledge of Arctic bioclimate and ecosystem dynamics and their inter-linkages. This will significantly increase the understanding of the long- and short-term bioclimatic variability in driving ecosystem responses and enable assessment of the resilience of Arctic terrestrial ecosystems.

The main tasks of the postdoctoral researcher are analyzing and modelling remotely sensed (RS) data (e.g. MODIS, Landsat, Sentinel, Planet). The postdoctoral researcher will compile field data with cloud-based RS data catalogues and high performance computing services, and analyze the circum-Arctic patterns of multiple vegetation indices and properties over the past four decades in respect to observed change in Arctic climate. The specific tasks and aims of the work can be partly adjusted according to the skills and interests of the appointed postdoctoral researcher.

The successful candidate is expected to have a PhD degree in remote sensing, physical geography, environmental science, or a related field. We are looking for a postdoctoral researcher with an interest in remote sensing, some background with ecosystem data and/or their statistical analyses, and experience or strong motivation to learn computing skills (e.g., R, Python, GIS and Google Earth Engine; any programming background is highly valued).

Finland is a member of EU, has high quality free schooling (also in English), generous family benefits and healthcare, and was recently ranked as the best country in the world for expat families and in the world’s top ten most livable cities. Finland and the Helsinki region possess top expertise in sciences in terms of a vibrant talent pool, leading research, strong support services and functioning collaboration networks. For more information about working at the University of Helsinki and living in Finland, please see https://www.helsinki.fi/en/university/working-at-the-university.

The starting salary of the postdoctoral researcher will be ca. 3300–3700 euros/month, depending on the appointees’ qualifications and experience. Furthermore, the University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development.

How to apply

Please submit your application consisting of (1) a cover letter (incl. research interest), (2) a curriculum vitae and a publications list in a single pdf file using the University of Helsinki Recruitment System by clicking the Apply for the position button below. Applicants who are employees of the University of Helsinki must submit their applications via the SAP HR portal. Deadline for applications is 15 August 2021.

For further information, please contact Professor Miska Luoto, miska.luoto(at)helsinki.fi.

Due date

15.08.2021 23:59 EEST

Read the job description at the university homepage

Apply for the position

Post expires on Sunday August 15th, 2021

Doc­toral stu­dents on re­gister-based crim­in­o­lo­gical research

The Faculty of Social Sciences, University of Helsinki, invites applications for the position of

1-2 DOCTORAL STUDENTS

for a four-year, full-time, fixed-term period starting 13 September 2021 (or as agreed).

The appointees will work at the Institute of Criminology and Legal Policy (KRIMO) in the research group of associate professor Antti Latvala. Latvala’s research utilizes nationwide register data from Finland and Sweden and family-based, genetically informed research designs, as well as other quasi-experimental methods to study criminality, mental health, and related factors. The appointees will contribute to a beginning project examining effects of parental incarceration on offspring mental health, criminality and developmental outcomes, or other criminality-related research projects. The appointees are expected to publish the results in top-level international peer reviewed scientific journals. The projects may include collaboration with researchers at Karolinska Institutet in Stockholm, Sweden.

The duties of the doctoral candidate are to work on his/her doctoral thesis and to complete his/her postgraduate studies. The duties also include teaching and other tasks. Teaching tasks can account for up to 5% of the annual working time and take place in the context of the Bachelor and Master’s programs in Social Research, Faculty of Social Sciences. Other tasks may include contributing to ongoing projects in the research group as well as preparing grant applications.

QUALIFICATIONS

Applicants must hold a master’s degree in (Quantitative) Social Sciences, Criminology, Psychology, Epidemiology/Public Health, or other relevant field; have strong quantitative methods skills and an excellent command of written English. Other requirements include proven ability and motivation, demonstrated through previous degree studies or otherwise, to pursue postgraduate studies and a doctoral degree according to the study plan and research proposal.

In addition, the appointee should apply for and obtain the right to pursue a doctoral degree at the University of Helsinki within the probationary period of six months of their appointment. See: www.helsinki.fi/en/research/doctoral-education/the-application-process-i….

WHAT WE OFFER

We are an equal opportunity employer and offer an attractive and diverse workplace in an inspiring environment with a variety of development opportunities and benefits. The annual gross salary range of a doctoral candidate will be approx. 29,700 – 39,000 euros, depending on the appointee’s qualifications and experience. In addition, University of Helsinki offers comprehensive services to its employees, including occupational health care and opportunities for professional development. Further information at www2.helsinki.fi/en/university/careers-at-the-university-of-helsinki. The appointee is expected to reside in Finland while employed by the University of Helsinki. The employment contract will include a probationary period of six months.

HOW TO APPLY

Applicants are requested to enclose with their applications the following documents. Please compile all documents as a single pdf file.

1) A curriculum vitae, clearly indicating type and level of qualifications.
2) A statement (max 1 page) explaining the applicant’s motivation to apply for the position and how his/her expertise would productively contribute to research on intergenerational effects in criminology, or other criminality-related topic.
3) Names and contact details for 1-2 references (please note that recommendation letters are not to be submitted at this stage).
4) A list of publications (optional).

For instructions about preparing the CV and list of publications, please see www2.helsinki.fi/en/faculty-of-social-sciences/faculty/applying-for-teaching-and-research-positions.

Please submit your application through the University of Helsinki Recruitment System via the link Apply for job. Applicants who are employees of the University of Helsinki must submit their application via the SAP HR portal, https://saphr.it.helsinki.fi/irj/portal. The application period closes on 15 August, 2021.

FURTHER INFORMATION

Further information about the positions and the research project may be obtained from associate professor Antti Latvala (antti.latvala@helsinki.fi), https://researchportal.helsinki.fi/en/persons/antti-latvala.

In case you need support with the recruitment system, please contact recruitment@helsinki.fi.

The University of Helsinki is the oldest and largest institution of academic education in Finland, an international scientific community of 40,000 students and researchers. In international university rankings, the University of Helsinki typically ranks among the top 100. The University of Helsinki seeks solutions for global challenges and creates new ways of thinking for the best of humanity. Through the power of science, the University has contributed to society, education and welfare since 1640.

The Faculty of Social Sciences is Finland’s leading research and education institution in the social sciences, and also the most diverse in terms of its disciplines. In several research fields the Faculty belongs to the top 50 in the international rankings. The Faculty has a strong international profile both in research and teaching programmes. The number of academic staff stands at 350. Each year the faculty awards some 350 Bachelor’s degrees, 400 Master’s degrees, and more than 40 doctoral degrees. For more information on the Faculty of Social Sciences, please visit Faculty website on www2.helsinki.fi/en/faculty-of-social-sciences.

Due date

15.08.2021 23:59 EEST

Read the job description at the university homepage

Apply for the position

Post expires on Sunday August 15th, 2021

Senior postdoc­toral re­searcher in Neuro­physiology

The in vivo rodent electrophysiology and imaging unit in Neuroscience Center, University of Helsinki is looking for

a SENIOR POSTDOCTORAL RESEARCHER IN NEUROPHYSIOLOGY

The Neuroscience Center (NC, https://www.helsinki.fi/en/helsinki-institute-of-life-science/units/neur…) is an international research unit within Helsinki Institute of Life Science (HiLIFE) of the University of Helsinki, a leading Nordic university with a strong commitment to life science research. NC aims at making fundamental discoveries about brain functions and especially translate research findings into improvements in the treatment, prevention and diagnosis of psychiatric and neurological disorders. The research in NC spans across several scales from stem cell research and molecular neuroscience to systems and cognitive neuroscience in both animal and human models. The research groups of NC conduct research in neuroscience at the highest international level and actively apply the results for the benefit of the society. NC collaborates actively with other units of HiLIFE and faculties of the University of Helsinki, Helsinki University Central Hospital, Aalto University and Neurocenter Finland.

The Neuroscience Center invites applications from outstanding candidates for a Senior Postdoctoral Researcher in Neurophysiology for a 3-year appointment, starting the earliest from October 2021.

The successful candidate is expected to have strong previous experience in in vivo neurophysiology, and in particular in the field of rodent brain imaging and/or electrophysiology. The selected candidate will perform research using the technologies and methods made available by the core and participate in maintaining and developing the activities the in vivo rodent imaging and electrophysiology research platform (https://www.helsinki.fi/en/infrastructures/helsinki-in-vivo-animal-imagi…), including user training. The core facility comprises of in vivo brain microscopy unit and platforms for in vivo electrophysiological recordings in both anesthetized and awake mice.

The research work will focus on the mechanisms of neurodevelopmental disorders and bridging findings from rodent models to human data. Previous research experience in rodent models as well as in vivo genetic and optogenetic manipulations in combination with in vivo electrophysiological or imaging techniques in considered as an advantage.

The qualification requirements include an applicable doctoral degree, excellent command of English as well as documented research skills (i.e. scientific publications) in the expected research field. Other requirements include the ability and motivation to pursue a scientific career, as demonstrated through publications or otherwise.

We offer an international, inspiring, and supportive research environment, along with excellent research facilities and in-house state-of-the-art technologies. NC hosts also other state-of-the-art infrastructures, including neuronal stem cell core and mouse behavioral phenotyping center. The members of NC also have an access to human brain imaging in the BioMag laboratory in the HUS Medical Imaging Centre and Aalto University facilities.

Finland is a member of the EU, has high quality free schooling (also in English) and generous family benefits and healthcare. Finland was recently ranked as the best country in the world for expat families, and Helsinki in the world’s top ten most livable cities. Finland and the Helsinki region possess top expertise in sciences in terms of a vibrant talent pool, leading research, strong support services and functioning collaboration networks. For more information about working at the University of Helsinki and living in Finland, please see https://www.helsinki.fi/en/university/working-at-the-university.

Salary will be based on the University salary system, starting at approx € 3400 /month, depending on the appointee’s qualifications and experience.

Applications are invited up to 15 August 2021 at 23:59 (EET).

The application must be submitted as one single pdf file through the University of Helsinki electronic recruitment system by clicking the link below. Applicants employed by the University of Helsinki must submit their application through the SAP HR portal. The application, written in English, should contain the following:
• Cover letter summarizing the candidate’s research experience in in vivo imaging and electrophysiology and why the candidate is interested in the position.
• Curriculum vitae
• List of publications
• Contact information of two referees

Further information: Sari Lauri, e-mail: sari.lauri (at) helsinki.fi
Technical support for using the recruitment system: rekrytointi (at) helsinki.fi

Due date

15.08.2021 23:59 EEST

Read the job description at the university homepage

Apply for the position

Post expires on Sunday August 15th, 2021