We are seeking a PhD fellow to investigate the role of fibroblasts in the cardiac disorder ARVC –arrhythmogenic right ventricular cardiomyopathy. The PhD fellow shall perform the required experimental work as well as analyze quantitative proteomics data. The project to be undertaken will involve in-depth characterization of the molecular changes taking place in a murine model of ARVC, as well as global protein quantification investigation of human cardiac biopsies from ARVC patients.
The candidate will be part of the Cardiac Proteomics group led by Associate Professor Alicia Lundby at the Department of Biomedical Sciences and the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen, Denmark. The research focus of the Cardiac Proteomics group is to use high-resolution LC-MS/MS to obtain insights beyond the current molecular understanding of the heart; both at the level of protein expression, as well as phosphorylation mediated protein signaling. We work closely together with cardiologists in the clinic to ensure high impact and translatability of our research.
Responsibilities and Tasks
The successful candidate will be working in a team of scientists across multiple scientific fields focused on improving our molecular understanding of cardiac pathophysiologies. The candidate will work closely with experimental biologists, bioinformaticians and geneticists to solve fundamental challenges in cardiac research. The position will be ideally suited to a person that has obtained a Master’s degree or similar and is interested in pursuing a career in research. The position provides an opportunity to develop expertise in quantitative mass spectrometry, cutting-edge discovery proteomics and integrative analysis of big data. Previous research experience is a requirement and ideally the candidate should have prior experience within cardiac research.
The PhD position could cover
- Unbiased data-driven analysis of large-scale proteomics datasets investigating cardiac protein expression profiles from human cardiac patients, as well as from a murine model of ARVC
- Isolation of ventricular cardiac fibroblasts at different ARVC disease stages and investigation of their molecular profile changes
- Bioinformatics data integration of proteomics and genomics datasets
- Design and conduction of experimental follow-up studies to test hypotheses generated
The candidate should:
- Hold a Master’s degree
- Have the ability and enthusiasm to learn new methods/techniques
- Have good communication skills in English, both oral and written
- Be highly ambitious and self-driven
- Have demonstrated early in his/her career a capacity for excellence
- Either have experience in high-resolution mass spectrometry (LC-MS/MS) and data analysis hereof (MaxQuant, Perseus, R) or experience in cardiac research
- Have an interest in bioinformatics and analysis of large-scale datasets
- Have a proven track record within molecular cardiac research
- Have a genuine interest in science and strong work ethics
- Be a team player
Overall a preferred applicant has an excellent academic track record, solid research experience and is highly motivated to perform experimental work as well as deploying bioinformatics analyses to extract novel findings of importance to cardiac (patho)physiology.
We offer an interesting and challenging job in an international environment focusing on cardiac research. You will become part of a research environment spanning cardiologists, geneticists performing next generation sequencing on cardiac patient samples, experimental groups performing follow-up experiments in model organisms such as zebrafish, mouse and pig as well as molecular biologists. We strive for academic excellence, collegial respect and freedom tempered by responsibility.
Salary and terms of employment
The appointment as a PhD fellow is fulltime for 3 years. It is conditioned upon the candidate’s successful enrolment in the PhD school at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the candidate.
The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the University’s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 26.886,84 DKK /approx. 3.567 EUR (October 2018-level) plus pension.
The Panum Institute, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark.
You can read more about the Cardiac Proteomics Group at www.lundbylab.com
You can read more about the Department of Biomedical Sciences at www.bmi.ku.dk/english
You can read more about the Center for Protein Research at www.cpr.ku.dk
Please submit your online application via the link in the advertisement on https://employment.ku.dk/phd/ no later than January 2nd 2019.
The File Must Include
Applications must be submitted as one PDF file containing all materials to be given consideration. Attach all your materials in English in one PDF file. The application should contain:
- application (cover letter)
- diploma (an official translation into English)
- list of publications
- Contact details for two referees
Applications and enclosures received after the deadline will not be considered.
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at www.employment.ku.dk
The University of Copenhagen encourages all interested applicants to apply for this position.
General information about PhD programs at the Faculty of Health and Medical Sciences is available at the Graduate School’s website
The Faculty of Health and Medical Sciences comprises approximately 7500 students, 1500 PhD students and 3200 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community.
Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.
Deadline: 2 January 2019
Unit: Det Sundhedsvidenskabelige Fakultet
Campus: Biomedicinsk Institut
Post expires on Wednesday January 2nd, 2019