Tag-arkiv: Karolinska Institutet

Postdoc position, Maintenance of neuronal identity

Karolinska Institutet, Department of Cell and Molecular Biology, Holmberg

The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology.

Division
The research group of Johan Holmberg is part of the Department of Cell and Molecular Biology (CMB) which recently moved to the new interdisciplinary research centre Biomedicum located at Campus Solna, Karolinska Institutet.

Background
The brain contains a large number of different neuronal subtypes that maintain their distinct identities over several decades despite continuous environmental fluctuation. Apart from the instructive information provided by transcription factors controlling cell type specific transcriptional programs, there is presumably also a need to maintain silencing of alternative transcriptional programs. The mechanisms governing permanent repression of aberrant transcription in mature neurons are not well understood. Our lab focuses on the role of repression of alternative gene programs for lifelong maintenance of serotonergic and dopaminergic identity. For a more extensive background see: Holmberg and Perlmann, Nature Review Genetics 2012 and Södersten, E. et al. Nature Commun. 2018. Besides exploring fundamental processes we also aim to understand how they influence clinically relevant topics including psychiatric disorders, neurodegeneration and aging. The group also harbour an interest in the understanding of the paediatric malignancy, neuroblastoma, see: Westerlund, et al. Proc Natl Acad Sci U S A 2017.

In this project we will generate and analyse large amounts of data from defined wild type/mutant mouse neuronal populations in order to understand the functional relevance of gene repression for safeguarding mature serotonergic and dopaminergic identity.

Position specific requirements
We are looking for an outstanding researcher able to analyse and integrate large sets of bulk and single cell RNA-seq with ChIP-seq data generated from restricted in vivo neuronal subpopulations. Additional experience with confocal image acquisition and analysis as well as with in vivo/in vitro standard methods (e.g. immunostaining, FACS, stereotactic injections, behavioural analysis and cell culture) will be considered as a distinct advantage. Thus we are primarily looking for a computational biologist with experience/interest in laboratory/animal work or an experimental biologist with extensive bioinformatic skill and interest.

The applicant must be able to communicate well in English.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • Cover letter stating the motivation to apply and key skills that match the profile 

The application is to be submitted on the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

First day of employmentas soon as possible
Reference number2-2626/2019
ContactJohan Holmberg, johan.holmberg@ki.se
Last application date14.Aug.2019 11:59 PM CET

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Post expires on Wednesday August 14th, 2019

Postdoctoral studies in a KA Wallenberg consortium dedicated to explore the molecular origins of breast cancer

Karolinska Institutet, Department of Oncology-Pathology, Group Göndör

At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. About 30 research groups with various cancer research profiles are involved and we have around 110 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

The project
We are seeking an outstanding candidate for a post-doctoral fellowship dedicated to explore the role of the epigenome and 3-dimensional nuclear architecture in the emergence of cancer stem-like cell states in breast cancer from entirely novel perspectives. The successful applicant is expected to drive a postdoctoral project in the labs of Anita Göndör and Rolf Ohlsson, as well as to participate in collaborative efforts within an interdisciplinary consortium consisting of five laboratories including pre-clinical, clinical and computer scientists. This consortium is aiming at uncovering hitherto unknown therapeutic targets in breast cancer, and is supported by a five-year grant from a major supporter of Swedish science, the KA Wallenberg Foundation. The successful applicant will employ state-of-the-art epigenomic techniques adapted to the analyses of single cells and single cell RNA-seq, and join a lab currently consisting of 5 PhD students, 4 postdocs and four affiliated professors.
Our lab is equipped with a Mi-seq machine and a 5-color confocal microscope, and is located within the Theme Cancer section of Bioclinicum at Karolinska Institutet.

https://ki.se/en/onkpat/anita-gondors-group

https://ki.se/en/onkpat/rolf-ohlsson-lab

For further information about our work, please consult the following recent publications: CD Mallet de Lima and Göndör A. Science 2018 Mar 16; 359(6381):1212-1213; Zhao et al, Mol Cell 59:984-97 (2015); Feinberg, Koldobiskiy and Göndör, Nature Review Genetics 17:284-99 (2016); Göndör and Ohlsson, Nature 2009; Sumida et al, BioRxiv 2018 doi: https://doi.org/10.1101/286583

Entry requirements
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.
The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

A PhD in relevant research areas (molecular and cellular biology) is mandatory. A strong scientific track record, supported by published papers particularly on the subject of chromatin research in well-recognized peer-reviewed journals and previous experience in chromatin research is advantageous. A high level of organizational and communicative skills, as well as an ability to independently perform experiments and implement interpretation of data is mandatory.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An employment application must contain the following documents in English:

  1. A complete curriculum vitae, including date of the thesis defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and any committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labor unions or student organizations, parental leave or similar circumstances
  5. Verification from the thesis defense committee or the equivalent (only if the thesis defense is scheduled within three months after the application deadline)

The application is to be submitted on the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

First day of employmentAccording to agreement
Reference number2-3215/2019
ContactAnita Göndör, anita.gondor@ki.seRolf Ohlsson, rolf.ohlsson@ki.se
Union representativeAndreas Lundqvist, SACO, 08 517 768 84Helen Eriksson, OFR, 08 517 762 79
Last application date30.Aug.2019 11:59 PM CET

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Post expires on Friday August 30th, 2019

Postdoctoral Researcher in biomaterials and tissue engineering

Labb prov.jpg

Karolinska Institutet, NVS

The Department of Neurobiology, Care Sciences and Society (NVS) conducts world leading research in aging, dementia, epidemiology and care sciences. This research extends from basic molecular and cell levels to clinical research and societal studies. NVS educates almost a third of KI students at basic and advanced levels. The Department has approximately 450 employees and a revenue 2018 of 490 million SEK. It comprises seven divisions, located at Campus Flemingsberg and Campus Solna.

Division
The research at the division of Neurogeriatrics is focused on neurodegenerative diseases, in particular Alzheimers disease and is strongly oriented towards translating findings from basic research into clinical practice.

The research group is located at Karolinska Institutet, campus Flemingsberg, and at SLU in Uppsala. We are currently five PhD students, two technicians, six post docs, two assistant professors, and two professors. We have developed the first biomimetic spinning method for production of artificial spider silk fibers. We have recently published several articles in high ranked journals (Andersson et al. Nat Chem Biol. 2017; Kronqvist et al. Nat Commun. 2017; Rising&Johansson. Nat Chem Biol. 2015). This project will be pursued with the Sköld/Risling laboratory in Biomedicum at campus Solna. We now want to expand the group with a one year postdoc postition with possibility of extension.

Duties
Spiders spin the toughest fiber known to man, and the fiber is well tolerated when implanted. This project aims at investigating if our artificial spider silk proteins (as coatings and fibers) can provide a suitable matrix for nerve cells and in the long run for nerve regeneration in animal models. The applicant is expected to produce artificial silk proteins in E.coli, purify them and make matrices and scaffolds. The material will be evaluated by culturing differentiated neuroblastomas, dorsal root ganglions, hippocampal nerve cells and Schwann cells. The best scaffolds may then be tested in animal models of peripheral nerve injury.

The successful candidate is expected to have a large interest in cell biology and tissue engineering, preferably with a focus on nerve tissue regeneration. Previous experience in culture and analysis of nerve cells is a requirement. Experience of animal work is a merit. The successful applicant is expected to enjoy practical lab work and independently generate and analyze data. The applicant should, when required, supervise doctorial students and master students in the lab. We work in collaboration with other groups and very interdisciplinary, which demands the applicant to be independent, creative, have a positive attitude and be collaborative. The applicant is expected to work at both KI campuses.

Entry requirements
Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. The applicant should have a doctoral degree in cell biology, medicine, biomedicine or similar topic. The successful candidate is expected to have a strong drive to pursue research, be organized and structured and have an ambitious and innovative attitude. The project is cross-disciplinary and pursued in collaboration with several research groups, and good collaborative skills are necessary. Previous documented and extensive practical experience of cell culture and analyses of cells or tissues derived from the nerve system is required. Experience of molecular biology and automated cell analyses are merits. Emphasis will be put on personal skills in the evaluation process. Very good ability to speak and write English is a requirement.

Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employmentPermanent position
Contract typeFull time
Number of positions1
Working hours100%
CityHuddinge
CountyStockholms län
CountrySweden
Reference number2-3962/2019
ContactAnna Rising, Senior Researcher,, +46 (0) 70-410 69 97, anna.rising@ki.seUlla Cronfalk-Hernlund, Head of Administration,, +46 (0) 8-524 868 18, ulla.cronfalk-hernlund@ki.seMaria Staiger, HR officer,, +46 (0) 8 524 837 79, maria.staiger@ki.se
Union representativeCarina Eklund, OFR, 08-585 826 65Henry Wölling, SEKO, 08-524 840 80Biborka Bereczky Veress, SACO, 46 70-173 85 75
Last application date13.Aug.2019 11:59 PM CET

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Post expires on Tuesday August 13th, 2019

Postdoctoral Researcher in intervention- and implementation research

Karolinska Institutet, Institutet för miljömedicin

The Institute of Environmental Medicine (IMM) is a department at Karolinska Institutet and an interdisciplinary research institution within the broad field of environmental medicine. IMM conducts cutting edge research within the areas of environmental and occupational medicine, toxicology, physiology, epidemiology, and biostatistics with the aim to clarify how environmental and lifestyle factors affect our health and which role genes have. IMM also serves as a scientific advisor to public authorities within the area of environmental medicine and IMM scientists participate in national and international expert groups.

Division
The postdoctoral researcher will be situated at the Institute of Environmental Medicine, the unit of intervention- and implementation research for worker health. The group is a multidisciplinary that consists of researchers in the field of occupational health, occupational health psychology, occupational health economics, health promotion, mental health and musculoskeletal health. The unit combines research on effective methods for the identification of risk factors for ill health with research on the development and evaluation of interventions for the promotion of health at the workplace.

The iSkol-project

Given today’s high prevalence of mental ill-health and related sick-leave among teachers an urgent need exists for a more sustainable working life for this professional group. One way of doing this is by improving schools’ social and organizational risk management. Recent reports have shown that many schools in Sweden lack a structured approach to the management of social and organizational risks. In 2015, we launched the first Swedish occupational health guideline to support a structured prevention of these risks at the workplace. The long-term goal of the iSkol-project is to support the implementation of this guideline within schools in order to improve the social and organizational risk management. By doing so we want to reduce risk factors for mental ill-health and related sick days. We are currently conducting a cluster-randomized controlled trial that compares the effectiveness of two implementation strategies for implementing the guideline in schools.


Duties
We are looking for a postdoctoral researcher, who can join the iSkol-project team. We are a team of junior and senior researchers who with great enthusiasm have been conducting the iSkol-project for the last 2,5 years. We have now come to the final year of the project and are keen to have a post-doctoral researcher onboard who can support us in quantitative data-analyses and manuscript-written in English. Duties will include data-cleaning, data-management, advanced statistical analysis and writing both scientific and popular-scientific articles. The position is for 1 year. 


Entry requirements
To be eligible for employment as postdoctoral researcher, the applicant must hold a Degree of Doctor, PhD, or have equivalent scientific expertise. We are looking for an independent researcher who has demonstrated experience with intervention- or implementation research studies evaluating intervention effectiveness. Knowledge of advanced statistical analysis-methods and statistical programs, such as SPSS is necessary. The applicant must also have experience in writing and publishing scientific articles. It is an advantage if the applicant has knowledge on organizational interventions. The applicant must be enthusiastic, precise, self-going, and responsible. Personal fit is important.


Application process

An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employmentTemporary position longer than 6 months
Contract typeFull time
First day of employmentAccording to agreement
SalaryMonthly salary
Number of positions1
Working hours100%
CitySolna
CountyStockholms län
CountrySweden
Reference number2-3855/2019
ContactLydia Kwak, Lydia.Kwak@ki.se
Union representativeBiborka Bereczky Veress, SACO, 070-173 85 75, biborka.bveress@ki.seAnne Boström, SEKO, 08-524 875 79, anne.bostrom@ki.seNiklas Andersson, OFR, 08-524 874 19, niklas.andersson@ki.se
Last application date11.Aug.2019 11:59 PM CET

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Post expires on Sunday August 11th, 2019

Marie Skodowska-Curie PhD student position in “Molecular Phenotyping of Parkinson’s disease iPS cells”

Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Molekylär Neurobiologi

A doctoral student is admitted to third-cycle/doctoral education. A doctoral education consists of supervised research, combined with courses and other educational activities. An individual study plan is established for each doctoral student. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

We invite applications for a PhD student position to be placed in the laboratory of Professor Ernest Arenas (http://ernestarenaslab.org/) at the Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics (MBB).

For more information regarding doctoral (PhD) education, see: http://www.ki.se/doctoral

Research environment
Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
The MBB department consists of 12 research divisions and about 350 employees. We conduct multidisciplinary research in multiple areas and education in Medicine and Biomedicine.

The Arenas laboratory focuses on understanding the entire life span of midbrain dopaminergic neurons, from development to neurodegeneration, and at devising new therapeutic strategies for Parkinson’s disease. We recently moved to a new building and excellent brand new research facilities are available.

The Arenas Lab is integrated in the Division of Molecular Neurobiology https://ki.se/en/mbb/research-division-of-molecular-neurobiology, a highly interactive, young, vibrant and very international research environment formed by seven research groups and about 70 people. English is our common language and it is used in all our activities. Our division provides a unique critical mass contributed by researchers with diverse backgrounds and expertise in multiple areas covering advanced genetics, cellular and molecular biology, high content single cell technologies, epigenetics, bioinformatics, imaging, biochemistry, multiple aspects of neuroscience, behavior, electrophysiology, developmental neurobiology, cellular reprogramming and stem cell biology.

The doctoral student project and the duties of the doctoral student
We are looking for a PhD student with interest and experience in the areas of cellular and molecular neurobiology, Parkinson’s disease genetics and bioinformatics. The student will develop a project involving single cell RNA-sequencing of Parkinson’s disease (PD)-induced pluripotent stem cells (iPSCs) and aiming at investigating the function of PD-relevant genes. The project will take advantage of a brain on a chip model of PD mimicking the nigrostriatal system.
The project will require capacity to work independently, but also in a collaborative manner. The student will have the opportunity to participate in training courses and perform research activities abroad (Italy, Spain and UK), will take PhD courses on the topic of the PhD project at KI, will participate in the research, seminars and educational activities of MBB, and will contribute to report the results of the project to the EU and to disseminate the results.

Eligibility requirements for doctoral education
In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree) or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

  • Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documentsKarolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

Skills and personal qualities
Main requirements:

– Master degree in Biomedical Sciences or Neurosciences.

– Less than 4 years of full-time research experience.

– Less than 12 months of residency in Sweden in the last 3 years prior to recruitment (EU mobility rule).

– Proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

For more information regarding the general entry requirements, please see:

https://ki.se/en/phd/entry-requirements-eligibility-for-doctoral-education

Specific requirements:

– The ideal candidate should have Python and R programming skills, knowledge of midbrain development, Parkinson’s disease and experience in at least two of these areas: single cell biology, stem cell biology, molecular biology and genetics.

– Strong motivation and capacity to pursue challenging research. The optimal candidate will be creative, critical, independent, open to new ideas, flexible, engaged, methodic and goal oriented.

– Excellent communication skills and proficiency in spoken and written English.

– Availability to travel nationally and internationally two to three times a year.

Desirable: 

– Experience in working with single-cell RNA-seq, dopaminergic differentiation of human pluripotent stem cells and Parkinson’s disease genetics.

– Previous training in a multidisciplinary international environment or outside of the country of origin or in a high profile lab.

Assessment criteria
A selection will be made among qualified applicants on the basis of the ability to benefit from doctoral education. Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research

– Analytical skills

– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

– Particular emphasis will be placed on the motivation, personal trajectory, skills and track record of the candidate.

The qualifications of the applicants will be evaluated on an overall basis.

Terms and conditions
The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process
Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.

Your application should contain the following documents:

  • A personal letter and a curriculum vitae (Swedish or English)
  • Degree projects and previous publications, if any (Swedish or English)
  • Any other documentation showing the desirable skills and personal qualities described above (Swedish or English)
  • Documents certifying your general eligibility (see A above)
  • Documents certifying your specific eligibility (see B above)

Selection
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

KI uses the following bases of assessment:

  • Documented subject knowledge of relevance to the area of research
  • Analytical skill
  • Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employmentPhD placement
Contract typeFull time
First day of employment1/10/2019
Salarymonthly
Working hours100%
CityStockholm
CountyStockholms län
CountrySweden
Reference number2-3484/2019
ContactErnest Arenas , +46 8-524 876 63
Last application date31.Jul.2019 11:59 PM CET

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Post expires on Wednesday July 31st, 2019

Post-doc in molecular PET imaging in non-human primates

Karolinska Institutet, Institutionen för klinisk neurovetenskap

The Department of Clinical Neuroscience (CNS) conducts research and education in the field of neuroscience from the molecular level to the society level. The clinical research and education is conducted in collaboration with Region Stockholm as well as other research groups from Karolinska Institutet and other universities.
Please visit our website for more information: ki.se/en/cns

Division
Brain Molecular Imaging Centre (BMIC) is a core facility for molecular imaging of the brain using positron emission tomography (PET). The aim of the core facility is to provide expertise and competence for brain imaging PET studies in human subjects and non-human primates (NHPs). BMIC supports research studies in psychiatric disorders, neurodegenerative disorders and neuropsychopharmacology. BMIC provides also broader expertise for key molecular PET imaging studies supporting drug development programs in other research and therapeutic areas. The access to NHPs at the Astrid Fagreus Laboratory (AFL) provides a fully translational research platform for rapid implementation and validation of new PET probes in human studies.  

Duties
The post-doc will be a part of Varrone´s Research Group at the Centre for Psychiatry Research (CPF). The post-doc will work together with the personnel involved in the non-human primate research, will be responsible for the analysis of the PET data and for the scientific presentation of the results. About 50% of the activity will conducted in collaboration with pharmaceutical companies, but the post-doc is also expected to contribute to the scientific production of the research group.    

Entry requirements
A person is eligible to be appointed Post-doc if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence.

In addition to this, the post-doc is expected to have good communication skills and pedagogical proficiency in order to supervise and teach PhD students or junior research personnel. Proficiency in English in writing and speaking is required. Knowledge in pre-clinical PET, kinetic modelling and radioligand development will be considered as a plus. To be able to work with NHP research the person has to have FELASA accreditation Function B or undergo training for obtaining such accreditation.

Application process
An application must contain the following documents in English:

  1. Curriculum vitae, qualifications and description of planned research, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/qualificationsportfolio).
  2. Date of planned public defense – if Degree of Doctor is not yet achieved
  3. A complete publication list.
  4. A summary of current work (maximum one page)

The application is to be submitted through the Varbi recruitment system. 

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employmentTemporary position longer than 6 months
Contract typeFull time
Number of positions1
Working hours100 %
CityStockholm
CountyStockholms län
CountrySweden
Reference number2-3118/2019
ContactAnders Ihrfors, 08-524 832 87Andrea Varrone, +46 70 744 27 28
Union representativeArsalan Amir, SACO, 08 – 517 733 37Henry Wölling, SEKO, 08-524 840 80Venus Azhary, OFR, 0707-124 127
Last application date02.Aug.2019 11:59 PM CET

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Post expires on Friday August 2nd, 2019

Doctoral (PhD) student position in pain research

Karolinska Institutet,

At the Department of Physiology and Pharmacology we teach and conduct internationally acclaimed, high-quality research in Physiology, Pharmacology, Anesthesiology and Intensive care. We have around 400 employees, 30 research groups, and 90 doctoral students. Our research fields include cellular signaling, cardiovascular and respiratory systems, neuropsychopharmacology, neuroinflammation, pharmacogenetics, regenerative medicine, Renal System, anesthesiology and intensive care, muscle physiology and pain. Our collaboration with the clinics at Karolinska University Hospital provides unique opportunities for translational research within our subjects. More information about research at http://ki.se/fyfa_english

A doctoral student is admitted to third-cycle/doctoral education. A doctoral education consists of supervised research, combined with courses and other educational activities. An individual study plan is established for each doctoral student. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

We are recruiting a doctoral (PhD) student. For more information regarding doctoral education at Karolinska Institutet (KI), see: http://ki.se/en/phd/about-doctoral-education-at-ki

Research group
The overall research mission for the molecular pain research group led by Prof. Camilla Svensson is to advance our understanding of how pain is induced and sustained, in particular in conditions with persistent pain such as in rheumatoid arthritis, osteoarthritis and fibromyalgia. In this context, we are exploring novel links between the adaptive immune system, activation of osteoclasts and satellite glial cells and regulation of pain signal transmission. Intracellular signaling pathways that are activated or deactivated in this process are being dissected and studied in relation to persistent pain. We use a number of behavioral, immunological, immunohistochemical, electrophysiological and molecular biological techniques to dissect pain pathways in vivo and in cell culture systems. The research group (10 PhD students, postdoctoral fellows and staff members) collaborate with preclinical as well as clinical researchers not only within Karolinska Institutet, but also at other Swedish and international universities. See below for more specific information about the doctoral education project and the duties of the student.

About the BonePain Network

We have 1 open positions for PhD fellows in the EU-funded Innovative Training Network BonePainII (www.bonepain.eu). BonePainII is a European Innovative Training Network to promote frontline research, innovation and education within bone pain. Millions in Europe and beyond suffer from bone pain, which is a debilitating complication of many musculoskeletal disorders such as arthritis and bone metastasis. The BonePainII network has participants from 6 European countries and encompasses 8 academic groups and 4 industries all committed to creating an outstanding training program for 15 early stage researchers (ESRs) to elucidate the mechanisms of bone pain and develop new medicines.

The project is funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 814244.

Project title: Autoantibodies and osteoclasts – novel links to chronic pain in rheumatoid arthritis

The main focus of the current PhD project will be to examine which and how autoantibodies derived from RA-patients’ B-cells induce pain hypersensitivity and increase neuronal excitability via activation of osteoclasts. There will be a specific focus on new disease-associated autoantibodies and the long-term consequence of these autoantibodies on the sensory nervous system. The student will work from both a cellular (pain neurons, osteoclasts, and B cell) and molecular (microRNA and long non-coding RNA) perspective and the project is placed in the interphase between neuroscience, immunology and bone biology. The student will  learn several techniques for analysis of joint pathology and bone erosion and immunological and molecular biological tools applied to cell culture systems . The project also includes in vivo behavioural assays and analysis of patient samples. The student will be part of a larger research network in Stockholm consisting of preclinical and clinical researchers.

Eligibility requirements for doctoral education
In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree) or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

  • Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documentsKarolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

Specific requirements for the Innovative Training Network (ITN)

All PhD students recruited in an ITN must be Early-Stage Researchers (ESR). ESR can be of any nationality and age, and they must comply with the LEVEL OF EXPERIENCE and MOBILITY RULE (see below).

Level of experience

Early-Stage Researchers (= PhD Students) must, at the date of recruitment by the beneficiary, be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree. The date of recruitment means the first day of the employment of the researcher for the purposes of the action (i.e. the starting date indicated in the employment contract or equivalent direct contract). Full-time equivalent research experience is measured from the date when the researcher obtained the degree entitling him/her to embark on a doctorate (either in the country in which the degree was obtained or in the country in which the researcher is recruited), even if a doctorate was never started or envisaged.

Mobility rule

Researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of the recruiting beneficiary for more than 12 months in the 3 years immediately before the recruitment date. Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status under the Geneva Convention are not taken into account.

Skills and personal qualities
We are seeking a highly motivated, talented student who has the maturity and desire to study hard and independently as well as work in a group setting. The day-to-day studies are to a large extent laboratory based and require self-motivation. In addition, the research is team based and the group have multiple ongoing collaborative projects and as such the applicant must have strong communication skills and an ability to interact effectively and work productively in a collaborative manner. The applicant must be fluent in English, with excellent communication and writing skills. A genuine high level of curiosity for research in general and in the pain field in particular is advantageous. Previous experience in the fields of neuroscience, immunology and/or behavioral pharmacology is considered an advantage for this project. Emphasis will be placed on personal skills, motivation and previous experience of laboratory work.

Key criteria for the assessment of applicants

  • Relevant skills and knowledge
  • Previous publications
  • Relevant work experience
  • The grades achieved during bachelor/master studies
  • Language skills
  • Assessment of the candidate’s motivation letter

The qualifications of the applicants will be evaluated on an overall basis.

Terms and conditions
The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process
Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.

Your application should contain the following documents:

  • A personal letter and a curriculum vitae (Swedish or English)
  • Degree projects and previous publications, if any (Swedish or English)
  • Any other documentation showing the desirable skills and personal qualities described above (Swedish or English)
  • Documents certifying your general eligibility (see A above)
  • Documents certifying your specific eligibility (see B above)

*All documents certifying the entry requirements must be scans of originals (scans of copies or certified copies will not be accepted). The scanned documents must be in color and both the front and the back of the documents must be scanned. Please note that there are specific documentation requirements for a number countries, please read the instructions at: http://ki.se/en/phd/entry-requirements-eligibility-fordoctoral-education

If an applicant claims equivalent konwledge (point 3 under general entry requirements above) for the eligibility assessment, a form has to be filled in and submitted. Please find more information here: https://ki.se/en/phd/assessing-equivalent-knowledge-for-general-eligibility-for-doctoral-education

Selection
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

KI uses the following bases of assessment:

  • Documented subject knowledge of relevance to the area of research
  • Analytical skill
  • Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

The selection process will include several steps. The most suitable applicants will proceed to the next step which includes personal interviews. All applicants will be informed when the recruitment is completed.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employmentPhD placement
Contract typeFull time
First day of employmentIn agreement
SalaryMonthly salary
Reference number2-3524/2019
ContactCamilla Svensson, camilla.svensson@ki.se
Union representativeBo Rydqvist, SACO, 08-524 872 67Niklas Andersson, OFR, niklas.andersson@ki.seHenry Wölling, SEKO, 08-524 840 80
Last application date31.Jul.2019 11:59 PM CET

Read the job description at the university homepage

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Post expires on Wednesday July 31st, 2019

Doctoral (PhD) student position in PET Radiochemistry

Karolinska Institutet, Department of Clinical Neuroscience

The Department of Clinical Neuroscience (CNS) conducts research and education in the field of neuroscience from the molecular level to the society level. The clinical research and education is conducted in collaboration with Region Stockholm as well as other research groups from Karolinska Institutet and other universities.
Please visit our website for more information: ki.se/en/cns

A doctoral student is admitted to third-cycle/doctoral education. A doctoral education consists of supervised research, combined with courses and other educational activities. An individual study plan is established for each doctoral student. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

Research group
Positron Emission Tomography (PET) is a translational molecular imaging technique increasingly used in biomedical research. It allows the investigation of bio-chemical transformations of drugs or other molecules in living systems and thereby offers possibilities to study physiology, molecular biology, energy metabolism, drug-receptor or drug-enzyme interactions etc. Moreover, PET is important not only from the diagnostic point of view, it can also play an important role in the discovery of new drugs. The PET research group at Karolinska Institutet is one of the leading research groups in the world in this area.

The doctoral student project and the duties of the doctoral student
Microfluidic technology rapidly growing in the field of synthetic chemistry. The main advantage of the microfluidic technique is the high surface to volume ratio, which can increase the speed of the labeling reaction and improve the overall efficiency of the labeling reaction process. In addition, of that the easily shielding of the small microfluidic device has made it in many regards, the ideal platform for the rapid type of radiolabeling required for PET.

The aim of this project to train the next generation of chemists with expertise in isotopic labeling and advanced medicinal chemistry through a first-class taught and research training program combined with a highly interactive plan; i) to develop automated cGMP‐compliant 11C, 18F, 68Ga labeled radiosynthesis using iMiLAB radiochemistry module and to apply the new labeling methods to drugs currently in development in order to provide solutions to the most pressing problems in drug innovation ii) to produce [11C]CH3I using plasma generation technology in a closed system to comply with GMP production of radioligands for clinical and preclinical use and iii) the 3rd aim of this study is based on the hypothesis of producing 68Ga with a 68Zn based target solution and further labeling of PET radioligands by 68Ga isotope using iMiLAB radiochemistry module.

We offer a first class education at Karolinska Institutet in collaboration with our colleagues in the Isotopics network.

Eligibility requirements for doctoral education
In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirementYou meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree) or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement
You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

  • Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documentsKarolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

Skills and personal qualities
We are looking for one motivated and skilled organic chemists/chemical engineer that can help us take the next steps in the development of methods for introducing 11C, 18F, 68Ga into radioligands for PET imaging.

It is desired that you have a science Master´s degree in Organic Chemistry or Chemical engineering.

Terms and conditions
The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process
Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.

Your application should contain the following documents:

  • A personal letter and a curriculum vitae (Swedish or English)
  • Degree projects and previous publications, if any (Swedish or English)
  • Any other documentation showing the desirable skills and personal qualities described above (Swedish or English)
  • Documents certifying your general eligibility (see A above)
  • Documents certifying your specific eligibility (see B above)

Selection
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

KI uses the following bases of assessment:

  • Documented subject knowledge of relevance to the area of research
  • Analytical skill
  • Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employmentPhD placement
Contract typeFull time
First day of employmentAs agreed
SalaryMonthly salary
Reference number2-3085/2019
Contact
Anders Ihrfors, 08-524 832 87Sangram
Nag, sangram.nag@ki.se
Union representative
Arsalan Amir, SACO, 08 – 517 733 37
Henry Wölling, SEKO, 08-524 840 80
Venus Azhary, OFR, 0707-124 127
Last application date21.Jul.2019 11:59 PM CET

Read the job description at the university homepage

Login and apply

Post expires on Sunday July 21st, 2019

Postdoctoral Researcher in transcriptomics of neurodegenerative disorders (scholarship)

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Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Molecular Neurobiology

Division
The Department of Medical Biochemistry and Biophysics (MBB) conducts research in basic science, particularly focusing on discovering the mechanisms that cause diseases. The candidate will be incorporated into the division of Molecular Neurobiology

Research group and project
A postdoctoral position is available in the recent established lab of Ana Muñoz-Manchado at Karolinska Institutet, one of the world’s leading biomedical research institutes. Our interest in the lab is focused in the investigation of the striatal neuronal diversity and how cell specific gene regulatory networks are affected by neurodegenerative processes in Parkinson’s disease, and how the neuron’s circuit functionality is changed using both mouse models and patient material.

Duties
The person will work with modeling parkinsonism in mice and analysis of human patient material in order to study the striatal transcriptomic changes using RNA single cell sequencing, and assessing the impact on the neural circuitry.

To apply for the position, the applicant should have obtained a PhD no more than five years before the position starts in the neuroscience field. The successful applicant is experienced in molecular biology and animal experimentation. Experience in bioinformatics and single cell data analysis (R-studio, matlab…) is meriting. The applicant is expected to be a highly motivated scientist, enthusiastic person, with high degree of independence, and be able to integrate in a team and collaborative environment. Possibility of attracting own funding will be also a plus. Fluency in English is a requirement (written and oral).

Entry requirements
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employmentPostdoctoral scholarship
Contract typeFull time
First day of employmentupon agreement
SalaryStipend
Working hours100%
CitySolna
CountyStockholms län
CountrySweden
Reference number2-3288/2019
Contact
Ana Munoz Manchado, +46 8 524 8694
Union representative
Anne Edgren, OFR/S, P, O, 08-52487570
Henry Wölling, SEKO, 08-524 840 80
Last application date31.Jul.2019 11:59 PM CET

Read the job description at the university homepage

Login and apply

Post expires on Wednesday July 31st, 2019