Research in the Qvortrup group is focused on the use of organic chemistry to solve problems in biology. This includes design and development of new improved drugs, as well as the use of synthetic molecules to systematically investigate the functions of genes, cells and biological pathways in living systems.
The PhD projects will explore the field of ‘bioconjugation chemistry’. More specifically, we will design and development new and effective strategies to link a protein with different substrates. As a proof-of-concept, we will demonstrate the use of the novel conjugation strategies for attachment of a linker-drug component to an antibody for synthesis of improved antibody-drug conjugates in cancer treatment.
The work will include the design, synthesis and characterization (NMR, IR and MS) of organic building blocks, as well as synthesis and in-depth structural characterizations of all new bioconjugates. Active dissemination of the obtained results, in scientific articles and through participation in international conferences, is an integral part of the job. Participation in supervision of students will be an integrated part of the job.
The successful candidate should have a Master’s degree in chemistry with a focus on synthetic organic chemistry. The successful candidate should thrive in a highly ambitious research group that aims to establish new research fields. The successful candidate should be highly motivated, eager to seek and share knowledge, able to work independently in a dynamic group environment, and should be confident in planning and carrying out complicated tasks. Good communication skills in both written and spoken English are expected.
The ideal candidate should have a strong background in experimental organic chemistry, including:
- Experience with peptide synthesis and purification (preparative HPLC).
- Experience with analysis of peptides (NMR, MS, CD)
- Experience with handling of biological reagents, including proteins.
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.
The Qvortrup group offers a demanding, exciting, and dynamic work environment.
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.
You can read more about career paths at DTU here.
Further information may be obtained from Assistant Professor Katrine Qvortrup, e-mail: email@example.com, or Head or Organic and Inorganic Chemistry Section, Professor Jens Øllgaard Duus, e-mail: firstname.lastname@example.org
Please submit your online application no later than 25 December 2018 (local time).
To apply, please open the link “Apply online”, fill out the online application form. The following must be attached in English:
- A letter motivating the application (cover letter)
- Curriculum vitae
- Grade transcripts and BSc/MSc diploma
- Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here)
Candidates may apply prior to obtaining their master’s degree but cannot begin before having received it.
Applications and enclosures received after the deadline will not be considered.
All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.
DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.
Deadline: 25 December 2018
Unit: DTU Chemistry
Read the job description and apply online
Post expires on Tuesday December 25th, 2018