Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology, Kutter
doctoral student is admitted to third-cycle/doctoral education. A
doctoral education consists of supervised research, combined with
courses and other educational activities. An individual study plan is
established for each doctoral student. For a doctoral degree, the
equivalent of four years of full-time doctoral education is required.
research group of Dr Claudia Kutter seeks applications for a Doctoral
(PhD) student position in the field of RNA and/or chromatin biology as
well as functional and/or comparative genomics. The Kutter lab has a
track record in deciphering molecular mechanism by which noncoding RNAs
(i.e. long noncoding, transfer and small RNA) regulate genes and genome
structure in mammalian somatic tissue and in the germline (Ernst et al,
NatComm, 2017; Rudolph et al, PLoS Genetics, 2016; Schmitt et al, Genome
Research, 2014; Kutter et al, PLoS Genetics, 2012; Kutter et al, Nature
Genetics 2011). The research program for this position focuses on gene
regulation during cell differentiation and disease progression in mouse
The group investigates the roles of noncoding RNAs
genome- and transcriptome-wide by employing a combination of next
generation sequencing technologies and high-throughput genetic screening
approaches, applying and developing experimental and computational
methods. The group uses an integrative and collaborative approach, and
works closely with experimental and computational groups at KI, Science
for Life Laboratory (SciLifeLab), and other local and international
The laboratory is located at SciLifeLab on the
Karolinska Institute campus in Stockholm. SciLifeLab offers an
attractive research environment, provides state-of-the-art
instrumentation and core facilities, and is home to the second largest
sequencing cluster in Europe. SciLifeLab is a joint effort between
Karolinska Institute, the Swedish Royal Institute of Technology, and
Stockholm University. It hosts research groups with diverse backgrounds
and expertise, creating a unique interface between basic and applied
biology, has strong expertise in *-omics approaches, bioengineering,
drug discovery, and translational medicine.
The doctoral student project and the duties of the doctoral student
human body consists of hundreds of highly specialized and
morphologically diverse cells, yet virtually every cell in the body
contains the same genetic information. To exert cell-specific functions,
high fidelity mechanisms restrict the expression and processing to only
a particular set of genes and transcripts. Abnormal cell behavior as
seen in many fatal human diseases, such as cancer, is often the
consequence of aberrant transcripts formation. The research program for
this position focuses on investigating the regulation of noncoding RNAs
during cell differentiation and disease progression, with a particular
interest on gene regulation, transcriptional processing and
understanding of the underlying molecular and cellular responses by
using diverse cell lines, mouse and human tissues as model system. The
individual study plan for this position has already been approved by the
KI funding for doctoral education (KID).
The successful applicant
will acquire basic and specialized knowledge and understanding in
chromatin, gene regulation, RNA biology, organ development and cancer
biology. The work implies to apply, master and develop innovative
research methodologies in genomics, transcriptomics and proteomics, next
generation sequencing and bioinformatics, statistics, molecular biology
and biochemistry, in which the group is specialized in. The post holder
is expected to take a strong lead in the project design and management
as well as data generation, analyses and interpretation under
consideration of ethical standards and scientific research conduct, and
collaborate with other team members.
The candidate will identify
and formulate scientific issues accurately, critically, autonomously and
creatively; plan, execute, understand and discuss research questions,
methodologies, results and interpretations within a given timeframe;
present research findings effectively to the group, national and
international research community, which also includes vigorous reporting
of the work and drafting of scientific manuscripts. The duties also
include to work in a team and to adhere to high scientific standards and
responsibilities (ethics). The ability to work in a highly
interdisciplinary and international environment and to engage in
continuous professional development is a must.
The primary project
supervisor is Assistant Professor Claudia Kutter (KI-MTC, SciLifeLab).
The candidate will be working with postdoctoral researchers, PhD
students and other group members in the Kutter lab and will be
co-supervised by Assistant Professor Emma Andersson (KI-CMB and BioNut)
and Professor Yihai Cao (KI-MTC).
Eligibility requirements for doctoral education
order to participate in the selection for a doctoral position, you must
meet the following general (A) and specific (B) eligibility
requirements at latest by the application deadline.
It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.
A) General eligibility requirement
You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:
- have been awarded a second-cycle/advanced/master qualification (i.e. master degree) or
satisfied the requirements for courses comprising at least 240 credits
of which at least 60 credits were awarded in the
advanced/second-cycle/master level, or
- have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*
Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.
*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.
B) Specific eligibility requirement
You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:
- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.
Follow the instructions on the web page English language requirements for doctoral education.
Verification of your documentsKarolinska
Institutet checks the authenticity of your documents. Karolinska
Institutet reserves the right to revoke admission if supporting
documents are discovered to be fraudulent. Submission of false documents
is a violation of Swedish law and is considered grounds for legal
Skills and personal qualities
We are looking for
an enthusiastic and highly motivated candidate who has a degree in
Genomics, Bioinformatics, Molecular Biology, Biomedicine, Genetics
and/or Biochemistry. Proven experiences in eukaryotic RNA biology, gene
regulation, transcriptome-wide studies, mammalian tissue culture
techniques and the CRISPR/Cas system and/or prior knowledge in
bioinformatics and R programming for statistical computing and graphics
is important. A strong interest in interdisciplinary experimental and
computational method development, and novel and creative thinking
abilities are essential. Applicants wishing to integrate computational
and experimental biology approaches are especially encouraged to apply.
ideal candidate should be collaborative, scientifically adventurous,
curiosity-driven, and should bring independent and original ideas into
the project. Any previous records of independent research as well as
productive interactions within a multi-disciplinary team environment
(e.g. first- and/or co-author publications in high profile journals) are
advantageous. Since the applicant will work in a multidisciplinary
environment the ability to work with other scientist and good
communication skills (proficiency in spoken and written English) are
Terms and conditions
The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.
your application and supporting documents through the Varbi recruitment
system. Use the button in the top right corner and follow the
Your application should contain the following documents:
- A personal letter and a curriculum vitae with contact details of three referees (English)
- Degree projects and previous publications, if any (English)
- Any other documentation showing the desirable skills and personal qualities described above (English)
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)
selection will be made among eligible applicants on the basis of the
ability to benefit from doctoral education. The qualifications of the
applicants will be evaluated on an overall basis.
KI uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject.
All applicants will be informed when the recruitment is completed.
Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.
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|Type of employment||PhD placement|
|Contract type||Full time|
|First day of employment||According to agreement|
|Number of positions||1|
|Contact||Claudia Kutter, email@example.com |
|Union representative||Niklas Andersson, OFR, firstname.lastname@example.orgHenry Wölling, SEKO, 08-524 840 80Biborka Bereczky Veress, SACO, 46 70-173 85 75 |
|Last application date||09.Sep.2019 11:59 PM CET|
Read the job description at the university homepage
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Post expires on Monday September 9th, 2019