Tag-arkiv: Karolinska Institutet

Postdoc in Neuroinflammation, with focus on resolving inflammation in the brain (scholarship)

The Department of Neurobiology, Care Sciences and Society (NVS) conducts world-leading research in aging, dementia, epidemiology and care sciences. This research extends from basic molecular and cellular levels to clinical research and societal studies.

The Division of Neurogeriatrics consists of about 85 employees. The division conducts experimental and translational research related primarily to Alzheimer’s disease and other neurodegenerative diseases, but also more general molecular mechanisms with biomedical relevance are studied.

The Schultzberg lab addresses fundamental questions in neuroinflammation with the aim to find new treatment targets in Alzheimer’s disease. Our studies build upon in vivo and in vitro models as well as on analysis of human clinical samples, in order to elucidate the molecular and cellular mechanisms for resolving neuroinflammation and regaining homeostasis in the brain. Resolution of inflammation in the brain is a relatively new research field and our studies aim to provide knowledge on the signals for resolving inflammation in the brain and whether stimulation or modulation of these is beneficial for neuronal functioning and eventually as a potential target for the treatment of patients.

Position

A postdoctoral position (scholarship) is now open in projects devoted to exploring the role of inflammation and its resolution in the brain, with particular attention to Alzheimer’s disease.

The postdoctoral fellow is expected to play a leading role in experimental design, experimentation, analysis, as well as presentation/publication of results.

Entry requirements

The applicant should be a highly motivated individual who can collaborate and function well in a team. We are looking for a person who holds a PhD and has an interest in neuroscience/neuroinflammation, and with skills preferably in more than one of the following areas: single cell RNA-sequencing, cell biology, lipidomics and histological methods. Previous experience with mouse animal work is also desirable and appropriate certificate for mouse animal work (FELASA C or equivalent) is a merit. Excellent English oral and writing skills is a requirement.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post-doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Stockholm (Solna)

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Reference numberSTÖD 2-5276/2020
ContactMarianne Schultzberg, Professor, Marianne.Schultzberg@ki.seJohanna Lundblad, HR-partner, Johanna.Lundblad@ki.se
Union representativeCarina Eklund, OFR, 08-585 826 65Taher Darreh-Shori, SACO, 08-524 835 29Henry Wölling, SEKO, henry.wolling@ki.se
Last application date15.Jan.2021 11:59 PM CET

Read the job description at the university homepage

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Post expires on Friday January 15th, 2021

Postdoctoral Researcher in: “Functional Genomics of Parkinson’s disease”

Do you want to contribute to improving human health?

We invite applications for a postdoctoral position in the laboratory of Professor Ernest Arenas: http://ernestarenaslab.org/. The position will be placed in the Division of Molecular Neurobiology, a cluster of 7 research groups forming a dynamic and collaborative research environment within the MBB department.

Our laboratory is located in the Biomedicum building, one of the most modern research centers in Northern Europe, within a world leading University, Karolinska Institutet. Our lab offers an inclusive, interactive, multidisciplinary, international research work environment, where you can develop your career and do science that can make a difference.

Your mission

We look for postdoctoral interested in working in a project aiming at: (i) identifying the function of genes associated to the risk of suffering Parkinson’s disease using CRISPR/dCas9 strategies and dopaminergic neurons derived from human pluripotent stem cells, (ii) assessing the contribution of these genes to disease phenotype in PD-iPS cells, and (iii) developing strategies to correct phenotypic abnormalities in PD-iPS cells.

The project is based on our recent characterization of (i) the cellular and molecular complexity of the developing mouse and human midbrain at the single cell level (La Manno et al., Cell, 2106), (ii) the identification of cell-types associated to the genetic risk of PD, as assessed by combining single cell RNA-seq data and genome-wide association data (Bryois et al., Nature Genetics, 2020), and (iii) ongoing studies aiming at defining changes in gene expression and chromatin at the single cell level in idiopathic and familial PD.

The successful candidate will participate in all the activities of the lab, including scientific meetings, international networks and education of medical/biomedical students.

Your profile

You are a PhD or a Postdoc with working on Parkinson’s disease, genetics, neuroscience, molecular, developmental or stem cell biology. You have demonstrated skills in molecular and cellular biology, biochemistry, cell-based screens and stem cell culture. The preferred candidate will have previous experience in Parkinson’s disease genetics or cellular mechanisms of PD. Knowledge or experience in genomics, transcriptomics, proteomics, lipidomics, bioinformatics, or drug screening will be an additional advantage. Publications in high profile journals and experience in working in a multidisciplinary international environment will be considered as merits. Applicants should have good communication skills and be proficient in spoken and written English.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

What do we offer?

Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

We offer a two-year (1+1 year) full time (100%) postdoctoral position starting in 2021. Our laboratory and our division offer a creative, collaborative, interdisciplinary and international research environment, where you will have the opportunity to seek personal development, enjoy science and make a difference.


Location:
Solna, Biomedicum

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Application

Your application must contain the following documents in English:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications.
  3. A summary of current work (no more than one page).
  4. Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline).
  5. A letter of motivation (no more than one page)
  6. Three references or reference letters

In assessing candidates we will place our emphasis on the personal trajectory, education, personal and technical skills, CV, merits and previous experience.

Welcome to apply at the latest 8th of January 2021.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Type of employmentTemporary position longer than 6 months
Contract typeFull time
First day of employmentUpon agreement
SalaryMonthly salary
Number of positions1
Working hours100 %
CityStockholm
CountyStockholms län
CountrySweden
Reference numberSTÖD 2-5200/2020
ContactErnest Arenas, Professor , ernest.arenas@ki.se
Union representativeVenus Azhary, OFR, 0707-124 127
Last application date08.Jan.2021 11:59 PM CET

Read the job description at the university homepage

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Post expires on Friday January 8th, 2021

Doctoral (PhD) student position in Cellular Biophysics – Astrocytes

Karolinska Institutet, Department of Women´s and Children’s Health

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Pediatric Cell and Molecular Biology Lab located in SciLifeLab and Karolinska Institute is looking for a motivated PhD student that will work on biophysical principles for astrocyte energy turnover in the tripartite neurological synapse. The principal supervisor will be Prof. Hjalmar Brismar and co-supervisors will be Dr Erdinc Sezgin (KI, SciLifeLab), Dr. Stefan Wennmalm (KTH, SciLifeLab), and Dr. Mia Lindskog (KI & Uppsala University).

Together with KTH we operate the national super-resolution microscopy laboratory at SciLifeLab and provides our lab members unique opportunities to develop and/or apply state-of-the-art imaging methodologies to solve biological mysteries.

Within the Department of Clinical Pediatrics we are currently offering two PhD positions, one in the Pediatric Cell and Molecular Biology Lab and one in the CSI:Nano Lab, both located in SciLifeLab. For information on the second position.

Karolinska Institute and SciLifeLab offer a creative and inspiring environment full of expertise and curiosity. SciLifeLab is an institution for the advancement of molecular biosciences in Sweden. It leverages the unique strengths of individual researchers across Sweden into a focused resource for the life science community. SciLifeLab provides access for thousands of researchers to the cutting-edge instrumentation and deep scientific expertise necessary to be internationally competitive in bioscience research. The facilities and expertise at SciLifeLab create a unique environment for carrying out health and environmental research at the highest level.

The PhD student will be based at SciLifeLab Solna (www.scilifelab.se) where the working atmosphere is international with English as the working language.

The doctoral student project and the duties of the doctoral student

The primary goal of the PhD project is to study how energy is regulated and astrocytes are polarized in order to create and support the tripartite neurological synapse. The core of this project is super-resolution microscopy studies of living cells with the aim to get new insights about the mechanisms of the dynamic interaction between astrocytes and synapses. This will give the student a background in two fast-growing fields with great potential for future use: super-resolution microscopy and astrocytic function.

Planned scientific learning outcomes of the project will be significant expertise in cellular biophysics, neuroscience and state-of-the-art super-resolution imaging. We will ensure this with weekly meetings, journal clubs where the student is encouraged to read and present scientific papers and attendance to international conferences where the student is encouraged to present her/his work. The student will be provided with the necessary supervision to gain expertise in writing, science communication and teaching.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement
You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree) or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documentsKarolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

Skills and personal qualities

Qualified to be employed as a PhD student is one who has obtained a MSc or has equivalent scientific competence. Applicants who have not completed a MSc at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s current university.

Necessary skills and personal qualities

  • BSc in life or natural sciences (biology, molecular biology, physics, chemistry or similar)
  • MSc in biology, biophysics or related field
  • Strong interest in cell biology
  • Experience in fluorescence microscopy
  • Proficiency in cell and molecular biology techniques
  • Good communication skills, team work abilities, willingness to help PhD/master students
  • Willingness to contribute to open and transparent science

Desirable skills and personal qualities

  • Experience in scientific programming (e.g. Phyton)
  • Experience in advanced bioimaging (spectroscopy, super-resolution techniques etc.)

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

https://api.kaltura.nordu.net/p/318/sp/31800/embedIframeJs/uiconf_id/23450616/partner_id/318?iframeembed=true&playerId=kaltura_player&entry_id=0_g04wq80a&flashvars[streamerType]=auto&flashvars[localizationCode]=en&flashvars[leadWithHTML5]=true&flashvars[sideBarContainer.plugin]=true&flashvars[sideBarContainer.position]=left&flashvars[sideBarContainer.clickToClose]=true&flashvars[chapters.plugin]=true&flashvars[chapters.layout]=vertical&flashvars[chapters.thumbnailRotator]=false&flashvars[streamSelector.plugin]=true&flashvars[EmbedPlayer.SpinnerTarget]=videoHolder&flashvars[dualScreen.plugin]=true&flashvars[Kaltura.addCrossoriginToIframe]=true&&wid=0_gg58khmj

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.

Your application should contain the following documents. We prefer that your application is written in English, but you can also apply in Swedish:

– A personal letter and a curriculum vitae 
– Degree projects and previous publications, if any 
– Any other documentation showing the desirable skills and personal qualities described above 
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Application Deadline: 6 January 2021

Visit CSI:Nano: https://www.csi-nano.org

Visit SciLifeLab: www.scilifelab.se

Visit SciLifeLab Facilities: http://www.scilifelab.se/facilities/alm/

Visit KBH: https://ki.se/en/kbh/department-of-womens-and-childrens-health

Want to make a difference? Join us and contribute to better health for all

Type of employmentPhD placement
Contract typeFull time
First day of employmentAccording to agreement
SalaryMonthly salary
Reference numberSTÖD 2-4877/2020
ContactKarin Björström, 08-524 823 67Hjalmar Brismar, hjalmar.brismar@ki.se
Union representativeHenry Wölling, SEKO, henry.wolling@ki.seBodil Moberg , OFR, 08-524 836 01John Inge Johnsen , SACO, john.inge.johnsen@ki.se
Last application date06.Jan.2021 11:59 PM CET

Read the job description at the university homepage

Login and apply

Post expires on Wednesday January 6th, 2021

ERC-funded Postdoctoral Researcher in single-cell immunology

Do you want to contribute to top quality medical research?

We are looking for an ambitious postdoc with solid single-cell immunology skills to join our highly accomplished team of immunologists in a project (GUT-SEQ) funded by the European Research Council (ERC). We offer a stimulating environment in a rapidly moving research frontier.

Your mission

The Mjösberg group (https://mjosberglab.wixsite.com/ilcs and https://ki.se/en/medh/jenny-mjosberg-group) studies the development, regulation and function of innate lymphoid cells (ILCs), in humans, and how these cells contribute to pathology in mucosal organs such as the lung and gut. The studies are translational as they involve advanced basic molecular and cellular immunological investigations of precious human tissue samples to discover novel disease mechanisms and therapy targets. The group is internationally recognized as a leader in the field through several high impact publications in recent years (Nat Immunol 2016, Nat Comm 2020, Cell Res 2020 etc).

The postdoc will continue the successful line of investigations utilizing single-cell RNA sequencing (scRNA-seq) to dissect human intestinal mucosal ILC and T cell biology in health and disease. The successful candidate will be part of a team in an ongoing project that involves dissection of gut-associate lymphoid tissues from human intestinal specimens and generation of scRNA-seq (SMARTseq and 10X genomics) data as well as multicolor flow cytometry data of human mucosal ILCs and T cells from these tissues. The data will be analyzed in close collaboration with bioinformaticians at SciLifeLab. As this is a team effort, excellent communication skills are essential, as is proven ability to work in multidisciplinary teams. It is expected that the postdoc also supervises students and other researchers if necessary, as well as contribute to common lab duties.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

The candidate must hold a PhD equivalent to a Swedish doctoral degree in the field of immunology. The candidate must fully master multidimensional (>20 parameters) flow cytometry analysis and sorting, as well as be experienced in scRNAseq. Experience in isolation and in vitro culturing of primary immune cells is a requirement, as is basic functional in vitro assessments of immune cell function such as intracellular cytokine stainings, ELISA etc. The candidate should be familiar with R software and have some experience analyzing scRNAseq data. The candidate should have a strong publication track-record. The candidate should be self-motivated, have good communications skills and a proven ability to interact effectively and work productively in an interdiciplinary team. Fluency in English is a requirement as well as some basic skills and willingness to learn Swedish.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.


Location:
Flemingsberg

Read more about the Center for Infectious Medicine here,
and more about the project you will be working on here.

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Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)
  • A personal letter explaining the interest in the position
  • Contact details for two referees

Welcome to apply at the latest 2021-01-31

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Type of employmentTemporary position longer than 6 months
Contract typeFull time
First day of employmentAccording to agreement
SalaryMonthly salary
Number of positions1
Working hours100%
CityHuddinge
CountyStockholms län
CountrySweden
Reference numberSTÖD 2-5215/2020
ContactJenny Mjösberg, jenny.mjosberg@ki.se
Union representativeBelinda Pannagel, SACO, belinda.pannagel@ki.seChristina Hammarstedt, OFR, christina.hammarstedt@ki.se
Last application date31.Jan.2021 11:59 PM CET

Read the job description at the university homepage

Login and apply

Post expires on Sunday January 31st, 2021

Doctoral (PhD) student position in Cellular Biophysics – Cell Signalling

Karolinska Institutet, Department of Women´s and Children’s Health

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

Cell Signalling, Immunity and Nanoimaging (CSI:Nano) Lab located in SciLifeLab and Karolinska Institute is looking for a motivated PhD student that will work on biophysical principles underlying cell signalling. The principal supervisor will be Dr Erdinc Sezgin and co-supervisors will be Dr Ilaria Testa (KTH, SciLifeLab), Dr Hjalmar Brismar (KI, KTH, SciLifeLab) and Dr Micheal Dustin (Oxford).

CSI:Nano Lab provides its members opportunity to develop and/or apply state-of-the-art imaging methodologies to solve biological mysteries. Necessary training on the advanced bioimaging technologies will be given to the students. CSI:Nano Lab gives the candidates opportunity to become fully independent researchers in interdisciplinary science within years.

Within the Department of Clinical Pediatrics we are currently offering two PhD positions, one in the CSI:Nano Lab and one in The Pediatric Cell and Molecular Biology Lab both located in SciLifeLab. For information on the second position.

Karolinska Institute and SciLifeLab offer a creative and inspiring environment full of expertise and curiosity. SciLifeLab is an institution for the advancement of molecular biosciences in Sweden. It leverages the unique strengths of individual researchers across Sweden into a focused resource for the life science community. SciLifeLab provides access for thousands of researchers to the cutting-edge instrumentation and deep scientific expertise necessary to be internationally competitive in bioscience research. The facilities and expertise at SciLifeLab create a unique environment for carrying out health and environmental research at the highest level.

The PhD student will be based at SciLifeLab Solna (www.scilifelab.se) where the working atmosphere is international with English as the working language.

The doctoral student project and the duties of the doctoral student

The goal of the PhD project is to develop advanced super-resolution techniques to visualize the role of nanoscale dynamic transient molecular interactions during cell signalling. Specific focus will be lipid-lipid and lipid-sugar interactions in the membrane of cells.  The student will be involved in developing technologies and biological application of these technique. 

Planned scientific learning outcomes of the project will be significant expertise in membrane biology, biophysics, immunology and state-of-the-art super-resolution imaging. We will ensure this with weekly meetings, journal clubs where the student is encouraged to read and present scientific papers and attendance to international conferences where the student is encouraged to present her/his work. The student will be provided with the necessary supervision to gain expertise in writing, science communication and teaching.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement
You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree) or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documentsKarolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

Skills and personal qualities

Qualified to be employed as a PhD student is one who has obtained a MSc or has equivalent scientific competence. Applicants who have not completed a MSc at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s current university.

Necessary skills and personal qualities

  • BSc in life or natural sciences (biology, molecular biology, physics, chemistry or similar)
  • MSc in biophysics or related field
  • Experience in bioimaging technologies (single molecule techniques, super resolution etc.)
  • Experience in membrane biology
  • Proficiency in basic cell and molecular biology techniques
  • Strong interest in cell biology and immunity
  • Good communication skills, team work abilities, willingness to help PhD/master students
  • Willingness to contribute to open and transparent science

Desirable skills and personal qualities

  • Expertise in scientific programming (e.g. Phyton) is an advantage but not essential

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

https://api.kaltura.nordu.net/p/318/sp/31800/embedIframeJs/uiconf_id/23450616/partner_id/318?iframeembed=true&playerId=kaltura_player&entry_id=0_g04wq80a&flashvars[streamerType]=auto&flashvars[localizationCode]=en&flashvars[leadWithHTML5]=true&flashvars[sideBarContainer.plugin]=true&flashvars[sideBarContainer.position]=left&flashvars[sideBarContainer.clickToClose]=true&flashvars[chapters.plugin]=true&flashvars[chapters.layout]=vertical&flashvars[chapters.thumbnailRotator]=false&flashvars[streamSelector.plugin]=true&flashvars[EmbedPlayer.SpinnerTarget]=videoHolder&flashvars[dualScreen.plugin]=true&flashvars[Kaltura.addCrossoriginToIframe]=true&&wid=0_gg58khmj

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.

Your application should contain the following documents. We prefer that your application is written in English, but you can also apply in Swedish:

– A personal letter and a curriculum vitae 
– Degree projects and previous publications, if any 
– Any other documentation showing the desirable skills and personal qualities described above 
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Application Deadline: 10 December 2020

Visit CSI:Nano: https://www.csi-nano.org

Visit SciLifeLab: www.scilifelab.se

Visit SciLifeLab Facilities: http://www.scilifelab.se/facilities/alm/

Visit KBH: https://ki.se/en/kbh/department-of-womens-and-childrens-health

Want to make a difference? Join us and contribute to better health for all

Type of employmentPhD placement
Contract typeFull time
First day of employmentAccording to agreement
SalaryMonthly salary
Reference numberSTÖD 2-4817/2020
ContactKarin Björström, 08-524 823 67Erdinc Sezgin, erdinc.sezgin@ki.se
Union representativeHenry Wölling, SEKO, henry.wolling@ki.seBodil Moberg , OFR, 08-524 836 01John Inge Johnsen , SACO, john.inge.johnsen@ki.se
Last application date06.Jan.2021 11:59 PM CET

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Post expires on Thursday December 10th, 2020

Postdoctoral Bioinformatician in Pain Omics (scholarship)

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Do you want to contribute to top quality medical research?

We invite applications for a joint postdoctoral position in Drs. Camilla Svensson and Kim Kultima’s research groups that explores cellular and molecular mechanisms underlaying chronic pain states omics technologies for improved healthcare, respectively. The position will be placed in the Department of Physiology and Pharmacology at the Karolinska Institutet, which has collegial, international and dynamic research environment. The Svensson lab is part the Center for Molecular Medicine (CMM) located on the premises of the Karolinska Hospital. We offer an exciting, open, and collaborative research work environment and project, where you can make a difference.

Your Mission

The Postdoctoral Fellow that join our teams will be investigating pain mechanisms in conditions such as fibromyalgia, rheumatoid arthritis and pelvic pain. The focus will be on systems biology, systems medicine, network medicine and related bioinformatics and data analysis of mass spectrometry based metabolomics/lipidomics, proteomics and other omics data generated from human biofluids (CSF, serum and plasma) of patients suffering from chronic pain states as well as from animal models. You will be working closely together with technicians, chemists, mass spectrometry experts and preclinical and clinical researchers with a mission to increase our ability to study pain from a translational perspective.

The aim is to advance our understanding of the regulation of pain transmission in relation to persistent pain.

Your Profile

You are a creative, hardworking and enthusiastic team player. You have a PhD in biotechnology, computational biology, bioengineering or another relevant field.

You have a strong background in bioinformatics or similarly. Documented practical experience of scripting using R, statistical and bioinformatics analyses of metabolomics, lipidomics, proteomics data and/or other types of omics data is considered a strong meritas well as an understanding of the molecular basis of pain signalling. Apart from omics data analyses, you are willing to take part in other aspects of experimental planning and analysis of data generated in vivo and in vitro studies.

You can work independently but also have the interpersonal and communication skills to succeed at working in a multidisciplinary team. You have a deep sense of responsibility, take initiatives and have capacity and flexibility to work with researchers and students with different expertise.

You have a very good written and spoken English and is a good communicator, both when it comes to  presentations and preparation of publications. You have good recommendations from previous supervisors/teachers.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. The position has a possibility of extending in to a employment after the scholarship period for an additional two years.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

We do we offer?

You will work in a creative, inspiring and vibrant research environment. You will be part of two research teams that are dedicated to undertaking translational research with the ultimate goal to uncover cellular and molecular reasons behind pain chronicity and contribute to the improvement of life quality for individuals suffering from chronic pain.

The appointment will be at the Karolinska Institutet but the applicant will spend part-time at Karolinska Institute and part-time at Uppsala University at the mass spectrometry unit located at Dept. of Clinical Chemistry and Pharmacology (Uppsala University Hospital). For more information please visit: http://ki.se/en/fyfa/molecular-pain-researchhttp://www.caramba.clinic 

You will receive postdoctoral training in the laboratories of Drs. Svensson and Kultima, who will provide mentorship and opportunities for personal and professional development and a platform for building a future career in research.

Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct cutting edge medical research and hold the largest range of medical education in Sweden.

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

First day of employmentUpon agreement
SalaryScholarship
Working hours100%
Reference numberSTÖD 2-4622/2020
ContactCamilla Svensson, Professor, camilla.svensson@ki.seKim Kultima, Assoc. Professor, kim.kultima@medsci.uu.se
Union representativeHenry Wölling, SEKO, henry.wolling@ki.seHelin Norberg, SACO, helin.norberg@ki.seGunnel Brolin, OFR, gunnel.brolin@ki.se
Last application date13.Dec.2020 11:59 PM CET

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Post expires on Sunday December 13th, 2020

Postdoctoral studies in reproductive biology & epigenetic inheritance (scholarship)

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Do you want to contribute to improving human health?

Division

The postdoc project will be conducted in Qiaolin Deng’s research group with the organizational affiliation to Dept. Physiology and Pharmacology. The research group is interested in lineage specification of germ cells and its implication in germ cell tumors and epigenetic inheritance of disease. Our goal is to better understand the mechanism of how genetic and epigenetic network controlling fate decisions in the temporal and spatial manner with the state-of-the-art technologies.

Please check our lab’s website for more information: www.thedenglab.org

Duties

The group has established several key resources and techniques in the lab including mouse reporter lines, human ESC culture and differentiation, single-cell RNA and ATAC-sequencing and LCM-seq that enable us to perform lineage tracing and fate mapping in unprecedent resolution.

We aim to address the following questions:
(1) the role of niche environment for initial germ cell specification;
(2) fail-safe mechanism of migration and origin for germ cell tumors;
(3) transgenerational inheritance of disease by germ cells.

The postdoctoral applicant is expected to lead the projects of DNA-barcoded lineage tracing and investigation of molecular mechanisms in epigenetic inheritance. The applicant will be also involved in experimental optimization for single-cell analysis of human tissue.

Entry requirements

We are looking for a highly-motivated candidate with a PhD degree in developmental biology, stem cell biology, molecular biology or related area. We expect the candidate to have a strong scientific background with relevant expertise especially in single cell biology. Experience from work with mouse and human stem cells, animal models and Crispr/Cas genome editing are a strength. Good knowledge of both spoken and written English and a positive team player are highly appreciated.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Biomedicum, Solna Campus

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

First day of employmentUpon agreement
SalaryScholarship
Number of positions1
Working hours100%
CitySolna
CountyStockholms län
CountrySweden
Reference numberSTÖD 2-4359/2020
ContactQiaolin Deng, head of section, qiaolin.deng@ki.se
Union representativeHenry Wölling, SEKO, henry.wolling@ki.seHelin Norberg, SACO, helin.norberg@ki.seGunnel Brolin, OFR, gunnel.brolin@ki.se
Last application date15.Dec.2020 11:59 PM CET

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Post expires on Tuesday December 15th, 2020

Postdoctoral Position in Epithelial Stem and Tumor Cell Biology (Scholarship)

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The Genander lab is located at Karolinska Institutet, Department of Cell and Molecular Biology (CMB) in Stockholm, Sweden. CMB is a department with a strong focus on basic science. Research groups are organized into three thematic programs: Developmental Stem Cell Biology, Cell Biology and Infection and Cancer. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology.

Focus of the lab

The Genander lab is looking for a talented and motivated postdoctoral fellow to join the team. We are interested in defining mechanisms regulating epithelial stem cells during tissue homeostasis and tumor formation. The current project will be centered around citrullination, a posttranslational modification influencing protein and histone tail properties, focusing on skin tumor initiation and development.

Entry requirements

Experience in mouse models is a requirement. Experience and interest in high-throughput genomic technologies involving next-generation sequencing is preferred. The working language is English, and the applicant is expected to be proficient in both spoken and written English.

More information about the Genander lab can be found here: http://ki.se/en/cmb/maria-genanders-group.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Stockholm

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)
  • Contact information of two references, recommendation letters are also welcome.

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

First day of employmentAccording to agreement
Reference numberSTÖD 2-4489/2020
ContactMaria Genander, Assistant professor, maria.genander@ki.se
Last application date31.Dec.2020 11:59 PM CET

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Post expires on Thursday December 31st, 2020

Postdoctoral researcher in synaptic physiology

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Do you want to contribute to top quality medical research?

The Department of Neuroscience includes several research groups working on different aspects of nervous system function, both under normal conditions and in various disease states. Research projects include a broad range of studies on the molecular and cellular levels, networks of neurons, and the organization of the nervous system as a whole. The Department has a flat organization with 40 research group leaders, of which 24 are full professors, and 65 PhD students.

Teaching represents a fundamental activity at the Department, which participates in several undergraduate courses and postgraduate education programs. Each year approximately 15 students receive their PhD from our Department and many of our graduates have gone onto distinguished careers in the academic or private sector.

The Division

We are interested in understanding molecular and synaptic activity of the basal ganglia and how the alterations of these physiological functions are responsible for different neuropathological conditions. To this end, we employ genetic mouse models (i.e. movement disorders, drug addiction and neurodevelopmental disorders) of neuropsychiatric disorders and a variety of cutting-edge technology (i. e. confocal and 2-photon imaging, behavioral analysis, fiber photometry, immunohistochemistry, molecular and cell biology standard technique).

Your mission

Candidates are expected to build and successfully execute an exciting, independent project within the lab research programs through active discussion and collaboration with the PI. 

Candidates are expected to be proficient in patch clamp electrophysiology or multiphoton microscopy and are required to be independent in the design, execution and analysis of the experiments.

We also expect the candidates to be active players within a scientific group with presentations and the involvement in scientific discussion.

This is a fixed-term employment for one year with the possibility of extension. 

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent. We especially welcome candidates who hold a Ph.D. or MD (awarded 2015 or later).

Experience with patch clamp electrophysiology, primarily in brain slices, is necessary. Hands-on experience with multiphoton microscopy and brain surgical procedures with viral expression systems are important additional requirements.

The candidates should also be proficient in computer and statistical programming (Matlab/Igor/R) for the development of routines and analysis of imaging and electrophysiology data.

The candidates should be highly organized and ambitious with excellent communication skills in English. Interpersonal skills are essential, and we emphasize the person’s ability as a team player and contributing to a friendly work environment.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: Solna

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Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

Welcome to apply at the latest 9 October 2020.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Type of employmentTemporary position longer than 6 months
Contract typeFull time
Number of positions1
Working hours100%
CityStockholm
CountyStockholms län
CountrySweden
Reference number2-3474/2020
ContactEmanuela Santini, emanuela.santini@ki.se
Union representativeBjörn Meister, SACO, 08-52487025, bjorn.meister@ki.seHenry Wölling, SEKO, 08-524 840 80, henry.wolling@ki.seMagnus Anå, OFR, 08-524 864 37, magnus.ana@ki.se
Last application date09.Oct.2020 11:59 PM CET

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Postdoctoral studies in structural biology of fertilization

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Karolinska Institutet, Department of Biosciences and Nutrition, Jovine (LJO)

The Department of Biosciences and Nutrition performs research and education in several areas of medical science including bioorganic chemistry, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, cellular virology, and nutrition. It offers an excellent international research and working environment, including around 300 scientists, students, administrative and technical personnel. The Department resides in the new biomedical research building Neo, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Division
The research group of Professor Luca Jovine (http://jovinelab.org) is looking for a postdoctoral fellow to investigate the molecular mechanism of egg-sperm interaction at fertilization by single-particle cryo-EM. The position is funded by a 5-year grant from the Knut and Alice Wallenberg foundation. In close collaboration with Alexey Amunts laboratory at Scilife (https://www.scilifelab.se/researchers/alexey-amunts/) and easy access to local cryo-EM facilities that together include 3 x Titan Krios with K3 detectors, a Talos Arctica with K2 and a Talos L120C with Ceta-D, we offer access to the most advanced infrastructure to maximize the chances for success of this ambitious and exciting endeavor. Therefore, joining our groups provides a unique opportunity to benefit from the strengths of two complementary labs and state-of-the-art technology, in order to tackle one of the most fundamental questions in biology and understand how life begins.

For recent examples, please see Nishimura et al. Nature Communications 10, 3086 (2019), https://www.nature.com/articles/s41467-019-10931-5, Raj et al. Cell 169(7):1315–26 (2017), http://www.cell.com/cell/fulltext/S0092-8674(17)30594-9, Mühleip et al. Elife e51179 (2019), https://elifesciences.org/articles/51179 and Perez Boerema et al. Nature Plants 4:212-217 (2018), https://www.nature.com/articles/s41477-018-0129-6

With its close integration of academic and clinical research, KI offer a highly international and collaborative environment for biomedical studies. In particular, the Department of Biosciences and Nutrition of KI has state-of-the-art equipment for recombinant protein expression in mammalian cells and bacteria, protein purification, sample characterization (SEC-MALS, microscale thermophoresis, bio-layer interferometry) and in-house X-ray data collection. For EM data collection, we have BAG access to the Cryo-EM Swedish National Facility nodes at Stockholm SciLifeLab and Umeå Core Facility for Electron Microscopy (UCEM), https://www.scilifelab.se/facilities/cryo-em/, as well as access to the newly established 3D-EM facility of KI , https://ki.se/cmb/3d-em; additionally, we have frequent BAG access to different synchrotron/EM data collection sites (BESSY, DLS, ESRF, MAX IV).

To support this position, a fellowship is available for two years that will be paid to the successful candidate as a tax-free scholarship, with possible extension of two additional years as postdoc employment (subject to positive evaluation). For additional information, please directly contact Luca Jovine and Alexey Amunts.

Qualifications
Candidates should have a Ph.D. degree and significant hands-on experience in structural biology. Although proven experience in single-particle cryo-EM and knowledge of helical reconstruction will constitute an advantage, excellent candidates with experience in X-ray crystallography and a strong interest in learning cryo-EM will also be taken into consideration. Additionally, previous experience in mammalian cell expression as well as purification and biochemical characterization of glycoproteins will be considered an asset. At least one first author paper in a high-quality international peer-reviewed journal, fluency in English (both written and oral), good team spirit and a very strong personal drive to excel in science are required.

Entry requirements
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A brief cover letter including a summary of your research experience (maximum two pages)
  • your motivation for applying, suitability for the position and project ideas (maximum one page)
  • contact details of at least two referees, one of which should preferably be the Ph.D. supervisor
  • copies of doctoral and other relevant degree certificates.

The application is to be submitted on the Varbi recruitment system.

Incoming applications will be evaluated continuously and the position could either start immediately or upon agreement.

We look forward to receiving your application!

Reference number2-534/2020
Contact Luca Jovine, Professor, +46-70-1497014 Alexey Amunts, Assistant Professor, +46-8-16 10 03Thomas Tinglöv, Head of Administration, +46-8-524 835 49
Union representative Henry Wölling, SEKO, +46-08-524 840 80Birgitta Lindqvist, OFR, +46-73-209 83 12
Last application date19.Apr.2020 11:59 PM CET

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Post expires on Sunday April 19th, 2020