Tag-arkiv: Karolinska Institutet

PhD Researcher in Biostatistics/Machine Learning

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The Department of Medical Epidemiology and Biostatistics (MEB) is among the largest departments of epidemiology in Europe with special focus on increasing our knowledge of the aetiology of different diseases. Our department consists of researchers, doctoral students, biostatisticians, data collectors and database administrators as well as administrative personnel, in total some 250 staff. The department is situated at campus Solna. Further information can be found at ki.se/meb

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

A doctoral student position is available within the biostatistics group at the Department of Medical Epidemiology and Biostatistics (MEB) at Karolinska Institutet (https://ki.se/meb), Stockholm. The research project is part of a cross-university collaboration within a national e-science program and will be carried out in collaboration with researchers both at MEB and at the Division of Robotics, Perception and Learning (RPL) at KTH Royal Institute of Technology (https://www.kth.se/rpl), Stockholm. The biostatistics group at MEB, KI comprises 5 professors, 3 senior lecturers, 9 PhD-level statisticians, 4 masters-level statisticians, and 10 doctoral students. The group is involved in a wide variety of research projects, including population-based cohort and case-control studies, twin and family studies, survival analyses, predictive modeling, genetic epidemiology and bioinformatics. The collaborating group at RPL, KTH comprises one professor, 6 doctoral students, two research engineers, and a varying number of master students. The group is targeted towards probabilistic machine learning and probabilistic deep learning, with a wide range of collaborations in medicine, veterinary science, autonomous vehicles, performing arts, and e-science.

The doctoral student project and the duties of the doctoral student

The aim of this doctoral project is to develop algorithms that can efficiently fit complex, latent variable models to large-scale Swedish health and population register data, such as data from the Swedish Multi-generation Register or the Stockholm PSA and Biopsy Register. The models include grouped survival models and joint models for time-to-event and longitudinal data.

There are a number of approaches for efficient approximate likelihood and Bayesian computations which have been developed and widely applied in machine learning algorithms that are not widely known in statistics. The idea of this project is to explore the use of some of these approaches in fitting more traditional, yet complex, biostatistical regression models to large-scale epidemiological data, where exact computations of likelihoods will be infeasible and Monte Carlo sampling techniques reach their limits. The doctoral project will be a mix of statistical theory, computational statistics and applications. The computational languages will primarily be R and C++.

The successful applicant’s time will be divided between MEB, KI, under the supervision of Mark Clements (Senior Lecturer in Biostatistics), Benjamin Christoffersen (Postdoctoral Researcher in Biostatistics) and Keith Humphreys (Professor in Biostatistics), and RPL, KTH, under the supervision of Hedvig Kjellström (Professor in Computer Science). You will have access to high-end GPU and CPU computational resources for your research.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

The position requires a second-cycle university degree in statistics/mathematics/computer science or a closely related field. Experience in mixed effects modelling, computational statistics or survival analysis would be ideal. The exact topic of the position will depend on the successful applicant’s background and interests.

Personal qualities for the role include being independent, structured, performance-oriented and with strong analytical abilities.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

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Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Want to make a difference? Join us and contribute to better health for all

Type of employmentTemporary position longer than 6 months
Contract typeFull time
First day of employmentAccording to agreement
SalaryMonthly salary
Number of positions1
Working hours100
CityStockholm
CountyStockholms län
CountrySweden
Reference numberSTÖD 2-2686/2021
ContactMark Clements, Mark.Clements@ki.seSofia Anderberg, sofia.anderberg@ki.se
Union representativeHenry Wölling, SEKO, henry.wolling@ki.seAnn Almqvist, SACO, ann.almqvist@ki.seNiklas Andersson, OFR, niklas.andersson@ki.se
Last application date25.Jun.2021 11:59 PM CET

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Post expires on Friday June 25th, 2021

Postdoctoral scholarship: Translational asthma research on lipid mediator regulation of small airway inflammation

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Do you want to contribute to improving human health?

Karolinska Institutet, Institute of Environmental Medicine

The Institute of Environmental Medicine (IMM) is an interdisciplinary research department at Karolinska Institutet. IMM conducts cutting edge research within the areas of environmental and occupational medicine, toxicology, physiology, pharmacology, epidemiology, and biostatistics with the aim to clarify how environmental and lifestyle factors affect our health. IMM also serves as a scientific advisor to public authorities within the area of environmental medicine and IMM scientists participate in national and international expert groups.

Position and environment

With the support of a dedicated grant from the Swedish Heart and Lung foundation, there is an opening for a post doctoral fellow at the unit for Experimental Asthma and Allergy Research at IMM. The unit has an internationally recognized, long-standing experience with functional and biochemical studies of prostaglandins, leukotrienes, lipoxins and other bioactive lipid mediators in the context of asthmatic airway inflammation.

Project

The goal is to define mechanisms of relevance to asthma that ultimately may become novel targets for future treatments. This post doctoral fellow will be responsible for a project where specific interactions between lipid mediators and key cytokines in type 2 as well as non-type 2 inflammation will be investigated (for model, see e.g. Manson et al J Allergy Clin Immunol. 2020; 145:808-81) using isolated tissues from the small airways of humans and guinea pigs. This is a physiological and pharmacological research project, but includes supporting techniques such as histology, transcriptomics, proteomics, and the measurement of mediator release using different methods.

Qualifications

We are searching for a highly motivated candidate with a commitment to experimental research in asthma and other lung diseases. Experience of physiological or pharmacological research is a strong merit, in particular familiarity with functional experiments using tissue organ baths or myographs. Practical knowledge of handling experimental animals is necessary, and basic Felasa certification would be another asset. Excellent communication skills and an ability to interact socially and scientifically with other post docs and students in the laboratory, as well as collaborators in various networks is essential. Good computer skills are necessary, as well as fluency in English which is the main language used in this work environment. Previous post doc experience and a strong publication record are also important qualities.

Those who have allergies to animals or illnesses that may be aggravated by daily exposure to laboratory animals and chemicals are not advised to seek this position.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

First day of employmentAccording to agreement
SalarySemiannually
Reference numberSTÖD 2-2283/2021
ContactMikael Adner, Lecturer senior, +46 8 524 874 01Jesper Säfholm, Assistant professor, +46 8 524 874 90
Union representativeAnne Boström, SEKO , +46 8 524 875 79Niklas Andersson, OFR , +46 8 524 874 19Anda Gliga, SACO-S , anda.gliga@ki.se
Last application date08.Jun.2021 11:59 PM CET

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Postdoctoral studies in Myocardial Genetics (Scholarship)

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Do you want to contribute to improving human health?

We are seeking a highly motivated and ambitious individual to join the research group of Professor Ralph Knöll as a Postdoctoral Fellow (Scholarship). The project will focus on elucidating the potential of RNA editing as a novel type of gene therapy. In addition, we will investigate novel approaches to treat heart failure such as targeting the sarcomere as well as evaluation of novel compounds in vivo.

This position offers direct collaborations with the Pharma Industry (i.e. AstraZeneca).

Your mission

The successful applicant will work on RNA editing and single cell RNA sequencing including its translational aspects. The work will focus on different types of biomechanical stress in vitro and in vivo and its effect on cardiac myocyte survival. This project includes work with genetically altered animals, stem cell biology, explanted human hearts, CRISPR and next generation sequencing technologies, including RNA and single cell RNA seq, with the aim to identify molecular / epigenetic mechanisms underlying heart failure and its translation into innovative medications.

We are looking for a researcher who has a strong work ethic, passion for solving difficult questions & challenges with the ability to design, plan, perform, and interpret original experiments in an independent and innovative environment. The candidates should have high integrity and be aware of the multicultural setting they are going to be located at.

Candidates should:

  • It is essential that the candidate has published at least one paper in an excellent peer-reviewed journal, preferably as a first author.
  • Have experience in basic science, preferably in single cell RNA seq / epigenetics, bioinformatics and the generation of genetically altered animals. Experience in stem cell biology and administration is an additional merit.
  • Have a strong background in cardiac myocyte biology. Experiences in cell death pathways is an asset but not mandatory.
  • Knowledge in zebrafish genetics is an add on Good experience in supervision of PhD students and master students is an asset but not mandatory.
  • Have the ability to work both independently and collaboratively in a group


Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Flemingsberg

Ralph Knöll group

Professor Ralph Knöll – AstraZeneca

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

First day of employmentAccording to agreement
Reference numberSTÖD 2-2418/2021
ContactRalph Knöll, ralph.knoll@ki.se
Union representativeBelinda Pannagel, SACO, Belinda.pannagel@ki.seElisabeth Henriksson, OFR, Elisabeth.henriksson@ki.seMari Gilljam, OFR, Mari.gilljam@ki.se
Last application date19.Jun.2021 11:59 PM CET

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Post expires on Saturday June 19th, 2021