Tag-arkiv: Karolinska Institutet

Three Postdoctoral Researchers in Epidemiology

Karolinska Institutet, Institutet för miljömedicin

The Institute of Environmental Medicine (IMM) is a department at Karolinska Institutet and an interdisciplinary research institution within the broad field of environmental medicine. IMM conducts cutting edge research within the areas of environmental and occupational medicine, toxicology, physiology, epidemiology, and biostatistics with the aim to clarify how environmental and lifestyle factors affect our health and which role genes have. IMM also serves as a scientific advisor to public authorities within the area of environmental medicine and IMM scientists participate in national and international expert groups.

Epidemiology at the Institute of Environmental Medicine (IMM)
The epidemiological research at IMM is focused on advancing knowledge about disease etiology and prognosis with an emphasis on environmental and lifestyle factors, and on methodological development and stringency. The research is based on large register based cohorts, as well as cohorts and case-control studies with extensive information from questionnaires and biological samples. Miguel Hernán, Kolokotrones Professor of Biostatistics and Epidemiology at the Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, USA is currently a Visiting Professor of Epidemiology at IMM, and the Postdoctoral researchers will have the opportunity to work together with Professor Hernán. We are now looking for three Postdoctoral Researchers for a 24-month Postdoctoral position.

Duties
The Postdoctoral Researchers are expected to conduct epidemiological research of relevance for public health epidemiology, cancer epidemiology, cardiovascular epidemiology, pharmacoepidemiology or relevant clinical epidemiology. One particular area will be comparative effectiveness research, with an emphasis on causal inference methods for complex longitudinal data from both observational studies and randomized trials, e.g. to assess effects of interventions on cardiovascular disease, cancer, and others. Other epidemiological research areas can also be covered depending on the interests of the applicant. The research will mainly be based on data from Swedish and Nordic population and health data registers, including also health care quality registers. The Postdoctoral Researchers are also expected to participate as teachers in epidemiology.

Qualifications
To be eligible, the applicant must have:

  • A doctoral degree related to epidemiology, statistics, or a related quantitative field.
  • A formal education in epidemiology or statistics.
  • Experience in handling large databases, excellent data management skills and a solid knowledge of common statistical software (as a minimum SAS and R).

Competences, skills and experiences considered meritorious:

  • Excellent writing skills and excellent command of written and spoken English.
  • An ability to collaborate with colleagues within and beyond the group, and to communicate with authorities, data holders and other data owner groups.
  • Previous supervision of PhD or Master students.
  • Formal pedagogical training.
  • Prior experience working in research outside of IMM.

Entry requirement
A person is eligible for a Postdoctoral position if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc.

Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances
  5. Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline)

The application is to be submitted through the Varbi recruitment system.

Type of employment Temporary position longer than 6 months
Contract type Full time
First day of employment According to agreement
Salary Monthly payment
Number of positions 3
Working hours 100 %
City Solna
County Stockholms län
Country Sweden
Reference number 2-5048/2018
Contact
  • Maria Feychting, Professor of Epidemiology, maria.feychting@ki.se
  • Anita Berglund, Ass. Professor of Epidemiology, anita.berglund@ki.se
Union representative
  • Niklas Andersson, OFR, +46 8 524874 19 / niklas.andersson@ki.se
  • Anne Boström, SEKO, +46 8 524 875 79 / anne.bostrom@ki.se
Last application date 22.Oct.2018 11:59 PM CET

Read the job description at the university homepage

Post expires on Monday October 22nd, 2018

Doctoral (PhD) student position in integrative omics data analysis

The Department of Medical Epidemiology and Biostatistics (MEB) is among the largest departments of epidemiology in Europe with special focus on increasing our knowledge of the aetiology of different diseases. Our department consists of researchers, doctoral students, biostatisticians, data collectors and database administrators as well as administrative personnel, in total some 250 staff. The department is situated at campus Solna. Further information can be found at ki.se/meb

We are recruiting a student for doctoral education.

For more information regarding doctoral (PhD) education, see: http://www.ki.se/doctoral.

Research group
At Department of Medical Epidemiology and Biostatistics (MEB) of Karolinska Institutet (KI), we carry out epidemiologic research in a wide range of medical areas, including cancer, psychiatry, neurological diseases, etc. Our projects aim to increase knowledge about causes of diseases and to translate the knowledge towards clinical application. Biostatistical analysis is of central importance in the interdisciplinary research conducted at MEB. Much of our methodological tools relies on statistical genetics, molecular epidemiology as well as biostatistics. MEB has the largest critical mass of academic biostatisticians in Sweden and is one of the largest among Nordic countries. Overall, we provide a stimulating and active research environment that facilitates both internal and external collaborations with world-class scientists.

This project is under supervision of an interdisciplinary team, including Dr. Xia Shen experienced in statistical genomics, statistical modeling and software development, Dr. Fang Fang with expertise in epidemiological studies such as the areas of psychological and neurological disease, Dr. Nghia Vu who is an expert in statistical and computational methods for cancer genomics data, and Prof. Yudi Pawitan with strong expertise in biostatistics, bioinformatics and high-throughput molecular data modeling. The supervisory team is highly experienced in the relevant subject areas and active in national and international collaborations.

The doctoral education project and the duties of the student
The overall aim of the project is to identify complex disease signatures such as neurological disorders and cancers on single cells and extracellular vesicles (EVs), by integrative analysis of our measured single-cell omics data, our uniquely available single-EV proteomics data, genome-wide association studies (GWAS) summary-level data, and other types of omics data. The project trains the doctoral student with sufficient omics data science expertise for modern precision medicine research.

The doctoral student expected to acquire broad knowledge of medical omics by doing the project under supervision and taking relevant courses; acquire in-depth experience in statistical computation and statistical software packages such as R and Python; develop analysis pipelines for single-cell/single-EV medical omics data; process big data for diverse interdisciplinary projects; develop scientific writing and deliver high-quality publications in international peer-reviewed journals.

Entry requirements for doctoral education at KI
To be eligible for doctoral education, the following requirements have to be met:

General entry requirements
A person meets the general entry requirements for doctoral/third-cycle/PhD education (according to Higher Education Ordinance Chapt 7, section 39) if he/she:

  1. has been awarded advanced/second-cycle/master qualification (i.e. master degree) or
  2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle/master level, or
  1. has acquired substantially equivalent knowledge in some other way in Sweden or abroad.

For more information regarding the general entry requirements, please see:
https://ki.se/en/phd/entry-requirements-eligibility-for-doctoral-education

Specific entry requirements
Proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school. Applicants who meet the general entry requirements (1 or 2 above) from a university in one of the Nordic countries fulfill the English language requirement.

For information on how other applicants can certify their English proficiency (such as through IELTS or TOEFL, previous upper secondary or university level studies), please see:
https://ki.se/en/phd/entry-requirements-eligibility-for-doctoral-education

The applicant is required to have at least 2 years of research experience in bioinformatics and data analysis. Experience in single-cell type of omics research is required. Programming skills in R/Perl/C++ is required. Experience in mathematical/statistical modeling is required. The applicant should have experience and good skills in graphics and data visualization.

Skills and personal qualities
Skills for interactive website interface design is desirable. We are seeking a highly motivated and creative student. The applicant should have good communication skills and ability to work productively in a team of researchers. Emphasis will be placed on personal ability and previous experience. Excellent ability to express themselves in speech and writing, including scientific writing, in English is a requirement.

Assessment criteria
A selection will be made among qualified applicants on the basis of the ability to benefit from doctoral education. Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research

– Analytical skill

– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

The qualifications of the applicants will be evaluated on an overall basis.

Terms and conditions
All doctoral students at KI receive financial support during their doctoral education and employment on a doctoral studentship is the most common sort of support.

Application process
The application must contain the following documents in Swedish or English:

  • A personal letter and a curriculum vitae
  • Academic degree diplomas, transcripts of records in original language and, if applicable, authorised translations
  • Copies of degree projects and any previous publications
  • Proof of English proficiency as stated in the specific requirement above

All documents certifying the entry requirements must be scans of originals (scans of copies or certified copies will not be accepted). The scanned documents must be in color and both the front and the back of the documents must be scanned. Please note that there are specific documentation requirements for a number countries, please read the instructions at:

https://ki.se/en/phd/entry-requirements-eligibility-for-doctoral-education

The application and supporting documents are to be submitted through the Varbi recruitment system.

Type of employment PhD placement
Contract type Full time
First day of employment According to agreement
Salary Monthly salary
Reference number 2-4865/2018
Contact
  • Lina Werner, HR-officer, Email: lina.werner@ki.se
  • Xia Shen, Assistant professor, Email: xia.shen@ki.se
Union representative
  • Ann Almqvist, OFR, ann.almqvist@ki.se
  • Ulrika Zagai, SACO, 08–524 871 84, ulrika.zagai@ki.se
  • Henry Wölling, SEKO, henry.wolling@ki.se
Published 17.Sep.2018

Post expires on Monday October 8th, 2018

Postdoctoral Researcher in T cell autoantigens in human chronic inflammatory diseases

Karolinska Institutet, Department of Medicine, Solna, Rheumatology division

The Department of Medicine, Solna, is one of the largest departments at Karolinska Institutet. The department consists of several units that are separated into different research groups. The core activities of the department are research, doctoral education and undergraduate education for medical and biomedical students. The research has three main profiles: allergy, cardiovascular medicine and inflammatory diseases.

Division
The Department of Medicine is since March 2015 one of the partners of a new SGC and IMI project focused on the discovery and validation of novel targets in inflammatory diseases (ULTRA-DD, Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery). The positions will be placed within the research group of Professor Vivianne Malmström´s group, Rheumatology unit, Department of Medicine, Karolinska Institutet, Solna

Project
We seek a cellular immunologist to work in a translational setting to establish patient-cell derived autoreactive T cell lines in the context of chronic inflammatory rheumatic disease in the research group of Professor Vivianne Malmström. The candidate will study both currently identified autoantigens and also screen for new ones via a modified fluorospot protocol developed in the collaborating laboratory of Professor Hans Grönlund.The candidate will also be included in active intrerational collaborations led by the group at Karolinska. The candidate will also be included in active international collaborations led by the group at Karolinska. These collaborations include a newly started program on the development of tolerizing therapies for rheumatoid arthritis (RTCure), and this and other international collaborations will provide the candidate with a large and active network in autoimmunity and therapy development.

The post doc candidate is further expected to study T cell effector functions and means to modulate those as a first basis for development of tolerogenic therapies, the work will give opportunities for international exchange studies in collaborative international settings.  A possible outcome will be to e.g. build animal models where patient-derived autoreactive TCR and IgG’s are introduced to allow a true mirror of the human rheumatic disease setting.

Duties
Grow autoreative T cell lines from patients with chronic rheumatic disease. Test T cell lines for autoreactivity by screeing a peptide library in fluorospot assays. Screen small molecules´ability to affect the autoreactivity. Summarise data, interpret and report conlcusions to collaborators. Paticipate in scientific discussions, group activities and international congresses

Entry requirements
PhD in biomedicine or biology, or comparable with focus on cellular immunology.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence.

Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances

The application is to be submitted through the Varbi recruitment system.

Type of employment Temporary position longer than 6 months
Contract type Full time
First day of employment 2018-10-01
Salary månadslön
Number of positions 1
Working hours 100
City Solna
County Stockholms län
Country Sweden
Reference number 2-4876/2018
Contact
  • Vivianne Malmström / professor, vivianne.malmstrom@ki.se
Union representative
  • Niklas Andersson, OFR, niklas.andersson@ki.se
Last application date 09.Oct.2018 11:59 PM CET

Post expires on Tuesday October 9th, 2018