PhD Position in Systems Biology and Single-cell Transcriptomics of Embryonic Stem Cells

Applications are invited for a PhD position in the areas of systems biology and single-cell transcriptomics of embryonic stem cells at the Functional Genomics and Metabolism Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark (SDU). You will be part of Natarajan lab investigating cell cycle and transcriptional regulation during embryonic development using a range of state-of-art single-cell imaging and transcriptomic approaches and CRISPR-Cas9 perturbations. Application deadline: 15 June 2018.

Project and job description
The project aims to investigate the single-cell dynamics of cell cycle regulators during embryonic development. We employ a variety of computational and experimental approaches including bulk and single-cell approaches to identify, understand and characterize cell cycle regulators that affect stem cell gene expression, cellular regulation, heterogeneity and cell-state and fate responses during differentiation. The project involves mouse embryonic stem cells culture, differentiation, CRISPR perturbation of different targets, bulk and single-cell functional genomics approaches (single-cell RNA-seq, ATAC-seq, ChIP-seq etc.), time-lapse imaging and various molecular and cellular biology approaches.

The chosen candidate will learn and interact with an inter-disciplinary team of experimental and computational biologists, collaborators across bio-imaging (DaMBIC), single-cell transcriptomics, sequencing, computational analysis (IMADA), and is expected to learn and draw from the expertise within the group, unit and department.

We seek an enthusiastic candidate with a background in cell/molecular biology or biochemistry. The candidate must have experience in mammalian cell culture, DNA/protein electrophoresis, DNA cloning, fluorescence microscopy, qPCR. Experience in Imaging, image-processing, bioinformatics and computational biology would be a strong advantage. Applicants with a primary Computational/ Bioinformatics background, but interested in systems biology PhD with some experimental component would also be considered.

Candidates should have a Master’s degree (or second year Master’s student) with a strong background in Molecular biology, Biochemistry or equivalent field.
Candidates with a degree in Computational Biology, Bioinformatics or relevant fields would be also considered. The applicant must be able to work independently, but also collaborate within an interdisciplinary environment. The applicant must have good organization and communication skills with proficiency in written and spoken English.

Application, salary etc.
Appointment as a PhD Research Fellow is for three (students who have completed their MSc) or four years (students who have not yet completed their MSc). Employment stops automatically at the end of the period. The holder of the scholarship is not allowed to have other paid employment during the three-year period.

The successful applicant will be employed in accordance with the agreement of 10 November 2015 on salaried PhD scholars between the Ministry of Finance and AC (the Danish Confederation of Professional Associations).

The successful candidate will be enrolled at this university in accordance with faculty regulations and the Danish Ministerial Order on the PhD Programme at the Universities (PhD order).

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

Application must be made in the form of a Declaration of Interest including the following:
• A research proposal/description of your approach to the above project (max one page excluding references)
• A letter stating your specific interest, motivation and qualifications for the project in question (max. two pages) (please attach this under box “Application form”)
• Detailed CV, including personal contact information
• Copies of diplomas, Bachelor as well as Master’s degree, including transcript of notes/grades
• At least two signed reference letters. Should your referees wish to send their letters directly to us, please have them use e-mail: mentioning your name and the title of the position in the subject line. And please note that these also need to reach us before deadline.

Further information about the PhD-study can be found at the homepage of the University.

Applications must be submitted electronically using the link “Apply online”. Attached files must be in Adobe PDF or Word format. Each box can only contain a single file of max. 10 Mb. We strongly recommend that you read How to apply before you apply.

Incomplete applications and applications received after the deadline will neither be considered nor evaluated. This also applies to reference letters.

Further information for international applicants about entering and working in Denmark.

Deadline: 1 June 2018
Unit: The Faculty of Science
Campus: Odense
Read the job description and apply online

Post expires on Friday June 1st, 2018