Tag-arkiv: Chalmers University of Technology

PhD student position in Learning Dynamical Systems in Combination Therapy

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The Department of Mathematical Sciences pursues internationally successful research and an extensive education.

Mathematics is fundamental to science and engineering and has an increasingly prominent part in other disciplines as well. Mathematics is also a subject in itself, and fundamental research is a necessary condition for future applications.

The Department is part of both Chalmers University of Technology and the University of Gothenburg and is situated in the middle of Campus Johanneberg. It is the largest mathematics department in the Nordic countries and has about 200 employees, with a number of research groups in mathematics and mathematical statistics which together provide a creative and cross-fertilizing setting.


Information about the project
The Department of Mathematical Sciences at Chalmers University of Technology and University of Gothenburg, together with the Fraunhofer-Chalmers Centre (FCC), is recruiting an industrial PhD student for a project on learning dynamical systems in drug discovery. Both the Department of Mathematical Sciences and FCC carry out world-class research and industrial projects with a focus on using mathematics as a technology. For more information, see our websites here and here.

We are currently looking for a highly motivated individual to join us in an exciting project working closely with the pharmaceutical industry to proceed beyond state-of-the-art modeling and simulation methodology and tools for pharmacokinetic and pharmacodynamics processes. A quantitative description of the dynamics of a pharmacological compound in the blood after drug administration, typically the plasma concentration of a drug as a function of time, is of fundamental importance in drug development. The task of developing mathematical models of this dynamical process is known by the name pharmacokinetic (PK) modeling. The time-varying plasma concentration may in turn be linked to the pharmacological effect, e.g., less pain, reduction in bacteria, or reduced fever using so called pharmacodynamic (PD) modeling.

A particular challenge in drug discovery and development is to assess the effect of combinations of therapies such as drug-drug or drug-irradiation. A data driven model based approach relying on pre-clinical data to rank combinations would be a highly useful tool for improving the rate of success in selecting drug combinations of high value.

An integrated framework has been developed at FCC for advanced PK/PD modeling and simulation, which provide means to describe PK/PD processes using both ordinary and stochastic differential equations. Learning dynamical models from data includes maximum likelihood estimation and Bayesian approaches using both parametric and non-parametric methods. Models can be fitted to data from single individuals as well as ensembles of data records from individuals assumed to be governed by the same mechanistic descriptions but with individual parameters (so called nonlinear mixed effects models). In this project the student will extend and adapt the framework in different ways to improve its performance and application to combination therapy when applied to an industrially relevant problem and data set(s), e.g., by exploring the use of particle Markov Chain Monte Carlo methodology, Gaussian process learning, and probabilistic programming.

The project will be performed in collaboration between the Fraunhofer-Chalmers Centre, the Department of Mathematical Sciences and Merck. The PhD student will be enrolled in a graduate school in the Department of Mathematical Sciences. The project is carried out as part of an existing collaboration between FCC and Merck. Furthermore, Merck supports the project with data and challenging applied problems and there will be opportunities for shorter or longer visits to the company during the course of the project.

Major responsibilities
As a PhD student you will be part of an international research environment while you expand your knowledge of the field and write your thesis. You will work together with a team of researchers and engineers with a thorough understanding of both applied mathematics and pharmaceutical applications. You are a team player with strong interest in industrial applications, but are also expected to work autonomously, to develop your own ideas and communicate results to the scientific community. In addition, the position will normally include 10% departmental work, mostly teaching duties. Totally, the graduate programme will thus comprise 4 years of study and research and 0.5 years of teaching.
Position summary
Full-time employment at FCC. Starting date: 1 June, 2019, or according to agreement.  

Qualifications
Applicants must have a strong background in the mathematical sciences. A master’s degree or a 4-year bachelor’s degree or an equivalent competence is required at the beginning of the employment.

Concurrent method development and implementation of algorithms is integral to the applied reseach carried out at FCC and good programming skills (e.g., Python, Mathematica, R) are therefore required.

In your application you should include all relevant work such as bachelor’s or master’s thesis and articles (provide an English summary if necessary) that you have authored or co-authored. Evidence of mathematical problem solving skills is significant, besides course grades.

The bachelor’s level teaching is normally in Swedish, although the teaching at the master’s and PhD levels is in English. Thus, good language skills are require.

Chalmers continuously strives to be an attractive employer. Equality and diversity are substantial foundations in all activities at Chalmers.

Our offer to youChalmers and FCC offer a cultivating and inspiring working environment in the dynamic city of Gothenburg

Application procedure
The application should be marked with Ref 20190082 and written in English. The application should be sent electronically and be attached as pdf-files, as below:

CV: (Please name the document: CV, Family name, Ref. number)
• CV
• Other, for example previous employments or leadership qualifications and positions of trust.
• Two references that we can contact.

Personal letter: (Please name the document as: Personal letter, Family name, Ref. number)
• 1-3 pages where you introduce yourself and present your qualifications.
• Previous research fields and main research results.
• Future goals and research focus. Are there any specific projects and research issues you are primarily interested in?

Other documents:
• Copies of bachelor and/or master’s thesis.
• Attested copies and transcripts of completed education, grades and other certificates, eg. TOEFL test results.

Please ue the button at the foot of the page to reach the application form. The files may be compressed (zipped).

Application deadline: 17 March 2019

For questions, please contact:
Stig Larsson, tillämpad matematik och statistik, stig@chalmers.se Mats Jirstrand, Fraunhofer-Chalmers Centre, matsj@fcc.chalmers.se
Torbjörn Lundh, tillämpad matematik och statistik, torbjorn.lundh@chalmers.se

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Chalmers University of Technology conducts research and education in engineering sciences, architecture, technology-related mathematical sciences, natural and nautical sciences, working in close collaboration with industry and society. The strategy for scientific excellence focuses on our eight Areas of Advance; Building Futures, Energy, Information & Communication Technology, Life Science, Materials Science, Nanoscience & Nanotechnology, Production and Transport. The aim is to make an active contribution to a sustainable future using the basic sciences as a foundation and innovation and entrepreneurship as the central driving forces. Chalmers has around 11,000 students and 3,000 employees. New knowledge and improved technology have characterised Chalmers since its foundation in 1829, completely in accordance with the will of William Chalmers and his motto: Avancez!
   


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Read the full job description at the university homepage

Post expires on Sunday March 17th, 2019

PhD student position in Geometric analysis and applications to microbe ecology

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The Department of Mathematical Sciences at Chalmers University of Technology and the University of Gothenburg has about 200 employees, and is the largest department of mathematics in Sweden. The department has three scientific divisions, Algebra and Geometry, Analysis and Probability Theory, and Applied Mathematics and Statistics, and conducts successful research in pure and applied mathematics and mathematical statistics.

We are located in a modern building at the center of Chalmers campus. More information about us can be found on our website: http://www.chalmers.se/math/

At the Department of Mathematical Sciences there are many internationally successful researchers in a wide variety of research areas. The division Analysis and Probability Theory conduct research in areas such as harmonic analysis and partial differential equations,  mathematical physics, probability and discrete mathematics, functional analysis, and kinetic theory. We are looking for one doctoral students to work in Geometric analysis and applications to microbe ecology (with supervisor Julie Rowlett), see http://www.math.chalmers.se/~rowlett/PhDPosition.pdf

Major responsibilities
As a PhD student you will be part of an international research environment while you expand your knowledge of the field and write your thesis. This gives opportunities for many inspiring conversations, a lot of autonomous work and some travel. You are expected to develop your own ideas and communicate scientific results orally as well as in written form. In addition, the position will normally include 20% departmental work, mostly teaching duties.

Position summary
Full-time temporary employment. The employment is limited to a maximum of four years with a possibility for an additional year for carried out departmental duties.

Qualifications
Applicants must have a strong background in mathematics. They must have obtained a master’s degree or a 4-year bachelor’s degree, or expect to complete that degree by August 15, 2019.

You should include all relevant work such as bachelor’s or master’s thesis and articles (provide an English summary if necessary) that you have authored or co-authored. Evidence of mathematical problem solving skills is significant, besides course grades.

The bachelor’s level teaching is normally in Swedish, although the teaching at the master’s and PhD levels is in English. Thus, good language skills are required.

Chalmers continuously strives to be an attractive employer. Equality and diversity are substantial foundations in all activities at Chalmers.

Our offer to youChalmers offers a cultivating and inspiring working environment in the dynamic city of Gothenburg
Read more about working at Chalmers and our benefits for employees.

Application procedure
The application should be marked with Ref 20190039 and written in English. The application should be sent electronically and be attached as pdf-files, as below:

CV: (Please name the document: CV, Family name, Ref. number)
• CV
• Two references that we can contact.

Personal letter: (Please name the document as: Personal letter, Family name, Ref. number)
• 1-3 pages where you introduce yourself and present your qualifications.
 

Other documents:
• Copies of bachelor and/or master’s thesis.
• Attested copies and transcripts of completed education, grades and other certificates, eg. TOEFL test results.

Please use the button at the foot of the page to reach the application form. The files may be compressed (zipped).

Application deadline: 17 March 2019

For questions, please contact:
Lyudmila Turowska, turowska@chalmers.se
Julie Rowlett, julie.rowlett@chalmers.se
Peter Hegarty, hegarty@chalmers.se


   



Chalmers University of Technology conducts research and education in engineering sciences, architecture, technology-related mathematical sciences, natural and nautical sciences, working in close collaboration with industry and society. The strategy for scientific excellence focuses on our eight Areas of Advance; Building Futures, Energy, Information & Communication Technology, Life Science, Materials Science, Nanoscience & Nanotechnology, Production and Transport. The aim is to make an active contribution to a sustainable future using the basic sciences as a foundation and innovation and entrepreneurship as the central driving forces. Chalmers has around 11,000 students and 3,000 employees. New knowledge and improved technology have characterised Chalmers since its foundation in 1829, completely in accordance with the will of William Chalmers and his motto: Avancez!
   




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Read the job description at the university homepage

Post expires on Sunday March 17th, 2019

Postdoctoral position in industrial biotechnology on xylanolytic yeasts

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The Department of Biology and Biological Engineering was founded January 1 2015, and started off with high ambitions. The aim was to grow and become a leading center of innovation by combining the latest research in life sciences with biochemistry. And the department got off to flying start. In its first year, the numbers for publication, citation and external funding have been excellent.

The department consists of four divisions, each conducting outstanding research in the areas of industrial biotechnology, systems biology, chemical biology and food science. The overall goal is to help build a sustainable society and improve human health.

Nearly 200 people from 20 countries are currently working at the department. The working environment is characterized by respect, cooperation, responsibility, creativity and job satisfaction.

The Department of Biology and Biological Engineering has summarized its mission in four points:
• To be an attractive environment for top-level researchers in biological engineering
• To deliver top-level research results and innovative solutions for use in a sustainable society
• To offer excellent education that develops creative engineers and scientists
• To be a major contributor to international visibility of Chalmers

Information about the division
The Division of Industrial Biotechnology (www.chalmers.se/indbio) is a highly international group, which since it’s establisment in 2008 has been very successful and now counts ~40 members. Research activities at the division focus on utilization of renewable raw materials for a sustainable production of fuels and chemicals. The research performed within the group spans from fundamental research to technology development and lab-scale applications, and includes enzymology and enzyme discovery, fermentation technology, metabolic engineering, bioelectrochemistry, and algal biotechnology. The division has an extensive instrument platform for analytics, molecular biology, fermentation and protein production and purification, which are all available for the project. In addition, core facilities with advanced equipment are available within both the Department and at the University campus.

Information about the project
We are seeking a highly motivated post-doctoral candidate for a project where the overall aim is to deepen our understanding of which yeast species can break down the xylan part of lignocellulosic biomass, and to identify and characterize new xylanolytic enzymes with unique properties that can be used in the industry for the production of biofuels and biochemicals. Bioinformatic data-mining, yeast and enzyme characterization and genomics and proteomics methods will be used to reached the project objectives. The project is funded by Carl Trygger foundation, and the successful candidate will be employed on a two year postdoc stipend.

Major responsibilities
The major responsibility as a Postdoc will be to perform research within the scope of the project and our group. The tasks also include writing project reports and scientific manuscripts, and you will be expected to share your research results both in presentation at the division/department and at international conferences. Being part of our research group also involves taking responsiblity for side tasks such as keeping the lab and instruments in good condition.

Position summary
Full-time temporary employment. The position is limited to a maximum of two years (1+1).

Qualifications
The candidate must hold a doctoral degree, generally not older than three years, in Biotechnology/Bioengineering, Microbiology, Molecular Biology or other related disciplines. Experience in Eukaryotic microbiology, Enzymology and Molecular biology techniques is required. Know-how of plant cell wall biotechnology, heterologous protein expression and secretion in yeast, omics and analytical techniques are highly qualifying merits.

The successful candidate has an outstanding academic track record and has published as first author in internationally recognized peer-reviewed journals. Important qualities are enthusiasm, to be able to drive and conclude projects independently, take own initiatives and discuss/develop own ideas, be creative and have a problem-solving ability. Excellent cooperation and social abilities are important, and the candidare must also be highly proficient in spoken and written English. If Swedish is not your native language, Chalmers offers Swedish courses.

Chalmers continuously strives to be an attractive employer. Equality and diversity are substantial foundations in all activities at Chalmers.

Our offer to youChalmers offers a cultivating and inspiring working environment in the dynamic city of Gothenburg
Read more about working at Chalmers and our benefits for employees.

Application procedure
The application should be marked with Ref 20190040 and written in English. The application should be sent electronically and be attached as pdf-files, as below:

CV: (Please name the document as: CV, Surname, Ref. number) including:
• CV, include complete list of publications
• Previous teaching and pedagogical experiences
• Two references that we can contact.

Personal letter: (Please name the document as: Personal letter, Family name, Ref. number) including:
• 1-3 pages where you introduce yourself and present your qualifications.
• Previous research fields and main research results.
• Future goals and research focus. Are there any specific projects and research issues you are primarily interested in?

Other documents:
• Attested copies of completed education, grades and other certificates.

Please use the button at the foot of the page to reach the application form. The files may be compressed (zipped).

Application deadline: 24 February 2019

For questions, please contact: 
Dr. Cecilia Geijer, Biology and Biological Engineering, cecilia.geijer@chalmers.se, +46(0)31 772 3852


Chalmers University of Technology conducts research and education in engineering sciences, architecture, technology-related mathematical sciences, natural and nautical sciences, working in close collaboration with industry and society. The strategy for scientific excellence focuses on our eight Areas of Advance; Building Futures, Energy, Information & Communication Technology, Life Science, Materials Science, Nanoscience & Nanotechnology, Production and Transport. The aim is to make an active contribution to a sustainable future using the basic sciences as a foundation and innovation and entrepreneurship as the central driving forces. Chalmers has around 11,000 students and 3,000 employees. New knowledge and improved technology have characterised Chalmers since its foundation in 1829, completely in accordance with the will of William Chalmers and his motto: Avancez!
   
Read the job description at the university homepage

Apply

Post expires on Sunday February 24th, 2019

PhD student position in Insights into Carbon Fibres in Structural Composite Batteries

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The main competencies at the department of Industrial and Materials Science are found in the areas of: Human-Technology Interaction | Form and Function | Modeling and Simulation | Product Development | Material | Production and in the interaction between these areas. The research develops the industrial process, from need to finished product while creating added value. To combine skills throughout the whole chain distinguishes the department both nationally and internationally. Here we gather internationally prominent researchers, in dynamic and outstanding research environments, as well as in national and international research networks.

Information about the division
The division of Material and Manufacture covers the entire value chain from the design, processing to characterization of materials. The division uses a number of technologies – powder metallurgy, electroplating, additive manufacturing, and material cutting – as well as a range of advanced characterization techniques. The work is multidisciplinary by nature and addresses topics that directly affect sustainability.

The project
The project focuses on structural composite batteries, a multifunctional battery integrating energy storage capabilities to structural components. It is a key enabling technology in realizing substantial weight savings on the system level. Imaging the doors and hoods of an electric car also store energy! Carbon fibres play dual roles in these batteries, reinforcements (as in carbon fibre composites) and negative electrodes (as in batteries). However, almost all carbon fibres were developed from the mechanical point of view; a fundamental understanding on the behaviour of carbon fibres under the dynamic electrochemical and mechanical processes in structural composite batteries, and on the relationship between their performance and microstructure are still largely lacking.

Within this project, we aim to gain a fundamental understanding on the microstructural evolution of carbon fibres under the coupled electrochemical and mechanical loading (charging/discharging cycles and simultaneous load-bearing) in structural composite batteries. The main activities include: 1) to build a novel in-situ platform in an electron microscope, which will enable us to study micro-structural-composite-batteries under electrochemical and mechanical loading live; 2) to gain a fundamental understanding on the interaction between lithium ions and carbon fibres, using transmission electron microscopy and atom probe tomography; 3) to gain a fundamental understanding on the interplay between electrochemical and mechanical loading. You will have the opportunity to work in a truly interdisciplinary team of scientists.

The project is financed by the Swedish Energy Agency.

Major responsibilities
The doctoral program is equivalent to four years of full-time studies, which include research, studies in courses (at least 60 course credits), and participation in seminars and conferences. The PhD student will develop the method for in-situ study of structual composite batteries in electron microscope to understand carbon fibres in dynamic electrochemical and mechanical processes. You must learn to use various advanced microscopy and microanalysis techniques, build the in-situ platform, and perform experiments in the platform. The student is also expected to develop his/her own scientific concepts and communicate the results of the research verbally and in writing (in English).

Apart from the scientific objective, the PhD student is expected to take part in teaching activities of maximum 20 % each year.

Position summary
Full-time temporary employment. The position is limited to 4 years. An extension of up to one year, for teaching, may be possible.

Qualifications
We seek a highly motivated and self-propelled person, who has a Master’s level degree in Materials Science, Engineering Physics or other relevant field.

You are able to work both independently and as part of a big team. Previous experience with batteries, and/or electron microscopy is an advantage.

You are fluent in oral and written English. Chalmers offers Swedish courses.

Chalmers continuously strives to be an attractive employer. Equality and diversity are substantial foundations in all activities at Chalmers.

Our offer to you
Chalmers offers a cultivating and inspiring working environment in the dynamic city of Gothenburg
Read more about working at Chalmers and our benefits for employees.

Application procedure
The application should be marked with Ref 20190035 and written in English. The application should be sent electronically and be attached as pdf-files, as below:

CV: (Please name the document: CV, Family name, Ref. number)
• CV
• Other, for example previous employments or leadership qualifications and positions of trust.
• Two references that we can contact.

Personal letter: (Please name the document as: Personal letter, Family name, Ref. number)
• 1-3 pages where you introduce yourself and present your qualifications.
• Previous research fields and main research results.
• Future goals and research focus. Are there any specific projects and research issues you are primarily interested in?

Other documents:
• Copies of bachelor and/or master’s thesis.
• Attested copies and transcripts of completed education, grades and other certificates, eg. TOEFL test results.

Please use the button at the foot of the page to reach the application form. The files may be compressed (zipped).

Application deadline: 10 March, 2019

For questions, please contact:
Associate Professor Fang Liu, Materials and Manufacture
fang.liu@chalmers.se, 0046 31 772 6786


   



Chalmers University of Technology conducts research and education in engineering sciences, architecture, technology-related mathematical sciences, natural and nautical sciences, working in close collaboration with industry and society. The strategy for scientific excellence focuses on our eight Areas of Advance; Building Futures, Energy, Information & Communication Technology, Life Science, Materials Science, Nanoscience & Nanotechnology, Production and Transport. The aim is to make an active contribution to a sustainable future using the basic sciences as a foundation and innovation and entrepreneurship as the central driving forces. Chalmers has around 11,000 students and 3,000 employees. New knowledge and improved technology have characterised Chalmers since its foundation in 1829, completely in accordance with the will of William Chalmers and his motto: Avancez!
   


Apply

Read the job description at the university homepage

Post expires on Sunday March 10th, 2019

2-4 Excellence PhD student positions within Excellence Initiative Nano

We are looking for the brightest minds among all Nano-interested students at Chalmers and world-wide. The winners are awarded with one PhD-postion each, which they can place at any Nano research group at Chalmers. This is the fourth of a yearly recurring call.

Most PhD student positions at Chalmers are announced by a specific research group, funded by a specific research project. With an Excellence PhD student position you have your own funding, which of course gives you far more freedom in choosing both research group and research project.

A PhD exam in Nano is the perfect start for your career, whether you aim at academic research at the highest level, advancing technology and business ideas in major companies or spinning off your own idea into a start-up company.

Chalmers’ Excellence Initiative Nano coordinates research on the unique chemical and physical phenomena that prevail at very small dimensions, and promote the development of technologies that utilise these phenomena. The results obtained have been commercialised in several areas, in particular at the interface of nanophysics and nanochemistry.

Major responsibilities
Your major responsibilities are to pursue your own doctoral studies. You are expected to develop your own scientific concepts and communicate the results of your research verbally and in writing, both in Swedish and in English. The position generally also includes teaching on Chalmers’ undergraduate level or performing other duties corresponding to 20 per cent of working hours.

Position summary
Full-time temporary employment. The position is limited to a maximum of five years.

Qualifications
The selection is based on three criteria:
1) Your MSc grade average
2) A two-page written reflection on research, e.g. your current MSc project and/or future plans.
3) An interview with the top candidates.

To be eligible to apply your MSc exam should not be older than June 2018. If you have not graduated at the time of application, the exam should be scheduled no later than June 2019. If you are already accepted in a PhD school at Chalmers, you are not eligible to apply.

If you win, you have to start your PhD position before the end of 2019, at the latest. The position can be placed at any research group connected to the AoA Nano at Chalmers. The research group has to approve.

The position requires sound verbal and written communication skills in English. Chalmers offers Swedish courses.

Chalmers continuously strives to be an attractive employer. Equality and diversity are substantial foundations in all activities at Chalmers.

Our offer to youChalmers offers a cultivating and inspiring working environment in the dynamic city of Gothenburg
Read more about working at Chalmers and our benefits for employees.

Application procedure
The application should be marked with Ref 20180676 and written in English. The application should be sent electronically and be attached as pdf-files, as below:

CV: (Please name the document: CV, Family name, Ref. number)
• CV
• Other, for example previous employments or leadership qualifications and positions of trust.
• Two references that we can contact.

Personal letter: (Please name the document as: Personal letter, Family name, Ref. number)
• A two-page written reflection on research, e.g. your current MSc project and/or future plans. 

Other documents:
• Copies of bachelor and/or master’s thesis.
• Attested copies and transcripts of completed education, grades and other certificates, eg. TOEFL test results.

Please use the button at the foot of the page to reach the application form. The files may be compressed (zipped).

Application deadline: 28 February, 2019

For questions, please contact:
Professor Bo Albinsson
E-mail: balb@chalmers.se
Phone: +46 31 772 3044

Professor Göran Johansson
E-mail: Goran.L.Johansson@chalmers.se 
Phone: +46 31 772 3237

   



Chalmers University of Technology conducts research and education in engineering sciences, architecture, technology-related mathematical sciences, natural and nautical sciences, working in close collaboration with industry and society. The strategy for scientific excellence focuses on our eight Areas of Advance; Building Futures, Energy, Information & Communication Technology, Life Science, Materials Science, Nanoscience & Nanotechnology, Production and Transport. The aim is to make an active contribution to a sustainable future using the basic sciences as a foundation and innovation and entrepreneurship as the central driving forces. Chalmers has around 11,000 students and 3,000 employees. New knowledge and improved technology have characterised Chalmers since its foundation in 1829, completely in accordance with the will of William Chalmers and his motto: Avancez!
   


Read the job description at the university homepage

Apply

Post expires on Thursday February 28th, 2019