Tag Archives: Karolinska

1-2 Postdoctoral researchers in the field of mitochondrial genetics (scholarship)

Do you want to contribute to improving human health?

The research at the Division of Molecular Metabolism aims at understanding the regulation of mitochondrial function and the role of mitochondrial dysfunction in disease and ageing. Using patient material and different animal models, our overall aim is to get insights into disease pathophysiology and to develop novel treatments. We are currently looking for 1-2 highly motivated postdoctoral researchers, to join the research group of Nils-Göran Larsson

Your mission

To study the role of mitochondrial function in health and disease. Mitochondria are essential for cell function and mitochondrial dysfunction has been implicated in a variety of hereditary diseases, age-related diseases and the normal ageing process. Using mouse models, biochemistry, molecular biology and modern -omics approaches, the group of Nils-Göran Larsson focuses on understanding molecular processes determining how mitochondrial function is regulated and the role of mitochondria in ageing and disease.

Your profile

Applications are invited from enthusiastic and motivated individuals with a PhD in molecular biology or genetics. Experience in mitochondrial research is not required, whereas experience in biochemistry, molecular biology, mouse genetics and different -omics methods is of advantage. Candidates with a background in bioinformatics are also of interest. Good documentation skills as well as proficiency in both spoken and written English are required. The successful candidates should be able and willing to work in a team to pursue his/her research. Personal suitability is of great importance when evaluating the applicants.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

The Division

The Division of Molecular Metabolism, Deparment of Medical Biochemistry and Biophysics, is located at the newly built and modern laboratory Biomedicum at Solna campus of Karolinska Institutet. Our research encompasses biochemical and genetic studies of patients with inherited diseases as well as basic scientific approaches to understand the regulation of mitochondrial metabolism. Patient material (tissues and cells), genetically modified fruit flies (Drosophila melanogaster) and mice (Mus musculus) are used in our studies. We offer an outstanding research environment and a close interaction between basic science and clinical science and diagnostics at the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital, Stockholm, Sweden. Excellent access to the most advanced resources in molecular and cell biology is available at the department and at the national core facilities at the Science for Life Laboratory.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis (max 2 pages)
  • A complete list of publications
  • A personal motivation letter, explaining your research interest (max 1 page)
  • Contact information of at least two references 

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-06 at 23:59
Unit: Division of Molecular Metabolism

Read the job description at the university homepage or apply.

Post expires on Tuesday December 6th, 2022

Postdoctoral studies in Neuroscience with focus on motivated behaviours

Do you want to contribute to top quality medical research?

Division

The Meletis laboratory, in the Department of Neuroscience, has two open positions for postdoctoral fellows to investigate the function of neuron subtypes during motivated behavior and decision-making, including circuit dysfunction in mouse models of stress and mood disorders. The project will address the in vivo role of molecularly defined neuron subtypes in the basal ganglia, hypothalamus, and the lateral habenula.

Duties

The research will be based on the functional investigation of the role of neurons and circuits in motivated behaviors through a number of advanced circuit approaches to target, record and manipulate molecularly defined neurons. The project will involve the use and development of genetically modified mice to target neuron subtypes using in vivo optogenetics and behavioral paradigms (freely moving and head-fixed) to define the contribution of specific circuits to motivated and aversive behavior. The project will benefit from ongoing projects that have established the identity and connectivity of neurons in candidate circuits based on single cell RNA-seq and monosynaptic rabies tracing.

Successful applicants will have the opportunity to work in a stimulating and collaborative environment with state-of-the-art infrastructure.

We expect applicants to have a strong determination to reveal the role of neurons and circuits to behavior, with extensive experience and interest in behavior, electrophysiology and/or in vivo imaging. Extensive knowledge in methods to quantify neuron activity, statistics and programming, are required.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-07 at 23:59
Unit: Meletis

Read the job description at the university homepage or apply.

Post expires on Wednesday December 7th, 2022

Postdoctoral Researcher in Computational Immunology

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC have about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations.

The research group of Dr Lisa Westerberg seeks a Postdoc (computational/experimental) in the field of computational Immunology to study immunodeficiency diseases and lymphoma. The Westerberg lab has a long track record in deciphering molecular mechanism for development of severe immunodeficiency diseases in children (https://ki.se/en/mtc/lisa-westerberg-group). Ongoing research in the Westerberg lab is focused on understanding the molecular mechanisms for development of immunodeficiency diseases with high incidence of lymphoma. The Westerberg lab uses a multidisciplinary and collaborative approach, working closely with research groups at KI, Karolinska University Hospital, Science for Life Laboratory (SciLifeLab), and with international research groups. Patient samples are obtained from national and international collaborators.

Your mission

As a Westerberg lab member, you will apply and integrate transcriptome-wide approaches based on bulk and single cell RNA sequencing to study gene expression changes during clonal evolution of lymphocytes and lymphoma cells. The project is focused on identifying gene expression profiles that can be interrogated in experimental work performed in the Westerberg lab. We aim to recruit an independent and motivated person who can set up and maintain workflows by implementing or adapting existing tools.

As a Postdoc you will be part of a multidisciplinary and collaborative research team active within the fields of immunodeficiency disease, lymphocyte biology, and lymphoma. The Westerberg lab investigates immunodeficiency diseases and lymphoma using state of the art immunological technology including Omics approaches (bulk and single cell RNA, immune receptor repertoire, and chromatin accessibility sequencing), advanced flow cytometry and high resolution microscopy, CRISPR/Cas and AAV gene editing, and usage of both patient samples and experimental models. These efforts aim to map key molecular events that contribute to the disease pathogenesis of immunodeficiencies and lymphoma and to drive the development of precision medicine.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

The applicant will participate in a project to investigate gene expression changes in pediatric patient samples. The applicant must have a strong background in genomics, computational biology, and statistics as well as experience in high-throughput sequence and gene expression data analysis. Excellent skills in programming (R/Bioconductor, UNIX), work in a Linux environment, and knowledge of biological databases and data integration as well as data visualization is required. Proven work in bioinformatics investigating gene RNAseq, scRNAseq, HiCseq, ATACseq) and performing integrative genomics analysis for human diseases is desirable. Furthermore, experimental knowledge in molecular biology, mammalian primary and cell lineage culture, and of immunological methods is an advantage.

Required skills:

  • Experience in the analysis of next generation sequencing data, such as RNAseq, ChiPseq and/or ATACseq data, with a proven record of publications
  • Firm knowledge in Linux environment and at least one programming language, such as Java
  • Expertise in R and foundations of statistics
  • Basic understanding of molecular immunology
  • Excellent communication skills and motivation to work collaboratively
  • Ability to work independently and manage multiple projects in parallel
  • Proficiency in spoken and written English

Desirable skills:

  • Experience in the analysis of single-cell data, such as scRNAseq, scATACseq, scBCR/TCRseq, HiCseq and/or Cut&Run
  • Experience in data integration of immune gene data sets
  • Familiarity with tools for workflows and software development such as GitHub Experimental knowledge of immunological methods

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

Welcome to apply at the latest 2022-12-16

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-16 at 23:59
Unit: Westerberg

Read the job description at the university homepage or apply.

Post expires on Friday December 16th, 2022

Postdoctoral Researcher in single-cell bioinformatics with focus on Polycystic ovary syndrome

Do you want to contribute to top quality medical research?

The research at the Department of Women’s and Children’s Health (KBH) deals with both basic and clinical science. The research takes place in seven divisions with separate scientific profiles. The units vary in size and have several research groups. We are also engaged in education on undergraduate (MD program), specialist (pediatric nurses, midwives, physicians), and postgraduate levels.

Groups:

Professor Angelica Lindén Hirschberg’s research group within the Division of Obstetrics and Gynecology is studying the basic hormonal mechanisms and genetic links between metabolism and reproduction Angelica Linden Hirschberg.  Her research group has international reputation in the field of gynecological endocrinology and metabolism.  Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of fertile age, is associated with hyperandrogenemia, as well as insulin resistance and compensatory hyperinsulinemia, and has been linked to subfertility and a broad variety of pregnancy complications. Our research in PCOS is translational from experimental in vitro studies to randomized controlled trials performed in collaboration with national and international research networks, such as the PCOS Nordic Network, and the PCOS International Guideline Development Group. We are currently investigating effects of lifestyle intervention and weight change on tissue specific metabolic markers.

The Baryawno research group is located at BioClinicum in Solna and affiliated with the Childhood Cancer Research Unit, Dept of Women’s and Children’s health, Karolinska Institutet. The group consists of 3 Ph.D. students. The focus of our research is within the microenvironment (niche) of stem cells and cancer. We are applying basic, translational and clinical approaches in our research including, single cell technologies, bioinformatics, immunology and molecular biology as well as functional analysis and development of preclinical animal- and in vitro-models. The postdoctoral candidate will be co-mentored by Dr Baryawno on the proposed project. More information on the work from the Baryawno lab can be found in recent publications (Baryawno et al., Cell 2019; Kfoury, Baryawno et al., Cancer Cell 2021; Verhoeven et al., Cell Reports Medicine 2022; Alchahin et al., Nature Communications et al., 2022, Olsen et al., JCI Insights 2022).

The postdoc project, your mission:

The current project will be focused on profiling, using single-cell RNA-sequencing, human endometrial, fat and muscle biopsy samples already obtained from PCOS patients and healthy subjects. The responsibilities of the postdoctoral fellow will be to design and perform single-cell RNA-sequencing experiments, including tissue processing and library preparations, by 10X Chromium Single Cell Solution, and further and analyze the data generated. The aim is to investigate the cellular and molecular landscape of PCOS in order to search for mechanisms of disease.

To write scientific articles and present data at international congresses.

To participate in meetings regarding general operation of the research group/division.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Applicants to this position should have a PhD in Molecular Biology, Biochemistry, Genetics, or related fields. A strong background in genomics, bioinformatics and statistics as well as experience in molecular biological methods, especially single-cell RNA-sequencing and gene expression data analysis techniques is essential for the position as well as with wet lab molecular biology methods such as tissue handling and in vitro culturing. Excellent skills in programming, knowledge of biological databases and data integration as well as data visualization are advantages. A high level of organizational and communicative skills, as well as an ability to independently perform experiments and implement interpretation of data is mandatory. Excellent command of written and spoken English is required.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Learn more about Prof Angelica Lindén Hirschberg’s research group  here 
Learn more about the research here
More about the Department of Women’s and Childen’s Health here

Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

Welcome to apply! 

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-14 at 23:59
Unit: Department of Women´s and Children’s Health

Read the job description at the university homepage or apply.

Post expires on Wednesday December 14th, 2022

Postdoctoral Researcher in Public health epidemiology

Postdoctoral Researcher in Public health epidemiology: Mental health of young LGBTQ people, population- and registrybased studies

Do you want to contribute to better health for all?

With us, you are part of an ambitious team analysing unique population-based registry and survey data on mental health of young LGBTQ people over time, aiming to contribute to better and equal mental health for all.  The team includes epidemiologists, statisticians, and researchers from The Glosh Research group at KI and the Sexual and Reproductive Health and Rights Unit (SRHR) at the Centre for Epidemiology and Social Medicine, Region Stockholm.

Your mission

You will analyze longitudinal survey and registry-based data from a population-based cohort, The Stockholm Public Health Cohort, on mental health of young LGBTQ people (including gay, lesbians, bisexuals, transpersons and people with gender dysphoria) over time (latest follow-up year 2022), as well as registry data from total population register linkages.

You will draft the manuscripts aiming for high impact and leading publications in the research field. You are expected to drive the development of the research field further, propose and lead further research and additional registry data collection, and actively seek research funding. You also assist with the research teams’ epidemiological and other research projects and collaborate with researchers in and outside the research group.

The project is funded by the Swedish Research Council for Health, Working Life and Welfare.

This is a 3 year project that starts with a 2 year position with possibility to prolong.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Requested qualifications:

  • You have demonstrated and excellent ability in epidemiological design and statistical analysis of large scale and longitudinal epidemiological data, such as Swedish registry-based or survey data.
  • You have large experience and are confident in registry-based research in Sweden.
  • You have excellent skills in one or more statistical packages.
  • You want to develop as an epidemiologist.
  • You have very good writing skills.
  • You have excellent knowledge of English language.
  • You are interested in LGBTQ health and in research in sexual and reproductive health in general.

Meritorious:

  • Knowledge of the Swedish language is a merit but not required.

Personal characteristics: You are used to work independently but have also very good collaboration skills. You are ambitious and self-motivated. You are efficacious and seek to reach goals within deadlines. 

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.


Location:
Solna

The Global and Sexual Health research group 

SRHR-Unit, Centre for epidemiology and community medicine (CES) within Region Stockholm 

Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

Welcome to apply at the latest 2022-12-12.

The application is to be submitted through the Varbi recruitment system.

 

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-12 at 23:59
Unit: Department of Global Public Health

Read the job description at the university homepage or apply.

Post expires on Monday December 12th, 2022

Postdoctoral Researcher in adipocyte culturing

Do you want to contribute to top quality medical research?

You are welcomed to join a young, dynamic research group working translationally to understand how human white adipose tissue impacts the emergence of cardiovascular disease. As a part of a well-established larger network of researchers in metabolism, atherosclerosis and cardiovascular inflammation we focus on identifying early disease mechanisms and novel therapeutic targets, focusing on human in vitro cell culture systems. 

Your mission

The postdoctoral project is focused on culturing adipocyte spheroids and investigating if alleviating adipose dysfunction can protect against the development of cardiovascular diseases. The project will also involve analysis of human sequencing data and the lipid handling dynamics of adipocytes, as well as training younger researchers in the lab.

Your profile

We are looking for an enthusiastic, creative and hard-working researcher with a PhD in a relevant discipline and a strong research background in experimental 3D adipocyte cell culture models, preferentially documented with several research publications. Applicants should be able to independently plan, perform, analyse and document 3D adipocyte culture experiments as well as performing post-culture analyses of lipid content, protein expression and adipocyte function. Experience with research animals is also a plus. Scientific expertise and an ambitious, pro-active and problem-solving attitude are highly valued. Excellent communication skills in spoken and written English are a must, as is the ability to work in a team.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location

The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within the research group headed by Associate Professor Carolina Hagberg (www.Hagberglab.com) in a team consisting of 4-5 people, working as an integrated part of the larger Cardiovascular Medicine division that comprises around 55 persons active both in basic and clinical research.

 

Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

 

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-07 at 23:59
Unit: Cardiovascular Medicine division

Read the job description at the university homepage or apply.

Post expires on Wednesday December 7th, 2022

Doctoral studies in Central Nervous System Regeneration

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Göritz laboratory is offering a stimulating, international research environment. We are part of the Department of Cell and Molecular Biology at the Karolinska Institute in Stockholm, Sweden, one of the world’s leading medical universities. The lab is located in Biomedicum, a state-of-the-art research building on Solna campus.

The doctoral student project and the duties of the doctoral student

We are seeking a highly motivated and self-driven doctoral student with a keen interest in CNS regeneration to study the mechanisms of fibrotic scarring in the context of demyelinating diseases.

Our lab investigates fibrotic scar formation and its impact on axonal regeneration and functional recovery following lesions to the central nervous system (CNS). We discovered a new population of perivascular cells, called type A pericytes, as the source of fibrotic scar tissue (Göritz et al., Science, 2011) and identified pericyte-derived scar formation as a therapeutic target to achieve axonal regeneration and functional recovery following spinal cord injury (Dias et al., Cell, 2018). Recently, we showed that fibrotic scarring by perivascular cells is a conserved mechanism in the adult mammalian CNS (Dias et al., Nature Com., 2021). The intended project builds on these findings and aims at further elucidating the mechanism of fibrotic scar formation in models of multiples sclerosis and its role for remyelination. You will use a number of innovative technologies in combination with genetic mouse models to identify cellular interaction partners and molecular pathways for in vivo target identification. Through combining in vivo lineage tracing with molecular expression profiling and in vivo pathway manipulation, the project will chart therapeutic opportunities for treating nerve/spinal cord damage in humans.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

We are looking for well educated, driven candidates, with a solid background in biochemistry, biomedicine or biology and a keen interest in neuroscience/regenerative medicine. A documented ability to independently carry out experiments/small research projects is required, as are good communication skills in spoken and written English. Experience with protein biochemistry, transgenic mouse models, CNS lesion models, imaging techniques, and/or bioinformatics are meriting.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-12 at 23:59
Unit: Department of Cell and Molecular Biology

Read the job description at the university homepage or apply.

Post expires on Monday December 12th, 2022

Postdoctoral position in focus on single-cell and spatial transcriptomics and epigenomics (scholarship)

Do you want to contribute to improving human health?

The position is based at unit of Molecular Neurobiology (MBB), at Karolinska Institutet, Stockholm, Sweden.

The Castelo-Branco research group is interested in the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage. We are focused on how interplay between transcription factors, non-coding RNAs and chromatin modifying enzymes contribute to the transition between states within the oligodendrocyte lineage, with the aim to design epigenetic based-therapies to induce regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis. Our research group has performed single cell omics and identified several cell states within the oligodendrocyte lineage in development and disease (Science 2016, Dev Cell 2018, Nature Medicine 2018, Nature 2019, Nature Biotechnology 2021, Neuron 20222 among others). Our findings suggest that oligodendrocyte lineage cells might present other functional properties than previously thought.

We have ongoing several projects with single-cell omics and more recently in spatial transcriptomics and epigenomics, and the successful candidate will be actively working in specific projects. The successful candidate will be integrated in a multidisciplinary team comprising computational, molecular and cellular biologists.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Our research group is based at the Department of Medical Biochemistry and Biophysics (MBB), at the Karolinska Institutet (KI), Stockholm, Sweden, within the Unit of Molecular Neurobiology. The Unit of Molecular Neurobiology has presently seven research groups, focused on several aspects of development, stem cell biology, neuroscience and cancer, providing a unique critical mass and expertize, and vibrant scientific environment. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Skills and personal qualities

We are looking for highly motivated, driven, inquisitive, enthusiastic person interested in our area of research, and ready to explore new avenues in science. The candidate should have a collaborative approach to research, working productively in a team and contributing to a good social environment in the laboratory. The applicant must have a PhD degree, and either strong experience in single-cell omics and/or transcriptomics/epigenomics, preferably within neuroscience.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of PhD defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work (nor more than 2 pages)
  • A selected list of publications (no more than 1 page)
  • A personal letter highlighting previous scientific accomplishments, technical expertize and why the candidate is interested in joining the host lab (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-03 at 23:59
Unit: Molecular Neurobiology

Read the job description at the university homepage or apply.

Post expires on Saturday December 3rd, 2022

Postdoctoral Researcher in Pharmaco-epidemiology of Upper Gastrointestinal Cancer

Do you want to contribute to improving human health?

The research group ‘Upper Gastrointestinal Surgery’ is located in the heart of KI’s main campus area in Solna. The group includes senior and junior researchers, biostatisticians, administrators, PhD candidates and students. We conduct research of diseases and surgery of the oesophagus and stomach with a focus on cancer. 

Project

The postdoctoral researcher will primarily examine how exposure to various medications influence the aetiology and survival in cancer of the oesophagus and stomach, i.e. upper gastrointestinal cancer. The project will be based on a large case-control study (Nordic Gastric and Esophageal Tumour Study, NordGETS) which contains data collected from national complete and high-quality registries in all five Nordic countries. Cases are all patients with a diagnosis of oesophageal or gastric cancer and controls are 10 times as many individuals from the background populations of the five countries. The study period is determined by the start of the prescribed drug registries in the participating countries (from 1994 onwards).

Supervisor

The formal supervisor is Jesper Lagergren, the research group leader. He is professor and consultant surgeon at KI and Karolinska University Hospital and member of the Nobel Assembly. He also holds a position as part-time professor at King’s College London. You can read more about him here: Jesper Lagergren

The postdoctoral researcher will be guided by Dr Giola Santoni, who is an experienced biostatistician with much knowledge in data management and analysis of large Nordic databases. You can read more about her here: Giola Santoni

Your mission

The work tasks mainly consist of research, including detailed planning of studies (study protocols), data management, statistical analyses and writing of scientific papers and grant applications. Teaching is limited, but may be conducted within our PhD courses, research seminars, journal clubs and methods clubs.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are looking for a skilled researcher with documented knowledge in epidemiology, ideally in cancer epidemiology and pharmaco-epidemiology. Experience and ability in data management and analysis of large databases. The formal requirement is a Degree of Doctor or corresponding competence.

Assessment

Applicants will mainly be evaluated based on their scientific qualifications and appropriate experience and skills in the work tasks and entry requirements described above. Documented skills in epidemiological research methodology, including pharmaco-epidemiology, are particularly qualifying. The applicant should have documented experience of analysing and interpreting research data and in writing excellent scientific articles in English. Documented knowledge and interest in cancer, particularly oesophageal and gastric cancer, are meriting. Important personal characteristics include curiosity, engagement, social competence and collaboration skills. Excellent knowledge in the English language (both orally and in writing) is required, not the least because English is the official language of the group.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.


Location: Solna

Read more about the group here Upper GI Surgery

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Welcome to apply at the latest December 11, 2022

The application is to be submitted through the Varbi recruitment system.

 

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-11 at 23:59
Unit: Department of Molecular Medicine and Surgery

Read the job description at the university homepage or apply.

Post expires on Sunday December 11th, 2022

Doctoral (PhD) student position in the area of dermatology and medical diagnostics

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within the research group of Onur Parlak. The Department of Medicine, Solna is one of the largest departments at Karolinska Institute. The core activities of the Department of Medicine are clinical and undergraduate education for medical as well as biomedical students, post-graduate education, including at present about 200 registered PhD students, and research in different areas of biomedicine. The department conducts research in a large number of areas. The proximity to patients is one of the department’s strengths. Conducting research in a clinical environment gives excellent opportunities to integrate basic research and patient-centred research. 

Parlak Lab is a newly established laboratory in the Division of Dermatology and Venereology that aims to use innovative science at the interface between biotechnology, materials science, and electronics to tackle the key area of critical importance to society – healthcare and biomaterials. Parlak Lab investigates the application of bioelectronics in medicine to meet the need for complex, dynamic environments and to develop novel devices for dermatological and neurological diseases. The overall aim of the lab is to develop new technologies to combat healthcare challenges and design novel tools for early diagnostics and solutions for digital medicine and remote monitoring.

The doctoral student project and the duties of the doctoral student

The doctoral project aims to develop a novel medical sensor technology to quantitatively measure the skin parameters for human skin wound. This will be achieved by designing epidermal bioelectronics devices measuring key physicochemical and biological biomarkers of the skin on human skin models.

With the ultimate goal of providing important new knowledge for human skin biology and improving wound monitoring and diagnostic, the doctoral student is expected to gain broad knowledge on:

  • – How to chart a spatiotemporal map of human skin by analysing the epidermal parameters.
  • – How to navigate physicochemical and structural routes by dissecting the core regulatory networks.
  • – How to develop an epidermal sensor to monitor skin wound and healing process to guide precise skincare.

The doctoral project will combine biosensor research with basic biochemistry, microbiology and microscopy to generate truly interdisciplinary doctoral research scientist. The result from the doctoral project will be a model platform and pave the way for novel molecular and cell-based bio sensing to implement preventative actions.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

We are looking for a highly motivated, curiosity-driven, inquisitive and enthusiastic person interested in our area of research and ready to explore new avenues in science. The candidate is expected to have a collaborative approach to research, work productively in a team, and contribute to a good social environment in the laboratory.

The applicant shall hold a Master´s degree (or equivalent) in natural or engineering sciences. The candidates with previous experience in microbiology, biosensors, polymer chemistry and cell culturing are not required but are considered important merit to reach the goal of the doctoral project. The applicant needs to have a high degree of independence and motivation but should have no problems working in a team, given the collaborative nature of the project. Fluency in English is a requirement.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

–[Video about Karolinska Institutet, how we all work towards “a better health for all”] –

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Location

The position is at the Department of Medicine, Solna, Division of Dermatology and Veneroeology, within the research group of Onur Parlak at the Centre for Molecular Medicine (CMM), located at the Karolinska Hospital’s area.

Onur Parlak lab

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-06 at 23:59
Unit: Department of Medicine, Solna

Read the job description at the university homepage or apply.

Post expires on Tuesday December 6th, 2022

Doctoral student – Blood-based biomarkers and dementia in a population setting

Do you want to contribute to top quality medical research?

 

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Department of Neurobiology, Care Sciences and Society (NVS) conducts world leading research in aging, dementia, epidemiology and care sciences. This research extends from basic molecular and cell levels to clinical research and societal studies. NVS educates almost a third of KI students at basic and advanced levels. The Department has approximately 450 employees and a revenue 2018 of 490 million SEK. It comprises seven divisions, located at Campus Flemingsberg and Campus Solna.

 

Aging Research Center (ARC), a division within NVS, is located at KI Campus Solna, Stockholm. It is a multidisciplinary academic environment, representing medicine (e.g., neurology, epidemiology, psychiatry, geriatrics), psychology (e.g., cognition, structural, functional, and molecular brain imaging), and social gerontology (e.g., sociology, public health, social epidemiology, social work). The center has around 75 employees, it has a strong focus on research with unique research resources, such as large-scale longitudinal studies and nationwide registries.

 

Most of the scientific activities in the research group are based on the ongoing population-based Swedish National Study on Aging and Care-Kungsholmen (SNAC-K), which includes people 60+ years who are followed up at regular intervals. The protocol includes extensive assessment of social, medical, biological, and genetic factors as well as a comprehensive cognitive battery. Further information is available at http://www.snac-k.se/.

The doctoral student project and the duties of the doctoral student

A doctoral student is admitted to third-cycle/doctoral education. A doctoral education consists of supervised research, combined with courses and other educational activities. An individual study plan is established for each doctoral student. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

We are looking for a highly motivated doctoral student who is interested in studying the clinical validity of blood-based biomarkers in dementia in a population setting and expanding our understanding of the biology of dementia in the oldest, by studying different possible pathways underlying the onset of the disorder.

The doctoral project will be based on a large-scale population study of older people and modern advanced statistical approaches will be used. Hence, it is a challenging project for a PhD student, especially from a clinical, epidemiological and biostatistical point of view. For that reason, we look for a PhD student with good knowledge in geriatric epidemiology and/or biostatistics. The doctoral student should be familiar with statistical software (such as Stata, SAS or SPSS). Furthermore, since clinical interpretation of the results of the studies is mandatory for the success of the projects, it would be advantageous if the student also has clinical experience from working with geriatric patients. For this reason, we look for a student with a degree in medical science, better if with a background in Clinical Neurology or Geriatrics.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

 

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

We are looking for a highly motivated candidate with experience in geriatric epidemiology.

The successful candidate:

 

  • Must have an educational background in health/medical sciences and hold a medical doctor degree with clinical experience preferably within neurology or geriatrics;
  • Must have excellent English skills in terms of oral and written communication
  • Should preferably have previous research and/or work experience related to aging health;
  • Should have good analytical skills
  • Should have good programming skills and experience working with longitudinal datasets and have experience of using statistical software such as SPSS, SAS, or Stata;
  • Should have a positive attitude towards team-work;
  • Should be eager to learn.

 

The successful candidate is expected to play critical role in formulating scientific research hypothesis, testing those hypotheses using proper study design, analyzing the data, presenting and interpreting the results, and writing scientific reports and articles in English.

 

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

 

 

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

https://ki.se/nvs

https://ki-su-arc.se/

 

 

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-09 at 23:59
Unit: Aging Research Center, ARC

Read the job description at the university homepage or apply.

Post expires on Friday December 9th, 2022

Doctoral (PhD) student position in Cardiometabolic disease and the immune system

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Malin lab (https://ki.se/en/meds/research-group-stephen-malin) is a young, dynamic research group working to understand how the immune system interacts with metabolic dysfunction and cardiovascular disease. As a part of a well-established larger network of researchers within the Cardiovascular Medicine Division at the Department of Medicine Solna, we focus on identifying early disease mechanisms, taking discoveries from our novel mouse disease models to patient samples. The project is part of the Leducq transatlantic Network in cardiovascular disease: https://www.fondationleducq.org/network/b-cells-in-cardiovascular-disease/ As part of this project, there will be opportunities for the scholars to perform research exchanges at Harvard University, Cambridge University, Icahn School of Medicine at Mount Sinai, University Of Vienna and University of Virginia. Recent publications from our lab: Gisterå et al, Circ Res. 2022 Jun 10;130(12). Caravaca et al Proc Natl Acad Sci. 2022 May 31;119(22), Jurado et al EMBO J. 2022 Apr 4;41(7), Calderon et al Sci Immunol. 2021 Jul 23;6(61), Liu et al Journal of Experimental Medicine 2020 Nov2; 217(11), Sedimbi et al Proc Natl Acad Sci 2020 Apr 21;117(16), Centa et al Circulation 2019 May 21;139(21), Centa et al Arterioscler Thromb Vasc Biol. 2018 Aug;38(8) 

The doctoral student project and the duties of the doctoral student

Our central question is: Do APOB-lipoproteins systemically alter normal physiological function before atherosclerotic plaque development, or does immune dysfunction only follow plaque formation? This fully funded doctoral project will address two discrete immune compartments: hematopoiesis and hematopoietic stem cells in the bone marrow and tissue-resident macrophages.  The aim of the project is to place APOB-lipoproteins driven perturbations of these in the context of atherosclerosis plaque development. Studies involve extensive histological and pathological analysis of our novel mouse models. This is combined with scRNA-seq, bulk RNA-seq, spatial transcriptomics, and spectral cytometry of tissues and secondary lymphoid organs, together with bioinformatic analysis.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

We are looking for a student with a keen interest in physiology and molecular medicine and motivation to discover novel disease mechanisms. Excellent communication skills in spoken and written English are a must, as is the ability to work in a team consisting of different nationalities and personalities. We encourage individuals from all biological backgrounds to apply, particularly those with interests in Immunology, Endocrinology, Metabolism, and Molecular Biology. Experience in mouse work and bioinformatics would be advantageous. However, the most important qualities are curiosity, determination, and a positive attitude.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

–[Video about Karolinska Institutet, how we all work towards “a better health for all”] –

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Location

The employment will be at the Department of Medicine, Solna. The Department consists of twelve divisions and each division consists of several research groups. This position is located within the research group of Stephen Malin at the Cardiovascular Medicine Division. The team currently has 5 people and is an integrated part of a larger research division which comprises around 55 basic and clinical researchers working on metabolism, cardiovascular disease and inflammation. The successful PhD student will work with many international colleagues, as well as participating in the larger cardiometabolic and immunology networks within Karolinska Institutet that organize yearly. The labs are located in the brand-new research building BioClinicum in Solna, with close proximity to both the clinics at the Karolinska Hospital and the research resources of Karolinska Institutet. The university has a nice green campus area with gym, cafeterias and several lunch options, as well as infrastructure for networking and career development for early career researchers.

Stephen Malin research group

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-16 at 23:59
Unit: Department of Medicine, Solna

Read the job description at the university homepage or apply.

Post expires on Friday December 16th, 2022

Postdoctor in human mucosal immunology of respiratory viral infections

Do you want to contribute to better health for all?

We are recruiting a new postdoctoral researcher to join our international research group conducting translational studies to understand respiratory viral infections. In particular, our research is focused on immune responses in blood and airways during influenza and COVID-19. We have established clinically well characterized patient cohorts of across disease severity that we have followed prospectively over time, and have large biobanks from these cohorts that are available for the project.

Your mission

You will work with samples collected from patients with SARS-CoV-2 or Influenza virus infection, as well as perform in vitro virus infections in biosafety level 2 and 3. By investigating the immune responses throughout the course of disease, we aim to find novel biomarkers that can aid in the understanding of how severe disease develops. You will also study how immune cells interact and are affected by virus infection in vitro

Your profile

The successful candidate should have documented experience and skills in experimental immunological work with influenza and COVID-19 patient blood and respiratory samples. The candidate should have well established knowledge in immunology, pathology and virology and experimental methods related to these fields. Documented skills and experience in cell culture and virus infections in biosafety level 2 and 3 is required, preferably with influenza viruses and SARS-CoV-2. It is an advantage if you are also proficient in advanced flow cytometry and cell sorting. The candidate should be able to communicate with others in English and be suitable for teamwork.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location

The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within the research group of Anna Smed-Sörensen, at the Division of Immunology and Allergy. https://ki.se/en/meds/research-group-anna-smed-sorensen

Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

 

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-02 at 23:59
Unit: Immunology and Allergy division

Read the job description at the university homepage or apply.

Post expires on Friday December 2nd, 2022

Postdoctoral studies in translational immunology focusing on autoimmunity and lymphoma affecting the skin (scholarship)

Do you want to contribute to top quality medical research?

Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Join our truly translational scientific constellation focusing on tissue inflammation: a creative and inspiring environment full of expertise and curiosity.

Division

The Department of Medicine, Solna, is one of the largest departments at Karolinska Institutet. The department consists of several units that are separated into different research groups. The core activities of the department are research, doctoral education and undergraduate education for medical and biomedical students. The research has three main profiles: allergy, cardiovascular medicine and inflammatory diseases.

The laboratory of Hanna Brauner is located in an excellent immunological research environment at the Centre for Molecular Medicine, CMM. The close proximity of the laboratory to the clinic at the Karolinska University Hospital also facilitates collaborations with clinicians of different fields and enables the analysis of fresh patient samples.

Duties

We seek a highly motivated postdoctoral fellow to join the team of MD PhD Hanna Brauner in focusing on finding novel pathogenic mechanisms and biomarkers for patients with autoimmunity and lymphoma.

We have access to unique clinical material, which we will assess in a truly translational approach, applying cutting edge methods to understand key clinical questions. The team of Hanna Brauner has a net-work of national and international collaborators among both basic science researcher and clinical researchers and is associated to the research group of professor Marie Wahren Herlenius.

Our main research interest is to understand pathways governing development of systemic inflammatory diseases and lymphoma and the link between those two, since patients with autoimmune diseases run an increased risk of developing lymphoma and other cancers. We will investigate possible immune mechanisms and tumor properties governing cancer development in patients with autoimmunity, including dermatomyositis and systemic lupus erythematosus. In addition, we focus on cutaneous T cell lymphoma, which is a rare type of lymphoma primarily engaging the skin. The unique accessibility of this disease allows for easy access to the tumor and the possibility to follow the development of the lymphoma and anti-lymphoma immune responses over time. Most of the patients with cutaneous T-cell lymphoma get an indolent disease, but for largely unknown reasons around 10-15% percent develop aggressive disease with high fatality. In these efforts our ultimate aims are to increase fundamental knowledge on the pathogenesis of cutaneous lymphoma and cancer in autoimmunity and aid earlier identification of patients at risk of aggressive disease. 

To reach our goal have set up a strong collaborative team of researchers and clinicians in dermatology, hematology, rheumatology, oncology, pathology, immunology and epidemiology to take a broad approach. Our research originates in clinical questions and patient material paired with high level basic science experimental investigations.

The position includes experimental work, primarily with clinical material and cell lines but possibly also animal experiments. Key techniques include in vitro assessments of immune cell phenotype and function, advanced flow cytometry, immunohistochemistry, spatial proteomics and transcriptomics, single cell RNA sequencing and confocal microscopy

Entry requirements

Applicants are required to have a PhD in immunology, cell biology or another relevant field. A strong publication record and ability to draft manuscripts is also desired. The successful applicant further has strong interpersonal skills, motivation and organizational and executive capacity.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location

The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within the research group of Marie Wahren-Herlenius, research team Hanna Brauner. Please see our websites for more information: https://staff.ki.se/people/hanna-brauner, https://ki.se/en/meds/hanna-brauner-team, https://centermolecularmed.wixsite.com/my-site/hanna-brauner-team

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-06 at 23:59
Unit: Rheumatology division

Read the job description at the university homepage or apply.

Post expires on Tuesday December 6th, 2022

Postdoctoral position focused on single-cell immune transcriptomics

Do you want to contribute to improving human health?

We are looking for an ambitious postdoctoral fellow with solid genome-wide bioinformatics and computational biology skills to join our highly accomplished team. We offer a stimulating environment in a rapidly moving research frontier. The successful candidate will be part of a cluster of other bioinformaticians working on similar topics. 

Your mission

The Buggert group conducts innovative studies of cell-mediated immunity in health, cancer, and viral disease. These studies are translational in nature and involve the usage of cutting-edge bulk- and single-cell technologies, including high-parameter flow cytometry, gene expression, RNA-seq, ATAC-seq, TCR-seq, and proteomics analysis to dissect the heterogeneity and function of memory T cell immunity. Through these platforms, we study different aspects of human memory T cell biology, with an overall aim to i) study the heterogeneity of circulating and resident memory T cells in human organ donors, ii) identify alternative functions of memory T cells in human tissues, and iii) understand how memory T cells maintain control of tumors and viral infections, such as HIV and SARS-CoV-2. The postdoctoral candidate will collaborate closely with our team members to continue the successful line of investigations utilizing single-cell RNA sequencing (scRNA-seq), scATAC-seq, and other similar technologies to dissect human memory T cell biology in health and viral disease.
The postdoctoral candidate will be a part of the Center for Infectious Medicine (CIM), Karolinska Institutet, a nationally leading and internationally competitive center for human translational immunology and infectious diseases research. The center consists of 17 independent research groups.
We are seeking one, potentially two, postdoctoral candidates with a Ph.D. who will work as an integrated researcher and bioinformatician in our team, being involved in several ongoing projects and driving their projects forward. We already have large sets of high-throughput sequencing data, including scRNA-seq (10x Genomics) and ATAC-seq data, as well as multicolor flow cytometry data of human T cells, which will be analyzed in close collaboration with our team members

Your profile

To be eligible for employment as a postdoctoral researcher, the candidate must hold a Ph.D. in immunology, bioinformatics, computational biology, or equivalent, and demonstrate research expertise and documented research experience after defending their doctoral dissertation.
The candidate should have been trained in computer science, bioinformatics, or computational biology during her/his Ph.D. studies. The candidate should fully master (requirement) R, be proficient in Python (Python Data Stack tools such as NymPY, SciPY, Pandas, scikit), and have solid Unix/Linux experience and statistical knowledge. The candidate should have experience in genome-wide NGS data analysis, particularly in working with scRNAseq from FASTQ to analyze data with 10x and other formats. Experience working in version-controlled systems and high-performance computing for analyses is meriting. Other merits include the ability to formalize biological questions into computational models to drive projects forward and provide advice on the experimental design before data generation. The candidate should be self-motivated, have good communication skills, and have a proven ability to interact effectively and work productively in an interdisciplinary team. Fluency in English is a requirement.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Flemingsberg

Read more about the Center for Infectious Medicine here.
Read more about the Buggert research group here.

Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

Welcome to apply at the latest 2022-12-01.

The application is to be submitted through the Varbi recruitment system.

 

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-01 at 23:59
Unit: Department of Medicine, Huddinge

Read the job description at the university homepage or apply.

Post expires on Thursday December 1st, 2022

Doctoral (PhD) student position in Behavior Genetics/Cognitive Psychology

Do you want to contribute to improving human health?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

A PhD student is now to be recruited for a research project in tight collaboration between MPI for Empirical Aesthetics (MPIEA) in Frankfurt am Main and the Department of Neuroscience at the Karolinska Institutet (KI) in Stockholm.

The doctoral student project and the duties of the doctoral student

Primal world beliefs are a recently-identified set of basic perceptions about the general character of reality (e.g. the world is boring) thought to have many psychological implications (Clifton et al. 2019). To date, Primals research is still limited and entirely based on cross-sectional phenotypic data making it difficult to address causality and familial confounding.

The proposed project is the first to explore the underlying etiology of Primal World Beliefs and the nature of the relationships between Primals and variables under five main themes, namely: Primals and (1) personality, (2) life stress, (3) mental and physical health, and (4) musical, cultural and social engagement. The project will utilize a large (N>30,000), longitudinal, genetically informative cohort of twins and address associations between Primals and a variety of phenotypes including central questions about causality, the importance of genetic and environmental factors, and their interplay.

Ideally, the candidate would spend the majority of his or her time at the MPIEA in Frankfurt. 

What do we offer?

A creative and inspiring environment full of expertise and curiosity, in a collaborative project between two of the world’s leading medical universities.

The MPI is a highly interdisciplinary and international scientific environment, with English being spoken in the laboratory. It is located in an attractive location with excellent infrastructure in Frankfurt’s Westend. You can expect a modern workplace with flexible working hours and a pleasant working atmosphere. Regular travel between the Karolinska Institute in Stockholm and the MPIEA in Frankfurt is required.

The vision of Karolinska Institutet (KI) is to pursue the development of knowledge about life and to promote a better health for all. At KI we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. KI collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. 

For this PhD position, the PhD employment is set at MPI but the PhD degree is held at KI. 

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

 

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

Requirements for this position are a Master’s degree, or equivalent, in behavior genetics, psychology, public health or a related field, as well as a high proficiency in oral and written English. A solid methods background in statistics, including structural equation modelling, twin and family designs, and/or molecular genetics as well as experience with handling of registry or big data is highly desirable.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

The start date for the position is negotiable and with the earliest in Feb, 2022. The selection process will continue until the position is filled.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-31 at 23:59
Unit: Department of Neuroscience

Read the job description at the university homepage or apply.

Post expires on Saturday December 31st, 2022

Doctoral (PhD) student position in the project “Regulation of lifespan by nutritional signals and the mitochondria”

The Department of Biosciences and Nutrition performs research and education in several areas of
medical science including aging, Alzheimer´s disease, biomaterials, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, bioorganic chemistry, immunology, and nutrition. It offers an excellent international research and work environment, including around 250 scientists, students, administrative and technical personnel. The Department resides in Neo at Campus Flemingsberg, a biomedical research building, aimed at being a creative and an open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

We are looking for a PhD student to join the research group of Christian Riedel. The research group studies the molecular mechanisms that regulate aging, in particular in response to nutrient availability. This research is conducted in C. elegans and in human cells, and combines biochemistry (e.g. proteomics), cytology, and modern sequencing techniques (e.g. ChIP-Seq and mRNA-Seq) with high-throughput genetic screening approaches (RNAi), to understand the regulation of aging at molecular and mechanistic resolution. The team consists of 3 Postdocs, 1 PhD student, occasional undergraduate students, and the group leader, which together provide a vibrant and stimulating research environment.

The doctoral student project and the duties of the doctoral student

Focus of this position is to explore an exciting new regulator of FOXO transcription factors (TFs) which we found to be required for FOXO TFs to promote longevity in response to low nutrient signals and disturbed mitochondrial function. This work is conducted both in C. elegans and in human cells. A substantial amount of preliminary data already exists, providing a good chance to bring this project to a high-impact publication over the course of the next 2-3 years. For this work, you will synergize with the aging biologists and a bioinformatician in our lab and have the support of a larger aging-focused and well-equipped research environment at our department. Further, you will be supported by co-supervisors with deep expertise in mitochondrial biology and metabolism.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

 

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

The successful applicant should have a solid background in Molecular Biology, Cell Biology, Genetics, and/or Biochemistry. Desirable are undergraduate or master degrees in biomedicine, biochemistry, molecular biology, cell biology, developmental biology, molecular genetics or similar. He/she is expected to be a talented, highly motivated, and hardworking student, with a good understanding of biochemical, molecular and genetic techniques, and an interest to work in model organisms. Prior expertise in aging biology or knowledge of C. elegans or mammalian cell culture techniques are appreciated, even though they are not essential. Emphasis will be placed also on personal suitability. The applicant should have good communication skills and be proficient in spoken and written English.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

–[Video about Karolinska Institutet, how we all work towards “a better health for all”] –

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Links to additional information

https://ki.se/en/bionut/department-of-biosciences-and-nutrition

https://ki.se/en/bionut/christian-riedel-group

http://riedellab.org/

 

 

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-18 at 23:59
Unit: Department of Biosciences and Nutrition

Read the job description at the university homepage or apply.

Post expires on Sunday December 18th, 2022

Postdoctoral Researcher in Geriatric Epidemiology

Do you want to contribute to top quality medical research?

This position as Postdoctoral Researcher is based on a project funded by the Swedish Research Council for Health, Working Life and Welfare (FORTE), which title is “Trajectories of care needs and care transitions after age 60: the interplay between individuals’ frailty, their environment, and personal perspectives”.

This project aims at increasing our knowledge concerning care needs and patterns of care utilization of frail and clinically complex older adults, to identify timely actions towards a more proactive and integrated healthcare. An increased rate of transition of frail individuals between healthcare (primary care, hospital) and social care providers (home care services, institutions) has been observed but not well characterized. At the same time, fragmented and idiosyncratic care transitions are arguably responsible for a quicker functional decline, which accelerates frailty development. Taking advantage of three well-characterized Swedish population-based studies part of the Swedish National Study on Aging and Care (SNAC), and of the National E-Infrastructure on Aging Research (NEAR) we will analyze data of over 7,000 individuals 60+, living in both urbanized and rural areas of three different Regions.

Your mission

A major task for the candidate will be to contribute conceptually as well as methodologically, to the research activities planned within the FORTE-funded project, under the supervision of Dr Davide Liborio Vetrano. In addition, there are possibilities to initiate individual research projects, based on the candidate´s interests. Production of reports and publications for submission to peer-reviewed journals, and other forms of dissemination will be central activities. The candidate will also be engaged in writing applications for funding. Finally, teaching at first- and second-cycle level at Karolinska Institutet will also be among the candidate’s tasks.

For more information about the project.

This is a temporary full-time position of two years.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are looking for a candidate that has the required background and the capability to work in a multidisciplinary team, to be independent and able to take initiatives as well as to find solutions proactively. The applicants must also possess good organizational skills, attention to detail, and communication abilities.

This position requires:

  • A PhD in Epidemiology or Public Health.
  • Very good clinical knowledge.
  • Work experience in data analysis and interpretation, preferably in the aging research field.
  • Clinical and research experience in the field of public health.
  • Good command of statistical software (e.g., Stata, SPSS, R).
  • Experience in working with different types of epidemiological data (i.e., population-based, clinical and administrative datasets)
  • Excellent written and oral communication skills.
  • Fluent in written and spoken English

It’s meritorious if you have:

  • Ability to work in a collaborative environment with researchers having quantitative and clinical backgrounds.
  • Interest in professional development in the field of epidemiology field.
  • Proactive attitude

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.


Location:
Solna

Information about ARC
Choose to work at KI – Ten reasons why

 

 

Application

An employment application must contain the following documents in English or Swedish:

  • A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

Welcome to apply at the latest 2022-11-30.

The application is to be submitted through the Varbi recruitment system.

 

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-11-30 at 23:59
Unit: Aging Research Center, ARC

Read the job description at the university homepage or apply.

Post expires on Wednesday November 30th, 2022

Doctoral (PhD) student position in Cognitive Neuroscience

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

In the research group of Assistant Professor Konstantina Kilteni (https://www.kiltenilab.org/), we aim to understand how the brain differentiates between sensations produced by our movements (for example, when we touch our body) from those generated by the environment or others (for example, when another person touches/tickles us). A core theme of our research is to understand how the brain uses motor information to perform this distinction during voluntary movements, and how it is related to certain personality traits that resemble the clinical symptoms of schizophrenia but in healthy non-clinical individuals. We use behavioral (psychophysics and kinematics), physiological (electromyography-EMG), and neuroimaging (magnetoencephalography – MEG, and functional magnetic resonance – fMRI) measures to address these questions. The lab is part of the Neuroscience department, in the Biomedicum centre at Karolinska Institute research campus, a vibrant, highly interactive, internationally-recognized center for medical research with outstanding research infrastructure, where you have the possibility to contribute to high-quality research at high international level.

The doctoral student project and the duties of the doctoral student

The project is focused on identifying how somatosensory perception is modulated over the time course of our actions, both at the behavioral and neural level. To this end, you will perform behavioral studies including psychophysical, kinematic, and electromyographic recordings, and structural/functional neuroimaging studies including the methods of magnetoencephalography, resting-state functional connectivity, diffusion tensor imaging and voxel-based morphometry.

 

The doctoral student is expected to:

 

  • lead the project under the supervision of the main supervisor and with support from two co-supervisors. Formal supervision will comprise of regular meetings with the main supervisor to discuss project progress and strategies to solve problems (at least once weekly, physically or virtually).
  • complete doctoral training, including courses and other research-related activities,
  • write the ethical application of the project,
  • design and conduct the experimental studies of the project,
  • perform statistical analysis with a gradual complexity progression,
  • write and revise scientific articles,
  • take part in weekly lab meetings and discuss science,
  • present the project outcomes at internal seminars and international conferences,
  • actively participate in the lab’s journal clubs,
  • collaborate on related projects led by others.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

 

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

  • You are a very motivated, innovative, and enthusiastic individual possessing an excellent analytical ability and a particular interest in human somatosensation and motor control, and advanced statistical modelling, including human brain data.
  • You are also interested in understanding the relationship between somatosensation and personality traits including schizotypy.
  • You are expected to display a high degree of contentiousness, initiative-taking, stamina and autonomy.
  • A Master in Psychology, Neuroscience, Medicine, Biomedicine, or equivalent is required.
  • Good-to-excellent coding skills in R, Python or MATLAB are expected.
  • Previous experience with psychophysics, fMRI, MEG/EEG will be highly appreciated.
  • Since the research group is international and project communication mainly occurs in English, the candidate must be proficient in writing and speaking English.
  • Knowing basic Swedish is beneficial but not required.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Video about Karolinska Institutet, how we all work towards “a better health for all”:


Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-01 at 23:59
Unit: Department of Neuroscience

Read the job description at the university homepage or apply.

Post expires on Thursday December 1st, 2022

Applications are invited for a PhD position in Onur Dagliyan’s Group

Do you want to contribute to top quality medical research?

Applications are invited for a PhD position in Onur Dagliyan’s Group at the division of Molecular Neurobiology. The lab’s research focus is to uncover experience-driven protein signaling mechanisms in the mouse brain by developing new technologies. The group is building a new interdisciplinary research program as there is an immense potential for new fundamental insights to be discovered.

The research group

Neuronal activity dependent molecular signaling processes are central for brain development and plasticity. These molecular events form the mechanistic basis of complex neural computation, learning and memory. The Dagliyan laboratory focuses on specific molecular events in neurons happening at different time scales, starting from the immediate modifications at the synapse, to longer time scale molecular events including gene expression, which are key processes for the behaviorally induced plasticity of neuronal circuits.

More information can be found at https://ki.se/en/mbb/onur-dagliyan-group

The Dagliyan lab is the newest member of the Unit of Molecular Neurobiology, composed of outstanding scientists applying interdisciplinary approaches to cutting-edge problems in a collaborative and stimulating environment. The unit is part of the Department of Medical Biochemistry and Biophysics residing in a new research building for Biomedical Research, Biomedicum, providing modern technological platforms and an open environment for interactions across departments and disciplines. For further information on the research unit: https://ki.se/en/mbb/research-division-of-molecular-neurobiology.

The doctoral student project and the duties of the doctoral student

While the principal investigator will work hard to achieve your career dreams, your mission will be to unravel molecular mechanisms by which sensory-driven neuronal gene expression is controlled. In particular, you will perform experiments including stereotactic injection of AAV into the mouse brain, mouse brain dissection, behavioral assays, imaging, biochemical analyses, single cell transcriptomics and genomics.The recruited PhD candidate is expected to play a leading role in experimental design, experimentation, analysis, as well as presentation/publication of results. You will also work with the collaborating laboratories to learn and adapt new techniques in case you do not have experience with the particular approach. You will also have a chance to collaborate with the scientists who are pioneers in their fields

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

 

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

The applicant shall hold a M.S. degree in one of the biological science fields. B.S or M.S. in neuroscience/neurobiology is a plus. The candidates with previous mouse-work experience will be prioritized. Prior experience in studies of electrophysiology, transcriptomics, genomics or 2-photon imaging is a plus. The applicant needs to have a high degree of independence and motivation but should have no problems to work in a team given the collaborative nature of the project. Fluency in English is a requirement.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2022-12-01 at 23:59
Unit: Department of Medical Biochemistry and Biophysics

Read the job description at the university homepage or apply.

Post expires on Thursday December 1st, 2022