Do you want to contribute to top quality medical research?

We are looking for an ambitious postdoc with solid single-cell immunology skills to join our highly accomplished team of immunologists in a project funded by the Swedish Cancer Society. We offer a stimulating environment in a rapidly moving research frontier.

Your mission

The Mjösberg group studies the development, regulation and function of innate lymphoid cells (ILCs), in humans, and how these cells contribute to pathology in mucosal organs such as the lung and gut. The studies are translational as they involve advanced basic molecular and cellular immunological investigations of precious human tissue samples to discover novel disease mechanisms, therapy targets and improved strategies for personalized treatment. The Mjösberg group consists of two team leaders, two PhD students, five postdocs and a lab manager working closely together with clinical partners at several Swedish hospitals and laboratory facilities at Science for Life Laboratories (SciLifeLab), Karolinska Institutet and abroad.

The Mjösberg group is internationally recognized as a leader in the field through several high impact publications in recent years (Nat Comm 2020, Cell Res 2021, Sci Imm 2022, Cell Rep Med 2023 etc). In particular, the postdoc will continue the successful line of investigations utilizing single-cell RNA sequencing (scRNA-seq) to dissect human intestinal mucosal lymphocyte biology in health and disease.

The project has already generated scRNA-seq data as well as multicolor flow cytometry data of human intratumoral lymphocytes and stromal cells in colorectal cancer. The postdoc will now analyze these data and perform functional experiments (in vitro differentiation, co-cultures etc) together with another postdoc in the team and gastrosurgeons at Karolinska University Hospital. As this is a team effort, excellent communication skills are essential, as is proven ability to work in multidisciplinary teams. It is expected that the postdoc also supervise students and other researchers if necessary, as well as contribute to common lab duties.

The postdoc will be a part of the Center for Infectious Medicine (CIM), Karolinska Institutet, which is a nationally leading and internationally competitive center for human translational immunology and infectious diseases research. The center consists of approximately 25 graduate students and 25 postdocs organized around 14 independent research groups.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

The candidate must hold a PhD equivalent to a Swedish doctoral degree in the field of immunology. The candidate must fully master multidimensional (>20 parameters) flow cytometry analysis and sorting, as well as be experienced in scRNAseq including analysis. Experience in isolation and in vitro culturing of primary immune cells is a requirement, as is basic functional in vitro assessments of immune cell function such as intracellular cytokine stainings, ELISA etc. The candidate should have a strong publication track-record. The candidate should be self-motivated, have good communications skills and a proven ability to interact effectively and work productively in an interdisciplinary team. Fluency in English is a requirement.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Flemingsberg

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 2024-03-31

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-03-31 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to improving human health?

We are seeking a curious and highly motivated postdoctoral researcher to join the Calvigioni Research Team at the Department of Neuroscience, Karolinska Institute in Stockholm, Sweden.

Division

The research focus of the team is the study of the neurobiology of stress sensitivity, anxiety disorders, stress-induced long-lasting brain states (Calvigioni et al., Nature Neuroscience, 2023) and maladaptive neurodevelopment, with a specific focus on sex differences and critical windows (i.e adolescence). We aim to identify the cellular and molecular state transition in projection-defined and genetically identified sensitive brain network, causal to stress-induced long-lasting disorders, as to the increased sensitivity in women and adolescence.

Our approach, long-term vision and methodology strive to ultimately uncover how single neurons encode stimuli of emotional valence in vivo in the healthy brain and identify the causality between activity modes/genetic cell states and behavioral transition to anxiety disorders.

Duties

The successful candidate will use genetic mouse models, stereotactic surgery and intersectional viral approaches combined with in vivo behaviours, optogenetics/chemogenetics manipulation, molecular biology and neuroanatomical analyses, in adult and developing mice.

The project will also involve dissecting the molecular and functional heterogeneity of relevant brain circuits using state-of-the-art single cell molecular (snSEQ, patchSeq) and functional profiling methods (ex-vivo patch-clamp electrophysiology, in vivo fiber photometry and single neuron calcium imaging).

Previous experience in the study of neuronal circuits in rodent models of stress or development is preferred but not essential. Candidates with experience in anatomical tracing/behavior/electrophysiology and/or imaging techniques will be prioritized. Experience with slice electrophysiology/ in vivo experiments/ neuroendocrinology/ RNA-sequencing and advanced data analysis will be considered and positively evaluated. Candidates with experience in single cell biology in other disciplines and a willingness to study the brain are also welcome.

A curious mind, positive attitude, high motivation and analytical approach to independent problem-solving are essential. The ability to work independently and proficiency in English are necessary.

The earliest start date is Spring 2024 but can be negotiated when the appropriate candidate is found.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A cover letter (describing goals and motivation)
• A summary of current work (no more than one page)
• At least 2 letters of reference (with contact details of refence) 

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-03-01 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to top quality medical research?

We invite applications for a postdoctoral position in the laboratory of Professor Ernest Arenas: http://ernestarenaslab.org/. The laboratory is part of the Division of Molecular Neurobiology, a cluster of 8 research groups forming a dynamic and collaborative research environment within the MBB department, at the Karolinska Institute. https://ki.se/en/mbb/research-division-of-molecular-neurobiology.

Our laboratory is located in Biomedicum, one of the largest and most modern research centers in Northern Europe, within a world leading University, Karolinska Institutet. We provide modern technological platforms and we offer an interactive, multidisciplinary and international research environment, where you can perform cutting edge science that makes a difference, address fundamental questions, and develop novel therapeutic strategies.

Your mission

We look for a researcher interested in stem cell biology, midbrain development, dopaminergic neurons and Parkinson’s disease. The successful candidate will work with human pluripotent stem cells and human tissue, and will perform amongst others, single cell omics, cell engineering and functional genomics experiments.

The project is based on previous and ongoing work from the lab aiming at defining human midbrain dopaminergic neuron development (La Mano et al., Cell, 2016; Braun et al., Science, 2023), human adult dopaminergic neurons (Siletti et al., Science, 2023) and Parkinson’s disease (Bryois et al., Nature Genetics, 2020) at the single cell level. This knowledge has helped to develop improved protocols for the generation of DA neurons from pluripotent stem cells (Nishimura, Stem Cell reports, 2022). We are now looking for postdoctorals interested in studying the function of genes involved in human DA neuron development, and in the degeneration of DA neurons in PD. Our goal is to develop novel cell replacement approaches for PD and strategies for interfering with pathogenic mechanisms of PD. This work is being supported by an ERC Advanced Grant aiming at developing precision cell replacement strategies for Parkinson’s disease (PreciseCell PD), the Wallenberg Foundation, an EU collaborative project (Neurostemcell-reconstruct), and an international ASAP (Aligning Science Across Parkinson’s) project to understand the underlying causes of PD.

Your profile

We look for a strongly motivated individual with a PhD, or about to defend a thesis, who has been working in the areas of neuroscience, neurobiology, developmental biology, stem cell biology, molecular biology, biotechnology, genetics, neurodegenerative diseases or related areas. The candidate should be interested in working in a challenging and stimulating project aimed at understanding different aspects of human dopaminergic neurons, form development to mechanisms of degeneration, and at developing novel therapeutic strategies for PD.

The candidate should have knowledge and experience in planning, performing and analyzing experiments in three or more of the following areas: differentiation of human IPS cells (2D or 3D), co-cultivation of neural cells, cell engineering (CRISPR and virus work), single cell/nuclei/spatial omics methods (RNAseq, ATACseq, Cut&Tag), FACS sorting, tissue sectioning, cell signaling (immunoprecipitation, western blot), confocal microscopy and image analysis, and functional assays (HPLC, electrophysiology, calcium recordings).

Knowledge of midbrain development, dopaminergic neurons and Parkinson’s disease, will be considered as important merits. Experience in computational biology, certification to perform stereotaxic surgery in rodents (FELASA or equivalent), and experience in working in international environments will be considered as additional merits.

Applicants should have good communication skills, be proficient in spoken and written English, be able to work independently, and enjoy collaborating and interacting with others.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

We offer a full time (100%) postdoctoral position starting in 2023, preferably before the summer. Our laboratory and our unit offer a creative, interactive, inclusive, and international research environment, where you can enjoy science and develop your career. The project also offers excellent opportunities for learning new methods, for interacting with multiple colleagues within our division and for collaborating with other research laboratories.

Our laboratory offers a modern state of the art working environment within the Karolinska Institutet, one of the world’s leading medical universities and home of the Nobel Prize in Medicine or Physiology. Karolinska Institutet holds the largest range of medical education in Sweden, conducts cutting edge medical research and has the mission of gaining basic biomedical knowledge and improving human health.

At Karolinska Institutet you will find a creative and inspiring environment with wide-ranging expertise and interests. You will have the opportunity to meet researchers working with a wide range of specialities and methods, giving you ample opportunity to exchange knowledge and experience across scientific fields of science, medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. A close relationship with health care providers contibute to creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Application

Your application must contain the following documents in English:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications.
• A letter of motivation (no more than one page)
• The name of three references or three reference letters
• Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline).

In assessing candidates we will place our emphasis on the personal trajectory, education, technical skills, CV, merits and previous experience.

Welcome to apply at the latest 2024-03-03

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-03-03 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to top quality medical research?

We are looking for a postdoctoral fellow for studies of brain degeneration in Lewy Body dementia (DLB) using advanced brain imaging methods. You will conduct work within the framework of a leading EU-project within the European Lewy Body dementia consortium and collaborate with reaserchers at Karolinska Institutet as well as international partners. 

The research group

The postdoctoral position is established in Dr. Daniel Ferreira’s research group, within the division for Clinical Geriatrics, department of neurobiology, care sciences and society (NVS). The research group’s workplaces are located in the Neo-building at KI´s South Campus Flemingsberg (https://staff.ki.se/neo). The Ferreira’s research group has a strong focus on neuroimaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) and its applications in aging and neurodegenerative diseases.

Your mission

This postdoctoral position will be primarily involved in a leading EU project on dementia with Lewy bodies (DLB), which is part of the European DLB consortium (https://www.e-dlb.com/).
Dementia Lewy Body is the second most frequent form of neurodegenerative dementia, right after Alzheimer’s disease. The goal of this project is to advance our current understanding of brain degeneration and disease progression in DLB by using state-of-the-art and advanced neuroimaging methods. The postdoctoral researcher will use neuroimaging software to investigate markers of neurodegeneration such as cortical thickness, regional volume, and hypometabolism, as well as methods developed in-house to assess brain cholinergic system and other aspects of neurodegeneration. Thus, the project involves an exciting mix of neuroimaging techniques and advanced mathematical modeling. An important task is harmonizing neuroimaging data across EU centers and perform quality control and curate the research database. The postdoctoral researcher will also be able to help coordinate neuroimaging studies within the European DLB consortium (https://www.e-dlb.com/) and other international cohorts as well as use data from Karolinska University Hospital. The postdoctoral fellow will work both independently and in close collaboration with the group leader, others in the research group and other research groups in the department and international. The postdoctoral fellow shall also apply for research grants, develop her/his own research and projects, and contribute to coordinating seminars and journal clubs within the department. There are possibilities to teach at advanced level and supervise students (e.g. Master’s, doctoral students).

Your profile

We are looking for a committed and driven person with a backround in engineering or brain-imaging as well as competence in data analysis and programming. The successful candidate should have basic knowledge in brain diseases, dementia or cognition. Experience in processing brain imaging data, magnetic resonance imaging (MRI), and positronemissiontomography (PET) is an advantage. Well-developed collaboration skills and proficient english, both written and orally are required. 

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Campus Flemingsberg – Blickagången 16 (building Neo), Huddinge

Read more about the Division of Clinical geriatrics

Read more about Daniel Ferreira Padilla´s research group

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work.
• A complete list of publications.
• A summary of current work (no more than one page).

Welcome to apply at the latest 23rd of February, 2024.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-02-23 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to top quality medical research?

We are looking for an ambitious PhD graduate with advanced skills in epigenomics and single cell profiling to perform cutting-edge research within two engaging and international research groups. This is an opportunity to contribute to high-quality research on an internationally competitive level at Karolinska Institutet and Scilifelab. We are looking for a highly motivated individual, who excelled during her/his doctoral studies, has substantial experience in developing single cell-based technologies, and strong documented interest in epigenetics.

As a postdoc in this project, you will be part of KIRI, the Karolinska Institutet Research Incubator, a unique initiative at KI to build a community for interdisciplinary research and breakthrough discoveries. You will have access to two PI:s that you can meet and interact with to facilitate the research process and increase the synergetic effects. As part of KIRI, you will also have the opportunity to meet other KIRI postdocs conducting state-of-the-art research, present your work at scientific events, and take part in KIRI activities. Read more about KIRI here. 

The research groups 

Fredrik Lanner is an expert in human embryology, stem cell and single cell biology. The Lanner lab develops pluripotent stem cell based cellular therapies and explores the mechanisms that control early human embryo development and pluripotency. The group is a mix of medical and basic-science oriented members including PhD students, postdocs, a senior bioinformatician and a lab manager, providing an inspiring environment to support the KIRI postdoc. The lab is fully equipped for innovative research in stem cell and human embryo research including embryo-manipulation equipment and it is integrated with the Reproduction medicine unit, within Karolinska University hospital.

Simon Elsässer has extensive experience in molecular biology, chromatin biochemistry, epigenomics and bioinformatics. The Elsässer group is an international and multicultural research group that focuses on applying new synthetic and chemical biology methods to understand chromatin structure and function. The group is located at the Science for Life Laboratory in Stockholm and includes senior and junior researchers, bioinformaticians, administrators, PhD students and undergraduate trainees.

Your mission

The proposed project provides a fantastic training opportunity for the KIRI postdoc, applying the most advanced embryo models available today with state of the art epigenomics technologies, generating a comprehensive epigenomic atlas of early human embryonic lineages and dissecting the network of transcription factors and epigenetic regulators defining early cell fates.

The successful candidate will be supervised jointly by the two PIs and be part of both research group activities while moving research as needed between the two laboratories. The ability to work independently and as part of a team is essential for this position.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Essential:

• Proven experience in developing epigenetic methods and experience with naive pluripotent stem cells
• Proven experience in developing cell-based techniques to profile human embryos and stem cell models
• Good communication skills in English
• Independent working skills, teamwork spirit and willingness to help PhD/master students

Desired:

• Strong expertise in microscopy 
• Proficiency in scientific programming and bioinformatic analysis

You should be highly motivated and interested in developing and performing epigenetic analysis of early human embryos and stem cell models. It is important that you are independent, take your own initiative and have very good cooperation skills. Furthermore, it is important that you are performance-oriented. We value personal qualities in the selection of candidates.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Scilifelab, Solna and Flemmingsberg

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest February 29th 2024.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-02-29 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC have about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations.

The research group

The Department of Microbiology, Tumor and Cell Biology announces an opportunity to join the group of Professor Karlsson Hedestam as a PhD student in immunology. The group studies adaptive immunity and immunogenetics using a combination of wet lab and computational approaches.

For more information, see http://ki.se/en/mtc/gunilla-karlsson-hedestam-group.

The doctoral student project and the duties of the doctoral student

B and T lymphocytes express highly polymorphic receptors encoded by genes that recombine in a combinatorial manner during lymphocyte development. This project will use high throughput genotyping techniques to investigate germline-encoded variations in T and B cell receptor genes and how they influence responses in autoimmune inflammatory diseases.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

• Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents: Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

We are looking for a candidate who has a medical degree (MD) and documented hands on skills in molecular biology, immunology, immunogenetics, single cell analysis and monoclonal antibody isolation, as well as experience in handling primary human immune cells and working with NGS data.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

• A personal letter and a curriculum vitae
• Degree projects and previous publications, if any
• Any other documentation showing the desirable skills and personal qualities described above
• Documents certifying your general eligibility (see A above)
• Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

• Documented subject knowledge of relevance to the area of research
• Analytical skill
• Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-02-27 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The doctoral student project and the duties of the doctoral student

We have a four-year full-time position as PhD student in our research group in Karolinska Institutet available to study childhood cancer in the brain and spinal cord. The aim of our research is to understand the processes that make these tumors so difficult to treat, and to identify possible targets for more effective treatments in the future.

We are mainly focusing our research on so-called ependymomas, which is one of the most common types of tumors in the brain and spinal cord. We compare ependymoma subtypes of different severity using multi-omics analyses of tumor samples to acquire a better understanding of the cell types present in the tumors, and the patterns of gene expression in various cell types. We are particularly interested in the cancer stem cells, the type of cells that are relatively resistant to treatment, and that give rise to recurring tumors and daughter tumors. We also culture tumor cells to be able to change their gene expression and control critical features of the cells. Tumor cells are also transplanted to mice to be able to study in detail the tumor cells over longer time periods, how they develop and change in an environment that resembles the conditions in the patient. Key questions in our research are the role of cancer stem cells, the molecular-genetic control of self-renewal of these cells, their transition in and out of quiescence and to more differentiated phenotypes.

As a PhD student you will learn a variety of techniques for gene expression analysis including the bioinformatical tools to analyze the data you acquire. You will use cell culture techniques, isolate cells with FACS, and apply reporter genes for this purpose. You will learn animal surgery and apply methods for stereotaxic injections to transplant tumor cells to mice, which may be monitored with magnetic resonance imaging (micro-MRI) or other imaging techniques. You will participate in designing your experiments, and most importantly, you will learn how to critically evaluate your results and relate them to previously published research data.

The research group

The Sundström research group is located in the BioClinicum research facilities of the Karolinska University Hospital. We have a long-standing interest in disorders of the brain and spinal cord, with a particular focus on stem cells in the tissue and as treatment. We are now expanding our research into the field of tumors in the brain and spinal cord, in close collaboration with the Baryawno research group at the unit for childhood cancer and surgery, Dept of Women’s and Children’s Health. We are also working closely together with other research groups at Karolinska Institutet, SciLifeLab, Royal Institute of Technology (KTH) and Stockholm University, forming a consortium on childhood diseases.

The Division of Neurogeriatrics consists of about 65 employees. The division conducts experimental and translational research related primarily to Alzheimer’s disease and other neurodegenerative diseases, but also more general molecular mechanisms with biomedical relevance are studied.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

For this position we are looking for a student with a master degree in biology/medicine, preferably with a focus on neurobiology and/or cancer. It is advantageous but not required to have documented experience in immunofluorescence microscopy, cell culture, flow cytometry/FACS, gene expression analysis (RNA-sequencing, Spatial transcriptomics/Visium etc.), molecular cloning (plasmid design, gene editing, CRISPR screening etc.), bioinformatic analysis and/or small animal surgery. A certificate of approved FELASA education is considered a merit. If you got your master degree more than 3 years ago, it is a merit if you worked with medical/biological/biochemical research and development after your master. You must have good communication skills in English as well as collaborative skills to allow you to work closely with other PhD students and post-docs.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

For more details of the main supervisor Dr. Xiaofei Li, and co-supervisor Dr. Erik Sundström, please see the links below

https://ki.se/en/people/xiaofei-li#publications

https://ki.se/en/people/erik-sundstrom

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-03-05 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to improving human health?

We are looking for an ambitious postdoctoral candidate that will contribute to advancing our understanding of how the oncoprotein MYC controls lymphocytes development through the regulation of topoisomerase activity, with the aim of developing strategies to hijacking MYC-driven lymphomas.

The project will be performed collaboratively between Laura Baranello Lab (Department of Cell and Molecular Biology) and Lisa Westerberg Lab (Department of Microbiology, Tumor and Cell Biology). The postdoctoral fellow will be located at Biomedicum, a top modern research building with a large repertoire of researchers and access to state-of-the-art infrastructure and facilities.

Our collaboration is at the intersection of chromatin biology, molecular immunology, and drug development aiming to reveal the molecular codes of cellular physiology and diseases.
The candidate will greatly benefit from this interdisciplinary environment, immersion in a highly stimulating and supportive research community, unique infrastructure, a buzzing capital, and scenic nature at your doorstep.

Your mission

The Baranello Lab – Drawing from our expertise in the fields of topoisomerase and cancer biology, we aim to answer fundamental questions about how transcription, replication and DNA topology are functionally coordinated in human cells. We use state-of-the-art approaches to assess transcriptomic, epigenomic and replisomic profiles, as well as advanced microscopy and drug screens to understand how topoisomerase regulation affects fundamental nuclear processes (key lab references: Baranello et al. Cell 2016; Wiegard et al. Molecular Cell 2021; Das et al. Molecular Cell 2022; Cameron et al. Science Advances 2023). The overall aim is to reveal novel cancer therapy targets and improved strategies for personalized treatment.

Recently we have identified a protein complex called “the topoisome” in which the oncoprotein MYC recruits and increases the catalytic activities of both Topoisomerase 1 and 2 to promote high transcriptional rates (Das et al. Molecular Cell 2022). The successful candidate will play a leading role in a full-time research project funded by the European Research Council Consolidator Grant, focused to address the key role of MYC-driven topoisome during B cells development. The outcome of this will inspire a new strategy to target MYC in lymphomas.
The project is a combination of practical laboratory tasks including master molecular biology, genomics, CRISPR-based genome editing, and computational analysis. The postdoc will plan and execute experiments, analyze data, interpret, and present the results, supervise students as well as write scientific articles, initially under partial supervision but with greater independence going forward.

We are a young and dynamic research team with a well-established collaborative network. The group is also associated to the laboratory of Dr. Levens at the National Institutes of Health (US) and Dr. Shiraige at Tokyo University (JP). The successful applicant will thus be part of multiple networks of recognized scientists.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

We are looking for a highly motivated, driven, enthusiastic person interested in our area of research, and ready to explore new avenues in science. The candidate should have a strong collaborative approach to research, be a team player as capable of performing tasks independently and contribute to a good social environment in the laboratory.

The candidate must have a PhD in medical sciences, molecular biology, molecular immunology, biochemistry or equivalent.

Requirements:

• Strong expertise in cell and molecular biology
• Expertise in genomics
• Expertise in transcription regulation
• Expertise in DNA topology
• Proficiency in scientific programming (e.g., R/Bioconductor, Python, UNIX)
• Interest in solving intricate scientific questions and willingness to help PhD/master students.
• Excellent interpersonal and communication skills (in English written and verbal). Emphasis will be also placed on personal suitability, fitting well into the current research group. 

What do we offer?

The two labs are eager to provide the fellow with an opportunity to develop and/or apply state-of-the-art methodologies to solve timely biological key questions. Necessary training on sequencing technologies and computational analysis will be given to the fellow. We are eager to give the candidates opportunity to become fully independent researchers in interdisciplinary science within years.

Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. 

Visit Baranello Lab: https://ki.se/en/research/groups/topoisomerases-chromatin-biology-and-cancer-laura-baranellos-group

Visit Department of Cell and Molecular Biology: https://ki.se/en/cmb/department-of-cell-and-molecular-biology

Location: Stockholm Campus Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English:

• A complete curriculum vitae (max 3 pages)
• A complete list of publications
• A letter describing previous accomplishments, technical expertise and why you want to work with us (no more than one-page, generic letters not accepted)
• Names and contact details of two scientists for reference letters

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-03-12 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to improving human health?

We are looking for an ambitious postdoctoral candidate that will work on advancing our understanding of how the oncoprotein MYC controls lymphocytes development through the regulation of topoisomerase activity, with the aim of developing strategies to hijacking MYC-driven lymphomas.

The project will be performed collaboratively between Laura Baranello Lab (Department of Cell and Molecular Biology) and Lisa Westerberg Lab (Department of Microbiology, Tumor and Cell Biology). The postdoctoral fellow will be located at Biomedicum, a top modern research building with a large repertoire of researchers and access to state-of-the-art infrastructure and facilities.

Our collaboration is at the intersection of chromatin biology, molecular immunology, and drug development aiming to reveal the molecular codes of cellular physiology and diseases. The candidate will greatly benefit from this interdisciplinary environment, immersion in a highly stimulating and supportive research community, unique infrastructure, a buzzing capital, and scenic nature at your doorstep.

Your mission

The Baranello Lab- Drawing from our expertise in the fields of topoisomerase and cancer biology, we aim to answer fundamental questions about how transcription, replication and DNA topology are functionally coordinated in human cells. We use state-of-the-art approaches to assess transcriptomic, epigenomic and replisomic profiles, as well as advanced microscopy and drug screens to understand how topoisomerase regulation affects fundamental nuclear processes (key lab references: Baranello et al. Cell 2016; Wiegard et al. Molecular Cell 2021; Das et al. Molecular Cell 2022; Cameron et al. Science Advances 2023). The overall aim is to reveal novel cancer therapy targets and improved strategies for personalized treatment.

Recently we have identified a protein complex called “the topoisome” in which the oncoprotein MYC recruits and increases the catalytic activities of both Topoisomerase 1 and 2 to promote high transcriptional rates (Das et al. Molecular Cell 2022). The successful candidate will play a leading role in a full-time research project funded by the European Research Council Consolidator Grant, focused to address the key role of MYC-driven topoisome during B cells development. The outcome of this work will inspire a new strategy to target MYC in lymphomas. The project is a combination of practical laboratory work including master molecular biology, genomics, CRISPR-based genome editing, and computational analysis. The postdoc will plan and execute experiments, analyze data, interpret, and present the results, supervise students as well as write scientific articles, initially under partial supervision but with greater independence going forward.

We are a young and dynamic research team with a well-established collaborative network. The group is also associated to the laboratory of Dr. Levens at the National Institutes of Health (US) and Dr. Shiraige at Tokyo University (JP). The successful applicant will thus be part of multiple networks of recognized scientists.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are looking for a highly motivated, driven, enthusiastic person interested in our area of research, and ready to explore new avenues in science. The candidate should have a strong collaborative approach to research, be a team player as capable of working independently and contribute to a good social environment in the laboratory. The candidate must have a PhD in medical sciences, molecular biology, molecular immunology, biochemistry or equivalent.

Requirements:

• Strong expertise in cell and molecular biology
• Expertise in genomics
• Expertise in transcription regulation
• Expertise in DNA topology
• Proficiency in scientific programming (e.g., R/Bioconductor, Python, UNIX)
• Interest in solving intricate scientific questions and willingness to help PhD/master students.
• Excellent interpersonal and communication skills (in English written and verbal). Emphasis will be also placed on personal suitability, fitting well into the current research group. 

What do we offer?

The two labs are eager to provide the fellow with an opportunity to develop and/or apply state-of-the-art methodologies to solve timely biological key questions. Necessary training on sequencing technologies and computational analysis will be given to the fellow. We are eager to give the candidates opportunity to become fully independent researchers in interdisciplinary science within years.

Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles you to several benefits through our collective agreement. Employees also have free access to our modern gym and receive reimbursements for medical care.

Visit Baranello Lab: https://ki.se/en/research/groups/topoisomerases-chromatin-biology-and-cancer-laura-baranellos-group

Visit Department of Cell and Molecular Biology: https://ki.se/en/cmb/department-of-cell-and-molecular-biology

Location: Stockholm, KI Campus Solna

[Video about a Karolinska Institutet, how we work towards “a better health for all”]

Application

An employment application must contain the following documents in English or Swedish:

• A complete curriculum vitae (max 3 pages)
• A complete list of publications
• A letter describing previous accomplishments, technical expertise and why you want to work with us (no more than one-page, generic letters not accepted)
• Names and contact details of two scientists for reference letters

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-03-12 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The adipocyte expresses over 4000 long non-coding RNAs (lncRNAs), many uniquely expressed in fat cells. However, how these polymeric molecules function in concert with the metabolic machinery of the cell is not well understood. In our laboratory, we investigate how lncRNAs adapt the adipocyte for specialised function, specifically in the context of lipid droplet metabolism. Our investigation focuses on lncRNAs that may underline compromised metabolic flexibility and contribute to cardiometabolic disease pathogenesis.

We integrate findings from well-characterized human white adipose tissue (WAT) biopsies and large population genetics to identify lncRNAs implicated in lipid metabolism and cardiometabolic disease. The disease-associated lncRNAs are investigated in human adipocyte cell models and using CRISPRi/a gene perturbation coupled to lipidomic/metabolomics, we aim to understand the effect of the lncRNA expression on adipocyte metabolism. In addition, we use gene variant editing in human adipocytes to understand how single nucleotide polymorphisms located in lncRNA gene loci lead to alterations in lipid droplet metabolism.

Our research group is based in the Unit of Endocrinology at the Department of Medicine-Huddinge. The group is expanding, and we will aim to hire additional PhD and Postdoctoral researchers, which will be advertised this year. The group interacts with the other research groups in the Unit of Endocrinology, including sharing lab space and lab meetings creating a dynamic and diverse research space that fosters collaboration on multiple projects. Please see the lab website for further details.   

Long noncoding RNA in the adipocyte – Alastair Kerr Research Group

The doctoral student project and the duties of the doctoral student

This doctoral project will explore how lncRNAs regulate lipid breakdown and in turn type-2 diabetes pathogenesis. The student will use omics and white adipose tissue clinical phenotype data to uncover novel lncRNAs associated to lipid breakdown. The student will progress these lncRNAs into molecular studies in human adipocytes, where they will use advanced molecular gene perturbation systems and in-house developed molecular methodology to uncover how these lncRNAs function at a molecular resolution. The doctoral student will be trained in how to examine clinical data to identify candidate lncRNAs and develop an investigational pipeline to understand how they function. The student will be involved in learning from current lab members and teaching future lab members that will be hired.  

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

Required

• The chosen candidate will have completed a Master’s degree in biology/Cell Biology/Molecular Biology/Biochemistry or another related subject and completed a wet laboratory based thesis project.
• A good knowledge of cell biology.
• Clear communication and documentation skills to be able to explain and replicate research findings. 
• An ability to work independently.  

Desirable

• Experience in cell culture as well as basic molecular biology techniques eg. Western blot analyses, qRT-PCR and similar methodology is highly advantageous.
• Documented skills in teaching practices.
• Experience in RNA biology.
• Experience in microscopy.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-03-07 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to top quality medical research?

The Department of Neuroscience includes several research groups working on different aspects of nervous system function, both under normal conditions and in various disease states. Research projects include a broad range of studies on the molecular and cellular levels, networks of neurons, and the organization of the nervous system as a whole. The Department has a flat organization with 40 research group leaders, of which 24 are full professors, and 65 PhD students.

Teaching represents a fundamental activity at the Department, which participates in several undergraduate courses and postgraduate education programs. Each year approximately 15 students receive their PhD from our Department and many of our graduates have gone onto distinguished careers in the academic or private sector.

Division

Join our dynamic and cutting-edge Santini-Laboratory at the Department of Neuroscience, Karolinska Institute. Our team is at the forefront of preclinical research, focusing on the physiology of the basal ganglia and its intricate role in shaping behavior. Comprising a team of dedicated scientists, we are committed to advancing our understanding of neurophysiological mechanisms using state-of-the-art techniques and innovative approaches.

Our research group is known for its collaborative and interdisciplinary environment, fostering a culture of continuous learning and professional growth. We employ a comprehensive approach, integrating neurophysiological investigations with behavioral studies to gain deeper insights into the complex interplay between microcircuits in the basal ganglia and behavior. We are interested in understanding how pathological alterations in the striatum are involved in generating behaviors in animal models of neurodevelopmental disorders. By leveraging cutting-edge technologies and animal models, we aim to make significant contributions to the field of neurophysiology, paving the way for the development of novel therapeutic interventions for neurodevelopmental disorders.

Duties

As a key member of our Research Group, you will play a crucial role in advancing our research objectives. We are looking for motivated young scientist with previous experiences with behavioral and/or electrophysiological approaches.

Your duties will include, but are not limited to:

1. Experimental Design and Execution: Develop and implement neurophysiological or behavioral experiments using animal models, specifically focusing on the basal ganglia. Design experiments for recording, analyzing, and interpreting neural activity in brain slices or in vivo to unravel the mechanisms underlying behavioral responses. We require a minimum experience in electrophysiology recordings and stereotaxic surgeries or behavioral neuroscience.
2. Data Analysis and Interpretation: Employ advanced data analysis techniques to extract meaningful insights from neurophysiological recordings. Collaborate with team members to integrate neurophysiological findings with behavioral outcomes, contributing to the understanding of the neural circuits governing behavior. We require the use of software for data analysis such as Igor, Python, R, etc…
3. Instrumentation and Technology Management: Maintain and optimize laboratory equipment for neurophysiological (or behavioral) experiments. Stay abreast of emerging technologies and methodologies in the field, ensuring the incorporation of cutting-edge tools to enhance research capabilities.
4. Collaboration and Teamwork: Work closely with interdisciplinary team members. Foster a collaborative atmosphere that encourages the exchange of ideas and expertise, driving innovation within the division. We require an adequate use and comprehension of the English.
5. Publication and Presentation: Contribute to the dissemination of research findings through peer-reviewed publications and presentations at scientific conferences. Engage with the broader scientific community to share insights and build networks within the field of neurophysiology and behavior. We require that the applicants have previous experience with writing of scientific reports.

This position offers a unique opportunity to be at the forefront of groundbreaking research, contributing to the advancement of knowledge in neurophysiology and its implications for understanding and treating neurodevelopmental disorders. Priority will be given to applicants that have a strong motivation to join our team and possess the technical requirements specified above.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-03-11 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to top quality medical research?

Join us at the department of Oncology-Pathology, Karolinska Institutet. The research group led by Martin Enge is specialized in methodology-driven analysis of patient data, especially in the field of single-cell multiomics. We combine cutting-edge method development with strong ties to the clinic, and aim to directly influence future clinical practice. 

Your mission

The project combines basic research with method development and will be centered around creating a unified diagnostic method based on joint genomic/mRNA sequencing and physical cell interaction (see: Zachariadis et al. Mol. Cell 2020, Andrews et al. Nat. Methods 2021, Enge et al. Cell 2017), and to use this method to better understand cancer evolution and how subclones persist treatment and cause relapse. It is a strictly data driven approach, and your main role will be to develop the computational methods involved. The project involves working closely with clinical collaborators, and directly contribute to improving future precision medicine.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Qualifications:

• We seek a highly motivated researcher with competence in computational biology.
• The candidate should have a collaborative approach to research, and be capable of spearheading this highly collaborative project.
• The ideal candidate has a strong foundation in computer science/computational biology.

Merits:

• Specific experience in analyzing sequence-level data on single cell level, R/Bioconductor and Python/Tensorflow will be useful but is not a requirement.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 4^th March.

The application is to be submitted through the Varbi recruitment system.

This position is for 2 years, with posibility of extension. 

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-03-04 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to top quality medical research?

Join us at the department of Oncology-Pathology, Karolinska Institutet. 

Division

The research group led by Martin Enge is specialized in methodology-driven analysis of patient data, especially in the field of single-cell multiomics. We combine cutting-edge method development with strong ties to the clinic, and aim to directly influence future clinical practice. 

Duties

The project combines basic research with method development and will be centered around creating a unified diagnostic method based on joint genomic/mRNA sequencing and physical cell interaction (see: Zachariadis et al. Mol. Cell 2020, Andrews et al. Nat. Methods 2021, Enge et al. Cell 2017), and to use this method to better understand cancer evolution and how subclones persist treatment and cause relapse. It is a strictly data driven approach, and your main role will be to develop the computational methods involved. The project involves working closely with clinical collaborators, and directly contribute to improving future precision medicine.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Qualifications:

• We seek a highly motivated researcher with competence in computational biology.
• The candidate should have a collaborative approach to research, and be capable of spearheading this highly collaborative project.
• The ideal candidate has a strong foundation in computer science/computational biology. 

Merits:

• Specific experience in analyzing sequence-level data on single cell level, R/Bioconductor and Python/Tensorflow will be useful but is not a requirement.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system at the latest 4^th March. 

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-03-04 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to top quality medical research?

Karolinska Institutet offers a unique environment in which to work with innovative researchers and state-of-the-art facilities to perform basic, pre-clinical and clinical research. We offer an engaging and international research environment where you will have the opportunity to contribute to high quality research at a leading international institution.  

Division

The role is based at the Department of Women’s and Children’s Health. The successful candidate will explore the role of extracellular vesicles (EVs) in skeletal growth during physiology and pathology.

Your mission

• Develop and implement research projects in conjunction with PI
• Independently design, conduct, execute and analyse experiments
• Actively follow and implement the scientific literature in your own work
• Write and edit manuscripts
• Actively participate in collaborative lab and project meetings
• Work towards research independence. Prepare grant applications from external granting agencies
• Help manage laboratory needs (such as ordering, training and compliance)
• Support our collaborative research environment and guide colleagues with technical and operational aspects of scientific research
• Present work at international conferences

The successful candidate will apply and develop protocols including in vitro and ex vivo culture, size exclusion chromatography, nanoparticle tracking analysis, flow cytometry, super-resolution microscopy, ex vivo organ culture, histological and histochemical staining, immunofluoresence, electron microscopy and other relevant technologies, as applicable.

Entry requirements

We are looking for an enthusiastic person with a curious mind who is passionate about furthering human knowledge and health through scientific research. You must be highly motivated and detail-oriented.

The successful candidate should:

• hold a PhD in molecular or cellular biology, biochemistry, bioengineering or a very closely-related discipline
• be structured and responsible
• have an inquisitive mentality
• enjoy working as part of a team
• be fluent in written and spoken English
• have expertise in standard techniques of molecular biology and cell biology

Expertise in at least one of the following areas is required:

• experience of working with extracellular vesicles
• publication track record of working with nanoparticles in biological settings
• have a detailed knowledge of models to study autophagy/endosomal trafficking/extracellular vesicles

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Biomedicum A4, Solna campus.

[Put links here – max 2, for example the department, research group or Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English:

• a CV (including date of the thesis defence, title of thesis, previous academic positions, academic title, academic distinctions, committee work and a complete list of publications)
• A complete list of publications
• A summary of current work (no more than one page)
• A personal letter outlining your reasons for applying and interest in the topic

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-03-10 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to top quality medical research?

We have an opening for a postdoctoral researcher wishing to join a multidisciplinary systems medicine project investigating the role of premature birth in the development of obstructive lung disease. The successful candidate will be joining a large research team of clinicians, experimental scientists, statisticians and bioinformaticians to investigate the role of early life events in the development of early onset obstructive lung disease.

Your mission

The overall project involves molecular characterization at the mRNA, miRNA, proteome and metabolome level from multiple lung compartments to construct a model of disease. The work will be conducted on one or several unique clinical cohorts designed to investigate different aspects of chronic obstructive airways disease, including but not limited to our newly launched post-COVID cohort, as well as our the LUNAPRE cohort (www.clinicaltrials.gov/ct2/show/NCT02923648). The latter consisting of very prematurely born individuals with or without bronchopulmonary dysplasia (BPD) in the neonatal period that have been followed since birth, as well as control groups of healthy and asthmatics born at term. The overall goals of these projects involve molecular sub-phenotyping and mechanistic investigations of the obstructive lung disease in this heterogeneous, relatively unknown, and rapidly growing patient group. The specific research projects will include RNA-seq, miRNA-seq and proteome characterizations of various compartments including single cell- or bulk sorted immune cells and extracellular vesicles from the lung of the patient cohort, as well as cell culture lung organoid model systems. The studies are performed in close collaboration with clinicians at both the Karolinska University Hospital and Sach’s Children’s Hospital at the Southern Hospital in Stockholm, enabling the successful candidate to be directly involved in translational systems medicine efforts.

Your profile

We are seeking a talented and highly motivated researcher with a Ph.D. in molecular biology or a related field, for a postdoctoral position in our lab. Practical experience within the respiratory field, coupled with expertise in bioinformatics and biostatistics, is crucial. Hands-on experience in working with human and animal samples, lung organoid work, analysis of PExA samples, and CRISPR-mediated gene editing are highly desirable. The successful candidate must possess excellent communication and collaborative skills; a demonstrated ability to interact socially and scientifically with other postdocs, students, and collaborators both within academia and industry is essential. Previous postdoctoral experience and a strong publication record within the respiratory biology field are strong merits.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location

The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within the Pulmonomics group which is a multidisciplinary research group, located at BioClinicum. As part of the Division of Respiratory Medicine, we are in integral part of the Center for Molecular Medicine (CMM), the Department of Medicine Solna as well as the Karolinska University hospital Department of Allergy and Respiratory Medicine. Our research interests can be broadly defined as developing a respiratory systems medicine framework for molecular sub-grouping of chronic inflammatory diseases of the lung. We focus equal efforts on translational studies in patient cohorts, and innovation & methodology development in the fields proteomics, multivariate modeling and data integration. Our translational systems medicine studies encompass profiling at multiple molecular levels (mRNA, miRNA, proteomes, metabolomes and lipid mediators) from multiple lung compartments (airway epithelium, alveolar macrophages, exosomes, and bronchoalveolar exudates) using a range of omics platforms, in combination with extensive clinical phenotyping. The strength of our approaches is the ability to integrate information from multiple molecular levels and anatomical locations both to improve the statistical power of detecting and defining molecularly distinct sub-groups in small patient cohorts, and to improve our understanding of disease mechanisms on a systems level.

Read more at  https://staff.ki.se/people/asa-wheelock or www.pulmonomics.net 

— [Video about a Karolinska Institutet, how we work towards “a better health for all”] —

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-02-23 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to better health for all?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Institute of Environmental Medicine (IMM) is a department at Karolinska Institutet with an excellent record of cutting-edge research in the disciplines of epidemiology and biostatistics, environmental medicine and toxicology. The epidemiological research at IMM is focused on advancing knowledge about disease etiology with an emphasis on environmental and lifestyle factors, and on methodological development and stringency. The research at the unit of Cardiovascular and Nutritional Epidemiology aims to clarify how various dietary exposures affect peoples’ health to enable effective prevention.

The doctoral student project and the duties of the doctoral student

The research performed by the doctoral student will include studies on the health and environmental impacts of following dietary guidelines. The project will utilize data from prospective cohort studies that include questionnaire and biomarker data. The doctoral student is expected to acquire broad knowledge and systematic understanding of the main research fields encompassed in the thesis work including molecular pathways influenced by the exposure, epidemiological theory and principles, and exposure assessment science. This will be accomplished through working on the project under supervision, taking relevant courses and participate in seminars and journal clubs. The student is also expected to acquire in-depth experience in the epidemiological methods applied, statistical computation and statistical software packages such as R and Stata in processing of data; further, to develop excellent scientific writing and deliver high-quality publications in international peer-reviewed journals and give presentations at scientific meetings and conferences.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

We are looking for a highly motivated PhD-candidate with a solid background within the field of biomedical sciences and with understanding of molecular biology. Excellent writing and communication skills in English are essential. As this project is an interdisciplinary research project it is recommended that the candidate has insights in different fields ranging from epidemiology to molecular biology. Experiences of nutritional epidemiology, environmental contaminants, sustainability, and diet-related climate impact is meritorious.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

https://ki.se/en/imm

https://ki.se/en/imm/unit-of-cardiovascular-and-nutritional-epidemiology

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-02-26 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to top quality medical research?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

The Department of Molecular Medicine and Surgery (MMK) and the research group of Vascular Surgery is looking for a curious and highly motivated Ph.D. student to join Prof. Ulf Hedin, Dr. David Marlevi, and Dr. Melody Chemaly to improve stroke risk prediction for patients with carotid atherosclerosis using a multidisciplinary combination of advanced image processing, dedicated bioinformatic analysis, and experimental vascular biology. Based in a dynamic translational research environment of vascular surgery, biology, and imaging, you will join a diverse research team focused on atherosclerotic plaque instability based on data from the Biobank of Karolinska Endarterectomies (BiKE): the world’s largest resource for molecular studies on carotid atherosclerosis, offering unprecedented opportunities for both scientific and clinical impact. 

The doctoral student project and the duties of the doctoral student

The overall goal of the proposed project is to investigate clinical, diagnostic, and molecular features of tissue hypoxia, angiogenesis and intraplaque haemorrhage (IPH) in relation to stroke risk, seeking to improve on current paradigms for clinical risk predictions and individualize diagnostic precision. Improving atherosclerotic risk prediction has been a primary focus of our team’s efforts over the last couple of decades, seeking insights into pathways steering plaque instability, as well as identifying novel biomarkers improving on clinical routine. A cornerstone of these developments lies in the Biobank of Karolinska Endarterectomies (BiKE); established by our group and where clinical, radiological, histological, and complete genomic, transcriptomic and proteomic profiling of plaque tissue and plasma exist from over 1000 patients, together representing the world’s largest resource for molecular characterization of human atherosclerosis. The PhD student project will use data available in the BiKE resource to explore the hypothesis surrounding IPH, leveraging image and bioinformatic analysis to extract correlations between clinical, radiological, and underlying biology in combination with an array of experimental investigations. Lastly, prediction models encompassing novel markers of IPH and IPH-related plaque risk will be invoked, with data-driven methods explored and implemented by the student.

As part of an individual research project, you will be responsible for setting up and evaluating data analysis, coupled clinical and benchtop experiments, define optimal scientific protocols, and write scientific articles and conference contributions to review and report the results of these investigations. Alongside the research project, the PhD student will work towards meeting the course requirements of the doctoral program, as outlined in the relevant rules and documentation available on the ki.se website.

Skills and personal qualities

We are looking for a highly motivated, independent, and analytical person, with:

• A degree or the equivalent in scientific data analysis, data science and machine learning , biomedicine or bioinformatics
• Skills in bioinformatics (Python, R or others) and biostatistics (SPSS, STATA etc.)
• Specific knowledge of big data analysis, quantitative medical image analysis, or application of data-driven methods for clinical application purposes in general and vascular applications in particular is advantageous, but not required.
• Experience from experimental cellular or vascular biology is meritorious, but not required.
• Previous experience with scientific data analysis is advantageous, with involvement in previous scientific publications meritorious.

Further, great emphasis will also be placed on personal competence, with an ambitious, systematic, and problem-solving attitude being central to the sought-after candidate. Excellent communication skills in both spoken and written English are a must, as is the ability to interact and work in a translational research team on national or international level. Dedication to open science is also central, with group work focused on open-source developments, data sharing, etc. We invite exceptional individuals from around the world to apply for this exciting opportunity.

What do we offer?

As part of the Vascular Surgery team we offer a unique translational research environment with wide-ranging expertise spanning clinical science, molecular biology, bioinformatics, and biomedical engineering, all working together to improve atherosclerotic and vascular disease diagnostics. Leveraging unique cohorts and biobank data, the student will also be directly involved in cutting-edge data-driven translational science, collaborating with international networks to push causal understanding of atherosclerotic plaque instability from clinical observation, to molecular understanding, and back to an improved diagnostic reality. Herein, participation in international workshops and conferences, as well as potential research visits to collaborating sites will be included in the expected work. Further, being deeply integrated with the clinical activities at the Karolinska University Hospital, direct access to state-of-the-art imaging equipment, diverse patient cohorts, and relevant computational resources provide excellent opportunities for ground-breaking research. The successful candidate will be capable of working efficiently and productively within a team, while also developing the professional ability to work independently on their specific project over time.

On a larger scale, Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-03-07 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to improving human health?

To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

The research group

Fuzik Lab is looking for an applicant for a PhD position (Circuit and Systems Neuroscience) at the Dept. of Neuroscience, Karolinska Institute, Stockholm, Sweden. The PhD program is funded by the KI-NIH program in Neuroscience. The PhD student will spend 50% (year 1-2) at the Dept. of Neuroscience, Karolinska Institute and 50% (year 3-4) at the National Institutes of Health, NICHD / DIR, Bethesda, USA.

The doctoral student project and the duties of the doctoral student

The applicant will join an active, enthusiastic, and well-equipped group studying fundamental properties of periaqueductal and hypothalamic neuronal pathways and neuromodulation primarily in panic and anxiety including the aspect of sex differences.

We study both physiological and pathological states of periaqueductal neuronal populations with viral tracing, Patch-clamp electrophysiology, Patch-Seq (Fuzik et al., 2016, Nature Biotechnology, Fuzik et al. 2019, PNAS), ex vivo all-optical voltage imaging and Voltage-Seq (Csillag et al. 2023, Nature Methods), in vivo optogenetics, and add a translational angle using systems neuroscience approaches (behavior tests, head-fixed in vivo electrophysiology (Calvigioni, Fuzik et al. 2023, Nature Neuroscience).

A PhD candidate with a neuroscience background is essential. Basic (even not documented) expertise in programming (Python, Matlab) is preferable, documented experience in microscopy optics is preferred, some experience with behavior tests, optogenetics is preferred, experience in electrophysiology and/or imaging techniques will be highly preferred.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

– Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B) can only be certified by the documentation requirement for doctoral education.

Skills and personal qualities

[Enter here skills and personal qualities necessary or desirable/advantageous for this project and for the ability to reach the outcomes of the doctoral education. Make it clear for the applicants what is necessary and what is only desirable. It is important that this section is well thought-through in order to help in the selection process.]

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

– A personal letter and a curriculum vitae
– Degree projects and previous publications, if any
– Any other documentation showing the desirable skills and personal qualities described above
– Documents certifying your general eligibility (see A above)
– Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

– Documented subject knowledge of relevance to the area of research
– Analytical skill
– Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-03-07 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to top quality medical research?

At the Division of Rheumatology at the Department of Medicine Solna, we conduct research on diseases affecting the musculoskeletal system, inflammatory as well as non-inflammatory. The Division of Rheumatology offers good opportunities to clinical and translational research on unique patient groups from the clinic along with biomedical and experimental animal research. 

Your mission

You will work with research projects in autoimmune diseases, systemic lupus erythematosus (SLE) in particular. Duties include independent work with coordination of projects and translational studies within SLE. In this key role, you will be entrusted with the management of our lab, with a primary focus on the organization and operation of biobanking for our projects, including sample handling (cell separation and other procedures, from draw to freezer). Your expertise will be pivotal in ensuring the quality and integrity of our sample collection, a cornerstone for our translational studies. You will also contribute to the education of students and young investigators, and to the design and conduct of projects.

Key responsibilities:

• Oversee the biobank, maintaining meticulous records of sample acquisition, storage, and utilization.
• Handle samples following study SOPs.
• You will be actively involved in leading-edge -omics studies, utilizing your expertise to drive meaningful insights from complex biological data.
• Contribute to the development and implementation of research projects that bridge the gap between bench and bedside.
• Mentor and collaborate with junior researchers, fostering an environment of scientific excellence and growth

Your profile

We are looking for you who have defended a doctoral thesis and pursued innovative research on and have a deep understanding of autoimmune diseases. You should be able to understand and speak Swedish at a basic level, and you should be fluent in English, both spoken and written. Great emphasis is placed on personal qualities. Excellent communication and collaboration skills are of utmost importance, as the successful candidate will work closely with fellow researchers and partners from the clinic and patient organizations. Previous experience of working with the current tasks, including laboratory assistance procedures, and research within genetics, omics, and precision medicine in SLE is meritorious. Previous research of translational nature within immunology is strongly meritorious.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location

The position is located within the Department of Medicine, Solna. The department consists of eleven divisions and each division consists of several research groups. The position is located within the research group Ioannis Parodis at the Centre for Molecular Medicine (CMM). The work touches on various aspects of SLE: https://ki.se/en/meds/team-ioannis-parodis

— [Video about a Karolinska Institutet, how we work towards “a better health for all”] —

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Deadline: 2024-03-06 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.

Do you want to contribute to top quality medical research?

We are looking for a Postdoctoral Researcher with an interest in Adoptive Cell Therapy and how it can be used as treatment. When joining our team, you will work in a research group conducting translational research, with an aim to improve cell therapy for patients with gynecological cancer or melanoma.

Division:

You would join the Stina Wickström/ Rolf Kiessling research team with a focus on improving existing and developing new novel T cell products used for adoptive cell therapy to treat patients with gynecological cancer or melanoma.

Your mission

We are looking for a highly motivated person with a strong background in immunology and tumor biology. The projects involve the development of human T cell technologies and evaluation of T cells from blood/tumor tissue from cancer patients, T cell repertoires and T cell function. The overall aim of the projects is to develop novel immunotherapies against cancer. Your daily work would include, primary cell culture, FACS analysis, functional T cell assays, sample collection etc.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Qualifications:

• The candidate should show verified skills particularly in in tumor immunology and immunotherapy of cancer and methodological expertise with a focus on human cellular immunology research.
• The candidate should be self-motivated.
• Have good communication skills. 
• Ability to interact effectively and work within a team.
• Fluency in English is a requirement.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world’s leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

The position will either be at Karolinska Insitutet or at Radiumhemmets forskningsfonder with an affiliation to Karolinska Insitutet.

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Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 4^th March. 

The application is to be submitted through the Varbi recruitment system.

The position will be 2 years, with possibility to extension. 

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Deadline: 2024-03-04 at 23:59
Unit: Forskargrupp Hartman

Read the job description at the university homepage or apply.