Tag-arkiv: Karolinska Institutet

Postdoctoral studies in Circuit and Systems Neuroscience

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Do you want to contribute to improving human health?

We are looking for an applicant for a postdoc position (Circuit and Systems Neuroscience) at the Dept. of Neuroscience, Karolinska Institute, Stockholm, Sweden. The applicant will join an active, enthusiastic and well-equipped group of neuroscientists studying fundamental properties of periaqueductal neuronal pathways and modulation primarily in panic and anxiety in the context of sex differences.

Division

We use transgenic mouse models to study both physiological and pathological states of periaqueductal neuronal populations at the basic level (Viral tracing, Patch-clamp electrophysiology, Patch-Seq (Fuzik et al., Nature Biotechnology 2016, Fuzik et al. PNAS 2019), in vitro voltage imaging), and add a translational angle using systems neuroscience approaches (behavior tests, head-fixed in vivo electrophysiology).

Duties

A postdoctoral candidate with a neuroscience background and with a PhD of not more than 2 years is preferred. The position is initially for 2 years and it may be prolonged based on progress and available funding. Experience in electrophysiology and/or imaging techniques is essential; experience with viral tracing, in vivo experiments, RNA-sequencing and advanced data analysis will be considered and positively evaluated.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)
  • Cover letter describing goals and motivation
  • Contact information for 3 references

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

First day of employmentAs soon as possible
Reference numberSTÖD 2-4964/2021
ContactJanos Fuzik, 0732222044
Last application date14.Feb.2022 11:59 PM CET

Read the job description at the university homepage

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Post expires on mandag februar 14th, 2022

Postdoctoral studies in tumor immunology/Immunotherapy

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Karolinska Institutet, Dept of Laboratory Medicine Huddinge/Division of Pathology
Department of Laboratory Medicine Huddinge/Division of Pathology (LABMED) consists of 7 divisions and is active in many areas of Laboratory Medicine. The department is involved in advanced basic, translational, clinical and epidemiological research. The department is one of the largest departments of education at Karolinska Institutet.

Do you want to contribute to top quality medical research?

Your mission

To be a postdoctoral researcher means to devote oneself to research. This position is including supervision of students, teaching, and administrative duties. We are looking for a highly motivated individual to join the group of Associate Professor Dhifaf Sarhan as a Postdoctoral Fellow to work on projects concerning the sex-immune dimorphism in the tumor microenvironment of solid tumors. The position is based at ANA Futura at Karolinska Institutet, Flemingsberg Campus and in collaboration with the Centre for Bioinformatics and Biostatistics (CBB). The Centre for Bioinformatics and Biostatistics (CBB) is a virtual centre located at the Karolinska Institutet’s (KI’s) Campus Flemingsberg. The centre offers expertise and scientific networking opportunities to the pre-clinical and clinical research environment. Activities of the centre include mentoring for early-stage researchers (PhD students and postdocs), support for project planning and grant writing, as well as seminars and discussion groups around bioinformatics and biostatistics methods and their application to biomedical data.

Through collaborations with clinicians and core facilities, basic and translational researcher, we have access to new world class unique infrastructure for developing new therapeutic strategies and studying the efficacy and safety of novel treatments in a translational setting and later in clinical trials.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

We invite applications from outstanding candidates with a strong background in the field of tumor microenvironment/immunology/immunotherapy combined with bioinformatic analysis skills. We are interested in individuals with a good track-record in the mentioned fields. The candidate should be creative, highly motivated and that aim to establish world leading research with a clear focus in the field of immunotherapy against cancer incorporating potential clinical value and patient outcomes.
Preferably, the applicant should have experience working with cell/tissue processing techniques, flow cytometry and analysis of flow cytometric data. Good cooperation, independence, communication skills, and bioinformatics and biostatistical skills are required including

– Experiences in bioinformatics data analysis

– Experiences in applying bioinformatics methods to analyse data including expression, genome sequence, epigenomics or metagenomics data

– Experiences in using R or python for data analysis are a plus. Good knowledge in written and spoken English is required.

A successful applicant will preferably start working during the spring 2022 but the exact timing and details of the position is open for discussion. This employment as postdoc is limited to 1 year with a possibility for extension to a maximum of 3 years.

What do we offer?

Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Flemingsberg

Read more about the Department of Laboratory medicineRead more about the Division of PathologyRead more about the Research Group

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Application

An employment application must contain the following documents in English or Swedish:

-A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
-A complete list of publications
-A summary of current work (no more than one page)

Welcome to apply at the latest 31st of January.

The application is to be submitted through the Varbi recruitment system.

Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.

Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Want to make a difference? Join us and contribute to better health for all

Type of employmentTemporary position longer than 6 months
Contract typeFull time
First day of employmentAccording to agreement
SalaryScholarship
Number of positions1
Working hours100%
CityHuddinge
CountyStockholms län
CountrySweden
Reference numberSTÖD 2-5675/2021
ContactDhifaf Sarhan, Associate Professor (Docent) , dhifaf.sarhan@ki.se
Union representativeCarina Eklund, OFR, 08-585 826 65Henry Wölling, SEKO, henry.wolling@ki.seAnnica Lindkvist, SACO, 08-524 837 46
Last application date31.Jan.2022 11:59 PM CET

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Post expires on mandag januar 31st, 2022

Postdoctoral studies in Computational Biology (scholarship)

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Do you want to contribute to top quality medical research?

In our research group, you will find a unique opportunity to cooperate closely with top researchers at the interface of vascular biology and neuroscience to jointly understand how the human brain becomes vulnerable during injury, neurodegeneration and aging. Our recent work (Månberg et al. Nature Medicine 2021) showed that vascular and glial cells contribute to dynamics of neurodegeneration and this project will aim to refine our understanding of cellular mechanisms, biomarkers and genetic risk of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Alzheimer’s disease. We offer an engaging and international research environment where you will have the opportunity to contribute to high quality research at the top international level.

Division

The successful candidate will join in the Applied Immunology & Immunotherapy group with dr. Sebastian Lewandowski.

The team is part of the Karolinska Neuroimmunology and Multiple Sclerosis (KNIMS) network which gathers around 40 researchers working on different aspects of the pathogenesis of Multiple Sclerosis (MS) and other neurodegenerative diseases, including genetics, epidemiology, immunology and epigenetics, with excellent clinical cohorts and experimental models. The Applied Immunology & Immunotherapy group is physically located at the Center for Molecular Medicine, a translational medical center with ~500 researchers working on complex diseases, and with extensive national and international collaborations. The Applied Immunology & Immunotherapy group studies why chronic neurodegenerative diseases occur, and then devise ways to prevent or treat them, applying a range of molecular immunological techniques, experimental models and patient cohorts.

Duties

We are looking for a candidate who has a PhD in bioinformatics, computer science, data analysis or similar field. The candidate is highly motivated and independent with experience in next-generation sequencing data analysis, computational genomics, medical statistics, computational biology and/or imaging analysis. The project combines single-cell, multi-omics data with large scale human genetics to investigate the cellular origin of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Alzheimers’ disease (AD). The postdoc candidate will cooperate closely with researchers in the team as well as with our collaborators and participate in projects that involves data analysis, visualization, and development of new computational methods for processing and analysis of large-scale omics data. We welcome applications from candidates with pure computational background and those combining experimental and theoretical approaches.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.


A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Center for Molecular Medicine, Solna campus, Karolinska Institute, Stockholm.

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all!

First day of employmentAccording to agreement
Reference numberSTÖD 2-5753/2021
ContactVendela Breeze, HR administrator, 08-524 832 82, vendela.breeze@ki.seSebastian Lewandowski, Research coordinator, sebastian.lewandowski@ki.seRobert Harris, Professor, robert.harris@ki.se
Union representativeVenus Azhary, OFR, 0707-124 127Henry Wölling, SEKO, henry.wolling@ki.seArsalan Amir, SACO, 0704831165
Last application date15.Feb.2022 11:59 PM CET

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Post expires on tirsdag februar 15th, 2022

Postdoctoral studies in tumor immunology (scholarship)

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Do you want to contribute to top quality medical research?

The main objectives of the Department of Oncology-Pathology are basic, translational and clinical research and educational activities related to cancer. Approximately 300 people from over 40 nations are currently working at the department. More than 30 research groups with various cancer research profiles are involved and there is around 120 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians. 

Division

The main objectives of the Department of Oncology-Pathology are basic, translational and clinical research and educational activities related to cancer. Approximately 300 people from over 40 nations are currently working at the department. More than 30 research groups with various cancer research profiles are involved and there is around 120 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians. 

Research group

The Department of Oncology-Pathology is searching for a PhD student to work with Drs. Charlotte Rolny and Ola Larsson to study the role of mRNA translation in macrophages during tumor development. Larsson and Rolny share the lab. More details about the groups can be found here.

Description of the project

One of the major challenges in anti-cancer therapy is to restrict invasiveness and metastatic dissemination. It is well established that Tumor Associated Macrophages (TAMs) are linked to tumor progression and poor survival. Therefore, shifting tumor-promoting macrophages towards a tumor-inhibitory phenotype is a therapeutic strategy. Rolny’s group mainly studies mechanisms underlying TAM mediated tumor growth, metastasis and local invasion in breast carcinoma and glioma. In this respect, we have recently shown that selective mRNA translation controls the TAM phenotype during tumor progression. The goal of the project is to further understand how selective mRNA translation control regulate macrophage phenotypes to see if this can be exploited for anti-cancer therapy.

Duties

The post-doctoral fellow will lead and execute the intended project according to timelines and set goals. The candidate will also present his/hers work at group meetings and annual retreats as well as national and international conferences.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Other requirements

The ideal candidate is highly motivated, with an outstanding completed PhD thesis (or equivalent) and a strong drive for a future career in research. The candidate should be capable of generating novel ideas, acquire knowledge independently and possess sufficient computational skills to evaluate and develop ongoing projects. It is preferable that the applicant has a background in tumor immunology. Fluency in spoken and written English is required. At least one paper in a high-quality international peer-reviewed journal is necessary to be considered and additional academic merits are also considered. Because of the scope of the project, knowledge and experience in animal work, flow cytometry analysis and confocal microscopy imaging is required. Previous experience with the most common molecular biology techniques including cloning of genes of interest, lenti-virus production, western blot analysis, qPCR etc. is essential. In addition, personal suitability will be a factor in the selection process.

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

First day of employmentUpon agreement
Reference numberSTÖD 2-5749/2021
ContactCharlotte Rolny, 08-524 800 00
Union representativeAndreas Lundqvist, SACO, andreas.lundqvist@ki.seHenry Wölling, SEKO, henry.wolling@ki.seHelen Eriksson, OFR, helen.eriksson@ki.se
Last application date18.Feb.2022 11:59 PM CET

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Post expires on fredag februar 18th, 2022

Postdoc in immunometabolism in RNA virus pathogenesis

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Do you want to contribute to top quality medical research?

The Department of Laboratory Medicine consists of seven divisions and is engaged in advanced basic scientific, clinical and epidemiological research. The department is also one of the largest departments of education at Karolinska Institutet. A postdoctoral position is now available at the Systems Virology Lab, Division of Clinical Microbiology. 
The postdoctoral position is available in the Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine in Huddinge (KI South Campus, Flemingsberg).

The research

The Systems Virology lab aims to identify the molecular mechanism of host-viral response against RNA viruses using multi-omics technologies and experimental assays. We aim to identify the components of the immune response that are required for natural immune protection and linked with disease severity that can be translated into the future development of vaccine and antiviral strategies against emerging and re-emerging viruses. The research team has both bioinformatics and experimental teams and works in an interdisciplinary research environment. The present postdoctoral position is towards the understanding the host-viral interactions in RNA virus targeting more towards flaviviruses, corona viruses including SARS-CoV-2 and Crimean Congo Hemorrhagic Fever Viruses. The potential candidate is encouraged to look into the group website https://ki.se/en/labmed/the-systems-virology-lab

The project

Are you interested to learn how our immune system interact with the viruses and we can explore virus weakness to eliminate it? We are looking for a Post-Doctoral researcher for our research theme, the correlates of immune protection against RNA viruses, who will work mainly to understand the immune-metabolic modulation during acute or chronic viral infection. A major focus of the work will be on virus-host cell interaction and to determine the signaling pathways that drive virus-induced disease biology in Flaviviruses and SARS-CoV-2. The ideal candidate will possess exceptional skills in virology, multi color flow cytometry, and/or cell biology. Preference will be given to those who worked with the BSL3 viruses mainly with Flaviviruses and immune modulation of cellular pathways in the cell lines and primary cells. Expertise in the field of metabolism, loss-of-function screens and reverse viral genetics including CRISPR-Cas9 would represent a major advantage.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

The potential candidate is qualified to apply for funding for start-up grants from Swedish or European Union within a couple of years. Please read about the qualifications in https://staff.ki.se/information-about-researching-as-a-postdoctoral-researcher

The candidate should have achieved the corresponding scientific competence, with first-authored publications in internationally leading journals in the immunological fields with strong knowledge in developing high-dimensional multi-color FACS panel.

What do we offer?

Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

The group has experience of two Swedish Research Council Establishment grants and several grants for Young Investigators. We will provide mentorship for applying grants potentially in own line of research within the field of emerging, re-emerging RNA viruses and encourage to apply several grants. 


Location: Flemingsberg

Read about the Department of Laboratory Medicine

Read about the Division of Clinical Microbiology

Read about the Research Group

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Application

An employment application must contain the following documents in English:

-A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
-A complete list of publications A summary of current work (no more than one page)
-Contact details to three professional references

Welcome to apply at the latest 31st of January 2022

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Type of employmentTemporary position longer than 6 months
Contract typeFull time
First day of employmentAccording to agreement
Number of positions1
Working hours100%
CityHuddinge
CountyStockholms län
CountrySweden
Reference numberSTÖD 2-5751/2021
ContactUjjwal Neogi, Research Group Leader, ujjwal.neogi@ki.seProf. Christian Giske, Division head, christian.giske@ki.se
Union representativeAnnica Lindkvist, SACO, +46 (8) 5248 3746 Carina Eklund, OFR, +46 (8) 585 826 65Henry Wölling, SEKO, henry.wolling@ki.se
Last application date31.Jan.2022 11:59 PM CET

Read the job description at the university homepage

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Post expires on mandag januar 31st, 2022

Post-doc position with a focus on protein biophysics, ligand interactions and structural biology

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Do you want to contribute to improving human health?

Postdoctoral researcher positions are available at the Department of Neuroscience at Karolinska Institutet in Stockholm, Sweden for motivated young researchers wishing to join a multidisciplinary project with critical next steps to understand and to modulate novel mechanisms of neuroendocrine signaling in the hypothalamus and pancreas. The research project is supported by a grant from the Novo Nordisk Foundation’s Nordic Neuroendocrine Program for the next 2 years.


Division

During the recent past, our laboratory has discovered novel members of the exocytosis release machinery for the stress hormone, CRH, as well as for insulin. Our work has particularly focused on a novel class of calcium-sensor proteins, their localization, biochemical characterization, typifying of their protein-protein interactions and the structural investigation of the protein-complexes. Herewith, postdoctoral fellows are recruited to take the project forward to analyze, on the one hand, in genetic models how these proteins program hormone release and, on the other, define strategies to pharmacologically inhibit their action. Relevant literature includes: Malenczyk K. et al. EMBO J. PMID:28637794; Romanov RA. et al. EMBO J. PMID:25430741, Fuzik J et al. PNAS PMID: 31796600 and Malenczyk K. et al. Mol Metab. PMID: 29910119). Understanding these checkpoints of hormone release are expected to provide means to modulate stress, post-traumatic stress disorder, anxiety and diabetes.

Post-doc position with a focus on protein biophysics, ligand interactions and structural biology:

The candidate will be expected to produce recombinant proteins and to identify and characterize protein-protein interactions, determine their biochemical and biophysical characteristics and study these in a biological context. Considering that drug-like small molecules interfering with these very protein-protein interactions are being developed, characterization of their binding specificity, affinity, and the structural basis of their binding by X-ray crystallography will be an important part of the work.

Duties

We are looking for a highly motivated candidate with a Ph.D. or equivalent degree in a field of medicinal chemistry, biochemistry, biophysics or structural biology. Documented expertise in characterizing protein-protein and protein-small molecule interactions and/or X-ray crystallography will be considered an advantage. The successful candidate will be expected to establish heterologous protein expression, carry out large scale protein purification, characterize the interactions of proteins and their ligands in vitro, and participate in structural studies aimed to determine on how protein partners interact. Outstanding communication skills and an ability to interact socially and scientifically within a multinational team in the laboratory, and with collaborators around Europe and overseas in excellence networks will be considered essential. Top-tier publications in any relevant field will be seen as a priority during the selection process.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Stockholm (Solna)

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

First day of employmentJanuary 2022
Reference numberSTÖD 2-4789/2021
ContactTibor Harkany, 08-524 876 56
Last application date31.Jan.2022 11:59 PM CET

Read the job description at the university homepage

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Post expires on mandag januar 31st, 2022

Doctoral (PhD) Student Position in Targeting NAD for Neuroprotection

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Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Department of Clinical Neuroscience and the research team of Pete Williams offers an exciting opportunity for a PhD Student in the field of translational neurobiology. The overall goal of the Pete Williams Lab is to develop clinically translational neuroprotective strategies for neurodegenerative disease focusing on neuronal metabolic and mitochondrial health. One current focus is the common neurodegeneration glaucoma.

The Pete Williams Lab is situated at St Erik Eye Hospital, Stockholm, and the doctoral student will have the chance to interact and work in an international environment with multidisciplinary basic research scientists, clinicians, and research clinicians. The student will be co-supervised by Assistant Professor James Tribble; an expert on animal models of neurodegeneration, and Associate Professor Peter Swoboda; an expert in C. elegans neurobiology.

The doctoral student project and the duties of the doctoral student

The Pete Williams lab has previously discovered metabolic dysfunction and mitochondrial abnormalities occurring prior to neurodegeneration in glaucoma (in glaucoma patients and animal models). These studies identified that NAD (nicotinamide adenine dinucleotide; an essential REDOX cofactor and metabolite) declines in the retina in an age-dependent manner and renders retinal ganglion cells susceptible to glaucoma-related stresses, driving neurodegeneration. Preventing NAD depletion via administration of nicotinamide (the amide of vitamin B3; an NAD precursor) or through gene therapy (targeting terminal enzymes for NAD production) provides a robust neuroprotection. We are now developing novel small molecules to target these enzymes, drive NAD production, and provide neuroprotection.

Developing novel small molecule compounds that increase NAD production will show genuine promise for targeted treatments for glaucoma and other neurodegenerations and give novel insight into the role of NAD in neurodegeneration.

Primary goals: The goal of this doctoral training program is to develop assays and to test novel NAD-generating compounds to prevent axon degeneration and mitochondrial dysfunction. Specifically, the student will:

(1) Establish a platform for neurodegeneration research using the model organism C. elegans,

(2) Develop axon degenerative and mitochondrial assays in C. elegans with relevance to sensory neuroscience research,

(3) Test and further refine novel NAD-generating small molecules to protect from mitochondrial dysfunction and axon degeneration.

The doctoral student will be the lead scientist in these projects with close supervision and training by the supervisors and members of their labs. The studies outlined will allow the student to advance their basic molecular biology knowledge to more modern and complex genetic manipulation and testing. The Williams lab is expert in identifying neurodegenerative processes and utilizing –omics analysis, and the Swoboda lab is expert in manipulating mitochondrial and neuronal pathways in C. elegans. Furthermore, this is an ideal opportunity for the doctoral student to work with larger datasets and gain practical transferable skills (e.g. statistics, R programming) to help in their transition to independence and future job prospects

We are looking to recruit a full-time student.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

We are looking for an ambitious candidate with enthusiasm for translational neurobiology. The successful candidate must meet the KI requirements for doctoral education, with a strong background in biomedical science, chemistry, neurobiology, computer science, or pharmacology, with relevant wet-lab experience.

Additional wet-lab knowledge specific to this project would be highly advantageous. Specifically, previous practical experience with C. elegans maintenance and use, molecular biology techniques, mitochondria/metabolism techniques and assays, computational biology/neuroscience, and/or drug testing are considerable substantial merits. 

We will start the selection process after the last application day.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

https://api.kaltura.nordu.net/p/318/sp/31800/embedIframeJs/uiconf_id/23450616/partner_id/318?iframeembed=true&playerId=kaltura_player&entry_id=0_g04wq80a&flashvars[streamerType]=auto&flashvars[localizationCode]=en&flashvars[leadWithHTML5]=true&flashvars[sideBarContainer.plugin]=true&flashvars[sideBarContainer.position]=left&flashvars[sideBarContainer.clickToClose]=true&flashvars[chapters.plugin]=true&flashvars[chapters.layout]=vertical&flashvars[chapters.thumbnailRotator]=false&flashvars[streamSelector.plugin]=true&flashvars[EmbedPlayer.SpinnerTarget]=videoHolder&flashvars[dualScreen.plugin]=true&flashvars[Kaltura.addCrossoriginToIframe]=true&&wid=0_gg58khmj

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Read more about Pete Williams

Read more about Pete Williams Lab

Want to make a difference? Join us and contribute to better health for all!

Type of employmentPhD placement
Contract typeFull time
First day of employmentAccording to agreement
SalaryMonthly salary
Number of positions1
Working hours100
CityStockholm
CountyStockholms län
CountrySweden
Reference numberSTÖD 2-5317/2021
ContactPete Williams, Research group leader, pete.williams@ki.seAnna Wendel, HR-Partner, anna.wendel@ki.se
Union representativeVenus Azhary, OFR, 0707-124 127Arsalan Amir, SACO, 08 – 517 733 37Henry Wölling, SEKO, henry.wolling@ki.se
Last application date23.Jan.2022 11:59 PM CET

Read the job description at the university homepage

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Post expires on søndag januar 23rd, 2022

PhD student position in skin, stem cell, and single-cell biology

Logo for Karolinska Institutet, doctoral positions

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Do you want to contribute to improving human health?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Kasper Lab: With our research – rooted within the fields of skin and stem cell biology – we aim to answer fundamental questions about tissue homeostasis, repair and regeneration. We use modern techniques such as single-cell transcriptomics, in vivo lineage-tracing, spatial mapping in situ and computational biology, to uncover the cellular behavior and molecular signals of individual cells in skin during health, repair and cancer development (key lab references: Joost et al. Cell Systems 2016; Joost et al. Cell Reports 2018; Joost*, Annusver* et al. Cell Stem Cell 2020; Sun*, Are* et al. eLife 2020). The overall aim is to understand human skin disorders, improve early cancer detection and uncover new regenerative strategies to restore skin.

We are a young and dynamic research team with a well-established collaborative network (http://kasperlab.org). The group is placed in Biomedicum, a top modern research building with a large repertoire of researchers and technologies including activities in forefront single-cell omics, mouse work, FACS and high-end microscopy.

The doctoral student project and the duties of the doctoral student

The PhD project focuses on understanding mammalian skin (mouse and human), for example, its cell-type composition depending on body location, how distinct modes of hair growth are regulated and what is the role of immune cells in skin health and skin disorders. The results of the PhD program will reveal how cells interact with each other and their surrounding to maintain or acquire their individual cell identity at single-cell resolution. A combination of experimental and computational state of the art techniques will be used, such as in vivo lineage tracing, organoid culture, single-cell transcriptomics, single-molecule FISH and computational biology.

The PhD program at the Karolinska Institutet corresponds to 4 years full time studies. The project is a combination of practical laboratory work (wet-lab work, imaging, mouse work) and computational analysis of single-cell transcriptomics/ATAC-seq data (programing in R and/or Python). The studies also include attending seminars, courses, and conferences. The PhD student will under supervision, and with time more independently, plan and execute experiments, analyze data, interpret, and present the results as well as write scientific articles.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

We seek a student with a background in molecular biology, biomedicine or equivalent, with an interest in learning programing languages to analyze single-cell data. The candidate should have a good team spirit, be self-motivated, and bring a keen interest in solving intricate scientific questions in tissue biology. Experience in working with molecular biology techniques, confocal microscopy, FACS analysis, basic programing skills, and the isolation and culture of primary cells is a strong plus; good team-work ability and to communicate in English (written and verbal) is required. Emphasis will be also placed on personal suitability, fitting well into the current research group.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

https://api.kaltura.nordu.net/p/318/sp/31800/embedIframeJs/uiconf_id/23450616/partner_id/318?iframeembed=true&playerId=kaltura_player&entry_id=0_g04wq80a&flashvars[streamerType]=auto&flashvars[localizationCode]=en&flashvars[leadWithHTML5]=true&flashvars[sideBarContainer.plugin]=true&flashvars[sideBarContainer.position]=left&flashvars[sideBarContainer.clickToClose]=true&flashvars[chapters.plugin]=true&flashvars[chapters.layout]=vertical&flashvars[chapters.thumbnailRotator]=false&flashvars[streamSelector.plugin]=true&flashvars[EmbedPlayer.SpinnerTarget]=videoHolder&flashvars[dualScreen.plugin]=true&flashvars[Kaltura.addCrossoriginToIframe]=true&&wid=0_gg58khmj

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)
– Two recommendation letters or contact details of two reference persons.  

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Want to make a difference? Join us and contribute to better health for all

Type of employmentPhD placement
Contract typeFull time
First day of employmentAccording to agreement
SalaryMonthly salary
Number of positions1
Working hours100
CityStockholm
CountyStockholms län
CountrySweden
Reference numberSTÖD 2-5732/2021
ContactMaria Kasper, maria.kasper@ki.se
Union representativeTaher Darreh-Shori, SACO, 08-524 835 29Magnus Anå, OFR, 08-524 864 37, magnus.ana@ki.seElisabeth Valenzuela, SEKO, 08-524 863 53

Read the job description at the university homepage

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Post expires on tirsdag januar 25th, 2022

Doctoral (PhD) position in DNA replication & Cancer Genetics

Logo for Karolinska Institutet, doctoral positions

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Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

In 2021 Assistant Professor Bennie Lemmens has started a new research group at Karolinska Institutet (KI) in Stockholm, focussed on DNA replication & Cancer Genetics. His team at KI aims to discover how human cells copy DNA and maintain genome stability. The Lemmens group also implements this knowledge to design better, more selective anti-cancer treatments. The lab is hosted in the Science for Life Laboratory (SciLifeLab), a national center for molecular biosciences with focus on health and environmental research.

The Lemmens group is formed by a young, dynamic and enthusiastic group of scientists of different backgrounds and knowledge and offers the perfect environment for a PhD candidate willing to learn and develop as an independent scientist. The group has obtained generous funding from KI faculty (incl.100% KID grant), the Swedish Research Council and the Mark Foundation for Cancer Research, which secures its activities in the long term. The group is also embedded in a highly collaborative and engaging Genome Biology division at the department of Medical Biochemistry and Biophysics (MBB), which makes it a great place to acquire new skills and scientific networks.

Research in the Lemmens laboratory aims at gaining fundamental insights into the cellular mechanisms that control genome stability. Of particular interest is discovery of targets for personalized cancer treatment using a range of genetics/CRISPR approaches as well as cutting-edge imaging methods, including live-cell, high-content, super resolution and expansion microscopy.

Understanding human biology and finding innovative cancer cures is a global team effort and the Lemmens laboratory works closely together with research pioneers around the world as well as many synergetic labs within the division, including the groups of Dr. Jiri Bartek, Dr. Oscar Fernandez Capetillo, Dr. Simon Elsässer and Dr. Nicola Crossetto, which are experts in cancer biology, cell-based screening, chromatin dynamics and DNA sequencing technologies, respectively.

The doctoral student project and the duties of the doctoral student

The student will be responsible for his / her own project and should be able to work well within a team of research group members and collaborators. The student should, with the guidance from the supervisor(s), be able to plan and perform experiments, analyse results, write scientific articles, and present results at scientific meetings.

The project is aimed to define how human cells start DNA replication and find new clues on how to improve cancer care. The forced proliferation of cancer cells compromises DNA replication fidelity and causes DNA replication stress. DNA replication stress promotes genome instability and cancer progression but also provides therapeutic opportunities. Therapeutic drugs that hinder the start of DNA replication show promising anti-cancer activities, especially for cancers lacking the tumorsuppressor p53. However, to date, surprisingly little is known about how human cells start DNA replication, hampering the design and validation of innovative therapies that act at the level of replication initiation. The doctoral student will create new human cell models to study the mechanism of DNA replication using cutting-edge protein depletion methods and CRISPR-based genome modification techniques. These cell models will be studied using advanced imaging and single-cell analysis platforms already established in the lab, allowing the student to detect DNA replication in time and space with high precision. The PhD student will practice a number of molecular and cellular techniques, including cell culture, RNAi, CRISPR-editing, immunofluorescence microscopy, live-cell imaging and 3D tissue expansion. An important aspect of the project is the use of automated microscopy in combination with image analysis in order to obtain information from different cell types and treatments. We believe this project will provide critical insight into the mechanism of human cell proliferation and provide new clues on how to design better, more selective cancer therapies. At the same time the project exposes the student to a wide variety of frontline techniques and intricate biological phenomena in both time and space, which, together with our support, will create an inspiring environment and solid foundation to grow as an independent scientist.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

Successful candidates are expected to be highly talented, motivated and enthusiastic. Applicants should have innovative thinking and be eager to solve problems. We especially put an emphasis on motivation and interest for research in cell biology and cancer genetics. A master degree in molecular medicine, biomedicine, or equivalent is highly desirable. Since the study involves various CRISPR methods and imaging techniques previous experience in gene technology and/or fluorescence microscopy is considered a merit.

Excellent communication skills and fluency in both written and spoken English is a request. The applicants should have strong organizational skills with the ability to work both in a group but also individually. Emphasis will be placed on personal suitability.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

https://api.kaltura.nordu.net/p/318/sp/31800/embedIframeJs/uiconf_id/23450616/partner_id/318?iframeembed=true&playerId=kaltura_player&entry_id=0_g04wq80a&flashvars[streamerType]=auto&flashvars[localizationCode]=en&flashvars[leadWithHTML5]=true&flashvars[sideBarContainer.plugin]=true&flashvars[sideBarContainer.position]=left&flashvars[sideBarContainer.clickToClose]=true&flashvars[chapters.plugin]=true&flashvars[chapters.layout]=vertical&flashvars[chapters.thumbnailRotator]=false&flashvars[streamSelector.plugin]=true&flashvars[EmbedPlayer.SpinnerTarget]=videoHolder&flashvars[dualScreen.plugin]=true&flashvars[Kaltura.addCrossoriginToIframe]=true&&wid=0_gg58khmj


Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Last day to submit your application is 26th of January 2022, 11:59 PM CET. 

For more information regarding our division and/or Karolinska Institutet, visit:

Research division of Genome Biology

KI – Your career continues here

KI Strategy 2030

Want to make a difference? Join us and contribute to better health for all

Type of employmentPhD placement
Contract typeFull time
First day of employmentUpon agreement
SalaryMonthly salary
Number of positions1
Working hours100%
CitySolna
CountyStockholms län
CountrySweden
Reference numberSTÖD 2-5362/2021
ContactBennie Lemmens, bennie.lemmens@ki.se
Union representativeAnurupa Nagchowdhury, OFR, anurupa.nagchowdhury@ki.seHongyan Xia, SACO, hongyan.xia@ki.se
Last application date26.Jan.2022 11:59 PM CET

Read the job description at the university homepage

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Post expires on onsdag januar 26th, 2022