Tag-arkiv: University of Gothenburg

PhD student position in Learning Dynamical Systems in Combination Therapy

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The Department of Mathematical Sciences pursues internationally successful research and an extensive education.

Mathematics is fundamental to science and engineering and has an increasingly prominent part in other disciplines as well. Mathematics is also a subject in itself, and fundamental research is a necessary condition for future applications.

The Department is part of both Chalmers University of Technology and the University of Gothenburg and is situated in the middle of Campus Johanneberg. It is the largest mathematics department in the Nordic countries and has about 200 employees, with a number of research groups in mathematics and mathematical statistics which together provide a creative and cross-fertilizing setting.


Information about the project
The Department of Mathematical Sciences at Chalmers University of Technology and University of Gothenburg, together with the Fraunhofer-Chalmers Centre (FCC), is recruiting an industrial PhD student for a project on learning dynamical systems in drug discovery. Both the Department of Mathematical Sciences and FCC carry out world-class research and industrial projects with a focus on using mathematics as a technology. For more information, see our websites here and here.

We are currently looking for a highly motivated individual to join us in an exciting project working closely with the pharmaceutical industry to proceed beyond state-of-the-art modeling and simulation methodology and tools for pharmacokinetic and pharmacodynamics processes. A quantitative description of the dynamics of a pharmacological compound in the blood after drug administration, typically the plasma concentration of a drug as a function of time, is of fundamental importance in drug development. The task of developing mathematical models of this dynamical process is known by the name pharmacokinetic (PK) modeling. The time-varying plasma concentration may in turn be linked to the pharmacological effect, e.g., less pain, reduction in bacteria, or reduced fever using so called pharmacodynamic (PD) modeling.

A particular challenge in drug discovery and development is to assess the effect of combinations of therapies such as drug-drug or drug-irradiation. A data driven model based approach relying on pre-clinical data to rank combinations would be a highly useful tool for improving the rate of success in selecting drug combinations of high value.

An integrated framework has been developed at FCC for advanced PK/PD modeling and simulation, which provide means to describe PK/PD processes using both ordinary and stochastic differential equations. Learning dynamical models from data includes maximum likelihood estimation and Bayesian approaches using both parametric and non-parametric methods. Models can be fitted to data from single individuals as well as ensembles of data records from individuals assumed to be governed by the same mechanistic descriptions but with individual parameters (so called nonlinear mixed effects models). In this project the student will extend and adapt the framework in different ways to improve its performance and application to combination therapy when applied to an industrially relevant problem and data set(s), e.g., by exploring the use of particle Markov Chain Monte Carlo methodology, Gaussian process learning, and probabilistic programming.

The project will be performed in collaboration between the Fraunhofer-Chalmers Centre, the Department of Mathematical Sciences and Merck. The PhD student will be enrolled in a graduate school in the Department of Mathematical Sciences. The project is carried out as part of an existing collaboration between FCC and Merck. Furthermore, Merck supports the project with data and challenging applied problems and there will be opportunities for shorter or longer visits to the company during the course of the project.

Major responsibilities
As a PhD student you will be part of an international research environment while you expand your knowledge of the field and write your thesis. You will work together with a team of researchers and engineers with a thorough understanding of both applied mathematics and pharmaceutical applications. You are a team player with strong interest in industrial applications, but are also expected to work autonomously, to develop your own ideas and communicate results to the scientific community. In addition, the position will normally include 10% departmental work, mostly teaching duties. Totally, the graduate programme will thus comprise 4 years of study and research and 0.5 years of teaching.
Position summary
Full-time employment at FCC. Starting date: 1 June, 2019, or according to agreement.  

Qualifications
Applicants must have a strong background in the mathematical sciences. A master’s degree or a 4-year bachelor’s degree or an equivalent competence is required at the beginning of the employment.

Concurrent method development and implementation of algorithms is integral to the applied reseach carried out at FCC and good programming skills (e.g., Python, Mathematica, R) are therefore required.

In your application you should include all relevant work such as bachelor’s or master’s thesis and articles (provide an English summary if necessary) that you have authored or co-authored. Evidence of mathematical problem solving skills is significant, besides course grades.

The bachelor’s level teaching is normally in Swedish, although the teaching at the master’s and PhD levels is in English. Thus, good language skills are require.

Chalmers continuously strives to be an attractive employer. Equality and diversity are substantial foundations in all activities at Chalmers.

Our offer to youChalmers and FCC offer a cultivating and inspiring working environment in the dynamic city of Gothenburg

Application procedure
The application should be marked with Ref 20190082 and written in English. The application should be sent electronically and be attached as pdf-files, as below:

CV: (Please name the document: CV, Family name, Ref. number)
• CV
• Other, for example previous employments or leadership qualifications and positions of trust.
• Two references that we can contact.

Personal letter: (Please name the document as: Personal letter, Family name, Ref. number)
• 1-3 pages where you introduce yourself and present your qualifications.
• Previous research fields and main research results.
• Future goals and research focus. Are there any specific projects and research issues you are primarily interested in?

Other documents:
• Copies of bachelor and/or master’s thesis.
• Attested copies and transcripts of completed education, grades and other certificates, eg. TOEFL test results.

Please ue the button at the foot of the page to reach the application form. The files may be compressed (zipped).

Application deadline: 17 March 2019

For questions, please contact:
Stig Larsson, tillämpad matematik och statistik, stig@chalmers.se Mats Jirstrand, Fraunhofer-Chalmers Centre, matsj@fcc.chalmers.se
Torbjörn Lundh, tillämpad matematik och statistik, torbjorn.lundh@chalmers.se

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Chalmers University of Technology conducts research and education in engineering sciences, architecture, technology-related mathematical sciences, natural and nautical sciences, working in close collaboration with industry and society. The strategy for scientific excellence focuses on our eight Areas of Advance; Building Futures, Energy, Information & Communication Technology, Life Science, Materials Science, Nanoscience & Nanotechnology, Production and Transport. The aim is to make an active contribution to a sustainable future using the basic sciences as a foundation and innovation and entrepreneurship as the central driving forces. Chalmers has around 11,000 students and 3,000 employees. New knowledge and improved technology have characterised Chalmers since its foundation in 1829, completely in accordance with the will of William Chalmers and his motto: Avancez!
   


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Read the full job description at the university homepage

Post expires on Sunday March 17th, 2019

PhD student position in the Mathematical Sciences

Diary id: PAR 2019/151
Employment level: Time limited employment (temporary)
Location: Deaprtment of Mathematical Sciences
Apply by: 2019-03-17

The Department of Mathematical Sciences at Chalmers University of Technology and the University of Gothenburg has about 170 employees, and is the largest department of mathematics in Sweden. The department has three scientific divisions, Algebra and Geometry, Analysis and Probability Theory, and Applied Mathematics and Statistics, and conducts successful research in pure and applied mathematics and mathematical statistics in a wide range of research areas.

We are located in a modern building at the center of Chalmers campus. More information about us can be found on our website http://www.chalmers.se/math/

Information about the research environment

At the Department of Mathematical Sciences there are many internationally successful researchers in a wide variety of research areas. We are looking for one doctoral student to work within the division of Algebra and Geometry. In the division we conduct research in areas such as algebraic and complex geometry, number theory, algebra and representation theory, and mathematical physics. More information about our division can be found here:

https://www.chalmers.se/en/departments/math/organisation/algebra-and-geometry/Pages/default.aspx

Job assignments

As a PhD student you will be part of an international research environment while you expand your knowledge of the field and write your thesis. This gives opportunities for many inspiring conversations, a lot of autonomous work and some travelling. You are expected to develop your own ideas and communicate scientific results orally as well as in written form. In addition, the position will normally include 20% departmental work, mostly teaching duties.

The employment is limited to a maximum of four years with a possibility for an additional year for carried out departmental duties.

Eligibility

The grounds of jurisdiction are regulated by the Higher Education Ordinance, Chapter 7, §§ 39, 40.

Applicants must have a strong background in mathematics.  They must have obtained a master’s degree or a 4-year bachelor’s degree or by some other means have fulfilled equivalent competence by the application deadline.  

It is important that you mention in the application your specific research interests.  You should also include all relevant work such as bachelor’s or master’s thesis and articles (provide an English summary if necessary) that you have authored or co-authored. Evidence of mathematical problem-solving skills is significant, in addition to course grades. 

The bachelor’s level teaching is normally in Swedish, although the teaching at the master’s and PhD levels is in English. Thus, good language skills are required. Experience in computer programming is meritorious as part of the teaching may be computer based.

Employment

Type of employment: Fixed-term employment, 4-5 years
Extent: 100 %
Location: Department of Mathematical Sciences, Gothenburg
First day of employment: August 15, 2019

Regulations for the evaluation of qualifications for education on a doctoral level are given in SFS 1998:80.
A new employment as a PhD student applies for a maximum of one year. The Appointment may be prolonged for up to two years at a time. The total employment period may not be longer than the equivalent of four years of full time time doctoral studies.

University applies local agreement on salaries of graduate students.

For further information regarding the position

Peter Hegarty, director of PhD studies in mathematics, email: hegarty@chalmers.se, tel. +46 (0)31 772 5371

Håkan Samuelsson Kalm, head of unit, email: hasam@chalmers.se, tel. +46 (0)31 772 3568

Unions

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

Closing date: March 17, 2019

Apply

Read the job description at the university homepage

The University of Gothenburg tackles society’s challenges with diverse knowledge. 38 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

Post expires on Sunday March 17th, 2019

Postdoctoral researcher in Human Computation

Diary id: PAR 2019/109
Employment level: Time limited employment (temporary) Location: Applied Information Technology
Apply by: 2019-02-27

The department of Applied Information Technology offers education and carries out research within the areas informatics, learning, communication and cognitive science in close collaboration with the industry and public sector. Development of the individual’s knowledge and ability to analyze, understand and handle the digitalization of society, different aspects of IT, interaction between people and interaction between people and technology are at focus.
The department is located at Campus Lindholmen and is a part of The IT faculty at The University of Gothenburg.

About 20 professors, researchers, lecturers and PhD students work at the division for Learning, Communication and IT. We work with questions concerning how IT changes the conditions for and creates opportunities for learning and communication in different contexts such as school, work life and leisure. Our research includes a broad range of research objects, theoretical perspectives and methods. We conduct a variety of design research and analytical studies of empirical conditions.

A list of the division’s publications can be found at: https://ait.gu.se/lkit/publikationer 

For more information about the division for Learning, Communication and IT, see: https://ait.gu.se/english/lcit 

Project description
The successful applicant will be employed by the University of Gothenburg and will be an active member of a research project group at the Department of Applied Information Technology with the goal of addressing the challenges of developing new ways of collaboration between humans and machines. Specifically, the research group will work on optimizing a hybrid configuration, involving both human and machine intelligence, which can make the most of the capability of both intelligences in a citizen science serious game in quantum physics, called Quantum Moves. This project will use a design science approach that combines research methodologies, such as exploratory lab studies using cognitive ethnography, focus groups and large-scale A/B testing, with the development of algorithms to make the game more interactive. The main expected outcome is a contribution to the design of cooperative human-computer systems able to solve outstanding scientific problems. The postdoc will be an integral part of all project activities, but his/her main responsibility will be to conduct the lab studies, the focus groups and the A/B testing.

This project offers a great opportunity to study this human-computer interaction process in the complete development stage. The starting point of this project is the ongoing development and research work on Quantum Moves done at the AU Ideas Center for Community Driven Research (CODER) at Aarhus University in Denmark, which has developed the platform ScienceAtHome, currently featuring several scientific games.  CODER aims to merge theoretical and experimental quantum research with online community efforts to explore the potential for online citizen science in this otherwise highly specialized field.

The successful applicant will work closely with the project leader, Dr. Marisa Ponti, as well as the programmers and researchers at ScienceAtHome (https://www.scienceathome.org/), led by Prof. Jacob Sherson.

This research project is funded by the Marianne and Marcus Wallenberg Foundation in Sweden. The postdoc will be the third member of the core project team and will have the opportunity to attend international conferences and publish.

Subject area
human-computer interaction, human computation

Job assignments
We are looking for a highly motivated researcher interested in human-computer interaction and/or human computation. The methodology in this project will involve an iterative interplay between observation, game development and evaluation. Specifically, the postdoc is expected to evaluate the interactions between individual players and different game versions by conducting cognitive ethnographic studies on how players use the features of the game interface to turn information into sense-making and decision-making. The findings of the evaluation will be used by the programmers at ScienceAtHome to develop a new and more interactive version of the game. The postdoc will conduct independent research under the supervision of a senior lecturer. In this project, we encourage cooperation initiatives with researchers both within the University of Gothenburg and in other relevant departments worldwide.

The position may involve some teaching as agreed upon with the Department of Applied Information Technology and the project manager.

Eligibility
To qualify as a postdoctoral researcher the applicant should hold a PhD, or a foreign degree that is deemed equivalent to a doctorate, in interaction design, human-computer interaction, cognitive science, or other relevant fields.
Those who have obtained a doctoral degree no longer than 3 years counting from last date of application should primarily be considered for the position. Also those who have obtained a doctoral degree longer than 3 years should be considered, should there be special reasons.

Assessment
Applicants shall:

  1. Have obtained a PhD.
  2. Have documented experience working in user observation, especially lab conducted controlled observation.
  3. Be fluent in English, oral and written.
  4. Be able to work collaboratively as well as independently.

Experience with, or knowledge of, A/B testing in software development and with cognitive ethnography are meritorious. Experience from having actively engaged in research in the international arena is meritorious too. Some experience with coding would also be meritorious.
Throughout the assessment, attention will be devoted to scientific documentation and to the skills relevant to the job assignment.

Employment
The position is a fixed-term employment of 24 months according to postdoctoral collective agreement, full time, and is placed at the Department of Applied Information Technology.
The start date is on June 1st 2019, or as soon as possible thereafter.
The University of Gothenburg offers a cultivating and inspiring working environment in the dynamic city of Gothenburg. Read more about working at our university and the benefits for employees.

Appointment procedure
The selection, interview and assessment will be undertaken by a local recruiting group.
Interviews may be held continuously.

For further information:
If you have questions regarding the position, please contact Senior Lecturer Marisa Ponti, phone: +46736213051
Regarding the appointment procedure, please contact Emil Fägerwall Ödman, Human Resources Officer, +46 31 786 29 04

Unions
Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply
In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application. 

The application must be in English and include:

  • A motivated application, including a cogent argument for how qualified you are for the position and brief statements of research and teaching plans
  • A full CV, including name, address, phone number, e-mail, previous and present employment and academic background
  • Documentation of academic degrees (copy of degree certificates, etc.)
  • Copies of max. 5 different publications that are relevant to the field
  • A numbered list of publications. The enclosed publications should be marked with an asterisk (*)

Closing date: 27th of February 2019 

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salary is determined on an individual basis.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

Apply

Read the job description at the university homepage

The University of Gothenburg tackles society’s challenges with diverse knowledge. 38 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

Post expires on Wednesday February 27th, 2019