Two-year Postdoc Position in Clinical Proteomics at the Steno Diabetes Center Copenhagen

This is an opportunity to join the Systems Medicine Research Group at Steno Diabetes Center Copenhagen (SDCC).

About the Systems Medicine Research Group
We specialize in the human metabolome and lipidome to design tests for clinical decision-making and to discover novel therapies. We do this by using state-of-the-art mass spectrometry instruments and bioinformatics tools. We plan to integrate clinical proteomics workflow in the laboratory and data analysis. We lead and are partners in various consortia focusing on type 1, type 2 diabetes, and related complications.

The Systems Medicine Research Group is headed by a research leader and currently involves ten scientists.

About the Project
In diabetes, when pancreas stops producing insulin, a cascade of metabolic dysregulations in the body follow. Inability of the cells to incorporate the glucose leads to various adverse effects, including nerve damage, namely neuropathy. Joining our group, you will become a central part of research project, where we will focus on biomarkers development for prediction of distal symmetrical polyneuropathy in type 1 diabetes. Through this translational project you will be able to influence real-life diagnostics applied to patients at Steno Diabetes Center.       

The Position
You will work within the Systems Medicine Research Group: 

• You are expected to work in personalized medicine and contribute to dissemination of results. 
• You will work with a quality mindset for creating reproducible research for the benefit of the patient. 
• You will be able to supervise and manage projects. 
• You will take responsibility in maintaining and developing pipelines for high-throughput mass spectrometry proteomics. 

You are expected to have: 

• Strong hands-on experience in mass spectrometry proteomics
• Expertise in plasma and tissue preparation for proteomics analysis
• Experience in data analysis and library development for MS-based proteomics
• Experience in high-flow liquid chromatography
• Experience in managing collaborative clinical research projects
• Have a proven record of publication of scientific results 
• A PhD in a relevant scientific area
• An interest in precision medicine and translational omics 

What we offer
We offer a career path that promotes taking a key role in clinical research projects. We have close interaction with clinicians for patient-related research and an international network with industry and academia for collaborative opportunities. 

There will be opportunity to supervise, apply for funding, to develop managing skills and to define and lead proteomics projects. 

Recruitment and employment
As part of the recruitment procedure the candidate’s qualifications will be assessed by an academic assessment committee. The employment is in accordance with the Capital Regions collective agreements.

Contact and Information
Applications for the position are accepted online before 15th June 2022. Interviews are expected to be held in the last week of June or first week in July with starting date of employment of 1st August 2022 or soon after. For further information about the position, please feel free to contact researcher Karolina Sulek or head of the group Cristina Legido Quigley on +45 3091 3393. We welcome applications from all candidates with the relevant professional background and qualifications.

About Steno Diabetes Center Copenhagen 
Steno Diabetes Center Copenhagen (SDCC) is an internationally leading diabetes hospital anchored in the Capital Region. SDCC is specialized in patient care, research, prevention of diabetes, and in education of health care professionals within diabetes. SDCC is the biggest diabetes hospital in Scandinavia and treats more than 11,000 people with diabetes from the Capital Region. For more information please visit www.sdcc.dk and follow us on LinkedIn and Twitter.
 

Facts

Job type

Steno Diabetes Center

Working hours

37

Job number

241204

Application due

15-06-2022

Contact us

Cristina Legido Quigley

Read the job description at the university homepage

Apply

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Post expires on onsdag juni 15th, 2022

We seek a highly motivated and independent postdoc/senior research scientist to support our efforts in studying protein interactions relevant for human physiology and disease. Our current research focus concerns proteins involved in matrix degradation (during cancer invasion and metastasis) and in intravascular lipid metabolism. The successful candidate will be responsible for maintaining and developing our pipeline of recombinant protein production using contemporary technologies as well as performing individual research projects within the project aims of the group.

Start: Preferably August 2022 or after agreement

Duration: Three years

Our research group

We are a small research group at the Finsen Laboratory and we focus on biochemical and biophysical characterization of disease relevant proteins and their ligands. We provide a detailed understanding on how a given pathway maintains homeostasis in normal physiology and why certain aberrations—such a missense mutations and natural polymorphisms—cause dysregulation in pathophysiology. Ultimately, we seek to use this information in translational pipelines – e.g. the clinical phase-2 trials with our uPAR-targeting peptide for non-invasive PET imaging of uPAR-expression in chronic inflammation and solid cancer (Front. Cell Dev. Biol. 2021, doi: 10.3389/fcell.2021.732015). For review on our research in intravascular lipid metabolism (Front. Cell Dev. Biol. 2021, doi: 10.3389/fcell.2021.702508).

We offer a highly dynamic and interactive research environment with an extensive national and international research network. Our attention is strictly focused on the scientific research and we seek to launch a joint effort to advance and keep momentum in our research—thus exploiting the synergy created in that process. And this is great fun!

Qualifications

We expect you to be a highly motivated and highly ambitious scientist with the following qualifications:

• A PhD in Life Science preferably with 2-4 year postdoctoral experience.
• Documented experience in producing high quality recombinant proteins in various heterologous host systems such as bacteria/yeast and mammalian cells.
• Documented experience in cell biology, molecular and biochemical techniques
• Documented experience in cryo-EM or HDX-MS is an advantageous but not a requirement.
• Proven ability to envision, plan and execute a research project. 
• Good organizational skills and flexibility.
• Excellent English skills written and spoken.

For further information regarding the position, please contact Group Leader Michael Ploug by email at m-ploug@finsenlab.dk

Place of employment

The employment is at The Finsen Laboratory, Rigshospitalet. The Finsen Laboratory is located in the Biocenter, close to the centre of Copenhagen. The Finsen Laboratory is headed by Professor, PhD Bo Porse and houses 6 research groups, each headed by a group leader. Currently we are approximately 70 staff members, including students and interns. We work in close collaboration with the research groups at BRIC, University of Copenhagen, www.bric.ku.dk.

Our research facilities include modern laboratories and a number of core facilities shared between the 23 research groups at Finsen Laboratory and BRIC. We have weekly journal clubs, data clubs, seminars with invited speakers and a young researchers club ASAP.                 

Please read more about the Ploug research group and Finsen Laboratory at www.finsenlab.dk

Terms of salary and employment

Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization.

The position is full time (37 hrs/week)

Application

Your application must be submitted electronically by clicking the link on the page. The application must include the following documents/attachments.

1. Motivated letter of application (max. one page).
2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
4. List of publications.
5. 2 letters of recommendation. To be taken into consideration, the letter must be signed by the supporting person on paper with institutional letter head and in PDF-format.

Application deadline: June 10th, 2022

We expect to have interviews in weeks 24 and 25.

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements.

Work hours

37 timer

Job number

240772

Application due

10-06-2022

Contact us

Michael Ploug
E-mail

Read the job description and apply at the Region´s homepage

Apply

Post expires on fredag juni 10th, 2022