Tag-arkiv: Karolinska Institutet

Novo Nordisk Postdoctoral Fellowship at Karolinska Institutet

Karolinska Institutet, at one of KI’s departments


Overview of the Position
Novo Nordisk is funding a prestigious fellowship programme at Karolinska Institutet (KI) for postdoctoral research fellows. The programme is focused on research in diabetes and its comorbidities, endocrinology and metabolism. It aims to support the development of a new generation of exceptional young early career diabetes researchers, who will become future leaders in the field, while further developing scientific excellence within diabetes and ultimately improving the lives of patients. As part of this programme, we are looking to recruit 4 outstanding postdoctoral research fellows.
Based at Karolinska Institutet, fellows will undertake a cutting edge research project, mentored by world-leading researchers in the field of diabetes, endocrinology and metabolism. In addition, it is anticipated that during the course of the fellowship, fellows will have the opportunity to spend up to 3 months in the research laboratories at Novo Nordisk outside Copenhagen, Denmark. Thus, fellows will gain insight into research conducted in both academia and industry. In order to increase coherence around the Fellowship programme, a number of events will be held throughout the year such as high profile lectures, symposia, etc. which the fellows will attend, both at Karolinska Institutet and at Novo Nordisk.
The fellowships are fully funded and salary is provided for a 3 year period. It is our intention that the positions will start in the autumn of 2019, though some flexibility with the start date might be possible.

Research Projects
The following 11 projects are available:

  1. Prinicipal Investigator Per-Olof Berggren Project Title Physiological and pathophysiological Ca2+ signaling in pancreatic islet cells.
  2. Principal Investigator Niklas Björkström Project Title Obesity-induced metabolic deregulation of tissue-resident NK cells in the development of fatty liver disease and insulin resistance, a “human multi-organ study”.
  3. Principal Investigators Magnus Bäck and Susanna Larsson Project Title Aortic Valve Stenosis – an Underestimated Comorbidity in Diabetes Mellitus.
  4. Principal Investigator Sofia Carlsson Project Title LADA-latent autoimmune diabetes in adults, risk factors and prognosis.
  5. Prinicipal Investigator Lisa Juntti-Berggren Project Title Apolipoprotein CIII, a target in the battle against diabetes and its comorbidities.
  6. Prinicipal Investigators Peder Olofsson and Stephen Malin Project Title Neural control of inflammation and metabolism in liver disease.
  7. Principal Investigators John Pernow and Per Eriksson Project Title The red blood cell as a novel mediator of vascular injury in type 2 diabetes.
  8. Prinicipal Investigators Mikael Rydén and Peter Arner Project Title Identifying the role of human white adipose tissue for the development of cardiovascular complications in type 2 diabetes.
  9. Prinicipal Investigator Kirsty Spalding Project Title Cell regeneration in the healthy and pathological human kidney.
  10. Principal Investigator Eckardt Treuter Project Title From co-repressor phosphorylation to epigenome therapy of fatty liver disease.
  11. Principal Investigators Juleen Zierath and Anna Krook Project Title Metabolic crosstalk and the regulation of insulin sensitivity in Type 2 diabetes.

Full details on each project and contact information to the PIs can be found at: https://ki.se/en/srp-diabetes/novo-nordisk-fellowships
As part of your application, you must select up to three of the projects, ranking them in order of preference. You should indicate your preferences in your Personal Letter and provide a rationale for your particular selections. If your application is successful, we will aim to match you with your first choice of project, but this cannot be guaranteed.

Key responsibilities of the selected applicant:

  • Plan, manage and conduct an agreed academic research project and associated activities; taking direction from the principal investigator and other colleagues in the laboratory as appropriate.
  • Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate.
  • Develop research questions, analyse detailed and complex qualitative and/or quantitative data from a variety of sources, and contribute original ideas for new research projects.
  • Coordinate multiple aspects of work to deliver novel research data in accordance with established timelines set between you and the principal investigator.
  • Develop ideas for generating research income, and present detailed research proposals to senior researchers.
  • Adapt existing and develop new scientific techniques and experimental protocols to support research.
  • Regularly write research articles at an international level for peer-reviewed journals, book chapters, and reviews.
  • Formally present your research and represent the research group at internal, national and international conferences and meetings; either with other members of the team or alone.
  • Informally present your research to the group at established meetings.
  • Provide scientific input into the research group both at meetings and practically where requested or appropriate.
  • Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques.

Selection Criteria
Essential 

  • A PhD in a medical/biological subject (to be completed in 2019), together with relevant experience.
  • The ability to manage your own academic research and associated activities.
  • A strong CV, having published in high impact journals and presented at international meetings.
  • Ability to contribute ideas for new research projects and research income generation.
  • Ability to work with meticulous attention to detail.
  • An enthusiastic interest in diabetes, endocrinology and metabolism research.
  • Evidence of excellent interpersonal skills and leadership, with the ability to communicate research ideas and results in a clear and logical way and the ability to confidently and effectively interact with colleagues and the broader research community.
  • Strong verbal and written communication skills in English.
  • A conscientious and enthusiastic working approach.
  • Excellent planning, organizational and problem solving skills.

Each Fellowship and research Projects is for up to three years. We will prioritize applicants who have the opportunity to complete the project and be employed for three years. Preference should be given to those who were awarded a PhD or attained equivalent research competence no more than three years prior to the expiry of the application period for the position as postdoc.

How to applyIf you consider that you meet the selection criteria, click on the Login and apply button on this page and follow the on-screen instructions to register as a user. You will then be required to provide information in a number of screens with your application details, relating to your skills and experience. When prompted, please provide details of three references (whom can be contacted if the applicant is invited to an interview). You will also be required to upload a CV and Personal Letter which explains how you meet the selection criteria for the post. The Personal Letter (maximum two pages) should explain your relevant experience which may have been gained in employment, education, or you may have taken time away from these activities as illness, military service, work for labour unions or student organisations, parental leave or similar circumstances. Additionally, your Personal Letter should also include a rationale for the 3 projects you have selected and justify your order of preference. Your application will be judged in part on the basis of how you demonstrate that you meet the selection criteria outlined above and we are happy to consider evidence of transferable skills or experience which you may have gained outside the context of paid employment or education.

Please save all uploaded documents to show your name and the document type.

The application is to be submitted through the Varbi recruitment system.

The closing date for applications is midnight CEST on Sunday 7th April, 2019.

Interviews will be held in June 2019.

Working at Karolinska Institutet
For further information about working at Karolinska Institutet, rules for visa/residence permit, insurance and accommodation please see: https://ki.se/en/staff/international-staff Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Read the job description at the university homepage

Login and apply

Type of employmentTemporary position longer than 6 months
Contract typeFull time
First day of employmentefter överenskommelse
Salarymånadslön
Number of positions4
Working hours100%
CitySolna
CountyStockholms län
CountrySweden
Reference number2-1622/2019
Union representativeTorkel Falkenberg, SACO, 08-524 838 68Magnus Anå, OFR, 08-524 864 37, magnus.ana@ki.seHenry Wölling, SEKO, 08-524 840 80
Last application date07.Apr.2019 11:59 PM CET

Post expires on Sunday April 7th, 2019

Research assistant – mitochondrial genetics

Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism

Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism
The Division of Molecular Metabolism (https://ki.se/en/mbb/research-division-of-molecularmetabolism) at the Department for Medical Biochemistry and Biophysics (https://ki.se/en/mbb/startpage) is located at the newly built and modern Biomedicum research laboratory (https://ki.se/en/staff/biomedicum) at Solna campus of Karolinska Institutet. Our research aims at understanding the regulation of mitochondrial function and the role of mitochondrial dysfunction in disease and ageing. The current research encompasses biochemical and genetic studies of patients with inherited diseases as well as basic scientific approaches to understand the regulation of mtDNA expression, mitochondrial biogenesis and mitochondrial metabolism. Both patient material (tissues and cells), genetically modified fruit flies (Drosophila melanogaster) and mice (Mus musculus) are used in these studies. The overall aim of the Division of Molecular Metabolism is to combine these different areas of research to get insights into disease pathophysiology and to develop novel treatments. The Division of Molecular Metabolism offers an outstanding research environment and a close interaction between basic science and clinical science and diagnostics at the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital, Stockholm, Sweden. The newly founded Max Planck Institute for Biology of Ageing – Karolinska Institutet Laboratory (MPI-KI laboratory) is also integrated into our laboratory. Excellent access to the most advanced resources in molecular and cell biology is available at the department and at the national core facilities at the Science for Life laboratory (https:// www.scilifelab.se).

Duties
We are currently looking for a Research Assistant to form an essential part of our research team in mitochondrial genetics, led by Professor Nils-Göran Larsson. The responsibilities of the Research Assistant will be varied and include:

*Performing diverse molecular biology techniques e.g. extracting RNA, DNA or protein from cells and/or mouse tissues, PCR, qRT-PCR and western blotting.
*Genotyping mice.
*Ordering, receiving, and distributing chemicals and laboratory supplies, and handling of invoices.
*Assisting with inventory and organization of chemicals and lab materials.
*Preparing and aliquoting reagents, for instance preparation of fly food

Qualifications
We welcome applications from candidates with academic qualifications at least corresponding to BSc in Biomedical Laboratory Science, Biomedicine, Molecular Biology, or other related fields. The successful candidate is a responsible, service-minded person with good communication and organizational skills who enjoys working with people and take pride in delivering work of good quality. The work requires:
*Excellent communication skills and a service focus.
*Good organizational skills and attention to detail.
*Previous experience of laboratory work and molecular biology techniques is an advantage.

The working language is English. Good knowledge of the Swedish language is an advantage. The applicant must be able to integrate well into the international and multidisciplinary environment. Personal suitability is therefore of great importance.

Application process
An employment application must contain the following documents in English or Swedish:

1. Curriculum vitae (max 2 pages)

2. Personal motivation letter (max 1 page)

3. Contact information of at least two references

The application is to be submitted in Varbi recruitment system.

At Karolinska Institutet a 6-month trial period is required for all permanent appointments.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.

Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.

Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Read the job description at the university homepage

Login and apply

Type of employmentTemporary position longer than 6 months
Contract typeFull time
First day of employmentupon agreement
SalaryMonthly
CityStockholm
CountyStockholms län
CountrySweden
Reference number2-1751/2019
ContactContact Camilla Koolmeister – head of divison , +46 8 524 830 39
Union representativeBiborka Bereczky Veress, SACO, 46 70-173 85 75Henry Wölling, SEKO, 08-524 840 80Anne Edgren, OFR/S, P, O, 08-524 87570
Last application date07.Apr.2019 11:59 PM CET

Post expires on Monday April 8th, 2019

Postdoctoral Researcher in Biology

Ming Wai Lau Centre for Reparative Medicine, KI, Hong Kong

Ming Wai Lau Centre for Reparative Medicine (MWLC) aims to contribute to the improvement of human health by conducting cutting-edge research in reparative medicine and related subjects, by creating a new platform for synergies between academia and innovation in Sweden and Hong Kong as well as China, and fostering future leaders in both academia and industry.

For more information, please visit ki.se/mwlc

Description of research group and project

The current research of Assistant Professor Sijie Chen aims at developing novel fluorescence-based tools and technology for biological research.

One postdoctoral researcher position is available in the following areas: biology, bioimaging, bio/biomedical engineering.

Qualifications

We are looking for a highly-motivated, creative researcher, who enjoys an interdisciplinary, open and collaborative environment, with the following qualifications, experience and skills:

  • Completion of a PhD or an equivalent degree in Life sciences, Bioengineering/Biomedical engineering, or related disciplines.
  • A strong publication record in peer reviewed journals.
  • The successful candidate is expected to have sufficient background knowledge in fluorescence techniques, cell imaging and or in vivo imaging, image processing and analysis, preferably high-content imaging/ high-content analysis.
  • Experience in mammalian cell (especially stem cell) culture, fluorescence microscopy, confocal microscopy, flow cytometry, basic biochemical and molecular biology techniques, is desired. Experience in super-resolution imaging, atomic-force microscopy, and programming is an advantage
  • Excellent written and oral communication skills in English.


The employment

This is a two-year full-time position, with the possibility of renewal.

The assignment is located at MWLC, Hong Kong, and the employment will follow local labour laws in Hong Kong.

A competitive remuneration package including 10% on top of basic salary (fully-taxable) intended as pension will be offered in addition to MPF employer’s contribution and medical benefits.

Entry requirement

Qualified to be employed as a Postdoctoral researcher is one who has obtained a doctorate or has equivalent scientific competence.

Application process

An employment application must contain the following documents in English:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Applicants should arrange to have at least two letters of reference

The application is to be submitted through the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Read the job description at the university homepage

Login and apply

Type of employmentTemporary position longer than 6 months
Contract typeFull time
First day of employmentAs soon as possible
Number of positions1
Working hours100%
CityHong Kong
CountryHong Kong
Reference number2-1316/2019
ContactSijie Chen, Assistant Professor, sijie.chen@ki.se
Last application date15.Apr.2019 11:59 PM CET

Post expires on Monday April 15th, 2019

Postdoctoral Researcher in Chemistry or Materials Science

Ming Wai Lau Centre for Reparative Medicine, KI, Hong Kong

Ming Wai Lau Centre for Reparative Medicine (MWLC) aims to contribute to the improvement of human health by conducting cutting-edge research in reparative medicine and related subjects, by creating a new platform for synergies between academia and innovation in Sweden and Hong Kong as well as China, and fostering future leaders in both academia and industry.

For more information, please visit ki.se/mwlc

Description of research group and project

The current research of Assistant Professor Sijie Chen aims at developing novel fluorescence based tools and technology for biological research, especially mechanobiology studies.

One position as postdoctoral researcher are available in the following areas: Fluorescent biosensors, materials science, chemistry

Qualifications

We are looking for a highly-motivated, creative researcher, who enjoys an interdisciplinary, open and collaborative environment, with the following qualifications, experience and skills: 

  • Completion of a PhD or an equivalent degree in chemistry, materials science or related disciplines.
  • A strong publication record in peer reviewed journals.
  • Knowledge of fluorescence, fluorescent probes and fluorescence based techniques. 
  • Experience and expertise in chemical synthesis, materials, biomaterials, and materials characterization, and/or fluorescent materials/sensors, and spectroscopy.
  • Experience in super-resolution microscopy, atomic-force microscopy, FLIM, is an advantage.
  • Excellent written and oral communication skills in English.

 The employment

This is a two-year full-time position, with the possibility of renewal.

The assignment is located at MWLC, Hong Kong, and the employment will follow local labour laws in Hong Kong.

A competitive remuneration package including 10% on top of basic salary (fully-taxable) intended as pension will be offered in addition to MPF employer’s contribution and medical benefits.

Entry requirement

Qualified to be employed as a Postdoctoral researcher is one who has obtained a doctorate or has equivalent scientific competence.

Application process

An employment application must contain the following documents in English:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Applicants should arrange to have at least two letters of reference

The application is to be submitted through the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Read the job description at the universtiy homepage

Login and apply

Type of employmentTemporary position longer than 6 months
Contract typeFull time
First day of employmentAs soon as possible
Number of positions1
Working hours100%
CityHong Kong
CountryHong Kong
Reference number2-1325/2019
ContactSijie Chen, Assistant Professor, sijie.chen@ki.se
Last application date15.Apr.2019 11:59 PM CET

Post expires on Monday April 15th, 2019

Postdoctoral Researcher in Bioinformatics

Department of Medicine, Solna, Dermatology and Venereology division

The Department of Medicine, Solna, is one of the largest departments at Karolinska Institutet. The department consists of several units that are separated into different research groups. The core activities of the department are research, doctoral education and undergraduate education for medical and biomedical students. The research has three main profiles: allergy, cardiovascular medicine and inflammatory diseases.

Division
The successful candidate will work in the wound healing research group headed by Dr. Ning Xu Landén (www.xulandenlab.com). The group belongs to the section of Dermatology and Venereology, Karolinska University Hospital Solna and the Ming Wai Lau Centre for Reparative Medicine (MWLC), and is physically located at the Centre of Molecular Medicine (CMM; https://www.cmm.ki.se/). The research is performed in an interdisciplinary setting with strong collaboration with clinical departments and other national and international research groups. The group has extensive experience in non-coding RNA research with well-established methodologies for studying the expression and function of non-coding RNAs in skin wound healing.

Duties
The chronic non-healing wound is a common and severe medical problem with unclear pathogenesis. The discovery of non-coding RNAs (ncRNAs) as powerful gene regulators provides hope in the quest to develop novel RNA-based treatments for a wide variety of diseases; however, the role of ncRNAs in human skin wound healing remains largely unexplored. We aim to reveal the expression and functional signatures of ncRNAs (primarily focusing on microRNAs, circular RNAs, and long ncRNAs) in human skin wound healing, and to identify ncRNAs that may be targeted in wound therapy. The current method spectrum of the group is centered around molecular biology, cell biology and biochemistry with human cells and tissues as well as mouse models but will be expanded.
We are looking for a postdoctoral researcher who will develop and implement bioinformatic approaches to analyze data generated with various high-throughput technologies to profile expression and modification of RNAs, RNA-protein-DNA interactome, chromatin accessibility and DNA methylation in human skin/wound tissues and cells. The work will include design of study, data processing, quality control, statistical analyses, data interpretation and presentation of findings in the form of scientific publications, grant applications and at conferences, as well as supervision of students. The tasks will be carried out in close collaboration with the bioinformatic cores at MWLC and National Bioinformatics Infrastructure Sweden (NBIS). We offer a very stimulating and welcoming working environment in a group of motivated co-workers with diverse competencies.

Entry requirements
Required skills of the successful candidate are:

  • A PhD or in exceptional cases expected to obtain soon, in Bioinformatics, Computational Biology, Biostatistics, Single-cell transcriptomics, or a related discipline including where sufficient bioinformatic expertise is demonstrated in life sciences.
  • Firm knowledge in Unix/Linux, R and at least one scripting language such as Perl or Python.
  • Experience in the analysis of next-generation sequencing data.
  • Experience in big data management.
  • Knowledge of relevant biological areas (chromatin and gene expression, genetics and epigenetics).
  • Excellent knowledge in biostatistics.
  • Experience in genomics data mining and visualization.
  • Ability to deliver high-quality scientific outputs with a strong publication record.
  • Good interpersonal skills and the ability to work both independently but also as a part of a large team.
  • Good knowledge of spoken and written English and good communication skills.

We will look favorably upon if the candidate has experiences in one or more of the following areas:

  • High-throughput screen deconvolution (genome editing including CRISPR-based, etc)
  • Single-cell transcriptomics
  • Comparative genomics
  • Systems biology
  • Integration of multiple genomics, epigenomics or proteomics datasets
  • Modelling of biological systems

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence.

Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system. Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Read the job description at the university homepage

Login and apply

Post expires on Sunday March 24th, 2019

Postdoctoral Researcher in HIV research related to antiretroviral therapy and cure

Karolinska Institutet,

The Department of Laboratory Medicine consists of 6 divisions and is active in many areas of Laboratory Medicine. The department is involved in advanced basic scientific, clinical and epidemiological research. The department is one of the largest departments of education at Karolinska Institutet.

Division
The Division of Clinical Microbiology conducts preclinical, translational, clinical and epidemiological research projects. The laboratory is located within the newly build facilities at Alfred Nobels Allé 8 (ANA8), Campus Flemingsberg. This new laboratory, ANA Futura, is creating a leading translational integrated research environment equipped for cutting-edge research, where the boundaries between institutions and clinics are torn down and researchers collaborate on the basis of common research profiles. The announced position will be placed in Professor Anders Sönnerborgs research group, which has a strong focus on pathogenesis, antiretroviral treatment and cure of HIV infection. The experimental research is focused on the interaction between HIV and antiretroviral drugs as well as mechanisms of viral latency.

Duties
The applicant will be joining the research group of professor Anders Sönnerborg and mainly work on viral latency and viral drug resistance in patients with human immunodeficiency infection as well as studying regulation of HIV latency using state of the art multiomic strategies (including single cell assays with combined epigenetic/transcriptomic/proteomic tools).

Our group has access to a large patient material and collaborates with a large number of similar centers around the world. We publish 15-25, well cited (current h-index 58), papers per year in renowened journals.

Entry requirements
A person is eligible to be appointed postdoc if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence. The persons appointed should primarily be the ones who have been granted a Degree of Doctor or have reached the corresponding competence.

Excellent knowledge in English, written and spoken, is a requirement.

We are looking for a person with profound knowledge in medical biology with a focus on microbiology, especially virology, and in biotechnological techniques. Experience of studies on antiviral therapy of chronic viral infections as well as on viruses which cause latent infection is required with focus on pathogenesis, viral replication, resistance development, latency reactivation and on immunology, especially host antiviral immune responses.

The applicant should be able to work with various cell culture systems in order to assess phenotypes and functionality of cells. He/she should have experience in setting up viral assays to evaluate antiviral efficacy, viral fitness and host immune responses and in various cellular and molecular techniques that allow genetic modification of cells ranging from cloning, to transduction experiments. 

Skills in the following techniques are mandatory: i) cell culture systems; both cell lines, primary cells and co-cultures, immune cell isolation from peripheral blood, cellular functionality assays, transfections; ii) flow cytometry analysis; discriminating immune cell subsets, cell surface and intracellular protein stainings, cell death assays; iii) viral assays; lentiviral transductions, virus propagation, viral infectivity experiments; iv) assays of antiviral efficiency; v) other techniques; DNA/RNA isolation from tissues or cells, ELISA, immunofluorescence, immunoprecipitation, luciferase reporter assays, PCR, protein purifications, quantitative PCR, reverse transcriptase, SDS PAGE, western blotting vi) RNA Scope. vii) next generation sequencing and sequence analysis is an extra assett.

Personal qualities
The person should be well organized, service-oriented and flexible. A positive and collaborative attitude is a pre-requisite for working in the Sönnerborg group and a great emphasize is put on the collaborative attitude of the applicant. Thus, of importance is that the candidate is well aquainted with collaborative work in a dynamic environment which includes strong social skills.

Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

A post-doc position is a fixed-term position. The first employment is for one year, with a possible extension of up to three years after evaluation.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employmentTemporary position longer than 6 months
Contract typePart-time
Number of positions1
Working hours50 %
CityHuddinge
CountyStockholms län
CountrySweden
Reference number2-817/2019
ContactAnders Sönnerborg, 08-5248000
Union representativeCarina Eklund, OFR, 08-5248000Emilie Hultin, Annica Lindkvist, SACO, 08-5248000Henry Wölling, SEKO, 08-5248000
Last application date27.Mar.2019 11:59 PM CET

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Read the job description at the university homepage

Post expires on Wednesday March 27th, 2019