PhD Positions in Adipocyte Signalling Using Advanced Functional Genomics

The Center for Adipocyte Signaling – ADIPOSIGN at the Functional Genomics & Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, invites applications from outstanding candidates who are interested in joining our team as PhD students. One of the PhD students will be affiliated with the Mandrup Group, the other will be affiliated with the Kornfeld Group. The positions are available from May 1, 2019 or as soon as possible thereafter. Application deadline: 1 April 2019.

ADIPOSIGN

ADIPOSIGN is a new centre established for a six-year period through a major grant from the Novo Nordisk Foundation. We combine experimental and computational systems’ approaches to obtain unprecedented insights into how fat cells receive and respond to signals at the level of the (epi)-genome and the cell membrane. Our goal is to understand how the signalling states of adipocytes depend on depot, gender and genetic variation, and how changes in these signalling states during development of obesity contribute to the pathophysiological consequences of obesity.

The centre involves the following PIs:

• Susanne Mandrup, Professor, Department of Biochemistry and Molecular Biology, University of Southern Denmark (Director)

• Jan-Wilhelm Kornfeld, Professor, Department of Biochemistry and Molecular Biology, University of Southern Denmark
• M. Madan Babu, Programme Leader, MRC Laboratory of Molecular Biology, Cambridge, UK
• Zach Gerhart-Hines, Associate Professor, Center for Basic Metabolic Research, University of Copenhagen.

ADIPOSIGN is associated with the Center for Functional Genomics and Tissue Plasticity (ATLAS) recently supported by a centre of excellence grant from the Danish National Research Foundation and directed by Susanne Mandrup.

The Functional Genomics & Metabolism Research Unit
The Mandrup and Kornfeld groups as well as the centre administration of ATLAS and ADIPOSIGN are located in the Functional Genomics & Metabolism Research Unit, at Department of Biochemistry and Molecular Biology, SDU. The research unit currently hosts five (soon seven) independent research groups focusing on various aspects of functional genomics as it pertains to the regulation of cellular differentiation and metabolism. The Research Unit constitutes an international, ambitious, highly dynamic, and well-equipped working environment. The unit and the department have state-of-the-art facilities for next generation sequencing, single-cell transcriptomics, flow cytometry, mass spectrometry, metabolomics, bioimaging and transgenic mouse work. Strategic research alliances exist with Odense University Hospital (OUH).

Research Project and Role
As a PhD student in ADIPOSIGN you will be engaged in this highly ambitious and interdisciplinary project. You will interact and collaborate closely with other researchers in the Mandrup and Kornfeld groups as well as with members of the groups of Zach Gerhart-Hines (Copenhagen) and M. Madan Babu (Cambridge). You will investigate adipocyte signalling states in isolated murine and human adipocytes using an array of functional genomics, proteomics and computational approaches. Some of these findings will be translated into functional studies in transgenic mouse models. You will also implement other experimental methods for analysis of adipocytes. You are expected to provide substantial general input to projects in our groups, and you will have the opportunity to develop your own ideas within our research frame.

Qualifications/Requirements
We are looking for highly motivated, dedicated and ambitious candidates with:

• A Master’s degree in Life Science, preferably Molecular Biology, Biomedicine, or Computational Systems Biology

• Documented experience with adipocyte biology, mouse models and/or NGS data analysis
• Certificate in Laboratory Animal Science (EU function ABD or similar) (preferable)
• Strong communication and collaborative skills and an interest in working in an interdisciplinary environment
• Proficiency in spoken and written English.
We offer:
• A three-year PhD position in a stimulating and supportive, international research environment
• Access to state-of-the-art equipment, facilities and infrastructure
• Opportunity to interact with an extensive network of national and international collaborators
• A competitive salary and social benefits (e.g. health coverage, parental leave, social security etc.)
• Dedicated assistance and support with various practical, social, and legal aspects (housing, visa, administration, tax etc.), especially for international candidates through our international staff office (ISO) and department.
For further information please contact Professor Susanne Mandrup (s.mandrup@bmb.sdu.dk) or Professor Jan-Wilhelm Kornfeld (janwilhelmkornfeld@bmb.sdu.dk).

Application, salary etc.
Appointment as a PhD Research Fellow is for three years. Employment stops automatically at the end of the period. The holder of the scholarship is not allowed to have other paid employment during the three-year period.

The successful applicant will be employed in accordance with the agreement of 10 November 2015 on salaried PhD scholars between the Ministry of Finance and AC (the Danish Confederation of Professional Associations). Please check links for more information on salary and taxation.

The successful candidate will be enrolled at this university in accordance with faculty regulations and the Danish Ministerial Order on the PhD Programme at the Universities (PhD order).

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

The application must be in English and include the following:
• A research proposal/description of your approach to the above project (max one page excluding references)
• A letter stating your specific interest, motivation and qualifications for the project in question (max. two pages) (please attach this under box “Application form”)

• Detailed CV, including personal contact information, education, work/research experience and skills relevant for the position, publications/manuscripts
• Copies of diplomas, Bachelor as well as Master’s degree, including transcript of notes/grades. If awaiting Master’s diploma, provide a written statement from the supervisor
• At least two signed reference letters (with referee contact details and relationship). Should your referees wish to send their letters directly to us, please have them use e-mail: anc@sdu.dk mentioning your name and the title of the position in the subject line. And please note that these also need to reach us before deadline.

Applications will be assessed by all PIs in the centre.

Shortlisting may be used in the assessment process.

Applicants will be informed of their assessment by the university.

Further information about the PhD-study can be found at the homepage of the University.

Applications must be submitted electronically using the link “Apply online”. Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.

Incomplete applications and applications received after the deadline will neither be considered nor evaluated. This also applies to reference letters.

Further information for international applicants about entering and working in Denmark.
Deadline: 1 April 2019
Unit: Faculty of Science
Campus: Odense
Read the job description and apply online

Post expires on Monday April 1st, 2019