Tag-arkiv: Umeå University

Postdoctoral Research Opportunity in Infection Biology

Institutionen för klinisk mikrobiologi

Apply

before 2021-01-07

  • Temporary position longer than 6 months
  • 100 %
  • Umeå

Postdoctoral Research Opportunity in Infection Biology at Umeå University, Sweden

Project: The type VI secretion system of Francisella tularensis

PI: Anders Sjöstedt

Postdoctoral position at the Department of Clinical Microbiology

The Department of Clinical Microbiology, Umeå University, is looking for a highly motivated postdoctoral researcher in the area of bacterial secretion systems and structural dissection of such secretion systems. The two year full-time position will be at the Department of Clinical Microbiology, Umeå University.

Qualification requirements

To qualify, the applicant must hold a doctoral degree or a foreign qualification deemed equivalent to a doctorate in Bacteriology, Molecular Biology or a similar area.

The applicant should have extensive experience working in the field of bacterial pathogenesis and have extensive experience of prokaryotic genetic systems. Experience of work with Francisella tularensis is meritoreous. The applicant must be able to work independently and excellent communication skills in English is a requirement.

Applicants who have completed a doctoral degree no more than three years before the application deadline are prioritized. If there are special reasons, applicants with a doctoral degree more than 3 years old could be considered.

Project description

The aim is to delineate the regulation of assembly and the functions of the components of the Type VI secretion systems (T6SS) of Francisella tularensis (Ft). Ft encodes an atypical T6SS, which allows this highly virulent, intracellular bacterium to invade and replicate within the cytosol of eukaryotic cells and the T6SS is thereby essential for Ft virulence. While T6SSs have been the focus of an intense research effort for over a decade, our understanding is still incomplete regarding many of the functions of T6SSs in general and that of Ft in particular.

One focus will be on the characterization of the baseplate, the foundation on which the external part of the machinery rests. Detailed structural knowledge is very limited regarding the Ft baseplate, a consequence of the low sequence identity between Ft T6SS components and those of prototypic T6SSs. The research will be carried out by generating specific mutants and constructs encoding tagged T6SS components. These will then be tested by a variety of techniques to detect the localization and secretion of the proteins, as well as their protein interaction partners. Specifically, we are conducting detailed analysis by means of two-hybrid interaction analysis, immunoprecipitation, ascorbate peroxidase 2 (APEX)-tagging, and confocal and electron microscopy methods. 

A second focus will be to further elucidate the critical role of the ClpB chaperone for the T6SS (Alam et al., Scientific Reports, 2018). We made the novel finding that its role for the control of T6S is dissociated from its role as essential for the heat shock response (Alam et al., Plos Pathogens, 2020). To further understand the underlying mechanisms is one aim. Much Ft research has focused on the control of T6SS assembly in the environmental bacterium F. novicida. Therefore, another aim will be to study clinically important Ft subspecies to see if the mechanism is conserved, with a special focus on ClpB and its role for the assembly/disassembly of the T6SS.

Webpages: https://www.umu.se/en/research/groups/anders-sjostedt/

https://www.umu.se/personal/anders-sjostedt/

Application

The application must contain the following documents in English: A one page cover letter highlighting your most important first-author publication in an international scientific journal and general research interests, a CV (max 2 pages) including a list of publications and contact information for two or three reference persons.

Submit the application electronically via Varbi. The documents should be compiled in one file in word or pdf-format. Last day of submission is 2021-01-07 (January 7).

Contact information

For further information, please contact Professor Anders Sjöstedt, Dept. of Clinical Microbiology. Anders.Sjostedt(at)umu.se

Welcome with your application!

Contact

Anders Sjöstedt

090-7851120

Registration number

AN 2.2.1-1626-20

Union representative

SACO

090-786 53 65

SEKO

090-786 52 96

ST

090-786 54 31

Read the job description at the university homepage

Apply before 2021-01-07

Umeå University wants to offer an equal environment where open dialogue between people with different backgrounds and perspectives lay the foundation for learning, creativity and development. We welcome people with different backgrounds and experiences to apply for the current employment. We kindly decline offers of recruitment and advertising help.

Post expires on Thursday January 7th, 2021

PhD Position in Structure Biology

Kemiska institutionen

Apply

before 2020-12-10

  • Temporary position longer than 6 months
  • 100%
  • Umeå

Description
A doctoral position in structural biology: development of drugs to block bacterial virulence factors is available in Professor Elisabeth Sauer-Eriksson’s laboratory at the Department of Chemistry, Umeå University. The goal of the project is to increase our understanding of bacterial virulence, i.e. how bacteria infect a host cell. The project is carried out in a multidisciplinary environment based on established collaborations with Professor Jörgen Johansson and Fredrik Almqvist at Umeå University, Professor José Vazquez-Boland at Edinburgh University and Professor Birgitte Kallipolitis at the University of Southern Denmark. The doctoral student will be trained in structural biology, protein production from different types of organisms, as well as biochemistry and biophysics. Our research focuses on a transcription factor in listeria, called PrfA, which acts as the main regulator of virulence gene expression and plays a central role in the conversion of listeria from a harmless saprophyte to a human pathogenic bacterium. We have previously identified a specific class of molecules, so-called 2-pyridones that can reduce the pathogenicity of listeria. The purpose of the doctoral student’s project is to i) develop these substances further towards functional drugs, and ii) study how various factors in the natural cellular environment control the PrfA regulation, in order to increase our understanding of the molecular mechanisms underlying virulence activation. The education in structural biology is mainly based on X-ray crystallography but can go in the direction of “single particle cryo EM” depending on the development of the project.

Working tasks
The aim of the project is to describe factors that govern the PrfA regulation in listeria and to develop inhibitors of PrfA through drug design based on structural studies. The expected tasks are summarized below:

  • Purification of PrfA from listeria according to established protocol. Cloning, expression and purification of PrfA-like transcription factors from other bacteria.
  • Structural studies on PrfA from listeria in various biologically relevant conditions or in complexes with designed inhibitors.
  • Structural biological analysis of native and inhibited PrfA from other pathogenic bacteria.
  • Biochemical and biophysical analysis of protein and protein complexes with, for example, light spectroscopy and calorimetric methods.
  • Writing of scientific articles.

Qualifications
To be admitted for studies at third-cycle level you are required to have completed a second-cycle level degree, or completed course requirements of at least 240 ECTS credits, of which at least 60 ECTS credits are at second-cycle level or have an equivalent education from abroad, or equivalent qualifications.

To fulfil the specific entry requirements to be admitted for studies at third-cycle level in chemistry, you are required to have completed first-cycle courses of at least 90 ECTS credits within the field of chemistry or another subject considered to be directly relevant to the specialization in question. Of those 90 ECTS credits, at least 15 ECTS credits shall have been acquired at second-cycle level within the specialization or an equivalent subject.

Good knowledge in English, both written and spoken, is a requirement. You must be strongly self-motivated and have the ability to work in a multidisciplinary work environment.

Terms of employment
The appointment aims at a PhD degree and the main task of the PhD student is to pursue their doctoral studies, which includes participation in research projects as well as postgraduate courses. In the assignments, teaching and other departmental work (up to a maximum of 20%) can be included. The employment is limited to four years full-time or up to five years when part-time teaching. The salary is fixed according to the local agreement for PhD students.


Application

A complete application should contain the following documents:

  • A cover letter including a description of your research interests and motivation for applying
  • A Curriculum Vitae
  • Certified copies of degree certificates or equivalent, including documentation of completed academic courses and obtained grades and other relevant certificates
  • Name and contact information of at least two reference persons

Applications must be submitted via our e-recruitment system no later than December 10 2020.

For more information please contact Professor Elisabeth Sauer-Eriksson, telephone number: +4690-786 7623, e-mail: Elisabeth.sauer-eriksson@umu.se

About us
Umeå University has a vibrant environment in “Integrated Structural Biology” that harbors 19 research groups with totally around 90 active people.  We have state of the art equipment for cryo EM, x-ray crystallography, NMR spectroscopy and high performance computation. Please visit www.biostruct.umu.se for more information. The Department of Chemistry is one of the largest departments within the Faculty of Science and Technology with a staff of approximately 200 of which approximately 40 are doctoral students, and a strong expanding research. The Department has three major research areas: Biological Chemistry, Environmental and Biogeochemistry, and Technical Chemistry. We are also a strong partner in the KBC, Chemical-Biological Center. Information about the postgraduate education can be found on the Faculty of Science and Technology website: www.umu.se/en/faculty-of-science-and-technology/education/doctoral-studies/chemistry/. For more information about working at Umeå University, https://www.umu.se/en/work-with-us/

Admission

By agreement

Contact

Elisabeth Sauer-Eriksson

090-786 76 23

Registration number

AN 2.2.1-1575-20

Salary

Monthly

Union representative

SACO

090-786 53 65

SEKO

090-786 52 96

ST

090-786 54 31

Read the job description at the university homepage

Apply

before2020-12-10

Umeå University wants to offer an equal environment where open dialogue between people with different backgrounds and perspectives lay the foundation for learning, creativity and development. We welcome people with different backgrounds and experiences to apply for the current employment. We kindly decline offers of recruitment and advertising help.

Post expires on Thursday December 10th, 2020

Postdoctoral researcher in human geography

Geografi

Apply

before 2020-12-31

  • Temporary position longer than 6 months
  • 100%
  • Umeå

The Department of Geography seeks applications for an open postdoc position. The successful applicant is expected to contribute to the project “Climate Change and the Double Amplification of Arctic Tourism: Challenges and Potential Solutions for Tourism and Sustainable Development in an Arctic Context”, financed by the Swedish research council FORMAS. For more information on the project see: https://www.umu.se/forskning/projekt/climate-change-and-the-double-amplification-of-arctic-tourism-challenges-and-potential-solutions-for-tourism-and-sustainable-development-in-an-arctic-context/

The project and duties

The postdoctoral project focuses on the geography of changing tourist flows to Arctic Sweden and the extent to which these changes have created issues around unforeseen ‘tourism bubbles’, over-tourism and land-use competition. It requires the conduction of in-depth qualitative case studies of places where local populations experience negative impacts from tourism and land-use conflicts. It will include interviews with a broad range of local stakeholders, collection of basic statistics, and eventually reviews of local newspapers. Experience of thematic and narrative analysis and the use of qualitative analysis software is an advantage. The successful candidate will be responsible for planning and carrying out research in collaboration with two of the project researchers, Linda Lundmark and Anna Zachrisson.

About employment

The employment contract starts in February 2021, for the duration of two years full time (up to 20 % could be devoted to departmental duties like teaching). The postdoctoral research fellow will be expected to carry out the majority of work in Umeå and to participate in common project and departmental activities.

Requirements

In order to be qualified for the position, the person must have achieved a doctoral degree in geography with a focus on human geography or equivalent. The main assessment criteria for the appointment are documented research skills and academic track record. It is an advantage for the applicant to be able to perform and analyse qualitative research in a Scandinavian language. The applicant must be fluent in English. We especially value candidates with documented interest in social and ecological sustainability issues related to tourism and land use conflicts in rural areas. It is also a merit if the candidate is familiar with social, political and geographical discourses in Sweden, as a context for drivers and outcomes of over-tourism and land use conflicts.

In the selection process, value will be given to knowledge of geographical perspectives and research experiences of over-tourism and land use conflicts. Priority should be given to candidates who have completed their doctoral degree no more than three years before the closing date of the application. A candidate who has completed their degree prior to this time period may be taken into consideration if special circumstances exist. Postdoctoral students who will teach or supervise should have relevant education.

We also want you to be flexible in your work; you should take initiative and be able to work independently. We want you to take full responsibility for the task at hand. The work also requires you to collaborate with others within and outside Umeå University.

Application

Applications are accepted via system Varbi. The application should contain:

– a complete CV, including full publication list

– a research plan describing the applicant’s research interests in relation to the position (max. 3 pages)

– the applicant’s three most representative publications

Information

For further information on the job position, contact the WP3 researcher, Linda Lundmark (linda.lundmark@umu.se). 

Contact

Emma Lundholm, head of department

090-786 71 72

Linda Lundmark, WP coordinator

090-786 63 60

Anna Zachrisson, WP coordinator

090-786 61 85

Registration number

AN 2.2.1-1572-20

Union representative

SACO

090-786 53 65

SEKO

090-786 52 96

ST

090-786 54 31

Read the job description at the university homepage

Apply

before 2020-12-31

Umeå University wants to offer an equal environment where open dialogue between people with different backgrounds and perspectives lay the foundation for learning, creativity and development. We welcome people with different backgrounds and experiences to apply for the current employment. We kindly decline offers of recruitment and advertising help.

Post expires on Thursday December 31st, 2020

PhD positions in Energy efficiency in buildings

Energiteknik

Apply

before 2020-12-18

  • Temporary position longer than 6 months
  • 100 %
  • Umeå

We are recruiting up to three PhD students in Energy Technology with specialization in Energy Efficiency in Buildings. The position will open on February 1, 2021 (exact starting date can be negotiated).

Project description
The development of a long-term secure energy supply is one of the global society’s biggest challenges. In that context, reducing the climate impact from the building sector has large impact. The scope for this call for new PhD students meets that challenge by targeting novel opportunities to propose, implement and evaluate strategies for increased building energy performance. This emphasizes deeper understanding of the impacts of alternative measures and strategies, especially how they may change spatially and temporally under climate change. Important perspectives for further investigation include research on how big-data together with machine learning can be used to evaluate energy savings and emission reductions. Building Information Modelling (BIM) are also included, as well as building construction process simulations, in order to achieve a smart and sustainable built environment.

Competence requirements
The applicant should have a Master of Science degree in energy technologies, construction engineering and management, statistics and data science, machine learning or equivalent qualifications. Prerequisites to be admitted to the postgraduate education include 240 ECTS credits of higher education studies, of which 60 ECTS credits should be on an advanced (master) level.

In addition to these general requirements, the applicant is required to have completed at least 120 ECTS credits in the fields of energy technologies, construction engineering and management, statistics and data science or other subjects directly relevant to the research. Applicants who in some other system, either within Sweden or abroad, have acquired largely equivalent knowledge are also eligible. The requirements must be fulfilled at the time of admission to postgraduate education and need not be met at the time of application.

As a PhD student, the applicant should have the ability to work systematically, thoroughly and independently, as well as in collaboration with others. Further, the applicant must be familiar with theoretical engineering science tools and have good working knowledge of the research area. The planned work requires an analytical and creative mind. The applicant should be Proficient user in both oral and written English. Courses and documented experience of working with simulations and statistical methods, big-data, machine learning, BIM and urban energy modelling are important merits.  

Terms of employment
The employment is expected to result in a doctoral degree and the main assignment for the doctoral student is thus to be active in research, study doctoral courses, and possibly participate in teaching of courses at undergraduate level. The employment is limited to four years at full time or up to five years if teaching or other departmental work (max 20 %) is performed. The salary is fixed according to the established salary level for doctoral students at the Faculty of Science and Technology, Umeå University.

Other information
The selection will be based on the following criteria:

  1. Merits applicable to the positions to date;
  2. Research potential expressed in relevant application documents;
  3. Interviews

Application
Your application should include the following:

  1. A cover letter with a brief description of your qualifications and motivation for applying, and your contact details (max. 2 pages)
  2. Curriculum vitae.
  3. Description of your future research interest relevant to the positions (max. 2 pages)
  4. Verified copies of relevant degree diploma(s) and certificates.
  5. A list of university courses with grades. Note that for international applicants the grading system should be briefly explained.
  6. A copy of master thesis and publications (if any).
  7. Contact information of two reference persons.

The application, including attached documents, must be written in English or Swedish. The application must be submitted no later than December 18th 2020 via Umeå University’s e- recruitment system Varbi.

Information
For more information contact

Professor Weizhuo Lu, +46 73 836 9536, weizhuo.lu@umu.se or

Professor Thomas Olofsson, +46 90-786 67 10, thomas.olofsson@umu.se or

Associate Professor Gireesh Nair, +46 90 786 88 04, gireesh.nair@umu.se

We look forward to receiving your application!

Admission

2021-02-01 or as agreed

Contact

Thomas Olofsson

090-7866710

Weizhuo Lu

073-836 95 36

Gireesh Nair

090-786 88 04

Registration number

AN 2.2.1-1596-20

Salary

Monthly Salary

Union representative

SACO

090-786 53 65

SEKO

090-786 52 96

ST

090-786 54 31

Read the job description at the university homepage

Apply

before 2020-12-18

Umeå University wants to offer an equal environment where open dialogue between people with different backgrounds and perspectives lay the foundation for learning, creativity and development. We welcome people with different backgrounds and experiences to apply for the current employment. We kindly decline offers of recruitment and advertising help.

Post expires on Friday December 18th, 2020

Postdoctoral position (2 years) in multivariate analysis and deep learning

Kemiska institutionen

Apply

before 2019-10-02

  • Temporary position longer than 6 months
  • 100%
  • Umeå

Department of Chemistry is looking for a postdoctor to a project where we will develop new e-science methods that fundamentally integrates Deep Learning and Multivariate analysis. The main task for the postdoctor will be to conduct R&D in multivariate analysis and deep learning. The employment is full-time for a period of two years with starting date as soon as possible or as agreed betweenthe two parties.

Project description and working tasks
In recent years, new tools, concepts and technologies, have brought new hope for fundamental understanding of chemistry, biology and medicine to drive the future development of systems medicine and systems biology. The main drivers have been new pioneering technologies (e.g. robotics, analytics, AI) in instruments that will fundamentally transform how research is conducted and the results thereof. Deep learning and multivariate analysis have both proven to be key data driven modelling technologies for delivering on this promise. The goal of this project is the integration of these new advanced data analytics solutions that builds on the complementary values of deep learning and multivariate analysis to model complex systems.

In this project we will develop new e-science methods that fundamentally integrates deep learning and multivariate analysis. We will apply and validate these methods in several ongoing projects, among others “Wine as a system” project – in collaboration with Stellenbosch, South Africa and Umeå Plant Science Centre (UPSC), from where we will take benefit of large-scale systems biology data, in a truly ambitious, yet realistic attempt to study wine from a systems biology perspective.

More specifically, this project will be focused on hybrid modeling, meaning integration of different modeling techniques, for example how multivariate analysis technology can be used to train and fine-tune deep learning models and vice-versa, how deep learning can be used as pretreatment tool for multivariate analysis.

In the working tasks are included:

  • Conducting R&D in multivariate analyses and deep learning
  • Developing methods for deep learning based analysis of unstructured data
  • Developing state-of-the-art algorithms in deep learning including methods for improving interpretation and robustness of deep learning models
  • Developing new workflows for efficient training of deep learning models when labels are scarce.

Qualifications
The required qualification is a doctoral degree or a foreign degree that is deemed equivalent in computer science, computer engineering, mathematics, physics or equivalent. To be eligible the degree must have been completed a maximum of three years before the end of the application period unless certain circumstances exist.

A solid understanding of linear algebra, algorithms, machine learning, optimization, numerical methods is required as well as experience with data science tools including scripting, preferably in Python. Good skills in English both spoken and written are required. A structured and solution-oriented approach and good communication skills and ability to work in a team are also requirements. Experience in Design-of-Experiments and data analytics is desirable.

Application
The application must contain the following documents:

  • A cover letter that describes qualifications, research interests, and motivation for application (maximum 2 pages)
  • A curriculum vitae, including a publication list
  • A copy of PhD thesis and relevant publications
  • A copy of doctoral degree certificate or equivalent and other relevant degree certificates and grades,
  • Name and contact information of at least two reference persons
  • Other relevant documents

Application should be written in English or Swedish. Applications must be submitted via our e-recruitment system Varbi no later than October 2, 2019.

For more information please contact Professor Johan Trygg, email: johan.trygg@umu.se

Information about the department
Department of Chemistry is the largest department in the Faculty of Science and Technology, with approximately 200 employees, including about 40 doctoral students, and with a strong and expanding research. Three major areas of research; Biological Chemistry, Environmental and Biogeochemistry and Technical Chemistry, represents the research and chemistry education of our department. We are also a strong partner in KBC, The Chemical-Biological Centre. For more information about working at Umeå University: www.umu.se/en/work-with-us/

Admission

As soon as possible or by agreement

Registration number

AN 2.2.1-1066-19

Salary

Monthly salary

Union representative

SACO

090-786 53 65

SEKO

090-786 52 96

ST

090-786 54 31

Read the job description at the university homepage

Apply

before 2019-10-02 Umeå University wants to offer an equal environment where open dialogue between people with different backgrounds and perspectives lay the foundation for learning, creativity and development. We welcome people with different backgrounds and experiences to apply for the current employment. We kindly decline offers of recruitment and advertising help.

Post expires on Wednesday October 2nd, 2019