Tag-arkiv: Karolinska Institutet

Postdoc position, Maintenance of neuronal identity

Karolinska Institutet, Department of Cell and Molecular Biology, Holmberg

The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology.

Division
The research group of Johan Holmberg is part of the Department of Cell and Molecular Biology (CMB) which recently moved to the new interdisciplinary research centre Biomedicum located at Campus Solna, Karolinska Institutet.

Background
The brain contains a large number of different neuronal subtypes that maintain their distinct identities over several decades despite continuous environmental fluctuation. Apart from the instructive information provided by transcription factors controlling cell type specific transcriptional programs, there is presumably also a need to maintain silencing of alternative transcriptional programs. The mechanisms governing permanent repression of aberrant transcription in mature neurons are not well understood. Our lab focuses on the role of repression of alternative gene programs for lifelong maintenance of serotonergic and dopaminergic identity. For a more extensive background see: Holmberg and Perlmann, Nature Review Genetics 2012 and Södersten, E. et al. Nature Commun. 2018. Besides exploring fundamental processes we also aim to understand how they influence clinically relevant topics including psychiatric disorders, neurodegeneration and aging. The group also harbour an interest in the understanding of the paediatric malignancy, neuroblastoma, see: Westerlund, et al. Proc Natl Acad Sci U S A 2017.

In this project we will generate and analyse large amounts of data from defined wild type/mutant mouse neuronal populations in order to understand the functional relevance of gene repression for safeguarding mature serotonergic and dopaminergic identity.

Position specific requirements
We are looking for an outstanding researcher able to analyse and integrate large sets of bulk and single cell RNA-seq with ChIP-seq data generated from restricted in vivo neuronal subpopulations. Additional experience with confocal image acquisition and analysis as well as with in vivo/in vitro standard methods (e.g. immunostaining, FACS, stereotactic injections, behavioural analysis and cell culture) will be considered as a distinct advantage. Thus we are primarily looking for a computational biologist with experience/interest in laboratory/animal work or an experimental biologist with extensive bioinformatic skill and interest.

The applicant must be able to communicate well in English.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • Cover letter stating the motivation to apply and key skills that match the profile 

The application is to be submitted on the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

First day of employmentas soon as possible
Reference number2-2626/2019
Contactohan Holmberg, johan.holmberg@ki.se
Last application date30.Sep.2019 11:59 PM CET

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Post expires on Monday September 30th, 2019

Postdoctoral researcher in metabolomics of respiratory disease

Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Chemistry II

The project: We have an opening for an individual wishing to join a multidisciplinary team aiming to understand mechanisms in asthma, COPD and other respiratory diseases. Chronic lung disease is one of the largest noncommunicable diseases globally, with 4 million deaths in 2012 alone. The successful candidate will be expected to use and further develop LC-MS-based methods for both non-targeted and targeted metabolomics. The primary focus of the position is to perform metabolomics analyses for the molecular sub-phenotyping of obstructive lung disease in multiple large cohort studies. In particular, we aim to examine the relationship between the onset of lung disease and early-life environmental exposure in an exposome approach. This work will be performed in birth cohorts designed to correlate antenatal and postnatal exposure with disease etiology. The acquired metabolomics data will be integrated into an overall “handprint” of multiomics data. Accordingly, the selected candidate will have significant opportunity to interact with other analytical groups and bioinformatics efforts from multiple laboratories internationally.

The Environment: The successful applicant will belong to the Integrative Molecular Phenotyping laboratory (http://metabolomics.se) in the Department of Medical Biochemistry and Biophysics. The Karolinska Institute is one of the world´s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. The Karolinska Institute accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at the Karolinska Institute has selected the Nobel laureates in Physiology or Medicine. The research environment includes working with state-of-the-art equipment, including multiple mass spectrometers in a new custom designed state-of-the art facility. This full-time position is temporary (two years), with potential for renewal for at least 2 more years.

Qualifications: We are looking for highly motivated candidates with a Ph.D. in mass spectrometry or bioanalytical chemistry and experience in small molecule mass spectrometry. Candidates should have demonstrated experience in LC-MS based metabolomics. We are especially interested in candidates with prior experience working with large clinical studies. Experience with computer programming (e.g., R, Matlab) and multivariate statistics (e.g., SIMCA) would be a significant merit. Excellent communication skills and an ability to interact socially and scientifically with other post docs and students in the laboratory and with collaborators in various networks are essential.

Entry requirements: A person is eligible for a position as Postdoctoral Researcher if she or he has obtained a PhD or a foreign qualification deemed equivalent to a doctorate, no more than five years before the last date of employment as postdoc. Applicants who have completed their degree no more than three years before the last date for applications will be given priority. Applications consisting of cover letter, full CV and references should be submitted via the KI varbi system. The start date is negotiable, but the selected candidate would ideally begin as soon as possible. Applications will be evaluated as they are received.

Further Information: For additional details of the department and research interests:

http://www.metabolomics.se/

http://www.mbb.ki.se

http://ki.se/en/startpage

Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.

Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employmentTemporary position longer than 6 months
Contract typeFull time
First day of employmentupon agreement
Salarymonthly
Number of positions1
Working hours100%
CityStockholm
CountyStockholms län
CountrySweden
Reference number2-3806/2019
ContactCraig E. Wheelock, Ph.D, +46 (0)8 5248-7630
Union representativeAnne Edgren, OFR/S, P, O, 08-524 87570Henry Wölling, SEKO, 08-524 840 80
Last application date03.Nov.2019 11:59 PM CET

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Post expires on Sunday November 3rd, 2019

Postdoctoral fellow on scholarship in Immunogenetics

Department of Biosciences and Nutrition, Pan-Hammarström (PHA)

The Department of Biosciences and Nutrition performs research and education in several areas of medical science including bioorganic chemistry, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, cellular virology, and nutrition. It offers an excellent international research and working environment, including around 300 scientists, students, administrative and technical personnel. The Department resides in the new biomedical research building Neo, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Research group
The research group of Prof. Qiang Pan-Hammarström works on the molecular mechanism of immunoglobulin gene diversification, genetics of primary immunodeficiency and B-cell lymphomagenesis. The research laboratory is located at campus Flemingsberg. For more information about the group, please see https://ki.se/en/bionut/research-group-qiang-pan-hammarstrom

Duties
The selected postdoctoral fellow candidate will work in our multidisciplinary team of researchers including clinicians, molecular biologists and bioinformaticians, and will be jointly supervised by Prof. Qiang Pan-Hammarström and Prof. Lennart Hammarström, two international leading experts in the primary immunodeficiency field.

The main tasks for the successful candidate are:  
1) Identification of new forms of primary immunodeficiency through multi-omic analysis, with focus on late B cell deficiencies. This will involve analysis, interpretation, and integration of high throughput data derived from sequencing of the whole exome/genome, transcriptome, metagenome, epigenome, proteome and single cell transcriptome. 
2) Functional characterization of patients with defects in late B cell development. This may involve standard B-, T- and NK- cell functional analysis, characterization of DNA damage and repair defects, gene editing by the CRISPR/Cas9 technology as well as using iPSC as models to study B cell development.
3) The postdoc fellow is expected to assume a major role in the writing of scientific publications and grant applications and contribute to supervise PhD and master students in the group.

Qualifications
We are seeking a highly skilled and motivated candidate for the immunogenetic team in our group. The applicant should have been awarded a PhD or equivalent degree in medicine, immunology, genetics, molecular biology or areas relevant to the announced position.
He/she should have achieved the corresponding scientific competence, with first-authored publications in internationally leading journals in the corresponding fields. Extensive research experience in next generation sequencing data analysis and state-of-art molecular and cellular biology techniques is required. The applicant must be able to work productively through collaborative interactions with team members. Furthermore, the candidate should possess excellent communicating and writing skills in English.

Bases of assessment
We stress scientific excellence and potential when assessing applicants. The applicants’ track record based on curriculum vitae and bibliography will be assessed. Evidence for independence, innovation and the capacity to work and publish in a multidisciplinary environment is weighted in ranking the applicants. Reference letters will be requested from the PhD supervisor(s) and considered from selected candidates.

Entry requirements
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six- months basis. In exceptional cases, shorter periods may be acceptable.

The position is 2 years.

Application process
An application must contain the following documents in English:

  • A complete curriculum vitae, including education, date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)
  • Two recommendation letters, including at least one from the PhD supervisor

The application is to be submitted on the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Reference number2-4393/2019
ContactQiang Pan Hammarström, +46-8-524 835 92Thomas Tinglöv, +46-8-524 835 49
Union representativeHenry Wölling, SEKO, +46-8-524 840 80Birgitta Lindqvist, OFR, +46-8-524 810 28
Last application date24.Sep.2019 11:59 PM CET

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Post expires on Tuesday September 24th, 2019

Postdoctoral researcher in Precision Cancer Medicine

Karolinska Institutet, Department of Oncology-Pathology, Forskargrupp Kallioniemi

At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. About 30 research groups with various cancer research profiles are involved and we have around 110 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

Research group Olli Kallioniemi
This position resides in the research group of Olli Kallioniemi, Director of Science for Life Laboratory, Professor of Molecular Precision Medicine, affiliated with both the Dept. Oncology and Pathology, Karolinska Institutet and the Science for Life Laboratory. The work will involve an exciting opportunity to practice precision cancer medicine research in a translational setting, with the aim to assign and optimize targeted treatments for individual cancer patients. Our disease focus is on acute myeloid leukemia (AML), ovarian and urological tumors (prostate, kidney and bladder). Our goal is to develop a systems biology framework to match targeted therapies and drug combinations using genomic, transcriptomic and proteomic profiling along with functional ex vivo drug testing on primary patient-derived cells (PDC) from cancer patients. We work through team science in close collaboration not only with other research groups, but also with clinicians, as well as with different technology platforms of the SciLifeLab. For more information : https://www.scilifelab.se/researchers/olli-kallioniemi/ 

Task Description
The tasks for this position involves the establishment of innovative drug testing assays in primary cell models, characterization of the models and integration of the datasets to inform patient treatment. The candidate is also expected to carry out project management tasks such as carrying out expected milestones within the project, budgeting and reporting as well as interacting not only with research but also clinical and pharma collaborators.

Qualifications
The successful candidate is expected to have a doctoral degree in biochemistry, biology, biotechnology, medicine or other relevant field. The candidate, is independent and motivated with a documented ability to carry out experimental research projects but also project management including excellent communication skills in spoken and written English. Previous expertize in primary model development from solid tumors and/or hematological cancers is beneficial. Experience with high throughput drug testing, assay development, high throughput high content microscopy and –omics technologies is highly valued. We stress research expertise and interest in collaborative science when assessing applicants.

Requirements:
– PhD in biochemistry, biology or medicine.
– Knowledge of cancer biology, precision cancer medicine and translational cancer research.
– Extensive experience in cell culture techniques, especially primary cell models. 
– Knowledge on high-throughput drug testing and assay development
– Experience in working as part of large multidisciplinary, collaborative research projects (“team science”).

Application process, salary and contract
An application must contain the following documents in English: Curriculum vitae, qualifications and description of planned research, presented in accordance with Karolinska Institutet’s qualifications portfolio. For more information: http://ki.se/qualificationsportfolio.

The application is to be submitted through the MyNetwork recruitment system. The salary is defined according to the KI salary system. The project is initially for one year contract with the possibility of extension with the preferred start date as soon as possible. SciLifelab
Science for Life Laboratory (www.scilifelab.se) is a leading national infrastructure for next-generation life science research in Sweden. SciLifeLab is jointly operated by the four host universities: Karolinska Institutet, KTH Royal Institute of Technology, Stockholm University and Uppsala University, and it has facilities in four other universities across Sweden. There are over 1 000 people working at SciLifeLab, either in research groups or in the infrastructure facilities, most of them in the KI Solna campus and in Uppsala.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employmentTemporary position longer than 6 months
Contract typeFull time
Number of positions1
Working hours100%
CitySolna
CountyStockholms län
CountrySweden
Reference number2-4544/2019
ContactPäivi Östling, paivi.ostling@ki.se, +46 (0)73 673 5762
Union representativeAndreas Lundqvist, SACO, 46 8 517 76884Helen Eriksson, OFR, 08 517 762 79
Last application date10.Nov.2019 11:59 PM CET

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Post expires on Sunday November 10th, 2019

Postdoctoral researcher in lipid analytical chemistry

Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Chemistry II

The project: We have an opening for an individual wishing to join a multidisciplinary project aimed to understand the role of lipid mediators in lung disease. Chronic lung disease is one of the largest noncommunicable diseases globally, with 4 million deaths in 2012 alone. The successful candidate will be expected to use and further develop mass spectrometry-based methods for quantification of lipid mediators (e.g., prostaglandins, leukotrienes) and related molecules. Analyses will involve development of novel chromatography approaches including chiral and UPC2 methods for applications in clinical cohorts as well as experimental models to map the biochemical role of lipid mediators in the pathobiology of lung disease. Functional studies will be performed in multiple cell types, in ex vivo lung tissue as well as in animal models to generate a biochemical map of both pro-inflammatory and pro-resolving lipid mediators.

The Environment: The successful applicant will belong to the Integrative Molecular Phenotyping laboratory (http://metabolomics.se) in the Department of Medical Biochemistry and Biophysics. The Karolinska Institute is one of the world´s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. The Karolinska Institute accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at the Karolinska Institute has selected the Nobel laureates in Physiology or Medicine. The research environment includes working with state-of-the-art equipment, including multiple mass spectrometers in a new custom designed state-of-the art facility. This full-time position is temporary (two years), with potential for renewal for at least 2 more years.

Qualifications: We are looking for highly motivated candidates with a Ph.D. in quantitative mass spectrometry or bioanalytical chemistry. The successful candidate will be expected to use and further develop mass spectrometry-based methods for metabolic profiling of lipid mediators. Accordingly, applicants must document their experience in small molecule mass spectrometry by LC-MS/MS as well as familiarity with quantification and method validation. Prior experience working with lipids is considered a merit as well as experience in cell culture and FACS analysis. Excellent communication skills and an ability to interact socially and scientifically with other members of the laboratory and with collaborators in various networks are essential.

Entry requirements: A person is eligible for a position as Postdoctoral Researcher if she or he has obtained a PhD or a foreign qualification deemed equivalent to a doctorate, no more than five years before the last date of employment as postdoc. Applicants who have completed their degree no more than three years before the last date for applications will be given priority. Applications consisting of cover letter, full CV and references should be submitted via the KI varbi system. The start date is negotiable, but the selected candidate would ideally begin as soon as possible. Applications will be evaluated as they are received.

Further Information: For additional details of the department and research interests:

http://www.metabolomics.se/

http://www.mbb.ki.se

http://ki.se/en/startpage


Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.

Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.

Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

Type of employmentTemporary position longer than 6 months
Contract typeFull time
First day of employmentupon agreement
Salarymonthly
Number of positions1
Working hours100%
CityStockholm
CountyStockholms län
CountrySweden
Reference number2-3804/2019
Contact Craig E. Wheelock, Ph.D, +46 (0)8 5248-7630
Last application date03.Nov.2019 11:59 PM CET

Read the job description at the unviersity homepage

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Post expires on Sunday November 3rd, 2019

Postdoctoral Researcher in Biochemist position on Metabolism (Scholarship)

Karolinska Institutet,

At the Department of Physiology and Pharmacology we teach and conduct internationally acclaimed, high-quality research in Physiology, Pharmacology, Anesthesiology and Intensive care. We have around 400 employees, 30 research groups, and 90 doctoral students. Our research fields include cellular signaling, cardiovascular and respiratory systems, neuropsychopharmacology, neuroinflammation, pharmacogenetics, regenerative medicine, Renal System, anesthesiology and intensive care, muscle physiology and pain. Our collaboration with the clinics at Karolinska University Hospital provides unique opportunities for translational research within our subjects. More information about research at http://ki.se/fyfa_english

Research Group and Project Description

A Postdoctoral position is available in the research group of Assoc. Professor Erik Norberg at the Department of Physiology and Pharmacology, Karolinska Institutet.
Tumor cells display metabolic profiles that are remarkably distinct from their normal tissue of origin. This is to ensure fulfillment of their higher bioenergetic/biosynthetic needs required to support rapid proliferation. Less is known about metabolic heterogeneity in seemingly identical cancer cells. We have previously identified metabolic heterogeneity in lymphomas that can be rationally targeted (Cancer Cell. 2012, Cell Death Differentiation. 2017) and more recently in lung adenocarcinomas (Cell Reports, 2017, Journal of Cancer, 2017). Our group focuses on understanding fundamental biochemical mechanisms underlying metabolic heterogeneity. Hence, we are currently trying to identify molecular regulators that shape the tumor metabolism and metabolic diversity, with the ultimate goal of identifying novel drug targets and biomarkers.  
We have recently conducted multiple parallel primary genome-wide siRNA screenings and secondary siRNA screenings to identify regulators of metabolism. We are now looking for highly motivated candidate(s) who can biochemically validate our hits.
For more information please see our published work that includes computational analyses:
Cell Reports 2017 Jun 13;19(11):2289-2303)
Journal of Cancer 2017;8(11):2088)
Cell Death Differentiation. 2017 Feb;24(2):251-262.
Cancer Cell 2012 Oct;22(4):547-60.

Duties
The candidate will conduct research within the field of biochemical cancer research with a focus on tumor metabolism. 

Entry requirements
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Other requirements
The candidate must have hands-on experience with:

  • – Expertise in protein expression demonstrated through the expression of several types of proteins using a wide range of methods and purification (using affinity and traditional chromatographic techniques), protein modification using enzymatic and chemical methods, and biophysical characterization.
  • – Experience with instrumentation essential for protein purification and characterization, especially AKTA FPLC and Agilent HPLC systems, SDS PAGE and Western Blot.
  • – Experience to analyse protein structures using computational approaches.

Desired skills

  • – Experience in proteomics and/or metabolomics.
  • – Mass Spectrometric analysis of proteins.
  • – Willingness to learn relevant cell biology approaches including measurement of cell growth, cell death and to perform transfections (CRISPR/Cas9 and siRNA).
  • – Experience with mammalian cell culture is preferred.

We seek exceptional, dedicated, self-motivated and hardworking individuals with a positive attitude and with substantial experience in biochemistry and cancer research. The candidate should have a strong background in biochemistry and have a strong track record (as shown by first-author publications in international peer-reviewed journals).

The candidate should be able to thrive and deliver results on goals in a fast-paced, dynamic and highly multi-tasking environment. The candidate is expected to contribute to scientific discussions and presenting outcomes to colleagues beyond maintaining detailed and organized records of project data and other materials as needed. Strong verbal and written communication skills in English are required.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Reference number2-4298/2019
Contact Erik Norberg, erik.norberg@ki.se
Union representative Göran Engberg, SACO, 08-524 867 17Niklas Andersson, OFR, niklas.andersson@ki.seElisabeth Valenzuela, SEKO, 08-524 863 53
Last application date28.Sep.2019 11:59 PM CET

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Post expires on Saturday September 28th, 2019

Doctoral (PhD) student position in Molecular Epidemiology and Omics of the Frailty Syndrome

Karolinska Institutet, MEB

The Department of Medical Epidemiology and Biostatistics (MEB) is among the largest departments of epidemiology in Europe with special focus on increasing our knowledge of the aetiology of different diseases. Our department consists of researchers, doctoral students, biostatisticians, data collectors and database administrators as well as administrative personnel, in total some 250 staff. The department is situated at campus Solna. Further information can be found at ki.se/meb

A doctoral student is admitted to third-cycle/doctoral education. A doctoral education consists of supervised research, combined with courses and other educational activities. An individual study plan is established for each doctoral student. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

Research Group
The PhD student will become a member of the Aging research group at MEB. The Aging group consists of four research groups led by Assistant professor Juulia Jylhävä, Associate professor Sara Hägg, Senior Professor Nancy Pedersen and Professor Kristina Johnell, respectively. The four research groups collaborate closely together and have common weekly group meetings. Researchers in the Aging group work widely with different topics of aging and aging diseases, such as frailty, cardiovascular disease, dementia and Parkinson’s disease. The main supervisor for this PhD position is Assistant professor Juulia Jylhävä, whose group focuses on the molecular epidemiology of frailty and aging biomarkers. The group is deeply collaborative, working with researchers in Denmark, Finland, US, UK and Germany. We make use of various epidemiological and omics approaches, and use multiple large datasets, such as the Swedish and Danish Twin Registry cohorts and the UK Biobank. Co-supervisors in this PhD project are Associate professor Sara Hägg (KI, MEB), Biostatistician Dr. Ralf Kuja-Halkola (KI, MEB) and Professor Chandra Reynolds (University of California – Riverside, Riverside, CA, US).

Area of responsibilities/description of the work
Applications are invited for a PhD research training position to work on aging-related frailty syndrome, focusing on the genetics, epigenetics, metabolomics and circulatory biomarkers underlying the disease. The work includes epidemiological and omics approaches as well as quantitative genetics (twin modeling). The applicant must have a strong interest in aging and aging-related disease, and aptitude to learn multiple methods within the different areas in the project. The PhD student will be part of the Doctoral programme in Epidemiology at KI that includes courses into epidemiology and biostatistics.

Eligibility requirements for doctoral education
In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline. It is your responsibility to certify eligibility by following the instructions on the web page: Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement
You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree) or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.
*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement
You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

  • Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documentsKarolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

Skills and personal qualities

  • The applicant should have a master’s degree in biomedical or health sciences, epidemiology, gerontology, genetics, bioinformatics, biostatistics, statistics or related discipline, and have a strong interest in aging and aging-related disease.
  • The applicant should have at least some knowledge or training in genetics and epidemiology
  • Programming skills in R is considered a strong merit.
  • Fluency in written and spoken English is required.
  • The applicant should be able to work well in a team, as well as having the ability to work independently.

Terms and conditions
The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process
Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.
Your application should contain the following documents:

  • A personal letter and a curriculum vitae (Swedish or English)
  • Degree projects and previous publications, if any (Swedish or English)
  • Academic transcripts, covering all courses you have taken as an undergraduate and Master’s student
  • Any other documentation showing the desirable skills and personal qualities described above (Swedish or English)
  • Documents certifying your general eligibility (see A above)
  • Documents certifying your specific eligibility (see B above)

Selection
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

KI uses the following bases of assessment:

  • Documented subject knowledge of relevance to the area of research
  • Analytical skill
  • Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employmentPhD placement
Contract typeFull time
First day of employmentAccording to agreement
SalaryAccording to agreement
Reference number2-4345/2019
Contact Juulia Jylhävä, juulia.jylhava@ki.seSofia Anderberg, sofia.anderberg@ki.se
Union representative Ann Almqvist, OFR, ann.almqvist@ki.seUlrika Zagai, SACO, ulrika.zagai@ki.seHenry Wölling, SEKO, henry.wolling@ki.se
Last application date30.Sep.2019 11:59 PM CET

Read the job description at the university homepage

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Post expires on Monday September 30th, 2019

Postdoc position, Maintenance of neuronal identity

Karolinska Institutet, Department of Cell and Molecular Biology, Holmberg

The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology.

Division
The research group of Johan Holmberg is part of the Department of Cell and Molecular Biology (CMB) which recently moved to the new interdisciplinary research centre Biomedicum located at Campus Solna, Karolinska Institutet.

Background
The brain contains a large number of different neuronal subtypes that maintain their distinct identities over several decades despite continuous environmental fluctuation. Apart from the instructive information provided by transcription factors controlling cell type specific transcriptional programs, there is presumably also a need to maintain silencing of alternative transcriptional programs. The mechanisms governing permanent repression of aberrant transcription in mature neurons are not well understood. Our lab focuses on the role of repression of alternative gene programs for lifelong maintenance of serotonergic and dopaminergic identity. For a more extensive background see: Holmberg and Perlmann, Nature Review Genetics 2012 and Södersten, E. et al. Nature Commun. 2018. Besides exploring fundamental processes we also aim to understand how they influence clinically relevant topics including psychiatric disorders, neurodegeneration and aging. The group also harbour an interest in the understanding of the paediatric malignancy, neuroblastoma, see: Westerlund, et al. Proc Natl Acad Sci U S A 2017.

In this project we will generate and analyse large amounts of data from defined wild type/mutant mouse neuronal populations in order to understand the functional relevance of gene repression for safeguarding mature serotonergic and dopaminergic identity.

Position specific requirements
We are looking for an outstanding researcher able to analyse and integrate large sets of bulk and single cell RNA-seq with ChIP-seq data generated from restricted in vivo neuronal subpopulations. Additional experience with confocal image acquisition and analysis as well as with in vivo/in vitro standard methods (e.g. immunostaining, FACS, stereotactic injections, behavioural analysis and cell culture) will be considered as a distinct advantage. Thus we are primarily looking for a computational biologist with experience/interest in laboratory/animal work or an experimental biologist with extensive bioinformatic skill and interest.

The applicant must be able to communicate well in English.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • Cover letter stating the motivation to apply and key skills that match the profile 

The application is to be submitted on the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

First day of employmentas soon as possible
Reference number2-2626/2019
ContactJohan Holmberg, johan.holmberg@ki.se
Last application date30.Sep.2019 11:59 PM CET

Read the job description at the university homepage

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Post expires on Monday September 30th, 2019

Postdoctoral research fellow at Department of Medical Biochemistry and Biophysics, Functional genomics

Labb odling.jpg

Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Functional genomics

Division
The Department of Medical Biochemistry and Biophysics consists of 11 research divisions which are involved in teaching and research within the fields of protein chemistry, redox biochemistry, metabolism, lipid research, inflammation research, structural biochemistry, molecular biochemistry, tissue biology, and developmental biology.

Area of responsibilities/description of work
A postdoctoral position to study the role of global transcription factor activity in cellular lineage determination (Wei et al., Nature Biotechnology 36: 521-529, 2018) is available immediately in the Division of Functional Genomics in the laboratory of Professor Jussi Taipale (https://ki.se/en/mbb/jussi-taipale-group).
The laboratory focuses on the study of transcriptional control of cell growth, using functional genomics and systems biology, and mouse genetic models. Jussi Taipale heads research groups at Karolinska Institute, University of Cambridge and University of Helsinki. The research groups consist of both experimental biologists and computer scientists. Current lines of work include high-throughput determination of binding sites and binding specificities of human transcription factors, and using this information to identify regulatory elements that control cell growth during normal development or in cancer. Identified elements are validated using cultured cells and mouse genetic models (see for example Hallikas et al., Cell 124:47-59, 2006; Kivioja et al., Nature Methods 9:72-74, 2011; Sur et al., Science 338:1360-1363, 2012; Jolma et al., Cell 152:327-339, 2013; Yan et al., Cell 154:801-813, 2013; Jolma et al., Nature 527:384-388, 2015; Yin et al., Science 356: eaaj2239, 2017; Zhu et al., Nature 562: 76-81, 2018).

The position is a Project employment.

Qualifications
To qualify the applicant must hold a doctoral degree or a foreign qualification deemed equivalent to a doctorate in Systems Biology, Molecular Biology, Biological engineering, Medicine or similar along with computational experience for analysing large sets of data. Applicants must be able to work independently and have good communication skills in English.

Entry requirements
A person is eligible as postdoctoral research fellow if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. We especially encourage applications from those who expect to complete their PhD within one year from current date and those who have completed their PhD less than 12 months ago.

Application process
An employment application should be a maximum of seven A4 pages in total, and must contain the following documents in English:

–  One page cover letter highlighting your 2 most important first-author publications in major international scientific journals

–  Two page CV including a list of major publications (reference only, no abstracts or full papers)

–  Two letters of recommendation, 1-2 pages each

The application is to be submitted through the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employmentTemporary position longer than 6 months
Contract typeFull time
First day of employmentUpon agreement
SalaryMonthly
Number of positions1
Working hours100%
CityStockholm
CountyStockholms län
CountrySweden
Reference number2-4029/2019
ContactInderpreet Sur , +46-8-52485204
Union representativeAnne Edgren, OFR/S, P, O, 08-524 87570Henry Wölling, SEKO, 08-524 840 80
Last application date30.Sep.2019 11:59 PM CET

Read the job description at the university homepage

Login and apply

Post expires on Monday September 30th, 2019