Tag-arkiv: Karolinska Institutet

Postdoctoral studies in epigenetic mechanisms underlying immuno-metabolic diseases (scholarship)

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The Department of Biosciences and Nutrition performs research and education in several areas of medical science including aging, Alzheimer, bioorganic chemistry, biomaterial, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, immunology, and nutrition. It offers an excellent international research and working environment, including around 250 scientists, students, administrative and technical personnel. The Department resides in Neo at Campus Flemingsberg, a biomedical research building, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Do you want to contribute to top quality medical research?

Our research is devoted to exploring the epigenetic mechanisms underlying immuno-metabolic diseases. We are seeking two highly motivated postdocs to join our efforts to better understand the role of chromatin-modifying corepressors (Project 1) and of cis-regulatory enhancers and silencers (Project 2) in these mechanisms. A strong emphasis will be on identifying and modulating potentially causal alterations associated with type 2 diabetes, atherosclerosis and non-alcoholic fatty liver disease.

Division

The two positions will be placed at the Department of Biosciences and Nutrition at the Karolinska Institutet South Campus. Our research team (led by Professor Eckardt Treuter and Assistant Professor Rongrong Fan) conducts pre-clinical research to better understand how key components of the epigenome, such as transcription factors, corepressors and cis-regulatory elements, control metabolic and inflammatory pathways in the context of obesity, type 2 diabetes, fatty liver disease and atherosclerosis (Nat Med 2016, Cell Rep 2018, Nat Comm 2019, Mol Met 2020, Mol Cell 2021).

For a detailed description of our laboratory and projects, please see our website;
https://ki.se/en/bionut/epigenetic-mechanisms-underlying-metabolic-inflammatory-diseases-eckardt-treuter

Duties

We offer separate projects for two postdocs and encourage all applicants to express their preferences and own ideas in their personal motivation letter.

Project 1 (mentor: Eckardt Treuter) will investigate the role of chromatin-modifying corepressor complexes that contain the signal-regulated subunit GPS2. Emphasis will be on identifying hitherto enigmatic mechanisms (involving signaling molecules, PTMs, interactomes) that trigger alterations of corepressor (sub-)complex function and target selection (i.e. transcription factors, enhancers, silencers) during disease progression. The postdoc will apply latest -omics profiling and genome-editing methods along with biochemical investigations, and utilize mainly in vitro models (cultured monocytes, macrophages and hepatocytes) along with samples derived from mouse models and humans.

Project 2 (mentor: Rongrong Fan) will investigate epigenetic mechanisms involving enhancer and silencer alterations in human metabolic disorders. The postdoc will explore new methods, and in combination with our existing epigenetic analytical techniques, he/she will explore the molecular features and disease-relevance of enhancer and silencer remodeling in both human samples and animal models. This project involves collaborations with clinicians from the adjacent Huddinge Hospital. The postdoc is also expected to perform combinative analysis to extract the clinical-relevant information from the multi-omics data.

Qualifications

We are inviting applications of highly motivated and talented candidates with a successful PhD (publications) in molecular biology, biomedicine, biochemistry, genetics or related fields. For both positions, a thorough understanding of transcription, chromatin and epigenetic mechanisms along with documented lab-wet skills in genomics and epigenomics approaches are essential. Additionally, biocomputational expertise to analyze -omics data is desired or expected to be acquired within the initial project stages (with help from more experienced lab members). For Project 2, previous experience in working with human primary cells and/or mouse models would be an advantage. Above that, the successful candidates will have excellent communication and organizational skills and can work both independently and as team players.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Karolinska Institutet South Campus Flemingsberg

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English:

  • A complete curriculum vitae, including date of the thesis defence, and brief summary of the PhD thesis, previous and current academic positions, academic title, academic distinctions, and committee work
  • A complete list of publications (with highlighting up to three most significant papers and explaining your individual contribution to each of them with 3-4 sentences)
  • A personal motivation letter with expressing your choice of the project and some ideas (no more than one A4 page)

The selection will be made among eligible applicants on basis of their qualifications and their suitability for the projects. All applicants will be informed when the recruitment process is completed.

This position will be financed by a tax-free postdoc scholarship paid out by Karolinska Institutet. The scholarship position is initially offered for one year but can be extended. There might also be a possibility to apply later for a postdoc position on salary depending on funding and after approval from Head of department.

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Reference numberSTÖD 2-2959/2021
ContactEckardt Treuter, Professor, +46-70-7563805Rongrong Fan, Assistant Professor, +46-70-062 35 85Thomas Tinglöv, Head of Administration, +46-8-524 835 49
Union representativeAnders Lindholm, OFR, +46-8-524 810 12Henry Wölling, SEKO, +46-8-524 840 80
Last application date07.Oct.2021 11:59 PM CEST

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Post expires on Thursday October 7th, 2021

Postdoctoral studies in placenta biology & epigenetic regulations of fetal development (scholarship)

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Do you want to contribute to better health for all?

The postdoc project will be conducted in Assoc prof. Qiaolin Deng’s research group with the organizational affiliation to Dept. Physiology and Pharmacology. The major research interests of the group are germ cell biology, developmental programming and epigenetic inheritance of diseases. Our goal is to better understand the causal relationship between uterine environment and fetal development together with offspring’s reproductive and metabolic health. During this process, we focus on epigenetic regulation involved in cell fate specification and maturation with the state-of-the-art technologies.

The group has established several key resources and techniques in the lab including mouse reporter lines, in vitro lentiviral manipulation on human PSC differentiation, single-cell RNA and ATAC-sequencing and LCM-seq that enable us to perform high-throughput genomic and epigenomic studies. We have in-house automated library preparation pipeline and own computational server.

Please visit out website https://thedenglab.org/ for more information.

Duties

Growing evidence suggests that several prenatal insults such as suboptimal nutrition, endocrine disruptors, maternal stress can result in long-term structural and functional changes in offspring and lead to their propensity to develop diseases, especially the metabolic syndrome. Placenta is a temporary organ but crucial for maternal fetal interactions. The concept of “placental origins of adult disease” stem from studies where placental development affects the fetus development linked to adult diseases. The molecular understanding of this process in human has just started thanks to different tools including single-cell sequencing and organoid culture.

In this project, we aim to address the following questions:
(1) what is the molecular features and pathological alteration of human placentas in women with polycystic ovary syndrome (PCOS)?
(2) what are the outcomes of such changes on fetal development and offspring reproductive and metabolic health?
(3) Can we modeling these features by organoid culture and set up platform for functional intervention?
(4) Can we validate candidates using relevant mouse models?

These tasks will be carried out in a stimulating and collaborative environment with a group of motivated co-workers with both experimental and computational competencies.

Your profile

We are looking for a successful candidate with following required skills:
• A highly motivated candidate with a PhD degree in placenta biology, stem cell biology, molecular biology or related area.
• Good track record working with mouse and human stem cells, organoid culture, animal models and Crispr/Cas genome editing.
• Experience with single-cell sequencing and data handling is a strength.
• Good interpersonal skills and the ability to work both independently but also as a part of a large team.
• Knowledge of relevant biological areas (chromatin and gene expression, genetics and epigenetics)
• Knowledge of both spoken and written English and good communication skills.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Biomedicum, Solna Campus

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications and a complete list of publications highlighting your contribution to each publication
  • A summary of current work (no more than one page)
  • A brief letter of motivation stating how your skills and background can contribute to the project
  • Contact information of two references, recommendation letters are also welcome

The application is to be submitted on the Varbi recruitment system. Interviews will be conducted on a rolling basis and the position might be fulfilled before last application date. Welcome to apply!

Want to make a difference? Join us and contribute to better health for all

First day of employmentUpon agreement
SalaryScholarship
Reference numberSTÖD 2-3595/2021
ContactQiaolin Deng, head of section, qiaolin.deng@ki.se
Union representativeHenry Wölling, SEKO, henry.wolling@ki.seHelin Norberg, SACO, helin.norberg@ki.seNiklas Andersson, OFR, niklas.andersson@ki.se
Last application date31.Oct.2021 11:59 PM CEST

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Post expires on Sunday October 31st, 2021

Postdoctoral scholarship: Translational asthma research on lipid mediator regulation of small airway inflammation

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Do you want to contribute to improving human health?

Karolinska Institutet, Institute of Environmental Medicine

The Institute of Environmental Medicine (IMM) is an interdisciplinary research department at Karolinska Institutet. IMM conducts cutting edge research within the areas of environmental and occupational medicine, toxicology, physiology, pharmacology, epidemiology, and biostatistics with the aim to clarify how environmental and lifestyle factors affect our health. IMM also serves as a scientific advisor to public authorities within the area of environmental medicine and IMM scientists participate in national and international expert groups.

Position and environment

With the support of a dedicated grant from the Swedish Heart and Lung foundation, there is an opening for a post doctoral fellow at the unit for Experimental Asthma and Allergy Research at IMM. The unit has an internationally recognized, long-standing experience with functional and biochemical studies of prostaglandins, leukotrienes, lipoxins and other bioactive lipid mediators in the context of asthmatic airway inflammation.

Project

The goal is to define mechanisms of relevance to asthma that ultimately may become novel targets for future treatments. This post doctoral fellow will be responsible for a project where specific interactions between lipid mediators and key cytokines in type 2 as well as non-type 2 inflammation will be investigated (for model, see e.g. Manson et al J Allergy Clin Immunol. 2020; 145:808-81) using isolated tissues from the small airways of humans and guinea pigs. This is a physiological and pharmacological research project, but includes supporting techniques such as histology, transcriptomics, proteomics, and the measurement of mediator release using different methods.

Qualifications

We are searching for a highly motivated candidate with a commitment to experimental research in asthma and other lung diseases. Experience of physiological or pharmacological research is a strong merit, in particular familiarity with functional experiments using tissue organ baths or myographs. Practical knowledge of handling experimental animals is necessary, and basic Felasa certification would be another asset. Excellent communication skills and an ability to interact socially and scientifically with other post docs and students in the laboratory, as well as collaborators in various networks is essential. Good computer skills are necessary, as well as fluency in English which is the main language used in this work environment. Previous post doc experience and a strong publication record are also important qualities.

Those who have allergies to animals or illnesses that may be aggravated by daily exposure to laboratory animals and chemicals are not advised to seek this position.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

First day of employmentAccording to agreement
SalarySemiannually
Reference numberSTÖD 2-2283/2021
ContactMikael Adner, Lecturer senior, +46 8 524 874 01Jesper Säfholm, Assistant professor, +46 8 524 874 90
Union representativeAnne Boström, SEKO , +46 8 524 875 79Niklas Andersson, OFR , +46 8 524 874 19Anda Gliga, SACO-S , anda.gliga@ki.se
Last application date08.Jun.2021 11:59 PM CET

Read the job description at the university homepage

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