Tag-arkiv: University of Gothenburg

PhD student position in Medical Science – Hormone secretion in white adipcotyes

The Department of Physiology is part of the Institute of Neuroscience and Physiology at Sahlgrenska Academy, the Faculty of Health and Care Sciences at the University of Gothenburg. The Department conducts research within the area of physiology. Several projects involve a close collaboration with the Sahlgrenska University Hospital. We offer undergraduate courses as parts of study programs in Medicine, Dentistry, Pharmacy, Speech and language pathology, Dental hygiene, Occupational therapy, Physiotherapy and the bachelor program of Cognitive Science. The research groups at the Department represent a broad range of research areas within the field of physiology.

Project title: Molecular and cellular regulation of white adipocyte adiponectin exocytosis – the role of caveolae and exosomes

Job assignments

General information about third-cycle studies: The PhD education in Medical Science corresponds to studies of 240 credits in total. The studies are equivalent to four year full-time and lead to a Degree of Doctor. The studies comprise carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see
https://medarbetarportalen.gu.se/sahlgrenskaakademin/forskarutbildning/?languageId=100001

Project: The aim of our research is to understand how secretion of the white adipocyte hormone adiponectin is regulated and how this control may be disturbed in metabolic disease. Adiponectin levels are decreased in obese/type 2 diabetic individuals and high adiponectin levels protect from development of diabetes, thus suggesting adiponectin as a promising pharmacological target for prevention and treatment of metabolic disease. The specific aim of this PhD project is to define the importance of caveolae (plasma membrane lipid raft invaginations) and exosomes (nanovesicles) for adiponectin release. Our hypothesis is that caveolae have an important function for release of adiponectin via an exosomal pathway.

Using a combination of high-resolution fluorescence microscopy studies in live cells and in vivo investigations in mice we will: 1) Define the dynamics and molecular control of adiponectin vesicle exocytosis; 2) Determine the role of caveolae and exosomes for exocytosis of adiponectin. The project also involves several standardised cell and molecular biological/biochemical techniques (cell culture, transfection/transduction, PCR, siRNA, ELISA, Western blot, cloning etc).

The PhD student will belong to the section of Metabolic Physiology. Extensive time, especially during the first year, will however be spent in the group of co-supervisor Sebastian Barg, Department of Medical Cell Biology, Uppsala University. I this group, the student will learn advanced fluorescence microscopy techniques, essential to establish the studies in Gothenburg. The PhD position offers an opportunity to conduct scientific research within highly motivated environments, with extensive competence within the topical research field as well fully equipped laboratories. Comprehensive mentoring, opportunities for conference presentations, and further support for career development will be provided.

Eligibility

To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

A person meets the general entry requirements for third-cycle studies if he or she:
1. has been awarded a second-cycle qualification
2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or
3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad

A person meets the specific entry requirements for third-cycle studies if he or she: has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

Assessment

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:
– specific knowledge and skills within the subject area and related research fields
– experience of scientific theory and relevant research methodology
– scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.

Documented experience in the field of metabolic health and disease, specifically with focus on regulation of hormone secretion and/or adipose tissue functionality, as well as in fluorescence microcopy techniques is of value. Good communication skills, and a very high level of commitment and curiosity about research in the current field are desirable.

Employment

Time limited employment (temporary), 4 years. Extent: 100%. Location: Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Physiology. First day of employment: as agreed.

Regulations for employment of doctoral students are given in SFS 1998:80. Only those who are admitted to third-cycle studies may be appointed to doctoral studentships. Those appointed to doctoral studentships shall primarily devote themselves to their studies. They may, however, work to a limited extent with educational tasks, research and administration according to the regulations.

The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. The total employment period may not exceed the time corresponding to full-time third-cycle studies for four years.

Salaries for doctoral students are regulated in a local agreement at the University.

For further information regarding the position

For more information about the project please contact the principal supervisor,
Charlotta Olofsson, Associate Professor, Phone +46 709 394 107, charlotta.olofsson@gu.se

Unions

Union representatives at the University of Gothenburg:
http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. Attach verified copies of your education and English proficiency proving your eligibility. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

Closing date 2018-12-17

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salaries for doctoral students are regulated in a local agreement at the University.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

The University of Gothenburg tackles society’s challenges with diverse knowledge. 38 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

Post expires on Monday December 17th, 2018

Research assistant at Department of Marine Sciences

Research assistant

The new Department of Marine Sciences is a multi-disciplinary academic environment including biology, chemistry, oceanography, geology and conservation.

Our teaching and research activities stretch from circulation under the polar ice to biogeochemical fluxes in the deep sea, and from shallow seagrass beds to cold-water coral reefs. In these environments, we study different levels of biological organization from genes, individuals and populations, to communities and ecosystems. We work within ecology, evolution, physiology, systematics and combinations of these fields in order to understand the impact of natural and anthropogenic changes of the environment. The department is placed at the main campus in Gothenburg and at the two marine research laboratories at Tjärnö and Kristineberg (www.marine.gu.se).

Job assignments

We seek a research assistant to join the Seagrass Ecology Lab, which is composed of an international team working on coastal ecosystem and benthic ecology. The assistant will help with developing mapping techniques using unmanned aerial and submersible vehicles in Sweden. The tasks will include field work, laboratory work and cartographic methods. The work will be based at Kristineberg station with extensive field work in Kosterhavet National Park, Gullmars fjord and Marstrand area. The candidate will be required to assist to meetings with coastal managers, present results and write reports. In addition, the candidate will be required to perform outreach activities related to the project.

Qualifications

The post requires a biology/environmental science graduate with an interest in coastal mapping, ideally with fieldwork and laboratory experience, who is prepared to work hard and flexibly, as part of a team. Candidates with previous experience in coastal mapping with knowledge on GIS tools will be given priority. Experience in drone handling, piloting and maintenance will be desirable. Small boat handling, SCUBA and snorkeling will be required.

The work requires the ability to independently plan, implement and analyze the experimental work. Good knowledge of English in both speech and writing is also a requirement.

Employment

The employment is full time based at Kristineberg marine station, for 7 months with extension possibility. The candidate is required to start on the 01-Feb-2019.

Appointment procedure

The application should preferably be written in English and contain:

  • A personal letter describing your experience and how to meet the criteria stated in the ad (max. one A4 page)
  • Merit list (CV)
  • Contact information (email address and phone number) to at least two reference persons who are aware of the applicant’s qualifications

For further information regarding the position

If you have questions regarding the position please contact Eduardo Infantes eduardo.infantes@marine.gu.se, or visit www.eduardoinfantes.com, +46 7662 29567

Unions

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement,

The University of Gothenburg tackles society’s challenges with diverse knowledge. 37 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.The University of Gothenburg promotes equal opportunities, equality and diversity.

Post expires on Sunday December 16th, 2018

PhD student in organic chemistry/structural biology

Research and graduate education at the department of chemistry and molecular biology comprises a wide scientific field from the atomic and molecular levels all the way through cells to intact organisms. Much of the phenomena studied here impact on our natural environment and living systems. We participate in undergraduate programs in chemistry, molecular biology, medicinal chemistry, biology, marine sciences, and pharmacy.

A third cycle education at our department will lead to a Ph.D. in Natural sciences, or Natural sciences with a specialisation in Chemistry, Biology or Biophysics. Ph.D. studies comprises four years at the post graduate level. The time period can be extended to 5 years in total through teaching and/or other departmental duties.

Information about the research group:

The successful candidate will be part of the research group of Dr Carl Johan Wallentin and work in close collaboration with Prof. Richard Neutze and Dr Gisela Brändén. Within the constellation of participating research groups a range of synthetic, biochemical and biophysical methods to study the structure, function and dynamics of membrane proteins. A special focus is on the development of new organic compounds and their effect on protein structure. Primarily, we utilize new methods within structural biology that rely on X-rays from synchrotrons and XFELs to track structural changes in proteins as they work. More information about the research group is found at

https://wallentingroup.com;

https://cmb.gu.se/english/about_us/staff/?languageId=100001&disableRedirect=true&returnUrl=http%3A%2F%2Fcmb.gu.se%2Fom_institutionen%2Fpersonal%2F%3FuserId%3Dxbragi&userId=xbragi;

https://cmb.gu.se/om_institutionen/personal?userId=xneuri

 Job assignments

Information about the job assignments

The PhD project will focus on the enzyme cytochrome oxidase that is part of the energy converting machinery of the cell. The candidate will develop new methods for the synthesis of organic compounds that upon external stimuli can initiate structural changes within proteins. The candidate will also conduct advanced structural biology experiments at X-ray facilities around the world. The experimental work as well as data processing will take place in close collaboration with other members of the research constellation and involve interactions with national and international partners.

Eligibility

To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements:

A person meets the general entry requirements for third-cycle courses and study programmes if he or she:
1. has been awarded a second-cycle qualification,
2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or
3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad.

To meet the specific entry requirements for third-cycle studies, applicants must: (i) have a second-cycle (advanced-level) degree in a relevant* subject area in the natural sciences, or (ii) have completed studies for at least 60 higher education credits at a second-cycle level in relevant subject areas in the natural sciences, or (iii) have completed a corresponding programme of relevance to the planned third-cycle programme, in Sweden or in another country, or have equivalent qualifications.

*Relevant for the planned third-cycle education

The specific entry requirements also include an acceptable command of spoken and written English. Guidelines for assessing English proficiency may include a minimum score of 550 on the TOEFL test (or 213 on the TOEFL-CBT, or 79 on the TOEFL-iBT).

Assessment

Regulations for the evaluation of qualifications for education on a doctoral level are given in SFS 1998:80.

The successful candidate is expected to be at ease collaborating with other scientists within a larger team, and to possess high quality communication skills. In addition, it is of great importance that the applicant is independent, shows enthusiasm for research, has a willingness to learn new skills, and is fluent in English (orally and in writing). Experience from synthetic organic chemistry is meriting.

 Employment

Type of employment: Fixed-term employment, Four years full time
Extent: 100 %
Location: Department of Chemistry and Molecular Biology, Gothenburg
First day of employment: as agreed upon

Regulations for the evaluation of qualifications for education on a doctoral level are given in SFS 1998:80.

A new employment as a PhD student applies for a maximum of one year. The Appointment may be prolonged for up to two years at a time. The total employment period may not be longer than the equivalent of four years of full time time doctoral studies.

University applies local agreement on salaries of graduate students.

Appointment procedure

Please apply online

The application shall include:

Cover letter with an explanation of why you apply for the position
CV including scientific publications
Copy of exam certificate
Two referees (name, telephone no, relation)

For further information regarding the position

För specifika frågor kontakta Carl Johan Wallentin, carl.wallentin@chem.gu.se
Questions regarding the third-cycle education: Martin Billeter, Director of third cycle education, +46(0) 31-786 3925, martin.billeter@gu.se
Questions regarding the employment: hr@cmb.gu.se

Unions

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

Closing date: 2018-12-31

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salaries for doctoral students are regulated in a local agreement at the University.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

The University of Gothenburg tackles society’s challenges with diverse knowledge. 38 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

Post expires on Monday December 31st, 2018