Tag Archives: Karolinska

Postdoctoral studies in Circadian Biology (scholarship)

Do you want to contribute to top quality medical research?

Within our research group you will find a unique opportunity to work with cutting edge research in the intersection between circadian rhythms, metabolism and neuroendocrinology. We offer an engaging and international research environment where you may contribute to high quality research on an internationally competitive level.


Division

Our group is an integral part of the unit of endocrinology at the department of medicine in Huddinge and is led by Paul Petrus.

Duties

We are looking for a highly motivated postdoctoral researcher interested in circadian biology. The aim of our research is to identify circadian mechanisms involved in metabolic- and mental- disorders. The successful candidate will drive a multidisciplinary project combining bioinformatic analyses as well as functional characterization using in vitro and in vivo systems. The goal of our research is to design interventions targeting the circadian system with therapeutic relevance for metabolic- and mental- morbidities.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Prior experience

The applicant is expected to have documented research experience within the field of circadian biology and/or metabolism and/or neuroendocrinology. Prior work using mouse models is a requirement and experience with metabolic- and/or behavioural- phenotyping is a plus. Bioinformatic skills (using R) and experience working with cell cultures is meritorious. 

Location: Flemingsberg, Stockholm

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

Welcome to apply at the latest September 16.

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-09-16 at 23:59
Unit: Department of Medicine, Huddinge

Read the job description at the university homepage or apply.

Post expires on Friday September 16th, 2022

Postdoctoral researcher in Bioinformatics – Medical Digital Twin Research Group at the Karolinska Institute

Do you want to contribute to improving human health?

We construct digital twins of individual patients based on omics- and clinical routine data. Those twins are computationally treated with thousands of drugs to find the drug or drugs that are optimal for the patient. The project is based on a multi-disciplinary international collaboration funded by the European Commission and the Nordic Research Council.

Your mission

Your role is to contribute to the design and computing of digital twins, in close collaboration with other bioinformatics, AI-, experimental and clinical researchers. This involves exciting and challenging tasks, which you can get a brief introduction to at our website. This website also includes links to publications and a recorded talk at Harvard.

Your profile

You should have PhD training in computational biology or bioinformatics relevant to our research. This should have resulted in publications with impact> 5, where you are a co-author. Experience of research in AI or machine learning are strong merits. The most important thing is that you have the ability to quickly learn, or develop, new methods and use them in interdisciplinary collaborations. Because cooperation requires trust, ability to co-operate and personal integrity are very important. It is also good if you are performance-oriented with clear career goals in academia or industry, which we can jointly plan for. Structured career planning is important for motivation, and has proven very successful for previous and present co-workers. You must take initiative and have a problem-solving analytical ability. We value personal qualities in the selection of candidates.

Eligibility requirements

Qualified to be employed as a postdoctor in bioinformatics is one who has obtained a doctorate in biology, medicine, mathematics, statistics, bioinformatics computer science or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent. 

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.


Location:
Solna

Swedish Digital Twin Consortium
Choose to work at KI – Ten reasons why

 

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Welcome to apply at the latest August 28, 2022. 

The application is to be submitted through the Varbi recruitment system.

 

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-08-28 at 23:59
Unit: Department for Clinical Science, Intervention and Technology

Read the job description at the university homepage or apply.

Post expires on Sunday August 28th, 2022

Postdoctoral studies in experimental kidney disease (scholarship)

Do you want to contribute to top quality medical research?

The Department of Clinical Science, Intervention and Technology at Karolinska Institutet offers a scholarship and a post-doc position on the topic of experimental kidney disease.

Division

We investigate kidney disorders in a translational research setting in order to understand disease mechanisms, apply new knowledge in diagnostics, improve prognosis assessment and develop new treatment strategies. Our division employs clinical and non-clinical researchers, with a particular focus on vascular aging, inflammation and disturbances in mineral metabolism associated with chronic kidney disease.

Duties

Characterisation of the transcriptomic response to Fibroblast Growth Factor 23 (FGF23) signalling in the healthy and diseased kidney on a single cell level using single cell RNA-sequencing and spatial transcriptomics. 

Entry requirements

You are qualified to be employed as a postdoctoral researcher if you have a doctorate or an equivalent scientific competence. The candidate should have extensive experience in experimental renal research, preferentially using animal models of kidney disease, and RNA sequencing analysis. Previous experience in FGF23 signalling is a strong merit. You should be highly motivated, ambitious, and have good communicative skills. We value personal qualities in the selection of candidates.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Huddinge

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-08-22 at 23:59
Unit: Department for Clinical Science, Intervention and Technology

Read the job description at the university homepage or apply.

Post expires on Monday August 22nd, 2022

Postdoctoral position focusing on intratumor heterogeneity and phenotypic plasticity

Do you want to contribute to top quality medical research?

Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching in immunology, infection biology, cell biology and cancer. Key words are multidisciplinary, bridging, translational, national and international collaborations.

Division
The Schlisio lab at Karolinska Institute, Sweden, seeks a postdoctoral fellow to work on molecular principles of tumor formation arising from the sympathoadrenal cell lineage (neuroblastoma, pheochromocytoma, paraganglioma) to explore cell of origin, disease initiation and tumor heterogeneity.

Your mission

We are seeking a motivated, creative post-doctoral candidate interested in exploring drivers of intratumor heterogeneity and phenotypic plasticity in sympathoadrenal tumors, such as childhood neuroblastoma and pheochromocytoma.

Intratumor heterogeneity and high plasticity account for therapy resistance. Causes of plasticity cell state transitions during tumor progression remain poorly understood. Currently, there is no effective treatment that addresses cancer heterogeneity. Systematic characterization of dynamic properties of intratumor heterogeneity and phenotypic plasticity can guide treatment strategies and improve clinical outcome for cancer patients. We aim at elucidating the origin and heterogeneity of sympathoadrenal malignancies, such as pheochromocytoma and childhood neuroblastoma by developing a new analytic and experimental approach based on single-cell transcriptomics with integrated mass spectrometry. We generated novel tumor mouse model systems and include human tumors to perform comparative differentiation trajectory analysis, to make predictions and, finally, to perform preliminary validations of envisioned tumor differentiation strategies.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

Successful applicants must have the ability to work both independently and collaboratively in a group and have good English communication skills.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

For more information about the group see: https://ki.se/en/mtc/schlisio-lab

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Welcome to apply at the latest 2022-08-21

The application is to be submitted through the Varbi recruitment system.

 

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-08-21 at 23:59
Unit: Department of Microbiology, Tumor and Cell Biology

Read the job description at the university homepage or apply.

Post expires on Sunday August 21st, 2022

Postdoctoral studies in mitochondrial biology

Do you want to contribute to top quality medical research?

Wredenberg group
We are looking for a highly motivated postdoctoral researcher interested in mitochondrial biology. Our research aims at identifying the molecular consequences of metabolic derangements, by understanding how mitochondria function within the metabolic system. For this, we use model systems, ranging from patient-derived samples, reprogrammed neuroepithelial stems cells to genetically modified animal models. We are specifically interested in the regulation of mitochondrial gene expression and post-transcriptional and post-translational modifications. The laboratory offers an outstanding research environment for basic and translational research with a close association to the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital.

For more information about the group, please visit. www.wredenberglab.com.

Division of Molecular Metabolism

We are part of the Division of Molecular Metabolism at the Department of Medical Biochemistry and Biophysics at the Karolinska Institute. Research at the division focus on understanding the regulation of mtDNA expression, using both molecular and structural approaches, study the role mitochondrial metabolism in neurodegeneration and cancer biology, as well as diagnose patients with inherited metabolic diseases. For more information, please visit: https://ki.se/en/mbb/research-division-of-molecular-metabolism.

Duties

The successful candidate is expected to drive a research project focusing on mitochondrial RNA metabolism and perform molecular biological experiments in a range of model systems. The successful candidate is further expected to analyse and present data and develop the project to its full potential.

Your profile

A strong background in molecular and mitochondrial biology and/or metabolism is favored. Comprehension in mouse and/or Drosophila genetics is preferred, but not required. Experience in handling large data and bioinformatic skill is meriting. A working knowledge of the English language is essential. Personal suitability is of great importance when evaluating the applicants.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Solna
www.wredenberglab.com
https://ki.se/en/mbb/research-division-of-molecular-metabolism

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all!

Deadline: 2022-08-21 at 23:59
Unit: Department of Medical Biochemistry and Biophysics

Read the job description at the university homepage or apply.

Post expires on Sunday August 21st, 2022

Doctoral (PhD) student position in public health informatics – prevention of problem gambling

Do you want to contribute to better health for all?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Digital Psychiatry Lab at the Centre for psychiatry research (Department of Clinical Neuroscience) is led by associate professor Philip Lindner and conducts clinical and other applied research in the field of digital psychiatry, with the goal of developing, evaluating and implementing new digital tools for the identification and treatment of mental health problems in different forms. One prominent research track of the group is the identification and prevention of problem gambling in online casinos and betting, where the digital setting allows for unique opportunities to use high-resolution Big Data and the interactive format, to detect and prevent problem gambling. The Digital Psychiatry Lab is happy to announce a doctoral student position within this track, in the field of public health informatics.

The doctoral student project and the duties of the doctoral student

The Digital Psychiatry Lab has entered into an academia-industry collaboration agreement with a licensed gambling provider with high ambitions and a demonstrated track record in responsible gambling and research therein. The goal of this agreement is to improve the identification and prevention of problem gambling, both through independent scientific evaluations of current responsible gambling measures and through the transfer of clinical and public health knowledge in the development of new such measures.

In addition to several academic supervisors (including main supervisor associate professor Philip Lindner), the doctoral student will have a co-supervisor employed by the gambling provider. The doctoral student will be involved in all stages of quantitative research, including acquiring the necessary approvals, study design, processing and analysis of large and complex datasets, and scientific writing. Through this, the doctoral student is expected to gain excellent and transferable skills, both soft (e.g. collaborative, project management) and hard (quantitative, computational), all the while authoring high-quality research with a great and immediate public health impact. In tandem, the experience and skills acquired will provide the doctoral student with excellent prerequisites for a continued career in research, public health, informatics, responsible gambling, or similar. A successful doctoral student will have the opportunity to engage in other projects headed by the Digital Psychiatry Lab, to broaden their research experience even more.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

 

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

For this interdisciplinary project, we will consider talented, organized, flexible, highly motivated individuals from a range of project-relevant backgrounds.

Requirements

  • An educational background in one or several of the following fields: psychology (clinical or other applied), public health, epidemiology, informatics, computer science, statistics, data science, social work, or quantitative sociology
  • Solid quantitative skills, including data processing and statistical analysis, with both the drive and the ability to quickly pick up new quantitative skills
  • Skilled in project management and an excellent collaborator

Merits

  • Can read and write Swedish sufficiently to comprehend laws and regulations without requiring translation, or demonstrated capacity to quickly learn new languages
  • Previous experience of conducting research, especially within academia-industry collaborations
  • Educational background and/or work experience within psychiatry or the addiction field, especially in the context of problem gambling
  • Knowledge of the Swedish gambling market and relevant legislation and regulations
  • Knowledge of the GDPR and the Swedish Ethical Review Act, as well as experience of the Swedish ethical review process
  • Experience with large longitudinal datasets with high temporal resolution
  • Experience with psychometrics and machine learning
  • Experience working with R and/or Python

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

 

 

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Read more about the research group here
Read more about Centrum för psykiatriforskning here

 

Want to make a difference? Join us and contribute to better health for all!

Deadline: 2022-09-04 at 23:59
Unit: Department of Clinical Neuroscience

Read the job description at the university homepage or apply.

Post expires on Sunday September 4th, 2022

Postdoc in Proteomics – Proteome analysis of breast cancer clinical cohorts

Do you want to contribute to top quality medical research?

 

At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. About 30 research groups with various cancer research profiles are involved and we have around 110 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

 

Your mission

We seek a highly motivated postdoc in proteomics, interested in addressing clinical research questions by using proteomics methodologies. The postdoc will generate mass spectrometry-based proteomics data of clinical cohorts to obtain biological understanding of cancer and identifying biomarkers. The position requires solid expertise in proteomics, communication skills and willingness to work in a team environment. The current position offers great possibility for innovative research combining proteomics and other omics data, together with a dedicated group of scientists.

Precision medicine refers to the tailoring of medical treatment to the individual characteristics of each patient. We are looking for a passionate postdoc interested in the concept of precision medicine using mass spectrometry-based proteomics. The work will span from generation to analysis of clinical mass spectrometry-based proteomics data, with the aim to define and understand the biology behind different breast tumor subgroups, how they relate to clinical outcome, and how this information can be used to guide therapy decisions.

The position will be placed in the Cancer proteomics Mass spectrometry research group headed by Professor Janne Lehtiö at Science for Life Laboratory (SciLifeLab). The Lehtiö group is a translational group aiming to improve cancer treatment using multi-omics tumor data analysis. The group members are from various disciplines working as a team to study genes and proteins in the context of biological networks, understand how tumor molecular changes impact the proteome and discover new disease biomarkers to be exploited therapeutically. Scientists and engineers in our group work closely together using a variety of technologies to generate novel knowledge about the biology of the disease and implement tools to support the clinical decision making in the oncology setting. The position is funded by and will involve collaboration within the RESCUER consortium, which consists of fifteen organizations from ten different countries.

SciLifeLab is a national infrastructure and research center in technology driven life sciences and Karolinska Institutet is one of the four founding universities for SciLifeLab. We offer a very stimulating and diverse work in a team of very motivated co-workers with expertise in cutting-edge technology.

Your profile

To be eligible for the postdoctoral position, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the postdoctoral education. The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Qualifications

  • PhD in biology, chemistry, medicine, or another relevant field.
  • Documented experience in generating and analyzing mass spectrometry-based proteomics data.
  • Working experience in large-scale omics data analysis, integration, and visualization.
  • Ability to interpret omics data in a biological context
  • Knowledge in statistical methods
  • Understanding of cell- and molecular wet-lab experimental methods.
  • Excellent communications skills
  • Fluent in English language

Additional merits

  • Knowledge and working experience of breast cancer
  • Knowledge of cancer biology and current translational cancer research
  • Programming experience in: Python and/or R

Since the position involves close interaction with several researchers, emphasis is placed on personal skills such as:

  • Very good collaborative skills
  • Excellent communication skills and analytical skills
  • Curious and eager to solve biological questions

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.


Location: SciLifeLab, Solna

 

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Welcome to apply at the latest August 17.

The application is to be submitted through the Varbi recruitment system.

 

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-08-17 at 23:59
Unit: Department of Oncology-Pathology

Read the job description at the university homepage or apply.

Post expires on Wednesday August 17th, 2022

Postdoctoral Researcher in Computational Cognitive Neuroscience

Do you want to contribute to better health for all?


Research group
The Brain, Body and Self Laboratory (PI: Henrik Ehrssson) use neuroimaging and behavioral methods to study how we come to experience our own body as an object distinct from the environment. Our aim is to characterize the perceptual rules and brain mechanisms whereby a central representation of one’s own body is constructed by the integration of signals from the different sensory modalities (e.g., vision, touch, and proprioception). We are also interested in the relationship between basic processing of sensory signals from the body, on the one hand, and higher order representations such as conscious self-awareness, self-concept and episodic memory.

Duties
We are seeking an experienced and talented cognitive neuroscientist with interest in psychophysics, EEG, and body representation and perceptual awareness research. The postdoc’s main duty is to conduct psychophysics and EEG studies on body ownership and multisensory bodily awareness. The postdoc is expected to design, plan, conduct, analyzing data, and write up first draft of manuscripts from human behavioral experiments and EEG studies on this research topic. Previous experience of psychophysics, signal-detection-theory, computational modeling, and EEG is a plus, as well as programming skills. 

What do we offer?
A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Entry requirements
At Karolinska Institutet the Postdoctoral Researcher position is regarded as an early career step after a doctoral degree. Qualified to be employed as a Postdoctoral Researcher is one who has obtained a doctorate or has equivalent scientific competence.  

Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances
  5. Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline)

The application is to be submitted through the Varbi recruitment system.

Interviews will start when applications are received until the position is filled.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-08-21 at 23:59
Unit: Department of Neuroscience

Read the job description at the university homepage or apply.

Post expires on Sunday August 21st, 2022

Doctoral (PhD) student position in Mucosal Immunology and ulcerative colitis

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The student will supervised by Associate Professor Eduardo Villablanca (a leader in the field of mucosal immunology, with an emphasis in intestinal homeostasis and IBD) and co-supervised by Dr. Charlotte Hedin, (clinical gastroenterology specialist at the Karolinska and PhD), and Associate Professor Jenny Mjösberg (a leader in innate lymphoid cell biology in IBD and colorectal cancer).

The student will be located within the Villablanca group, which is part of the Immunology and Allergy Division at the Department of Medicine, Solna and is located at the Center of molecular Medicine (CMM). The Villablanca lab has available all the equipment necessary for molecular and cellular biology is available. The PhD student will have access to FACS analyser and sorters, confocal microscopy and all the basic equipment to perform the proposed research. The student will also have access to core facilities and Services at the department and SciLifeLab, which include sequencing, imaging, informatics services and animal housing and maintenance. In addition, Dr. Villablanca is the co-director of the single cell RNA sequencing (scRNAseq) core at CMM, taking responsibility in the operation of the Chromium 10X drop-based system. Our group works in an inspiring and interactive research environment at the Karolinska University, Solna and has ongoing collaborative projects with national and international colleagues.

The doctoral student project and the duties of the doctoral student

In this study plan, the student will gain insights into the mechanisms that underlie IBD progression and response to treatments with the final goal of identifying potential therapeutic strategies that promote intestinal regeneration. In particular, the student will further characterize the host microbiota interaction by using spatial transcriptomics and single-cell RNAseq, and will further characterize the recently stratified UC patients; namely UC1 and UC2 (Czarnewski P., Nat Comm, 2019). This project provides an excellent opportunity to combine clinical and experimental studies to investigate IBD and generate relevant translational knowledge. Methodological techniques are well stablished in collaboration with Dr. Villablanca, and patient recruitment has already started under the supervision of Dr. Hedin.

The student will masterize experimental models of intestinal inflammation and will acquire a deep understanding of mucosal immunology and bioinformatics. In addition, the student will obtain comprehensive knowledge in molecular biology and microscopy techniques, including analyses of human samples. The student will also acquire a deep knowledge of IBD as well as demonstrate understanding of ethics, project and experimental design, basic bioinformatics analysis and laboratory work. The project includes integration of clinical data of IBD patients’ dietary intake, medications, other environmental exposures and body composition with molecular data, giving the student possibility to develop his/her skills in statistical and bioinformatics analyses. Finally, the student will learn in vitro and ex vivo work. The student is expected to attend international conferences and spend a period abroad (Broad Institute, Boston). 

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

The applicant must be efficient, thorough, a good communicator in English, have experience from laboratory work, communicating science in the format of conferences and publications, be flexible and have collaborating skills and enjoy working in an international and dynamic team. The applicant should have a strong motivation to the study the field mucosal immunology and understanding of IBD. The applicant must have experience in wet and dry lab work and also in using experimental models (e.g. zebrafish) of intestinal inflammation. Earlier involvement in human and mouse IBD related as well as bioinformatics research is a merit. The project requires high organization skills and management of patient datasets as well as good communication with colleagues and clinicians.

The applicant must have good analytic skills and basic knowledge of some statistical software for data analysis, preferably R. The applicant should fulfil basic conditions to be able to work with bioinformatics analyses that includes documented good and broad knowledge and understanding in mathematics.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

–[Video about Karolinska Institutet, how we all work towards “a better health for all”] –

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Location

The employment will be at the Department of Medicine, Solna. The Department consists of twelve divisions and each division consists of several research groups. This position is located within the research group of Eduardo Villablanca, at the Immunology and Allegry division. 

Eduardo Villablanca group

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-08-14 at 23:59
Unit: Department of Medicine, Solna

Read the job description at the university homepage or apply.

Post expires on Sunday August 14th, 2022

Postdoctoral researcher in personalized medicine of infectious diseases

Do you want to contribute to top quality medical research?

At the Division of Infectious Diseases, Department of Medicine, Solna, we perform research and education in infectious diseases in close collaboration with the Karolinska University Hospital. The research is translational, and involves clinical, epidemiological and experimental research in areas such as sepsis, pneumonia, meningitis, covid-19, HIV, malaria, tuberculosis, antibiotic resistance, and healthcare associated infections.

Our research group (Team Pontus Naucler) has built a unique infrastructure to perform high-quality large-scale analyses of clinical data where we have access to clinical data from electronic health records during the last 10 years in Region Stockholm (>20 million health care episodes).

The aim of the postdoctoral project is to investigate risk factors for healthcare-associated infections and to develop fully-automated predictive screening algorithms for early detection of infections as well as improved antibiotic treatment. This will lead to personalized treatment and management according to each patient’s needs, as part of the paradigm-shift towards personalized medicine in infectious diseases.

You will work in a dynamic research group consisting of epidemiologists, clinicians, bioinformaticians, and computer scientists. In collaboration between KI and KTH, you will perform first-class research using traditional epidemiological and statistical methods as well as state-of-the-art machine learning techniques and natural language processing.

Your mission

As a postdoctoral researcher you will develop and implement prediction models and perform epidemiological research with a focus on antibiotic treatment and healthcare-associated infections.

You will be involved in epidemiological study design, data management, statistical analyses and scientific writing of articles, reports and presentations. Analyses also include machine learning techniques to study complex data.

 There are opportunities for initiation of your own research projects and to supervise students.

Your profile

The ideal candidate should hold a Doctoral (or be near completion) degree in medicine, epidemiology, statistics, biostatistics, mathematics, computer science, health data sciences or a related field. An advantage is having worked with large amounts of clinical data or registers, and knowledge of programs such as R, STATA, SAS or Python. You should have experience of independent work, good communication and teamwork skills. A requirement is good knowledge of English, knowledge of Swedish is beneficial. Knowledge of statistics, machine learning techniques, database management, an understanding of clinical work, or infectious diseases is an advantage.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to drive the development of knowledge about life and to promote a better health for all. Here, we conduct successful medical research and have the largest range of medical education in Sweden. Karolinska Institutet is a state university. This means you get good benefits through our collective agreement, generous holiday and a good occupational pension. You get to practice freely in our modern gym and receive reimbursement for medical care.

Location

The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within the research group of Professor Anna Färnert and team Pontus Naucler in the Division of Infectious Diseases https://ki.se/en/meds/research-group-anna-farnert and https://ki.se/en/meds/team-pontus-naucler

Want to make a difference? Find a job with us – and contribute to better health for all

Deadline: 2022-08-21 at 23:59
Unit: Department of Medicine, Solna

Read the job description at the university homepage or apply.

Post expires on Sunday August 21st, 2022

Postdoctoral Researcher in Computational Biology

Do you want to contribute to top quality medical research?

In our research group, you will find a unique opportunity to work closely with top researchers at the interface of vascular biology and neuroscience to jointly understand how the human brain becomes vulnerable during injury, neurodegeneration and aging. Our recent work (Månberg et al. Nature Medicine 2021) showed that vascular and glial cells contribute to dynamics of neurodegeneration and this project will aim to refine our understanding of cellular mechanisms, biomarkers and genetic risk of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Alzheimer’s disease. We offer an engaging and international research environment where you will have the opportunity to contribute to high quality research at the top international level.

Your mission

We are recruiting a highly motivated and independent postdoc candidate with experience in next-generation sequencing data analysis, computational genomics, medical statistics, computational biology and/or imaging analysis. The project combines single-cell, multi-omics data with large scale human genetics to investigate the cellular origin of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Alzheimer’s disease (AD). The postdoc candidate will work closely with researchers in the team as well as with our collaborators and be responsible for data analysis, visualization, and development of new computational methods for processing and analysis of large-scale omics data. We welcome applications from candidates with pure computational background and those combining experimental and theoretical approaches.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

Qualifications

  • PhD in Bioinformatics, Computer science, Mathematics, Biostatistics, Neuroscience, or similar field.
  • Proficiency in written and spoken English. Previous work with large-scale data analysis, integration and visualization.
  • Experience with NGS (10x platform, Smart-Seq) or other high-throughput/dimensionality methods
  • Proficiency in scripting language (Python or R) database development, maintaining & sharing code repositories.
  • Curiosity to solve fundamental biological questions and enthusiasm to lead new independent projects.
  • Ability to formalize a biological question into a computational model.

Merits

Experience with:

  • Analysis of ATAC-seq and other open chromatin datasets
  • Network analysis
  • Biostatistics
  • Meta-analysis.
  • SNP calling from NGS data
  • Working with wet lab scientists

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.


Location:
Solna


Read more about the Department of Clinical Neuroscience

 

 

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Welcome to apply at the latest 2022-08-29.

The application is to be submitted through the Varbi recruitment system.

 

Want to make a difference? Join us and contribute to better health for all!

Deadline: 2022-08-29 at 23:59
Unit: Department of Clinical Neuroscience

Read the job description at the university homepage or apply.

Post expires on Monday August 29th, 2022

Postdoctoral studies in tumor microenvironment (scholarship)

Do you want to contribute to top quality medical research?

 

The Department of Oncology-Pathology is searching for a postdoctoral fellow to work with Dr. Rolny and co-workers on gene expression programs governing tumor-associate macrophage (TAM) phenotypes during tumor development. The research groups encompass wet-lab knowledge that spans from state-of-the-art molecular biology to complex animal tumor models. More details about the groups can be found at here.The research group has longstanding collaborations and interaction with researchers, and also have weekly research group meetings with scientist within the tumor microenvironment field and is a member of the Swedish Tumor Microenvironment Program (https://igp.uu.se/storm/about-storm) and the Breast Cancer Theme Center (https://ki.se/en/research/brect-breast-cancer-theme-center).

Your mission

The Rolny lab focuses on mechanism that governs TAMs immunosuppressive and pro-metastatic functions. Over the years, Rolny and co-workers, have provided evidence that reprograming of TAM pro-tumor phenotype into an anti-tumor phenotype is a valid anti-cancer strategy. We have now pinpointed a unique pathway that regulates TAM pro-tumor functions that may pave way for development of novel anti-cancer targets. We are seeking a motivated, creative post-doctoral candidate interested in exploring drivers of TAMs pro-tumoral functions. Studies will include state-of the art molecular biology, animal tumor models and patient material with the overarching goal to shed light on signaling pathways that govern TAM functions. The post-doctoral fellow will lead and execute the intended project according to timelines and set goals.

Your profile

The ideal candidate is highly motivated, with an outstanding completed PhD thesis (or equivalent) and a strong drive for a future career in research. The candidate should be capable of generating novel ideas, acquire knowledge independently and possess sufficient computational skills to evaluate and develop ongoing projects. It is preferable that the applicant has a background in tumor biology. Fluency in spoken and written English is required. At least one paper in a high-quality international peer-reviewed journal is necessary to be considered, additional academic merits will also be taken into an account. Because of the scope of the project, knowledge and experience in animal work, flow cytometry analysis and confocal microscopy imaging is required. Previous experience with the most common molecular biology techniques including cloning of genes of interest, lenti-virus production, western blot analysis, qPCR etc. is essential. In addition, personal suitability will be a factor in the selection process.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Solna, Stockholm

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system August 23rd at the latest.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-08-23 at 23:59
Unit: Department of Oncology-Pathology

Read the job description at the university homepage or apply.

Post expires on Tuesday August 23rd, 2022

Doctoral (PhD) student position in Integrative Physiology/Immunology and metabolism

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Integrative Physiology research group focuses on mechanisms underlying metabolic disorders with particular, but not exclusive, focus on insulin resistance in skeletal muscle. Using novel methodology developed in the group to incubate and analyse human skeletal muscle samples ex-vivo, we were the first to demonstrate defects in insulin stimulation of intracellular signalling molecules in patients with insulin resistant type 2 diabetes mellitus. The effects of exercise and muscle contraction in regulation of insulin sensitivity both whole body and in muscle is also a key area of investigation, as are effects of skeletal muscle immobility and/or denervation. Clinical investigations in, parallel with primary human skeletal muscle cultures, where skeletal muscle cells are grown in vitro from patient biopsies, and model organisms are used to approach metabolic disease from a multidisciplinary angle in order to address gene and protein regulation, cell physiology and whole body metabolism.

The doctoral student project and the duties of the doctoral student

Obesity and type 2 diabetes are associated with chronic activation of the immune system. Inappropriate inflammatory responses and the accumulation of immune cells in metabolic tissues contributes to the development of insulin resistance and the cardiometabolic complications associated with type 2 diabetes. Skeletal muscle is the major contributor to post-prandial regulation of glucose levels and therefore a key player in the development of type 2 diabetes. However, inflammatory responses affecting muscle metabolic responses are poorly characterized. 

Small molecules derived from arachidonic acid play important roles in inflammatory responses, and several eicosanoids are increased by exercise. We recently discovered that eicosanoid receptors are expressed in skeletal muscle cells and our preliminary results suggest that activation of those receptors in skeletal muscle cells alters glucose metabolism. Altogether, these data suggest a role of eicosanoid signaling in skeletal muscle immunometabolic responses, but this has to date not been investigated.

Overall aim

The present PhD project focuses on the effects of eicosanoid signaling on insulin responses and inflammation in skeletal muscle. And will include the following projects:

  • Identification of eicosanoid-mediated pathways regulating the metabolic responses. Using transcriptomics, phosphoproteomics and literature review, the PhD student will identify eicosanoids involved in metabolic responses. A background in bioinformatics is an advantage.
  • Metabolic characterization of eicosanoid signalling in human skeletal muscle. Using primary skeletal muscle cell cultures, the PhD student will measure glucose uptake, substrate oxidation and metabolic pathway activation in response eicosanoids.
  • Selective targeting of skeletal muscle eicosanoid signalling. Selectively targeting of muscle with agonists in vivo may be challenging. We therefore propose to determine the specific binding partners of the receptors of interest in skeletal muscle compared to other tissues. Identification of co-receptors specific to skeletal muscle could provide with unique ways to selectively target skeletal muscle metabolism in vivo.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

 

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

  • Ability to contribute ideas for new research projects.
  • Ability to work with meticulous attention to detail.
  • An enthusiastic interest in diabetes research.
  • Evidence of excellent interpersonal skills, with the ability to communicate research ideas and results in a clear and logical way and the ability to confidently and effectively interact with colleagues and the broader research community.
  • Strong verbal and written communication skills in English.
  • A conscientious and enthusiastic working approach.
  • Excellent planning, organizational and problem-solving skills.
  • A background in bioinformatics, particularly R programming is a plus.
  • Skills in cell culture and quantitative RT PCR is an advantage.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Video about Karolinska Institutet

https://ki.se/fyfa/integrativ-fysiologi

https://ki.se/en/fyfa/department-of-physiology-and-pharmacology

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-08-31 at 23:59
Unit: Department of Physiology and Pharmacology

Read the job description at the university homepage or apply.

Post expires on Wednesday August 31st, 2022

Postdoctoral Position in Computational Biology of Parkinson’s Disease at the single-cell level

Do you want to contribute to top quality medical research?

We invite applications for a postdoctoral position (2+2 years) in the laboratory of Professor Ernest Arenas: http://ernestarenaslab.org/. The laboratory is part of the Division of Molecular Neurobiology, a cluster of 8 research groups forming a dynamic and collaborative research environment within the MBB department, at the Karolinska Institute https://ki.se/en/mbb/research-division-of-molecular-neurobiology.

Our laboratory is located in Biomedicum, one of the largest and most modern research centers in Northern Europe, within a world leading University, Karolinska Institutet. We provide modern technological platforms and facilities. We offer an interactive, multidisciplinary and international research environment, where you can perform cutting edge science that makes a difference, address fundamental questions, and contribute to the development of novel therapies to combat neurodegeneration.

Your mission

We are looking for a creative computational biologist seeking to study neurodegeneration in Parkinson’s disease at the single cell level. The project involves analysis of single cell RNA-seq, multiome and in situ sequencing data generated from different brain regions of control and Parkinson’s disease patients.

You will use your experience in performing bioinformatics analyses of sequencing data, to analyze and integrate transcriptomics and epigenomics data. You will have your own project, and you will be encouraged to address challenging questions, think independently and develop high impact research. You will interact and collaborate with other lab members working in the dry and the wet lab. The successful candidate will also have the opportunity to supervise students and to achieve personal development.

The project is partially supported by an ERC Advanced Grant (PreciseCell PD, 2021-2026) and by a Collaborative Research Network (CRN) program of the Aligning Science Across Parkinson’s (ASAP) initiative implemented through The Michael J. Fox Foundation, which aims at understanding the cause and molecular mechanisms underlying PD. This project is part of the long-term efforts of the lab aiming at identifying the cellular and molecular diversity of the nervous system (La Manno et al., 2016, Cell), at understanding cell-to-cell interactions (Toledo et al., BioRxiv doi: 10.1101/155846) and at deciphering the cause and mechanisms of PD (Bryois et al., 2020 Nature Genetics).

Your profile

The successful candidates should have (or be close to completing) a PhD in Genetics, Biochemistry, Systems Biology, Computational Biology, Biology, Neuroscience, Medicine or a related field. The applicants should be familiar with sequencing data (analysis and integration), and be comfortable analyzing large-scale datasets. Applicants interested in any of the above research areas and/or interested in developing a novel research direction will be considered.

The ideal candidate should have demonstrated skills in computational biology, with experience in one or more of the following: scripting (e.g. Python, R), basic knowledge of LINUX/UNIX command line and terminal, and analysis of sequencing data. Experience in single cell data analysis, gene regulatory networks, genomics (transcriptomics and/or epigenomics), and machine learning or neural networks would be a plus. Wet lab experience in single cell genomics or FACS, or knowledge of development, neuroscience or nerodegeneration will be considered as additional merits, but are not necessary.

You are expected to be able to work independently, to have your own project and to interact with other researchers in the dry or wet-labs, and to have a good command of written and spoken English.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

What do we offer?

We offer a 2+2 years full time (100%) postdoctoral position with possible start as soon as September 2022. Our laboratory and our unit offer an inspiring, creative, interactive and international research environment, where you can develop your career and enjoy top academic science.

The project offers excellent training opportunities, an outstanding research network and opportunities to interact and collaborate with world leading laboratories and researchers around the world working in the area of computational biology and PD.

Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.


Location:
Solna, Biomedicum

Application

Your application must contain the following documents in English:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications.
  • A summary of current work (no more than one page).
  • A letter of motivation (no more than one page)
  • Three references or reference letters
  • Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline).

In assessing candidates we will place our emphasis on the personal trajectory, education, technical skills, CV, merits and previous experience.

You are welcome to apply at the latest by the 2nd of September 2022

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-09-02 at 23:59
Unit: Department of Medical Biochemistry and Biophysics

Read the job description at the university homepage or apply.

Post expires on Friday September 2nd, 2022

Postdoctoral Researcher/The Strategic Research Programme for Diabetes (2)

Do you want to contribute to top quality medical research?

The Strategic Research Programme for Diabetes (SRP Diabetes) at Karolinska Institutet is funding a prestigious fellowship programme for postdoctoral research fellows. The Programme is focused on research in diabetes and its comorbidities. With this postdoctoral programme SRP Diabetes aims to support the next generation of exceptional young scientists within the diabetes area, including both experimental and clinical research. To promote cross-fertilization between research environments, we encourage scientists wishing to pursue postdoctoral training in a different university from where they carried out doctoral studies. Full details on the project and contact information to the PI can be found at: SRP diabetes postdoctoral fellowships
Based at Karolinska Institutet, fellows will undertake a cutting-edge research project, mentored by world-leading researchers in the field of diabetes. To increase coherence around the Fellowship programme, several events will be held throughout the year such as high-profile lectures, symposia, etc. which the fellows will attend.
The fellowships are fully funded, and salary is provided for a 2-year period. It is our intention that the positions will start in the autumn of 2022, though some flexibility with the start date might be possible.

Research Project (2)

Exosomal miRNAs and effects on skeletal muscle metabolism.

We are interested in understanding how skeletal muscle insulin sensitivity is altered, both in response to pathology such as type diabetes, and as a response to physical exercise. This fellowship programme is focused on the role of miRNAs in this regard, in particular miRNAs in small extracellular vesicles (also called exosomes. We have previously identified several miRNA which are dysregulated in skeletal muscle in subjects with type 2 diabetes, and which contribute to changes in metabolism and insulin signalling, including let7 (Jiang et al., 2013), miR-29 (Massart et al., 2017) and mIR20b (Katayama et al., 2018). Since miRNAs are able to target multiple genes simultaneously, miRNAs provide a potential mechanism for efficiently modulating a whole pathway to change or alter the functional properties in specific target tissues.
Objectives; A key observation is that primary cultures of human skeletal muscle from people with type 2 diabetes maintain an impaired response to insulin even after several passages in culture, implicating a genetic (or epigenetic) component. This project is focused on elucidating the role of exosomes, and in particular miRNA carried in exosomes in directing this effect.  We aim to identify miRNAs in media from skeletal muscle cultures established from people with normal glucose tolerance or type 2 diabetes. Identified miRNAs will be studied to determine functional effects of the identified miRNAs in different metabolic target tissues including skeletal muscle.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

Key responsibilities of the selected applicant:

  • Plan, manage and conduct an agreed academic research project and associated activities.
  • Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate.
  • Develop research questions, analyse detailed and complex qualitative and/or quantitative data from a variety of sources, and contribute original ideas for new research projects.
  • Coordinate multiple aspects of work to deliver novel research data in accordance with established timelines set between you and the Principal Investigator.
  • Adapt existing and develop new scientific techniques and experimental protocols to support research.
  • Regularly write research articles at an international level for peer-reviewed journals, book chapters, and reviews.
  • Formally present your research and represent the research group at internal, national and international conferences and meetings, either with other members of the team or alone.
  • Informally present your research to the group at established meetings.
  • Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques.

Selection Criteria
Essential 

  • A PhD in a medical/biological subject (to be completed in 2022).
  • The ability to manage your own academic research and associated activities.
  • A strong CV, having published in high impact journals and presented at international meetings.
  • Ability to contribute ideas for new research projects and research income generation.
  • Ability to work with meticulous attention to detail.
  • An enthusiastic interest in diabetes research.
  • Evidence of excellent interpersonal skills and leadership, with the ability to communicate research ideas and results in a clear and logical way and the ability to confidently and effectively interact with colleagues and the broader research community.
  • Strong verbal and written communication skills in English.
  • A conscientious and enthusiastic working approach.
  • Excellent planning, organizational and problem-solving skills.

Desired

  • Track record in metabolic disease, assessment of insulin action in skeletal muscle and analysis of miRNAs is a merit.
  • Bioinformatic experience of analysis of gene expression

Each Fellowship and research Project is for up to two years. We will prioritize applicants who have the opportunity to complete the project and be employed for two years. Preference should be given to those who were awarded a PhD or attained equivalent research competence no more than three years prior to the expiry of the application period for the position as postdoc.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

For further information about working at Karolinska Institutet, rules for visa/residence permit, insurance and accommodation please see: International staff


Location: Solna

How to apply

If you consider that you meet the selection criteria, click on the Login and apply button on this page and follow the on-screen instructions to register as a user. You will then be required to provide information in a number of screens with your application details, relating to your skills and experience. When prompted, please provide details of three references. You will also be required to upload a CV and Personal Letter which explains how you meet the selection criteria for the post. The Personal Letter (maximum two pages) should explain your relevant experience which may have been gained in employment, education, or you may have taken time away from these activities as illness, military service, work for labour unions or student organisations, parental leave or similar circumstances. Your application will be judged in part on the basis of how you demonstrate that you meet the selection criteria outlined above and we are happy to consider evidence of transferable skills or experience which you may have gained outside the context of paid employment or education

Please save all uploaded documents to show your name and the document type.
The application is to be submitted through the Varbi recruitment system.

The closing date for applications is midnight CEST on 31 August, 2022.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-08-31 at 23:59
Unit: Department of Molecular Medicine and Surgery

Read the job description at the university homepage or apply.

Post expires on Wednesday August 31st, 2022

Doctoral (PhD) student position in molecular studies on human vaginal wound healing

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The PhD student will be working in an interdisciplinary environment, in strong collaboration between clinical departments, experts within basic science and other national and international research groups.

We have a translational approach to our research initiatives. One long-term goal is to develop tissue engineering for urogenital tissue reconstruction. Therefore, we want to investigate the role of non-coding RNAs for tissue healing, tissue re-modelling and expansion.

Our approach is to use several strategies to re-create functional tissues by combining cells/tissue with different biomaterials and to evaluate wound healing responses. Eventually, wound healing and tissue reconstruction could be enhanced by actions of microRNAs in diseased tissues, such as malformations, inflammation, and scarring, that are in need for surgical reconstruction.

The PhD-student will work in the research group for Tissue Engineering at Bioclinicum floor 10, and with the research group for Gynaecology at Bioclinicum floor 9, both belonging to the Department of Women’s and Children’s Health at KI.

The Tissue Engineering laboratory is situated at two sites, at Bioclinicum in Stockholm and at Rigshospitalet in Copenhagen, Denmark. At present, a professor, a senior researcher, a laboratory manager and two PhD students are part of the group.

The laboratory team in the Gynaecology group consists of a professor, an associate Professor, and an assistant professor, one senior postdoc, a BMA and three PhD students.

The doctoral student project and the duties of the doctoral student

There are several congenital conditions affecting the formation of vaginal canal.  Tissue engineering may provide a way to improve surgical corrections and improve the wellbeing and reproductive capabilities of the affect population. We have identified a knowledge gap on the biological mechanisms that determine a normal healing of the human vagina. In general, wound healing could be defined as the tissues natural capacity to replace injured cells and to heal wounds.

This PhD project aims at giving a deep education in basic science and tissue healing biology. The project involves the exploration of transcriptomics during normal vaginal tissue healing. The doctoral student will work on clinical samples for studies in human primary cell cultures and will learn and practice several molecular cell biology methods including isolation, expansion and creation of vaginal 3D models, immunofluorescence, western blot, gene editing, cell transfection, digital PCR, microscopy, histological preparations, and studies in small animal models. A part of the study will involve bioinformatic analysis of gene expression profiles.

Furthermore, the student will take part in other related studies during the PhD program, that are assigned within the research groups. The student will be expected to work as a part of a team, taking responsibility for the progress of the work in a structured manner, with open communication with peers and the supervisors.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

We are looking for an engaged and motivated student with strong and genuine interest in research. The candidate should have a master degree or equivalent in biomedicine, cellular biology, medicine or related disciplines. Good communicative skills are highly valued.

Necessary skills and personal qualities:

  • Interest in medical research
  • Experience in basic molecular and cell biology techniques
  • Fluent/proficient in English both oral and written communication
  • Willingness to share knowledge and experience (i.e. Help and teach master students and peer-students)
  • A mind set for team work
  • Good habits related to laboratory work documentation

Meritorious skills and personal qualities (But not a prerequisite)

  • Experience in working with methods related to non-coding RNAs and RNA research
  • Experience in 3d culture
  • Experience in RNA sequence experimental bioinformatic analysis

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

 

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

https://ki.se/kbh/vavnadsrekonstruktion

https://ki.se/en/kbh/experimental-research

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-09-04 at 23:59
Unit: Department of Women´s and Children’s Health

Read the job description at the university homepage or apply.

Post expires on Sunday September 4th, 2022

Postdoctoral researchers in Cell transplantation for Parkinson’s disease

Do you want to contribute to better health for all?

We invite applications for a postdoctoral position in the laboratory of Professor Ernest Arenas: http://ernestarenaslab.org/. The laboratory is part of the Division of Molecular Neurobiology, a cluster of 8 research groups forming a dynamic and collaborative research environment within the MBB department, at the Karolinska Institute. https://ki.se/en/mbb/research-division-of-molecular-neurobiology.

Our laboratory is located in Biomedicum, one of the largest and most modern research centers in Northern Europe, within a world leading University, Karolinska Institutet. We provide modern technological platforms and we offer an interactive, multidisciplinary and international research environment, where you can perform cutting edge science that makes a difference, address fundamental questions, and develop novel therapeutic strategies.

Your mission

We look for postdoctoral researchers interested in stem cell biology and in developing cell replacement strategies for Parkinson’s disease. The successful candidate will transplant neural progenitors derived from pluripotent stem cells in transgenic mouse models of Parkinson’s disease (PD) or in 6-hydroxydopamine models of PD. Applicants will work on one of the two following projects:

1) Identification of the optimal cell preparation and cell composition to achieve precise and effective cell replacement with the minimal number of cells and cell types. Focus will be placed on appropriate integration of cells in the host brain at an anatomical level (establishment of afferent and efferent projections); at a functional level (electrophysiological, neurochemical and behavioral analysis); and at a molecular level, by using as single cell methodologies.

2) Identification of the optimal pluripotent stem cell line engineered to decrease or avoid immune response. This project will focus on the defining the capacity of the different cell lines to reduce the recruitment of immune cells, the inflammatory response, and the local damage to the transplanted cells and to the host brain.

These two projects are based on previous and ongoing work from the lab in which human developmental knowledge (La Mano et al., 2016, Cell) has been used to develop new protocols and strategies (Nishimura, 2022, in preparation) for cell replacement in animal models of PD (Rivetti di val Cervo, 2017, Nature Biotechnology). These projects are part of an ERC Advanced Grant aiming at developing precision cell replacement strategies for Parkinson’s disease (PreciseCell PD, 2021-2026) and of an international collaborative project of the EU (Neurostemcell-reconstruct, 2019-2024), respectively.

Your profile

You are interested in the project and you have a PhD or are about to defend your thesis in the areas of neuroscience, regenerative medicine, biomedicine, development, molecular biology, neurobiology, neuropharmacology or related areas. You have good knowledge of the basal ganglia and you have experience in planning, performing and analyzing experiments involving one or more of the following items: Stereotaxic surgery, rodent models of Parkinson’s disease, cultivation of stem cells, cell transplantation, viral tracing, behavioral analysis, confocal microscopy, electrophysiology or molecular biology. Knowledge of midbrain development, dopaminergic neurons, single cell RNA-sequencing, FACS, and experience in working in international environments will be considered as additional merits. Priority will be given to applicants with FELASA or equivalent training and certification to work with rodents. Applicants should have good communication skills and be proficient in spoken and written English.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

What do we offer?

We offer a two-year (1+1 year) full time (100%) postdoctoral position starting in September 2022. Our laboratory and our unit offer a creative, interactive, inclusive, and international research environment, where you can enjoy science and develop your career.

The project offers excellent training opportunities, outstanding research networks and opportunities to interact and collaborate with world leading laboratories and top researchers working in the area of regenerative medicine and PD.  

Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.


Location:
Solna, Biomedicum

Application

Your application must contain the following documents in English:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications.
  • A summary of current work (no more than one page).
  • A letter of motivation (no more than one page)
  • Three references or reference letters,
  • Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline).

In assessing candidates we will place our emphasis on the personal trajectory, education, technical skills, CV, merits and previous experience.

You are welcome to apply at the latest by the 2nd of September 2022

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-09-02 at 23:59
Unit: Department of Medical Biochemistry and Biophysics

Read the job description at the university homepage or apply.

Post expires on Friday September 2nd, 2022

Doctoral (PhD) student position in the project “Mechanisms of Amyloid Formation and Inhibition in Parkinson’s disease”

The Department of Biosciences and Nutrition performs research and education in several areas of medical science including bioorganic chemistry, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, cellular virology, and nutrition. It offers an excellent international research and working environment, including around 250 scientists, students, administrative and technical personnel. The Department resides in the new biomedical research building Neo, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

We are looking for a doctoral student in the research group of Assistant Prof. Axel Abelein and Prof. Jan Johansson. The research group studies protein misfolding and amyloid structures related to neurodegenerative diseases, in particular Alzheimer’s and Parkinson’s disease, as well as biomaterials. The working space is located in Neo, KI Campus South in Flemingsberg, at the Department of Biosciences and Nutrition. The group consists of one professor, two assistant professors, two senior scientists and six post-docs and PhD students, providing a stimulating and supportive environment for a new PhD student.

More information about the group and research can be found at our homepage:
https://ki.se/en/bionut/laboratory-for-protein-misfolding-and-assembly

The doctoral student project and the duties of the doctoral student

This PhD project concerns the study of amyloid formation in neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease, and the implication of molecular chaperones, in particular the BRICHOS domain. BRICHOS has excellent properties as an anti-amyloid molecular chaperone, inhibiting amyloid formation and associated toxicity and is hence a promising candidate for novel treatment approaches.

The aims of the project are (I) to better understand the molecular mechanisms of Parkinson’s disease and to find potential therapeutic strategies based on BRICHOS and (II) to develop new tools for diagnosis of neurodegenerative disorders.

This PhD project is multidisciplinary and combines protein biochemistry and structural biology in the context of neurodegenerative diseases. For the PhD student this project offers excellent opportunities to perform cutting-edge research in a friendly and inspiring work environment, learn state-of-the-art biochemical and biophysical techniques with the possibility to contribute to the search of new protein-based therapeutics.

The PhD student will perform major parts of the experimental work of this project and will plan the experiments, analyze the data and interpret and summarize the results. The work will be conducted both independently and together with other team members, and the PhD student is encouraged to develop own ideas. Courses of 60 credits related to the research topic are also included in the doctoral project, as well as participating in supervision of undergraduate students and attending international scientific conferences.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

 

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

This project covers many areas, including gene cloning and mutagenesis, recombinant protein production and purification, analytical biochemistry assays, optical spectroscopy, protein aggregation kinetics, protein structure determination techniques (NMR, EM) and others. Suitable backgrounds of the candidate include studies in protein biochemistry, biophysics, biotechnology, life science, biomedicine, or similar topics.

The candidate should have theoretical knowledge and practical experience in at least some of the described biochemical and/or biophysical techniques. Experience in working with proteins associated with amyloid formation is advantageous.

The successful candidate is expected to have a strong drive to pursue research, be organized and structured, work independently and have an ambitious and innovative attitude. The project is cross-disciplinary and pursued in collaboration with other research groups, and hence good collaborative skills are necessary. Emphasis will be put on personal skills in the evaluation process. Very good ability to speak and write in English is a requirement.

If you have any questions please do not hesitate to contact the group leaders.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

–[Video about Karolinska Institutet, how we all work towards “a better health for all”] –

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

www.bionut.ki.se

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-08-19 at 23:59
Unit: Department of Biosciences and Nutrition

Read the job description at the university homepage or apply.

Post expires on Friday August 19th, 2022

Postdoctoral Researcher in Rare Skeletal Diseases

Do you want to contribute to improving human health?

The postdoctoral position is placed in the Clinical Genetics research group at MMK with Professor Outi Mäkitie and Professor Richard Rosenquist Brandell as project leaders. The research is focused on identifying genetic causes and molecular mechanisms in rare skeletal diseases. The group works closely with the Metabolic Bone Disease group at the University of Helsinki.

Your mission

We aim to recruit a highly motivated postdoctoral researcher with a strong research background in molecular genetics and rare skeletal diseases. The aim of the project is to identify new genetic causes for skeletal disorders with osteoporosis, abnormal mineral homeostasis, short stature, or deformities, and to characterize the molecular mechanisms through which the genetic defects lead to these diseases. The study includes patients and families who suffer from these rare diseases. We use mainly whole-genome sequencing and RNA-sequencing to identify the disease-causing gene defects.

Skills and personal qualities

We are interested in candidates with prior experience on a variety of genetic methods, e.g., exome and whole-genome sequencing data analysis, Sanger sequencing, and transcriptome analysis as well as familiarity with high performance computing environment, Linux, phyton, R scripting or other programming language. Other advantageous skills may include data analysis of short- and long-read sequencing (e.g., Oxford Nanopore, PacBio) as well as optical mapping (e.g., Bionano), and experience with whole genome methylation analysis. Once a disease-causing gene variant is found, the researcher will work together with other experts in the team to establish in vitro cell models to validate the findings.

The appointed person will be expected to work with molecular biologists, physicians and bioinformaticians, as well as to actively participate in national and international collaborative research projects. We are looking for an enthusiastic, ambitious, open-minded, and socially skilled person who can collaborate with others, is flexible and willing to take an active role in carrying the project forward. The successful candidate should be self-motivated and able to keep up to date and gain information on developments of the relevant research field, have excellent interpersonal and communication skills, organizational skills, and the ability to work productively and dynamically in a team, as well as take individual responsibility. The selected candidate will work in close collaboration with other members of the team; hence emphasis is put on personal suitability.

Your profile

Applicants are required to have completed a PhD degree or higher in a field related to the position, such as genetics, medicine, biomedicine, biotechnology, or similar. It is considered as an advantage if the applicant has completed the doctoral degree within the last three years; this term can be extended if there are special reasons. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.
Further requirements are:

  • Documented experience in molecular genetics and skeletal research.
  • Experience working in or familiarity with high performance computing environment, Linux, phyton, R scripting or any other programming language
  • Documented ability to write scientific articles and a track record of publications in international refereed journals.
  • Excellent communication skills and the ability to work both independently and in collaboration with colleagues in diverse fields, including clinical staff, and the ability to document work.

Personal suitability is an important criterion.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.


Location:
Solna

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Welcome to apply at the latest August 15, 2022

The application is to be submitted through the Varbi recruitment system.

 

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-08-15 at 23:59
Unit: Department of Molecular Medicine and Surgery

Read the job description at the university homepage or apply.

Post expires on Monday August 15th, 2022

Postdoctoral position in the area of single-cell genomics

Do you want to contribute to top quality medical research?

The position is based at unit of Molecular Neurobiology (MBB), at Karolinska Institutet, Stockholm, Sweden, at the Ana Mendanha Falcão research group (also at University of Minho, Portugal) and joint with Castelo-Branco research group.

Ana Mendanha Falcão is a research group leader focusing on the role of the choroid plexus in diseases such as multiple sclerosis. Her team aims to investigate the choroid plexus as a source of biologically active molecules to the central nervous system, in order to influence disease dynamics. The choroid plexus is studied as an alternative target for disease therapies since it can be modulated by peripheral blood and it can substantially alter the brain composition both in terms of biologically active molecules and immune cell content.

The Castelo-Branco research group is interested in the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage. Our research group has performed single nuclei/cell RNA-Seq  and ATAC-seq and identified several cell states within the oligodendrocyte lineage in development and disease (Nature Medicine 2018, Nature 2019, Neuron 2022), including an immune state that might be relevant for the etiology and/or progression of MS

Your mission

We have ongoing projects with single-cell genomics, and the successful candidates will be actively working in specific projects under Falcao’s group together with Castelo-Branco’s group. The successful candidates will be integrated in a multidisciplinary team comprising computational, molecular and cellular biologists.

Your profile

We are looking for a highly motivated, driven, inquisitive and enthusiastic person interested in our area of research, and ready to explore new avenues in science. The candidates should have a collaborative approach to research, working productively in a team and contributing to a good social environment in the laboratory. The applicants should have competencies in bioinformatics and computational biology and strong programming skills (R and/or Python and/or others), UNIX and LINUX systems knowledge, familiarity with data science a big data. The successful candidate will be working in specific projects involving single-cell genomics on the areas of interest Falcao’s group. Research experience and expertise in analysis of sequencing data is highly desirable. Wet lab experience is not required but it is an advantage.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Our research group is based at the Department of Medical Biochemistry and Biophysics (MBB), at the Karolinska Institutet (KI), Stockholm, Sweden, within the Unit of Molecular Neurobiology. The Unit of Molecular Neurobiology has presently seven research groups, focused on several aspects of development, stem cell biology, neuroscience and cancer, providing a unique critical mass and expertize, and vibrant scientific environment. 

Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.


Location: Solna, Biomedicum

Application

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.

An employment application must contain the following documents in English:

  1. A complete curriculum vitae, including date of the PhD defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work (nor more than 4 pages)
  2. A selected list of publications (no more than 2 pages)
  3. A personal letter highlighting previous scientific accomplishments, technical expertize and why the candidate is interested in joining the host lab (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or student organizations, parental leave or similar circumstances
  5. Verification from the thesis defense committee or the equivalent (only if the thesis defense is scheduled within three months after the application deadline)
  6. 2 Reference letters (to be uploaded in Varbi if already available, or to be sent directly to ana.mendanha.falcao@ki.se after the first selection round)

Selection
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Welcome to apply at the latest 2022-08-31

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-08-31 at 23:59
Unit: Department of Medical Biochemistry and Biophysics

Read the job description at the university homepage or apply.

Post expires on Wednesday August 31st, 2022